{"id":"https://openalex.org/W2338765899","doi":"https://doi.org/10.1152/ajpcell.1993.265.1.c47","title":"Stimulation of the slow calcium current in bullfrog skeletal muscle fibers by cAMP and cGMP","display_name":"Stimulation of the slow calcium current in bullfrog skeletal muscle fibers by cAMP and cGMP","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W2338765899","doi":"https://doi.org/10.1152/ajpcell.1993.265.1.c47","mag":"2338765899","pmid":"https://pubmed.ncbi.nlm.nih.gov/8393285"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1993.265.1.c47","doi":"https://doi.org/10.1152/ajpcell.1993.265.1.c47","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1993.265.1.c47","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079707680","display_name":"Tushar G. Kokate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. G. Kokate","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Cincinnati,College of Medicine, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Cincinnati,College of Medicine, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039090382","display_name":"Judith A. Heiny","orcid":"https://orcid.org/0000-0001-8206-1111","observed_orcids":["https://orcid.org/0000-0001-8206-1111"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. A. Heiny","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Cincinnati,College of Medicine, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Cincinnati,College of Medicine, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109128802","display_name":"Nicholas Sperelakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Sperelakis","raw_affiliation_strings":["Department of Physiology and Biophysics, University of Cincinnati,College of Medicine, Ohio 45267-0576"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, University of Cincinnati,College of Medicine, Ohio 45267-0576","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":1.4155,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.82252964,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"265","issue":"1","first_page":"C47","last_page":"C53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slow-calcium-current","display_name":"slow calcium current","score":0.9779999852180481},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.9950000047683716},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.46399998664855957},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8180000185966492},{"id":"https://openalex.org/keywords/beta-adrenergic-stimulation","display_name":"beta-adrenergic stimulation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/current-voltage-characteristics","display_name":"current-voltage characteristics","score":0.9380000233650208},{"id":"https://openalex.org/keywords/channel-modulation","display_name":"channel modulation","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2776020765","wikidata":"https://www.wikidata.org/wiki/Q54087553","display_name":"Bullfrog","level":2,"score":0.9335616827011108},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5998713374137878},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5574013590812683},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5545185208320618},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5259687900543213},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4691430926322937},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.46452295780181885},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43666499853134155},{"id":"https://openalex.org/C2777995097","wikidata":"https://www.wikidata.org/wiki/Q422462","display_name":"Guanosine","level":2,"score":0.4335973262786865},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.41903257369995117},{"id":"https://openalex.org/C2780994212","wikidata":"https://www.wikidata.org/wiki/Q422511","display_name":"Cyclic guanosine monophosphate","level":3,"score":0.41317862272262573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34154409170150757},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.32419610023498535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17887800931930542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09810850024223328},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011892","descriptor_name":"Rana catesbeiana","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpcell.1993.265.1.c47","doi":"https://doi.org/10.1152/ajpcell.1993.265.1.c47","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1993.265.1.c47","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:8393285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8393285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.935.9573","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.935.9573","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajpcell.physiology.org/content/ajpcell/265/1/C47.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1722671133","display_name":null,"funder_award_id":"AR-40243","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4574220777","display_name":null,"funder_award_id":"HL 22619","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7215919793","display_name":"OPTICAL STUDIES OF T-SYSTEM FUNCTION IN E-C COUPLING","funder_award_id":"5r01ar040243-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7798019519","display_name":"MOLECULAR MECHANISMS OF HEART FAILURE","funder_award_id":"P01HL022619","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W152157807","https://openalex.org/W940147798","https://openalex.org/W1495691424","https://openalex.org/W1972583385","https://openalex.org/W1974164985","https://openalex.org/W1983873507","https://openalex.org/W1984120106","https://openalex.org/W1985715879","https://openalex.org/W1990536199","https://openalex.org/W2009292667","https://openalex.org/W2044315058","https://openalex.org/W2044539288","https://openalex.org/W2052733759","https://openalex.org/W2053034856","https://openalex.org/W2061102484","https://openalex.org/W2061839869","https://openalex.org/W2070560195","https://openalex.org/W2085550628","https://openalex.org/W2095196015","https://openalex.org/W2115749066","https://openalex.org/W2118782930","https://openalex.org/W2131310568","https://openalex.org/W2131649189","https://openalex.org/W2134921936","https://openalex.org/W2135944328","https://openalex.org/W2142027022","https://openalex.org/W2150530454","https://openalex.org/W2160903407"],"related_works":["https://openalex.org/W2118782930","https://openalex.org/W2135944328","https://openalex.org/W2417504645","https://openalex.org/W2465776762","https://openalex.org/W2048990297","https://openalex.org/W1982004318","https://openalex.org/W1994278460","https://openalex.org/W2474920060","https://openalex.org/W2141064996","https://openalex.org/W1755579335"],"abstract_inverted_index":{"The":[0,64,79,100,146],"effects":[1,81,97,171],"of":[2,41,49,82,92,113,143,148],"adenosine":[3],"3',5'-cyclic":[4,9],"monophosphate":[5,10],"(cAMP)":[6],"and":[7,32,84,115,130,182],"guanosine":[8],"(cGMP)":[11],"on":[12,86,98,151,172],"slow":[13,134,174,186],"calcium":[14,133],"currents":[15],"(ICa)":[16],"were":[17,88],"investigated":[18],"using":[19],"the":[20,39,46,111,121,144,166,173,185],"Vaseline-gap":[21],"voltage-clamp":[22],"technique":[23],"in":[24,38,110,120,136,153,160,164,177],"bullfrog":[25,137,154],"skeletal":[26,138,155],"muscle":[27,139,156,179],"cut":[28,47],"fibers.":[29,50],"Both":[30,51],"cAMP":[31,74,83,129,180],"cGMP":[33,85,131,183],"induced":[34],"a":[35,117],"pronounced":[36],"increase":[37,109],"amplitude":[40,112],"ICa":[42,87,114,152],"when":[43],"applied":[44,104],"to":[45,57],"ends":[48],"cyclic":[52,149],"nucleotides":[53,94,150,168],"also":[54,106],"decreased":[55],"time":[56],"peak":[58],"current":[59],"at":[60],"all":[61],"membrane":[62],"potentials.":[63],"current-voltage":[65,122],"relationship":[66],"was":[67],"shifted":[68],"toward":[69],"more":[70],"negative":[71],"potentials":[72],"by":[73],"as":[75,77],"well":[76],"cGMP.":[78],"potentiating":[80],"additive.":[89],"8-Bromo":[90],"analogues":[91],"both":[93,128],"had":[95],"similar":[96],"ICa.":[99,145,187],"beta-adrenergic":[101],"agonist":[102],"isoproterenol,":[103],"extracellularly,":[105],"produced":[107,116],"an":[108],"leftward":[118],"shift":[119],"relationship.":[123],"These":[124],"results":[125],"suggest":[126],"that":[127,159],"modulate":[132],"channels":[135],"fibers,":[140],"causing":[141],"stimulation":[142],"effect":[147],"contrasts":[157],"with":[158],"mammalian":[161],"cardiac":[162,178],"muscle,":[163],"which":[165],"same":[167],"produce":[169],"opposite":[170],"ICa,":[175],"i.e.,":[176],"stimulates,":[181],"inhibits,":[184]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}