{"id":"https://openalex.org/W2338762004","doi":"https://doi.org/10.1182/blood.v122.21.400.400","title":"Genomic Comparison Of Clonal B-Cells In Waldenstrom Macroglobulinemia (WM) Versus IgM MGUS","display_name":"Genomic Comparison Of Clonal B-Cells In Waldenstrom Macroglobulinemia (WM) Versus IgM MGUS","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2338762004","doi":"https://doi.org/10.1182/blood.v122.21.400.400","mag":"2338762004"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.400.400","doi":"https://doi.org/10.1182/blood.v122.21.400.400","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.400.400","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057189669","display_name":"Bruno Paiva","orcid":"https://orcid.org/0000-0003-1977-3815","observed_orcids":["https://orcid.org/0000-0003-1977-3815","https://orcid.org/0000-0002-0128-8849"]},"institutions":[{"id":"https://openalex.org/I4210134045","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca","ror":"https://ror.org/03em6xj44","country_code":"ES","type":"facility","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034","https://openalex.org/I4210134045"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Bruno Paiva","raw_affiliation_strings":["Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain,","institution_ids":["https://openalex.org/I4210134045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004453681","display_name":"Luis Antonio Corchete","orcid":"https://orcid.org/0000-0003-4577-8599","observed_orcids":["https://orcid.org/0000-0003-4577-8599"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210138819","display_name":"Centro de Investigaci\u00f3n del C\u00e1ncer","ror":"https://ror.org/04rxrdv16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819"]},{"id":"https://openalex.org/I4388891778","display_name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer de Salamanca","ror":"https://ror.org/043vr8e29","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4388891778"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Luis A Corchete","raw_affiliation_strings":["Centro de Investigaci\u00f3n del C\u00e1ncer, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer/Consejo Superior de Investigaciones Cient\u00edficas-Universidad de Salamanca, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n del C\u00e1ncer, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer/Consejo Superior de Investigaciones Cient\u00edficas-Universidad de Salamanca, Salamanca, Spain,","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210138819","https://openalex.org/I4388891778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047866471","display_name":"Norma Carmen Gutierrez","orcid":"https://orcid.org/0000-0001-5834-9510","observed_orcids":["https://orcid.org/0000-0001-5834-9510"]},"institutions":[{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Norma Gutierrez","raw_affiliation_strings":["Hematology, Hospital Universitario de Salamanca, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital Universitario de Salamanca, Salamanca, Spain,","institution_ids":["https://openalex.org/I4210099034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069753479","display_name":"Mar\u00eda\u2010Bel\u00e9n V\u00eddriales","orcid":"https://orcid.org/0000-0001-5049-3673","observed_orcids":["https://orcid.org/0000-0001-5049-3673"]},"institutions":[{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Mar\u00eda-Bel\u00e9n Vidriales","raw_affiliation_strings":["Hospital Universitario de Salamanca, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Salamanca, Salamanca, Spain,","institution_ids":["https://openalex.org/I4210099034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032268486","display_name":"Irene Aires\u2010Mej\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210134045","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca","ror":"https://ror.org/03em6xj44","country_code":"ES","type":"facility","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034","https://openalex.org/I4210134045"]},{"id":"https://openalex.org/I4388891778","display_name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer de