{"id":"https://openalex.org/W2339104264","doi":"https://doi.org/10.1371/journal.pone.0152414","title":"Geographical and Ethnic Distributions of the MTHFR C677T, A1298C and MTRR A66G Gene Polymorphisms in Chinese Populations: A Meta-Analysis","display_name":"Geographical and Ethnic Distributions of the MTHFR C677T, A1298C and MTRR A66G Gene Polymorphisms in Chinese Populations: A Meta-Analysis","publication_year":2016,"publication_date":"2016-04-18","ids":{"openalex":"https://openalex.org/W2339104264","doi":"https://doi.org/10.1371/journal.pone.0152414","mag":"2339104264","pmid":"https://pubmed.ncbi.nlm.nih.gov/27089387","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4835080"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0152414","doi":"https://doi.org/10.1371/journal.pone.0152414","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0152414","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152414&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152414&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070156520","display_name":"Xingmin Wang","orcid":"https://orcid.org/0000-0001-5655-9012","observed_orcids":["https://orcid.org/0000-0001-5655-9012"]},"institutions":[{"id":"https://openalex.org/I4210090327","display_name":"Liuzhou Maternal and Child Health Hospital","ror":"https://ror.org/00fbwv278","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingmin Wang","raw_affiliation_strings":["Department of Gynecology, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China","institution_ids":["https://openalex.org/I4210090327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100554130","display_name":"Jinjian Fu","orcid":"https://orcid.org/0000-0003-1912-5885","observed_orcids":["https://orcid.org/0000-0003-1912-5885"]},"institutions":[{"id":"https://openalex.org/I4210090327","display_name":"Liuzhou Maternal and Child Health Hospital","ror":"https://ror.org/00fbwv278","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinjian Fu","raw_affiliation_strings":["Department of Gynecology, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China","institution_ids":["https://openalex.org/I4210090327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049762977","display_name":"Qianxi Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090327","display_name":"Liuzhou Maternal and Child Health Hospital","ror":"https://ror.org/00fbwv278","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianxi Li","raw_affiliation_strings":["Department of Gynecology, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China","institution_ids":["https://openalex.org/I4210090327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065298197","display_name":"Dingyuan Zeng","orcid":"https://orcid.org/0000-0002-4271-5632","observed_orcids":["https://orcid.org/0000-0002-4271-5632"]},"institutions":[{"id":"https://openalex.org/I4210090327","display_name":"Liuzhou Maternal and Child Health Hospital","ror":"https://ror.org/00fbwv278","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090327"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dingyuan Zeng","raw_affiliation_strings":["Department of Gynecology, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, China","institution_ids":["https://openalex.org/I4210090327"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065298197"],"corresponding_institution_ids":["https://openalex.org/I4210090327"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.965,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.66382979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"e0152414","last_page":"e0152414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mthfr-a1298c-polymorphism","display_name":"MTHFR A1298C polymorphism","score":0.996999979019165},{"id":"https://openalex.org/keywords/mtrr-a66g-polymorphism","display_name":"MTRR A66G polymorphism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/methylenetetrahydrofolate-reductase","display_name":"methylenetetrahydrofolate reductase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/methionine-synthase-reductase","display_name":"methionine synthase reductase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/folate-metabolism","display_name":"folate metabolism","score":0.7179999947547913},{"id":"https://openalex.org/keywords/genetic-polymorphism-frequency","display_name":"genetic polymorphism frequency","score":0.5709999799728394},{"id":"https://openalex.org/keywords/regional-variation","display_name":"regional variation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.7279999852180481},{"id":"https://openalex.org/keywords/allele-and-genotype-frequencies","display_name":"genotype and allele frequencies","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2778087339","wikidata":"https://www.wikidata.org/wiki/Q18029587","display_name":"MTRR","level":5,"score":0.9711966514587402},{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.8769226670265198},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6871325969696045},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.5694692134857178},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5326870083808899},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5124562382698059},{"id":"https://openalex.org/C107029721","wikidata":"https://www.wikidata.org/wiki/Q19188","display_name":"Mainland China","level":3,"score":0.48682302236557007},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.48565948009490967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4188048541545868},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4157964885234833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3093799948692322},{"id":"https://openalex.org/C191935318","wikidata":"https://www.wikidata.org/wiki/Q148","display_name":"China","level":2,"score":0.28049129247665405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.239704430103302},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20064452290534973},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.19601139426231384},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005287","descriptor_name":"Ferredoxin-NADP