{"id":"https://openalex.org/W2338780225","doi":null,"title":"[Absorption and pharmacokinetics of radix rehmanniae in rats].","display_name":"[Absorption and pharmacokinetics of radix rehmanniae in rats].","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2338780225","mag":"2338780225","pmid":"https://pubmed.ncbi.nlm.nih.gov/24358782"},"language":"zh","primary_location":{"id":"pmid:24358782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24358782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yao xue xue bao = Acta pharmaceutica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101968371","display_name":"Jie Zhong","orcid":"https://orcid.org/0000-0003-0147-9781","observed_orcids":["https://orcid.org/0000-0003-0147-9781","https://orcid.org/0009-0009-7910-5430"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhong","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhao-dan Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhao-dan Tan","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762629","display_name":"Tianming Wang","orcid":"https://orcid.org/0000-0002-9232-6192","observed_orcids":["https://orcid.org/0000-0002-9232-6192"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian-ming Wang","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101685439","display_name":"Rong Shi","orcid":"https://orcid.org/0000-0001-5884-6023","observed_orcids":["https://orcid.org/0000-0001-5884-6023"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Shi","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yue-ming Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue-ming Ma","raw_affiliation_strings":["School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China","institution_ids":["https://openalex.org/I4210098460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210098460"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.28436158,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"48","issue":"9","first_page":"1464","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9585000276565552,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rehmanniae-radix","display_name":"Radix Rehmanniae","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9390000104904175},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.7059999704360962},{"id":"https://openalex.org/keywords/catalpol","display_name":"catalpol","score":0.9240000247955322},{"id":"https://openalex.org/keywords/aucubin","display_name":"aucubin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ajugol","display_name":"ajugol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/plasma-drug-quantitation","display_name":"plasma drug quantification","score":0.5920000076293945},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.8009999990463257},{"id":"https://openalex.org/keywords/rat-plasma","display_name":"rat plasma","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2776160005","wikidata":"https://www.wikidata.org/wiki/Q1050267","display_name":"Catalpol","level":3,"score":0.9828017950057983},{"id":"https://openalex.org/C2779632648","wikidata":"https://www.wikidata.org/wiki/Q418014","display_name":"Aucubin","level":4,"score":0.8589168787002563},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.774627685546875},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7535810470581055},{"id":"https://openalex.org/C2779091547","wikidata":"https://www.wikidata.org/wiki/Q287565","display_name":"Radix (gastropod)","level":2,"score":0.7359877228736877},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.7287148833274841},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6129944920539856},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5459091663360596},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.5306552648544312},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4869907796382904},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.41866233944892883},{"id":"https://openalex.org/C2778413156","wikidata":"https://www.wikidata.org/wiki/Q416840","display_name":"Iridoid","level":3,"score":0.3720020055770874},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.13058879971504211},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.11356392502784729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09389975666999817},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011714","descriptor_name":"Pyrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032267","descriptor_name":"Rehmannia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057888","descriptor_name":"Iridoid Glucosides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D057888","descriptor_name":"Iridoid Glucosides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D057888","descriptor_name":"Iridoid Glucosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057889","descriptor_name":"Iridoid Glycosides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D057889","descriptor_name":"Iridoid Glycosides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D057889","descriptor_name":"Iridoid Glycosides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24358782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24358782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Yao xue xue bao = Acta pharmaceutica Sinica","raw_type":"Journal Article"},{"id":"mag:2338780225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24358782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W149122395","https://openalex.org/W1489601464","https://openalex.org/W1513403182","https://openalex.org/W1975462840","https://openalex.org/W2007340717","https://openalex.org/W2008280722","https://openalex.org/W2015746346","https://openalex.org/W2019266385","https://openalex.org/W2021188598","https://openalex.org/W2027454658","https://openalex.org/W2031860429","https://openalex.org/W2076662047","https://openalex.org/W2078093423","https://openalex.org/W2096238685","https://openalex.org/W2105649494","https://openalex.org/W2135732933","https://openalex.org/W2182593958","https://openalex.org/W2320733175","https://openalex.org/W2351604558","https://openalex.org/W2368163776","https://openalex.org/W2380139322","https://openalex.org/W2382401149"],"related_works":["https://openalex.org/W2349638362","https://openalex.org/W2378745922","https://openalex.org/W2389056424","https://openalex.org/W2360801959","https://openalex.org/W2352602864","https://openalex.org/W4383302100","https://openalex.org/W2362074063","https://openalex.org/W250194552","https://openalex.org/W1988219309","https://openalex.org/W2069321469"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"absorption":[3],"and":[4,35,47,54,78,88,90,126,130,136,146,154,171,175,179],"pharmacokinetic":[5,102],"study":[6,103],"of":[7,29,40,69,104,113,128],"Radix":[8,43,65,118],"Rehmanniae":[9,119],"was":[10,108,165],"studied":[11],"by":[12],"liquid":[13],"chromatography":[14],"coupled":[15],"with":[16],"mass":[17],"spectrometry":[18],"method":[19,85,92],"after":[20,110],"oral":[21,111],"administration":[22,112],"to":[23,58,122],"rats.":[24,123],"By":[25],"comparing":[26],"the":[27,60],"chromatograms":[28],"ultraviolet,":[30],"full":[31],"scan,":[32],"extracted":[33],"ion":[34],"selective":[36],"reaction":[37],"monitoring":[38],"(SRM)":[39],"standard":[41],"solution,":[42],"Rehmanniae,":[44],"blank":[45],"plasma":[46,49,98],"rat":[48,97],"post":[50],"drug":[51],"administration,":[52],"catalpol":[53,87,129,170,174],"ajugol":[55,131,176],"were":[56,81,99,132,177],"found":[57],"be":[59],"main":[61],"compounds":[62,95],"absorbed":[63,106,178],"from":[64],"Rehmanniae.":[66],"Plasma":[67],"concentrations":[68],"aucubin,":[70],"dihydrocatalpol,":[71],"rehmannioside":[72,75,79],"A":[73],"(or":[74],"B/":[76],"melittoside)":[77],"D":[80],"very":[82],"low.":[83],"Quantitative":[84],"for":[86,93,169],"aucubin":[89],"semi-quantitative":[91],"other":[94],"in":[96],"established.":[100],"The":[101],"those":[105],"components":[107],"conducted":[109],"6":[114],"g":[115],"x":[116,141,159,161],"kg(-1)":[117],"water":[120],"extract":[121],"Cmax,":[124],"t(1/2)":[125],"AUC(0-infinity)":[127],"(2349.05":[133],"+/-":[134,138,144,148,152,156],"1438.34)":[135],"(104.25":[137],"82.05)":[139],"ng":[140,158],"mL(-1),":[142,162],"(0.86":[143],"0.32)":[145],"(0.96":[147],"0.37)":[149],"h,":[150],"(4407.58":[151],"2734.89)":[153],"(226.66":[155],"188.38)":[157],"h":[160,168],"respectively.":[163],"tmax":[164],"at":[166],"1.00":[167],"ajugol.":[172],"Both":[173],"excreted":[180],"rapidly.":[181]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