Salamanca","ror":"https://ror.org/043vr8e29","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4388891778"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Irene Aires-Mejia","raw_affiliation_strings":["IBSAL, IBMCC (USAL-CSIC), Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBSAL, IBMCC (USAL-CSIC), Salamanca, Spain,","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210134045","https://openalex.org/I4388891778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103453418","display_name":"Mar\u00eda Luz S\u00e1nchez","orcid":"https://orcid.org/0009-0004-8048-4259","observed_orcids":["https://orcid.org/0009-0004-8048-4259"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Maria Luz Sanchez","raw_affiliation_strings":["Servicio General de Citometr\u00eda y Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio General de Citometr\u00eda y Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain,","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034728534","display_name":"Paloma B\u00e1rcena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Paloma Barcena","raw_affiliation_strings":["Servicio General de Citometr\u00eda y Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio General de Citometr\u00eda y Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain,","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032091177","display_name":"Cristina Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-5543-5154","observed_orcids":["https://orcid.org/0000-0002-5543-5154"]},"institutions":[{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Cristina Jimenez","raw_affiliation_strings":["Hospital Clinico de Salamanca, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinico de Salamanca, Salamanca, Spain,","institution_ids":["https://openalex.org/I4210099034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059482051","display_name":"Ram\u00f3n Garc\u00eda\u2010S\u00e1nz","orcid":"https://orcid.org/0000-0003-4120-2787","observed_orcids":["https://orcid.org/0000-0003-4120-2787"]},"institutions":[{"id":"https://openalex.org/I4210099034","display_name":"Complejo Hospitalario de Salamanca","ror":"https://ror.org/0131vfw26","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ramon Garcia-Sanz","raw_affiliation_strings":["Hospital Clinico de Salamanca, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinico de Salamanca, Salamanca, Spain,","institution_ids":["https://openalex.org/I4210099034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008759843","display_name":"Enrique M. Ocio","orcid":"https://orcid.org/0000-0002-5765-0085","observed_orcids":["https://orcid.org/0000-0002-5765-0085"]},"institutions":[{"id":"https://openalex.org/I4210134045","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca","ror":"https://ror.org/03em6xj44","country_code":"ES","type":"facility","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034","https://openalex.org/I4210134045"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Enrique M. Ocio","raw_affiliation_strings":["Hospital Universitario de Salamanca - IBSAL, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Salamanca - IBSAL, Salamanca, Spain,","institution_ids":["https://openalex.org/I4210134045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036725271","display_name":"Fernando Escalante","orcid":"https://orcid.org/0000-0003-4501-9066","observed_orcids":["https://orcid.org/0000-0003-4501-9066"]},"institutions":[{"id":"https://openalex.org/I4210160075","display_name":"Hospital Universitario de Le\u00f3n","ror":"https://ror.org/05gn84d31","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210160075"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Fernando Escalante","raw_affiliation_strings":["Complejo Hospitalario de Le\u00f3n, Leon, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complejo Hospitalario de Le\u00f3n, Leon, Spain,","institution_ids":["https://openalex.org/I4210160075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041612097","display_name":"Jos\u00e9\u2010\u00c1ngel Hern\u00e1ndez\u2010Rivas","orcid":"https://orcid.org/0000-0003-4550-757X","observed_orcids":["https://orcid.org/0000-0003-4550-757X"]},"institutions":[{"id":"https://openalex.org/I4210087353","display_name":"Hospital