Reductase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005843","descriptor_name":"Geography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0152414","doi":"https://doi.org/10.1371/journal.pone.0152414","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0152414","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152414&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmid:27089387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27089387","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4835080","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4835080/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:061e64c19d064a43b6322b0549cd939f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/061e64c19d064a43b6322b0549cd939f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 4, p e0152414 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/3182809","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Geographical_and_Ethnic_Distributions_of_the_MTHFR_C677T_A1298C_and_MTRR_A66G_Gene_Polymorphisms_in_Chinese_Populations_A_Meta_Analysis/3182809","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0152414","doi":"https://doi.org/10.1371/journal.pone.0152414","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0152414","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0152414&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2339104264.pdf","grobid_xml":"https://content.openalex.org/works/W2339104264.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1465021535","https://openalex.org/W1560343627","https://openalex.org/W1931181957","https://openalex.org/W1963595709","https://openalex.org/W1964435302","https://openalex.org/W1973562097","https://openalex.org/W1976205360","https://openalex.org/W1985645468","https://openalex.org/W1998319251","https://openalex.org/W2000432796","https://openalex.org/W2003261053","https://openalex.org/W2007426167","https://openalex.org/W2022236323","https://openalex.org/W2022732874","https://openalex.org/W2031153354","https://openalex.org/W2031262735","https://openalex.org/W2041569847","https://openalex.org/W2044170424","https://openalex.org/W2060462654","https://openalex.org/W2066461313","https://openalex.org/W2069806334","https://openalex.org/W2070446449","https://openalex.org/W2123906001","https://openalex.org/W2125435699","https://openalex.org/W2126930838","https://openalex.org/W2129606441","https://openalex.org/W2129669525","https://openalex.org/W2133906445","https://openalex.org/W2136312140","https://openalex.org/W2141188445","https://openalex.org/W2141348444","https://openalex.org/W2144717748","https://openalex.org/W2155638653","https://openalex.org/W2157823046","https://openalex.org/W2157862480","https://openalex.org/W2163749485","https://openalex.org/W2185596274","https://openalex.org/W2348521507","https://openalex.org/W2348703453","https://openalex.org/W2352964428","https://openalex.org/W2355446994","https://openalex.org/W2358308792","https://openalex.org/W2360224873","https://openalex.org/W2361753943","https://openalex.org/W2362282322","https://openalex.org/W2363389193","https://openalex.org/W2367268935","https://openalex.org/W2368335614","https://openalex.org/W2368403023","https://openalex.org/W2369336902","https://openalex.org/W2374147243","https://openalex.org/W2376230681","https://openalex.org/W2378571413","https://openalex.org/W2379071012","https://openalex.org/W2383048556","https://openalex.org/W2385189444","https://openalex.org/W2386142294","https://openalex.org/W2388493236","https://openalex.org/W2389744922","https://openalex.org/W2390425306","https://openalex.org/W2392877114","https://openalex.org/W2393555363","https://openalex.org/W2414613443","https://openalex.org/W2430740380","https://openalex.org/W2472250032","https://openalex.org/W2978557000","https://openalex.org/W4211145790","https://openalex.org/W7039377716"],"related_works":["https://openalex.org/W1973562097","https://openalex.org/W1998319251","https://openalex.org/W2554495961","https://openalex.org/W2558963268","https://openalex.org/W4400787356","https://openalex.org/W2368403023","https://openalex.org/W1465021535","https://openalex.org/W2063255046","https://openalex.org/W3026296095","https://openalex.org/W2905043892"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,27,81,98,120,146,165],"geographical":[2,144,191],"and":[3,14,16,41,106,131,142,152,172,192,202],"ethnic":[4,140,193],"distributions":[5,65],"of":[6,29,38,44,66,88,92,116,126,148,167,198],"the":[7,35,39,64,89,93,124,127,149,157,168,177,181,196,199,207],"polymorphic":[8],"methylenetetrahydrofolate":[9],"reductase":[10,19],"(MTHFR)":[11],"mutations":[12],"(C677T":[13],"A1298C)":[15],"methionine":[17],"synthase":[18],"(MTRR)":[20],"mutation":[21],"(A66G)":[22],"remain":[23],"heterogeneous":[24],"in":[25,51,70,75,195,206],"China.":[26,53],"goal":[28],"this":[30],"study":[31,118],"was":[32],"to":[33],"estimate":[34],"pooled":[36],"frequencies":[37,125,147,166,197],"alleles":[40],"associated":[42],"genotypes":[43,174],"these":[45],"gene":[46,134,204],"polymorphisms":[47,135,205],"among":[48,211],"healthy":[49,72],"populations":[50,73],"Mainland":[52,76,161],"OBJECTIVE":[54],"AND":[55],"METHODS:":[56],"We":[57],"systematically":[58],"reviewed":[59],"published":[60],"epidemiological":[61],"studies":[62,110],"on":[63],"3":[67],"genetic":[68],"variants":[69],"Chinese":[71,212],"living":[74],"China":[77,162],"through":[78],"a":[79,114],"meta-analysis.":[80],"relevant":[82],"electronic":[83],"databases":[84],"were":[85,96,101,111],"searched.":[86],"All":[87],"raw":[90],"data":[91],"eligible":[94],"citations":[95],"extracted.":[97],"frequency":[99],"estimates":[100],"stratified":[102],"by":[103],"geography,":[104],"ethnicity":[105],"sex.":[107],"RESULTS:":[108],"Sixty-six":[109],"identified":[112],"with":[113],"total":[115],"92277":[117],"participants.":[119],"meta-analysis":[121,187],"revealed":[122],"that":[123],"MTHFR":[128],"C677T,":[129,200],"A1298C,":[130,201],"MTRR":[132],"A66G":[133,203],"varied":[136],"significantly":[137],"between":[138],"different":[139],"groups":[141],"along":[143,156,176],"gradients.":[145],"677T":[150],"allele":[151],"677TT":[153],"genotype":[154],"increased":[155],"southern-central-northern":[158],"direction":[159,179],"across":[160,180],"(all":[163,183],"Pvalues\u22640.001).":[164,184],"1298C,":[169],"1298CC,":[170],"66G":[171],"66GG":[173],"decreased":[175],"south-central-north":[178],"country":[182],"CONCLUSIONS:":[185],"Our":[186],"strongly":[188],"indicates":[189],"significant":[190],"variations":[194],"folate":[208],"metabolism":[209],"pathway":[210],"populations.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
