{"id":"https://openalex.org/W2338749006","doi":null,"title":"Discontinuation of biologics in patients with rheumatoid arthritis.","display_name":"Discontinuation of biologics in patients with rheumatoid arthritis.","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2338749006","mag":"2338749006","pmid":"https://pubmed.ncbi.nlm.nih.gov/24129132"},"language":"en","primary_location":{"id":"pmid:24129132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24129132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015953107","display_name":"Yoshiya Tanaka","orcid":"https://orcid.org/0000-0002-0807-7139","observed_orcids":["https://orcid.org/0000-0002-0807-7139"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiya Tanaka","raw_affiliation_strings":["The First Department of Internal Medicine, School of Medicine, University of Occupation and Environmental Health, Japan. tanaka@med.uoeh-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Department of Internal Medicine, School of Medicine, University of Occupation and Environmental Health, Japan. tanaka@med.uoeh-u.ac.jp","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089112324","display_name":"Shintaro Hirata","orcid":"https://orcid.org/0000-0002-2474-9943","observed_orcids":["https://orcid.org/0000-0002-2474-9943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shintaro Hirata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038444798","display_name":"Benazir Saleem","orcid":"https://orcid.org/0000-0001-8719-7800","observed_orcids":["https://orcid.org/0000-0001-8719-7800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benazir Saleem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018678002","display_name":"Paul Emery","orcid":"https://orcid.org/0000-0002-7429-8482","observed_orcids":["https://orcid.org/0000-0002-7429-8482","https://orcid.org/0000-0002-4136-3436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Emery","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.4872,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.97343206,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"4 Suppl 78","first_page":"S22","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/biologic-discontinuation","display_name":"biologic discontinuation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8939999938011169},{"id":"https://openalex.org/keywords/sustained-remission","display_name":"sustained remission","score":0.7110000252723694},{"id":"https://openalex.org/keywords/treatment-holidays","display_name":"treatment holidays","score":0.6169999837875366},{"id":"https://openalex.org/keywords/long-standing-rheumatoid-arthritis","display_name":"long-standing rheumatoid arthritis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/inadequate-response-to-methotrexate","display_name":"inadequate response to methotrexate","score":0.7639999985694885},{"id":"https://openalex.org/keywords/flare-rate","display_name":"flare rate","score":0.41200000047683716},{"id":"https://openalex.org/keywords/structural-progression","display_name":"structural progression","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9593714475631714},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.9047825336456299},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8137896656990051},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5852534770965576},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5313431024551392},{"id":"https://openalex.org/C2779722408","wikidata":"https://www.wikidata.org/wiki/Q1536078","display_name":"TNF inhibitor","level":4,"score":0.508290708065033},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.46830880641937256},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4557807147502899},{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.41983214020729065},{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.35469868779182434}],"mesh":[{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018501","descriptor_name":"Antirheumatic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:24129132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24129132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:2338749006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24129132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1964215887","https://openalex.org/W1969236873","https://openalex.org/W1987522198","https://openalex.org/W1993827639","https://openalex.org/W2000253156","https://openalex.org/W2005429018","https://openalex.org/W2009735641","https://openalex.org/W2013493693","https://openalex.org/W2025591723","https://openalex.org/W2039057018","https://openalex.org/W2044940757","https://openalex.org/W2053691719","https://openalex.org/W2059665945","https://openalex.org/W2062696198","https://openalex.org/W2062890136","https://openalex.org/W2075327204","https://openalex.org/W2080959738","https://openalex.org/W2105500082","https://openalex.org/W2106469048","https://openalex.org/W2110826367","https://openalex.org/W2112953069","https://openalex.org/W2116843833","https://openalex.org/W2121376617","https://openalex.org/W2128713459","https://openalex.org/W2138742783","https://openalex.org/W2152553239","https://openalex.org/W2155109530","https://openalex.org/W2156996668","https://openalex.org/W2162760878","https://openalex.org/W2302566711","https://openalex.org/W2325767523","https://openalex.org/W2329342124"],"related_works":["https://openalex.org/W2017067157","https://openalex.org/W2989167577","https://openalex.org/W2554653436","https://openalex.org/W3201537829","https://openalex.org/W2119390151","https://openalex.org/W1987522198","https://openalex.org/W7095388990","https://openalex.org/W2562717918","https://openalex.org/W2551791884","https://openalex.org/W108172154"],"abstract_inverted_index":{"The":[0,124,175],"use":[1],"of":[2,10,25,42,51,55,126,177,188,194,203],"early":[3,80,178],"aggressive":[4],"treatment":[5,24,95,179,205],"combined":[6],"with":[7,64,88,96,104,142,180],"the":[8,23,49,115,191,201],"availability":[9],"biological":[11,56],"agents":[12,57],"targeting":[13],"pro-inflammatory":[14],"cytokines":[15],"such":[16],"TNF":[17,98,181],"and":[18,36,45,71,100,107,155,183],"IL-6":[19],"has":[20,58,131],"greatly":[21],"advanced":[22],"rheumatoid":[26],"arthritis":[27],"(RA).":[28],"Clinical":[29],"remission":[30,87,120,130,197],"is":[31,121],"a":[32,168,195],"realistic":[33],"primary":[34],"goal":[35],"its":[37],"maintenance":[38],"leads":[39],"to":[40,113,134,145],"stabilisation":[41],"structural":[43],"deterioration":[44],"functional":[46,90],"remission.":[47],"With":[48],"achievement":[50],"sustained":[52,85,118,129],"remission,":[53],"discontinuation":[54,125],"emerged":[59],"as":[60],"an":[61],"important":[62],"consideration,":[63],"subsequent":[65],"reductions":[66],"in":[67,137,148,162],"medication-induced":[68],"side":[69],"effects":[70],"health":[72],"costs.":[73],"Evidence":[74],"from":[75],"studies":[76],"suggests":[77],"that":[78],"MTX-na\u00efve,":[79],"RA":[81,106,140],"patients":[82,103,141,167],"can":[83],"achieve":[84],"biologic-free":[86,119,196],"no":[89],"or":[91,198],"radiographic":[92],"progression,":[93],"after":[94,128],"combination":[97,176],"inhibitors":[99,182],"MTX.":[101],"For":[102,165],"long-standing":[105,139],"who":[108],"have":[109,159],"previous":[110],"inadequate":[111,143],"responses":[112],"MTX,":[114,146],"evidence":[116],"for":[117],"less":[122],"convincing.":[123],"TNF-inhibitors":[127],"been":[132,160],"shown":[133],"be":[135,173],"possible":[136],"some":[138],"response":[144],"particularly":[147],"Japanese":[149],"patients.":[150],"However,":[151],"high":[152],"flare":[153],"rates":[154],"adverse":[156],"long-term":[157],"outcomes":[158],"documented":[161],"other":[163],"studies.":[164],"these":[166],"biologic":[169],"dose-reduction":[170],"regimen":[171],"may":[172],"preferable.":[174],"MTX":[184],"plus":[185],"tight":[186],"control":[187],"inflammation":[189],"provide":[190],"best":[192],"chance":[193],"at":[199],"least":[200],"possibility":[202],"'biologic":[204],"holidays'.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