General De Segovia","ror":"https://ror.org/004qj2391","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210087353","https://openalex.org/I4210123620"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jose Hernandez","raw_affiliation_strings":["Hospital General de Segovia, Segovia, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital General de Segovia, Segovia, Spain,","institution_ids":["https://openalex.org/I4210087353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046467543","display_name":"Rebeca Cuello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157802","display_name":"Hospital Cl\u00ednico Universitario de Valladolid","ror":"https://ror.org/04fffmj41","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210157802"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Rebeca Cuello","raw_affiliation_strings":["Hematology, Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain,","institution_ids":["https://openalex.org/I4210157802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059635260","display_name":"Alfonso Garc\u00eda de Coca","orcid":"https://orcid.org/0000-0002-4942-060X","observed_orcids":["https://orcid.org/0000-0002-4942-060X"]},"institutions":[{"id":"https://openalex.org/I4210157802","display_name":"Hospital Cl\u00ednico Universitario de Valladolid","ror":"https://ror.org/04fffmj41","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210157802"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Alfonso Garcia de Coca","raw_affiliation_strings":["Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain,","institution_ids":["https://openalex.org/I4210157802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108495326","display_name":"Magdalena Sierra","orcid":"https://orcid.org/0009-0006-4292-4991","observed_orcids":["https://orcid.org/0009-0006-4292-4991"]},"institutions":[{"id":"https://openalex.org/I4210128281","display_name":"Hospital Virgen de la Concha","ror":"https://ror.org/02bhk3j29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210128281"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Magdalena Sierra","raw_affiliation_strings":["Hematology, Hospital Virgen de la Concha, Zamora, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital Virgen de la Concha, Zamora, Spain,","institution_ids":["https://openalex.org/I4210128281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067074864","display_name":"Maria-Carmen Montes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128281","display_name":"Hospital Virgen de la Concha","ror":"https://ror.org/02bhk3j29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210128281"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Maria-Carmen Montes","raw_affiliation_strings":["Hospital Virgen de la Concha, Zamora, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Virgen de la Concha, Zamora, Spain,","institution_ids":["https://openalex.org/I4210128281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068600380","display_name":"Tom\u00e1s Jos\u00e9 Gonz\u00e1lez\u2010L\u00f3pez","orcid":"https://orcid.org/0000-0001-9575-1816","observed_orcids":["https://orcid.org/0000-0001-9575-1816","https://orcid.org/0000-0003-2458-2554"]},"institutions":[{"id":"https://openalex.org/I4210115949","display_name":"Hospital Universitario de Burgos","ror":"https://ror.org/01j5v0d02","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115949"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Tomas Jose Gonzalez-Lopez","raw_affiliation_strings":["Hematology Service, Hospital Universitario de Burgos, Burgos, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Service, Hospital Universitario de Burgos, Burgos, Spain,","institution_ids":["https://openalex.org/I4210115949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079149467","display_name":"Josefina Galende","orcid":"https://orcid.org/0000-0001-6542-4961","observed_orcids":["https://orcid.org/0000-0001-6542-4961"]},"institutions":[{"id":"https://openalex.org/I4210120075","display_name":"Hospital El Bierzo","ror":"https://ror.org/028d75n58","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210120075"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Josefina