{"id":"https://openalex.org/W2339690356","doi":null,"title":"Potential New Drugs in Lymphoma","display_name":"Potential New Drugs in Lymphoma","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2339690356","mag":"2339690356"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-280546","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280546","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039714899","display_name":"Maryam Delforoush","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maryam Delforoush","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039714899"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/picropodophyllin","display_name":"picropodophyllin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/igf1r-inhibition","display_name":"IGF1R inhibition","score":0.8830000162124634},{"id":"https://openalex.org/keywords/melflufen","display_name":"melflufen","score":0.9950000047683716},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":0.7639999985694885},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.8569999933242798},{"id":"https://openalex.org/keywords/usp14","display_name":"USP14","score":0.9639999866485596},{"id":"https://openalex.org/keywords/uchl5","display_name":"UCHL5","score":1.0},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5049999952316284},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.8709999918937683},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.8164243698120117},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.5884720683097839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48265939950942993},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45020925998687744},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4322133958339691},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35384654998779297},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23180899024009705},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09979099035263062}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-280546","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2339690356","doi":null,"is_oa":false,"landing_page_url":"https://diva-portal.org/smash/get/diva2:913920/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-280546","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":149,"referenced_works":["https://openalex.org/W25955319","https://openalex.org/W252068182","https://openalex.org/W817554668","https://openalex.org/W1486022931","https://openalex.org/W1495776442","https://openalex.org/W1504583071","https://openalex.org/W1540060031","https://openalex.org/W1599013943","https://openalex.org/W1728781233","https://openalex.org/W1859891679","https://openalex.org/W1886247904","https://openalex.org/W1901299664","https://openalex.org/W1916070238","https://openalex.org/W1964840824","https://openalex.org/W1965180444","https://openalex.org/W1968314156","https://openalex.org/W1968544465","https://openalex.org/W1971344938","https://openalex.org/W1976158386","https://openalex.org/W1979199037","https://openalex.org/W1979816280","https://openalex.org/W1981042444","https://openalex.org/W1983309704","https://openalex.org/W1985645817","https://openalex.org/W1987177036","https://openalex.org/W1987292510","https://openalex.org/W1988817337","https://openalex.org/W1992076386","https://openalex.org/W1995870656","https://openalex.org/W2006070956","https://openalex.org/W2006845846","https://openalex.org/W2009002059","https://openalex.org/W2009220642","https://openalex.org/W2009512645","https://openalex.org/W2010399667","https://openalex.org/W2014404730","https://openalex.org/W2014436895","https://openalex.org/W2014698797","https://openalex.org/W2017580443","https://openalex.org/W2017978260","https://openalex.org/W2018796139","https://openalex.org/W2019874087","https://openalex.org/W2020789296","https://openalex.org/W2021536610","https://openalex.org/W2021942056","https://openalex.org/W2026496528","https://openalex.org/W2027971058","https://openalex.org/W2028938256","https://openalex.org/W2030105242","https://openalex.org/W2031885687","https://openalex.org/W2035135710","https://openalex.org/W2035836563","https://openalex.org/W2037994583","https://openalex.org/W2038199574","https://openalex.org/W2038444072","https://openalex.org/W2041629407","https://openalex.org/W2044306036","https://openalex.org/W2045399297","https://openalex.org/W2046334248","https://openalex.org/W2051458654","https://openalex.org/W2051540789","https://openalex.org/W2055742427","https://openalex.org/W2057237017","https://openalex.org/W2057456103","https://openalex.org/W2058015212","https://openalex.org/W2059857139","https://openalex.org/W2060510604","https://openalex.org/W2061049933","https://openalex.org/W2061621597","https://openalex.org/W2062457956","https://openalex.org/W2062518754","https://openalex.org/W2062548737","https://openalex.org/W2065288309","https://openalex.org/W2066671159","https://openalex.org/W2067340670","https://openalex.org/W2067653691","https://openalex.org/W2071738118","https://openalex.org/W2074433596","https://openalex.org/W2079818523","https://openalex.org/W2082497184","https://openalex.org/W2086061986","https://openalex.org/W2087175804","https://openalex.org/W2089171551","https://openalex.org/W2089242301","https://openalex.org/W2090762862","https://openalex.org/W2091188527","https://openalex.org/W2093221289","https://openalex.org/W2094955298","https://openalex.org/W2108235397","https://openalex.org/W2108539626","https://openalex.org/W2110947561","https://openalex.org/W2111716055","https://openalex.org/W2114321011","https://openalex.org/W2117230954","https://openalex.org/W2118875599","https://openalex.org/W2122639773","https://openalex.org/W2122709209","https://openalex.org/W2126779872","https://openalex.org/W2129156541","https://openalex.org/W2132930280","https://openalex.org/W2134168335","https://openalex.org/W2134618140","https://openalex.org/W2136060045","https://openalex.org/W2136128861","https://openalex.org/W2136262994","https://openalex.org/W2136426653","https://openalex.org/W2136945691","https://openalex.org/W2136962826","https://openalex.org/W2137216850","https://openalex.org/W2138102966","https://openalex.org/W2138899183","https://openalex.org/W2139902096","https://openalex.org/W2140485109","https://openalex.org/W2140823047","https://openalex.org/W2141652450","https://openalex.org/W2147246240","https://openalex.org/W2148659964","https://openalex.org/W2150587745","https://openalex.org/W2150680216","https://openalex.org/W2153716391","https://openalex.org/W2153794129","https://openalex.org/W2154907045","https://openalex.org/W2155464214","https://openalex.org/W2157364449","https://openalex.org/W2158267770","https://openalex.org/W2160305510","https://openalex.org/W2160585059","https://openalex.org/W2162693374","https://openalex.org/W2165308914","https://openalex.org/W2168554267","https://openalex.org/W2169001502","https://openalex.org/W2169302611","https://openalex.org/W2170329898","https://openalex.org/W2170513194","https://openalex.org/W2170550731","https://openalex.org/W2172242534","https://openalex.org/W2216659987","https://openalex.org/W2256209050","https://openalex.org/W2257585231","https://openalex.org/W2274888609","https://openalex.org/W2276528744","https://openalex.org/W2279785667","https://openalex.org/W2293169917","https://openalex.org/W2305142474","https://openalex.org/W2346726371","https://openalex.org/W2395516240","https://openalex.org/W2402503908","https://openalex.org/W2414282448","https://openalex.org/W3161684974"],"related_works":["https://openalex.org/W817554668","https://openalex.org/W2952577661","https://openalex.org/W2139902096","https://openalex.org/W1950479217","https://openalex.org/W2100859832","https://openalex.org/W4200029042","https://openalex.org/W2979579528","https://openalex.org/W2606495220","https://openalex.org/W2548322658","https://openalex.org/W2983605676"],"abstract_inverted_index":{"Lymphomas":[0],"are":[1,12,51,329,340],"malignant":[2,78],"tumours":[3],"arising":[4],"from":[5],"cells":[6,88,128,189],"in":[7,89,134,153,159,181,193,197,207,237,251,264,280,296,313,320,347],"the":[8,24,29,97,108,121,233,245,257,265],"lymphatic":[9],"system.":[10],"They":[11],"classified":[13],"as":[14,190,192,307],"B-cell":[15,25,35],"lymphomas,":[16,26],"T-cell":[17],"lymphomas":[18,41],"and":[19,64,72,105,184,222,239,243,259,270,327,336],"Hodgkin":[20],"lymphoma":[21,36,127,188],"(HL).":[22],"Of":[23],"one":[27],"of":[28,75,100,111,124,147,172,175,187,213,235,256,272,275],"most":[30],"common":[31],"is":[32,149],"diffuse":[33],"large":[34],"(DLBCL).":[37],"Many":[38],"patients":[39,47,282],"with":[40,81,130,262,290],"can":[42],"be":[43,115,315],"successfully":[44],"treated":[45],"however":[46],"who":[48],"relapse":[49],"or":[50,83,161],"refractory":[52,162],"have":[53],"a":[54,70,138,145,154,194,202,210],"poor":[55],"prognosis,":[56],"warranting":[57],"further":[58,205,316],"investigations":[59],"to":[60,247],"identify":[61],"potential":[62,98,330,342],"targets":[63,309,343],"develop":[65],"novel":[66,211],"drugs.":[67],"Picropodophyllin":[68],"(PPP),":[69],"potent":[71],"selective":[73],"inhibitor":[74,212],"IGF-1R,":[76],"inhibits":[77,216],"cell":[79,182,241],"growth":[80,260],"low":[82,132],"no":[84],"toxicity":[85,133],"on":[86,126,293],"normal":[87],"preclinical":[90],"models.":[91],"In":[92,165,228,298],"paper":[93,166,229,299],"I,":[94],"we":[95,168,231,301],"investigated":[96,232],"benefits":[99],"using":[101],"PPP":[102,112,125],"against":[103],"DLBCL":[104,238,281],"found":[106],"that":[107,303,324],"anti-tumor":[109],"effects":[110,123],"might":[113],"possibly":[114],"explained":[116],"by":[117],"IGF-1R-unrelated":[118],"mechanism(s).":[119],"However,":[120],"inhibitory":[122],"together":[129],"its":[131],"vivo":[135],"makes":[136],"it":[137],"promising":[139],"drug":[140,334],"candidate":[141,203],"for":[142,204,286,310,332,344],"treatment.":[143,208,252],"Melflufen,":[144],"derivative":[146],"melphalan,":[148],"currently":[150],"being":[151,201],"evaluated":[152],"clinical":[155,273,333],"phase":[156],"I/II":[157],"trial":[158],"relapsed":[160],"multiple":[163],"myeloma.":[164],"II,":[167],"confirmed":[169],"previous":[170],"reports":[171],"superior":[173],"potency":[174],"melflufen":[176,199],"over":[177],"melphalan.":[178],"Being":[179],"active":[180],"lines":[183,242],"primary":[185],"cultures":[186],"well":[191],"xenograft":[195],"model":[196],"mice,":[198],"considered":[200],"evaluation":[206],"bAP-15,":[209],"proteasome":[214,258,276,294,311,345],"activity,":[215],"ubiquitin":[217,223],"specific":[218],"peptidase":[219],"14":[220],"(USP14)":[221],"carboxyl-terminal":[224],"hydrolase":[225],"L5":[226],"(UCHL5).":[227],"III,":[230],"activity":[234],"b-AP15":[236,328],"HL":[240],"compared":[244],"results":[246],"standard":[248],"drugs":[249],"used":[250],"Results":[253],"showed":[254],"inhibition":[255],"inhibition/cytotoxicity":[261],"IC50-values":[263],"micromolar":[266],"range.":[267],"Treatment":[268],"failure":[269],"lack":[271],"benefit":[274],"inhibitors":[277,295,312,346],"like":[278],"bortezomib":[279],"inspired":[283],"us":[284],"investigating":[285],"possible":[287],"new":[288,308,341],"targets,":[289],"major":[291],"focus":[292],"DLBCL.":[297,348],"IV,":[300],"suggested":[302],"UCHL5":[304,337],"and/or":[305,338],"USP14,":[306],"DLBCL,":[314],"evaluated.":[317],"The":[318],"findings":[319],"this":[321],"thesis":[322],"suggest":[323],"PPP,":[325],"Melflufen":[326],"candidates":[331],"development":[335],"USP14":[339]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