Galende","raw_affiliation_strings":["Hospital Comarcal del Bierzo, Ponferrada, Ponferrada, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Comarcal del Bierzo, Ponferrada, Ponferrada, Spain,","institution_ids":["https://openalex.org/I4210120075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022580411","display_name":"Abelardo B\u00e1rez","orcid":"https://orcid.org/0000-0001-8982-6105","observed_orcids":["https://orcid.org/0000-0001-8982-6105"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Abelardo B\u00e1rez","raw_affiliation_strings":["Hospital Ntra Sra de Sonsoles, \u00c1vila, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Ntra Sra de Sonsoles, \u00c1vila, Spain,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103732042","display_name":"Jos\u00e9 Mar\u00eda Alonso","orcid":"https://orcid.org/0000-0002-1433-5616","observed_orcids":["https://orcid.org/0000-0002-1433-5616"]},"institutions":[{"id":"https://openalex.org/I4210114784","display_name":"Hospital Rio Carrion","ror":"https://ror.org/02atpex25","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114784"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jose M Alonso","raw_affiliation_strings":["Hematology, Hospital R\u00edo Carri\u00f3n, Palencia, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital R\u00edo Carri\u00f3n, Palencia, Spain,","institution_ids":["https://openalex.org/I4210114784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080587560","display_name":"Emilia Pardal","orcid":"https://orcid.org/0000-0001-7712-7876","observed_orcids":["https://orcid.org/0000-0001-7712-7876"]},"institutions":[{"id":"https://openalex.org/I4210161885","display_name":"Hospital Virgen del Puerto","ror":"https://ror.org/05peke140","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210161885"]},{"id":"https://openalex.org/I4405267187","display_name":"Grupo Espa\u00f1ol de Linfomas y Trasplante Aut\u00f3logo de M\u00e9dula \u00d3sea","ror":"https://ror.org/01jptam04","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4405267187"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Emilia Pardal","raw_affiliation_strings":["Hospital Virgen del Puerto, GELTAMO, Plasencia, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Virgen del Puerto, GELTAMO, Plasencia, Spain,","institution_ids":["https://openalex.org/I4210161885","https://openalex.org/I4405267187"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088409474","display_name":"Alberto \u00d3rf\u00e3o","orcid":"https://orcid.org/0000-0002-0007-7230","observed_orcids":["https://orcid.org/0000-0002-0007-7230"]},"institutions":[{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Alberto Orfao","raw_affiliation_strings":["Servicio General de Citometr\u00eda y Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio General de Citometr\u00eda y Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain,","institution_ids":["https://openalex.org/I184999862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029159537","display_name":"Mar\u00eda\u2010Victoria Mateos","orcid":"https://orcid.org/0000-0003-2390-1218","observed_orcids":["https://orcid.org/0000-0003-2390-1218"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I184999862","display_name":"Universidad de Salamanca","ror":"https://ror.org/02f40zc51","country_code":"ES","type":"education","lineage":["https://openalex.org/I184999862"]},{"id":"https://openalex.org/I4210134045","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca","ror":"https://ror.org/03em6xj44","country_code":"ES","type":"facility","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034","https://openalex.org/I4210134045"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria-Victoria Mateos","raw_affiliation_strings":["Hospital Universitario Salamanca, IBSAL, IBMCC (USAL-CSIC), Salamanca, Spain,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Salamanca, IBSAL, IBMCC (USAL-CSIC), Salamanca, Spain,","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210134045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020989412","display_name":"Jes\u00fas F. San Miguel","orcid":"https://orcid.org/0000-0002-9183-4857","observed_orcids":["https://orcid.org/0000-0002-9183-4857"]},"institutions":[{"id":"https://openalex.org/I4210134045","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca","ror":"https://ror.org/03em6xj44","country_code":"ES","type":"facility","lineage":["https://openalex.org/I184999862","https://openalex.org/I4210099034","https://openalex.org/I4210134045"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jesus F San Miguel","raw_affiliation_strings":["Hematology, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Hospital Universitario de Salamanca-IBSAL, Salamanca, Spain","institution_ids":["https://openalex.org/I4210134045"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5004453681","https://openalex.org/A5008759843","https://openalex.org/A5022580411","https://openalex.org/A5032091177","https://openalex.org/A5032268486","https://openalex.org/A5034728534","https://openalex.org/A5036725271","https://openalex.org/A5041612097","https://openalex.org/A5046467543","https://openalex.org/A5047866471","https://openalex.org/A5057189669","https://openalex.org/A5059482051","https://openalex.org/A5059635260","https://openalex.org/A5067074864","https://openalex.org/A5068600380","https://openalex.org/A5069753479","https://openalex.org/A5079149467","https://openalex.org/A5080587560","https://openalex.org/A5088409474","https://openalex.org/A5103453418","https://openalex.org/A5103732042","https://openalex.org/A5108495326"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I184999862","https://openalex.org/I4210087353","https://openalex.org/I4210099034","https://openalex.org/I4210114784","https://openalex.org/I4210115949","https://openalex.org/I4210120075","https://openalex.org/I4210128281","https://openalex.org/I4210134045","https://openalex.org/I4210138819","https://openalex.org/I4210157802","https://openalex.org/I4210160075","https://openalex.org/I4210161885","https://openalex.org/I4388891778","https://openalex.org/I4405267187"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"400","last_page":"400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waldenstrom-macroglobulinemia","display_name":"Waldenstr\u00f6m macroglobulinemia","score":0.9779999852180481},{"id":"https://openalex.org/keywords/myd88-l265p-mutation","display_name":"MYD88 L265P mutation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/clonal-b-cells","display_name":"B cell clones","score":0.8679999709129333},{"id":"https://openalex.org/keywords/copy-number-abnormalities","display_name":"copy number abnormalities","score":0.8980000019073486},{"id":"https://openalex.org/keywords/chromosomal-imbalances","display_name":"chromosomal imbalances","score":0.7889999747276306},{"id":"https://openalex.org/keywords/disease-transformation","display_name":"disease transformation","score":0.5},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.40400001406669617},{"id":"https://openalex.org/keywords/genomic-profiling","display_name":"genomic profiling","score":0.3919999897480011},{"id":"https://openalex.org/keywords/multiparameter-flow-cytometry","display_name":"multiparameter flow cytometry","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.5820000171661377},{"id":"https://openalex.org/keywords/1q-deletion","display_name":"1q deletion","score":0.328000009059906},{"id":"https://openalex.org/keywords/17p-deletion","display_name":"17p deletion","score":0.6140000224113464},{"id":"https://openalex.org/keywords/18q-deletion","display_name":"18q deletion","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2781038049","wikidata":"https://www.wikidata.org/wiki/Q1778287","display_name":"Waldenstrom macroglobulinemia","level":3,"score":0.7177606821060181},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.6033965349197388},{"id":"https://openalex.org/C2776391228","wikidata":"https://www.wikidata.org/wiki/Q4118092","display_name":"Macroglobulinemia","level":3,"score":0.5923232436180115},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5019450187683105},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.49761608242988586},{"id":"https://openalex.org/C2776553844","wikidata":"https://www.wikidata.org/wiki/Q79451","display_name":"Immunoglobulin M","level":4,"score":0.48329856991767883},{"id":"https://openalex.org/C67982717","wikidata":"https://www.wikidata.org/wiki/Q24724397","display_name":"Glycophorin","level":3,"score":0.45494580268859863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4357052445411682},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3996146321296692},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36351537704467773},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3217945992946625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2904629111289978},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.24839851260185242},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2335103452205658},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.19062352180480957},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.15995851159095764},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.14582356810569763}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.400.400","doi":"https://doi.org/10.1182/blood.v122.21.400.400","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.400.400","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4247536070","https://openalex.org/W1963495263","https://openalex.org/W7212380397","https://openalex.org/W2574746636","https://openalex.org/W2950856478","https://openalex.org/W4389234126","https://openalex.org/W2587728357","https://openalex.org/W2007851220","https://openalex.org/W4310112279","https://openalex.org/W4413791465"],"abstract_inverted_index":{"Abstract":[0],"It":[1],"is":[2],"hypothesized":[3],"that":[4,46,485,640,652,655,660],"similarly":[5],"to":[6,95,396,441,507,565,587,677],"multiple":[7],"myeloma,":[8],"also":[9,264,353,558],"in":[10,42,51,103,243,266,277,281,288,295,303,337,377,383,536,560,575,627],"WM":[11,82,113,172,194,251,296,360,418,490,629],"there":[12],"may":[13,664],"be":[14,49],"a":[15,58,108,197,429,459,649],"continuum":[16],"between":[17,355,409,464],"IgM":[18,43,66,125,168,190,244,278,307,325,356,372,414,644],"MGUS,":[19,169,191,357,415],"smoldering":[20],"(SWM)":[21],"and":[22,97,166,171,193,202,218,250,258,283,327,359,365,417,438,502,527,622,658],"symptomatic":[23],"WM,":[24,657],"rather":[25],"than":[26],"these":[27],"entities":[28],"being":[29,603],"considered":[30],"as":[31,119,121,391,475,477,505,520,550,609],"separate.":[32],"The":[33,127],"very":[34],"low":[35],"frequency":[36],"of":[37,61,63,81,110,181,199,260,339,346,349,362,387,402,455,467,481,497,594,619,656,675],"MYD88":[38,71,153],"L265P":[39,154],"initially":[40],"reported":[41],"MGUS":[44,67,245,308,326,373,645],"suggested":[45],"this":[47],"could":[48],"implicated":[50],"disease":[52,269,389],"transformation.":[53],"However,":[54],"using":[55],"sensitive":[56],"ASO-PCR":[57],"significant":[59],"proportion":[60],"patients":[62,64,114,123,195,252,342,374,419,435,646],"with":[65,124,222,321,428,654],"already":[68,301,573,647],"harbors":[69],"the":[70,74,78,99,178,267,340,384,388,397,452,456,465,478,487,522,528,540,588,620,628,661],"mutation.":[72],"Thus,":[73,290],"molecular":[75,650],"mechanisms":[76],"driving":[77],"malignant":[79],"transformation":[80],"remain":[83],"largely":[84],"unknown.":[85],"Here,":[86],"we":[87,433],"used":[88],"high-sensitive":[89],"8-color":[90],"multidimensional":[91],"flow":[92],"cytometry":[93],"(MFC)":[94],"detect":[96],"sort":[98],"specific":[100,460],"B-cell":[101,523,591],"clone":[102,630,663],"BM":[104,133,231,443,483,577,669],"samples":[105],"(N=31)":[106],"from":[107,163,230,234,306,413,445,643,666],"total":[109],"22":[111],"newly-diagnosed":[112],"(8":[115],"symptomatic,":[116],"14":[117],"SWM)":[118],"well":[120,476],"9":[122,129],"MGUS.":[126],"later":[128],"cases":[130],"had":[131],"negative":[132],"biopsy,":[134],"but":[135],"light-chain":[136],"restricted":[137],"clonal":[138,161,182,304,411,468,537,561,570,595,641],"B-cells":[139,162,183,233,305,412,444,469,473,484,494,571,579,596,642],"(typically":[140],"CD22low,":[141],"CD25+,":[142],"sIgM+,":[143],"LAIR1-)":[144],"were":[145,241,300,534,557,572,625],"identified":[146],"by":[147,210,569],"MFC":[148],"(median":[149,361],"1.74%,":[150],"range":[151],"0.2%-7.04%).":[152],"was":[155,263,312,335,352,462,545,597],"detected":[156,242,265,382],"on":[157],"FACS-sorted":[158,410],"(purity":[159],"\u226597%)":[160],"9/9,":[164],"13/14":[165],"7/8":[167],"SWM":[170,192,247,358,416],"patients,":[173],"respectively.":[174],"We":[175],"first":[176],"compared":[177,439,506,586],"genomic":[179,216,291,398],"profile":[180,651],"through":[184],"high":[185],"density":[186],"Cytoscan750K":[187],"array.":[188],"Overall,":[189],"showed":[196,375,420,495],"median":[198],"2,":[200,364],"1.5,":[201],"3":[203,268,366],"copy":[204],"number":[205,345],"abnormalities":[206],"(CNA)/case,":[207],"respectively":[208],"[defined":[209],">25":[211],"consecutive":[212],"imbalanced":[213],"markers/segment,":[214],">100Kb":[215],"size":[217],"<50%":[219],"overlapping":[220],"variants":[221],"patient-paired":[223],"control":[224],"DNA":[225,229],"(n=6),":[226],"or":[227,298,555,615],"unpaired":[228],"normal":[232,442,472,482,509,576,582,590,633,667],"20":[235],"healthy":[236,446],"donors].":[237],"Whole":[238],"chromosomal":[239,261],"imbalances":[240,292],"(+18),":[246],"(+3,":[248],"+12)":[249],"(+4,":[253],"+12,":[254],"+18,":[255],"+19).":[256],"Gain":[257],"deletion":[259],"arms":[262],"stages:":[270],"3q+,":[271],"6q-,":[272,284],"8p-,":[273],"13q-,":[274],"17p-,":[275,285],"18q+":[276],"MGUS;":[279],"11q-":[280],"SWM;":[282],"18q+,":[286],"22q-":[287],"WM.":[289],"typically":[293],"observed":[294],"(3q+,6q-":[297],"18q+)":[299],"detectable":[302],"patients.":[309],"Trisomy":[310],"4":[311],"not":[313],"present,":[314],"nor":[315],"CNA":[316],"at":[317,333],"4q33-34":[318],"(previously":[319],"ascribed":[320],"increased":[322],"susceptibility":[323],"for":[324],"WM).":[328],"One":[329],"minimal":[330,378],"amplified":[331],"region":[332],"8q11.23":[334],"noted":[336],"6":[338],"31":[341],"(19%).":[343],"Median":[344],"copy-number-neutral":[347],"loss":[348],"heterozygosity":[350],"(CNN-LOH)":[351],"similar":[354],"3,":[363],"CNN-LOH/case,":[367],"respectively).":[368],"Of":[369],"note,":[370],"two":[371],"CNN-LOH":[376],"deleted":[379],"regions":[380],"often":[381],"aggressive":[385],"forms":[386],"such":[390,519,549,608],"6q16.1and":[392],"6q25.3.":[393],"In":[394,605,635],"accordance":[395],"profiles,":[399],"preliminary":[400],"analysis":[401,513],"gene":[403],"expression":[404],"profiles":[405],"(GEP;":[406],"HumanGene":[407],"1.0ST)":[408],"virtually":[421],"no":[422],"deregulated":[423,600],"genes":[424,499,548,567,602,607],"(SAM":[425],"Excel":[426],"add-in":[427],"FDR":[430],"q-value<10-5).":[431],"Consequently,":[432],"grouped":[434],"together":[436],"(n=14)":[437],"them":[440],"donors.":[447],"Moreover,":[448],"taking":[449],"into":[450],"consideration":[451],"aberrant":[453],"phenotypes":[454],"Waldenstr\u00f6m\u2019s":[457,662],"clone,":[458],"comparison":[461],"made":[463],"GEP":[466,593],"vs":[470,580,631],"CD22+/CD25-":[471,508,581],"(n=6)":[474],"small":[479],"subset":[480],"display":[486],"typical":[488],"CD22low/CD25+":[489,578,589,632,668],"phenotype":[491],"(n=4).":[492],"Clonal":[493],"de-regulation":[496],"776":[498],"(92":[500],"down-":[501],"684":[503],"up-regulated)":[504],"B-cells.":[510,562,583,634,670],"By":[511],"enrichment":[512],"(Ingenuity":[514],"Pathways),":[515],"top":[516],"upstream":[517],"regulators":[518],"IFNg,":[521],"receptor":[524,542],"(BCR)":[525],"complex,":[526],"synovial":[529],"apoptosis":[530],"inhibitor":[531],"1":[532],"(SYVN1)":[533],"activated":[535],"B-cells,":[538],"while":[539],"IL1":[541],"antagonist":[543],"(IL1RN)":[544],"inhibited.":[546],"Well-known":[547],"PRDM1,":[551],"CD27,":[552],"IL2R\u03b1":[553],"(CD25)":[554],"TRAF3":[556],"up-regulated":[559,574],"Noteworthy,":[563],"up":[564],"27":[566],"over-expressed":[568],"Accordingly,":[584],"when":[585],"counterpart,":[592],"far":[598],"less":[599],"(185":[601],"infra-expressed).":[604],"fact,":[606],"IL1R2,":[610],"TLR4,":[611],"TNFRSF1A,":[612],"IGF1R,":[613],"FCER1G":[614],"TNFSF13B":[616],"(target":[617],"molecules":[618],"NFKB":[621],"IL-6":[623],"pathways)":[624],"down-regulated":[626],"summary,":[636],"our":[637],"results":[638],"show":[639,648],"overlaps":[653],"suggest":[659],"arise":[665],"Disclosures:":[671],"No":[672],"relevant":[673],"conflicts":[674],"interest":[676],"declare.":[678]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}