{"id":"https://openalex.org/W2338570342","doi":null,"title":"Estrogen receptor alpha allows the adipokine, leptin, to function as a growth factor for breast cancer cells.","display_name":"Estrogen receptor alpha allows the adipokine, leptin, to function as a growth factor for breast cancer cells.","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W2338570342","mag":"2338570342"},"language":"en","primary_location":{"id":"mag:2338570342","doi":null,"is_oa":false,"landing_page_url":"https://cebp.aacrjournals.org/content/15/12_Supplement/A126","pdf_url":null,"source":{"id":"https://openalex.org/S2764672815","display_name":"Cancer Epidemiology and Prevention Biomarkers","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Epidemiology and Prevention Biomarkers","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107701475","display_name":"Michael E. Grossmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Grossmann","raw_affiliation_strings":["University of Minnesota- Hormel Institute, Austin, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota- Hormel Institute, Austin, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026272589","display_name":"Kassandra L. Poffenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kassandra L. Poffenberger","raw_affiliation_strings":["University of Minnesota- Hormel Institute, Austin, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota- Hormel Institute, Austin, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091650526","display_name":"Nancy K. Mizuno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy K. Mizuno","raw_affiliation_strings":["University of Minnesota- Hormel Institute, Austin, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota- Hormel Institute, Austin, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018209009","display_name":"Katai J. Nkhata","orcid":"https://orcid.org/0000-0002-5119-8278","observed_orcids":["https://orcid.org/0000-0002-5119-8278"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katai J. Nkhata","raw_affiliation_strings":["University of Minnesota- Hormel Institute, Austin, MN"],"raw_orcid":"https://orcid.org/0000-0002-5119-8278","affiliations":[{"raw_affiliation_string":"University of Minnesota- Hormel Institute, Austin, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101624471","display_name":"Amitabha Ray","orcid":"https://orcid.org/0000-0003-1240-6887","observed_orcids":["https://orcid.org/0000-0003-1240-6887"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amitabha Ray","raw_affiliation_strings":["University of Minnesota- Hormel Institute, Austin, MN"],"raw_orcid":"https://orcid.org/0000-0003-1240-6887","affiliations":[{"raw_affiliation_string":"University of Minnesota- Hormel Institute, Austin, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005181620","display_name":"Margot P. Cleary","orcid":"https://orcid.org/0000-0003-0320-4722","observed_orcids":["https://orcid.org/0000-0003-0320-4722"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margot P. Cleary","raw_affiliation_strings":["University of Minnesota- Hormel Institute, Austin, MN"],"raw_orcid":"https://orcid.org/0000-0003-0320-4722","affiliations":[{"raw_affiliation_string":"University of Minnesota- Hormel Institute, Austin, MN","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1961766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.09369999915361404,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.9750000238418579},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7889999747276306},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.7020000219345093},{"id":"https://openalex.org/keywords/leptin-receptor","display_name":"leptin receptor","score":0.8399999737739563},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5040000081062317},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.640999972820282},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.6940000057220459},{"id":"https://openalex.org/keywords/aromatase","display_name":"aromatase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/leptin-deficiency","display_name":"leptin deficiency","score":0.7639999985694885},{"id":"https://openalex.org/keywords/leptin-receptor-deficiency","display_name":"leptin receptor deficiency","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8080000281333923},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.8539999723434448},{"id":"https://openalex.org/keywords/breast-tumor-growth","display_name":"breast tumor growth","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8813211917877197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7194334268569946},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6999030113220215},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.686116635799408},{"id":"https://openalex.org/C14372207","wikidata":"https://www.wikidata.org/wiki/Q7072306","display_name":"Leptin receptor","level":4,"score":0.6115314960479736},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5793976187705994},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5655562877655029},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46592044830322266},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42981263995170593},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3923277258872986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35163018107414246},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.11463966965675354}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2338570342","doi":null,"is_oa":false,"landing_page_url":"https://cebp.aacrjournals.org/content/15/12_Supplement/A126","pdf_url":null,"source":{"id":"https://openalex.org/S2764672815","display_name":"Cancer Epidemiology and Prevention Biomarkers","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Epidemiology and Prevention Biomarkers","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2111923039","https://openalex.org/W230794157","https://openalex.org/W2035811939","https://openalex.org/W2011540227","https://openalex.org/W2052461288","https://openalex.org/W2787094723","https://openalex.org/W2955792968","https://openalex.org/W2924172601","https://openalex.org/W3148261934","https://openalex.org/W2018930974"],"abstract_inverted_index":{"Fifth":[0],"AACR":[1],"International":[2],"Conference":[3],"on":[4,336,438],"Frontiers":[5],"in":[6,85,89,159,237,247,289,306,325,364,376,388,394,402,425],"Cancer":[7,456],"Prevention":[8],"Research,":[9],"Nov":[10],"12-15,":[11],"2006\n\nA126":[12],"\n\nObesity":[13],"is":[14,141,318,443],"a":[15,142,180,334],"risk":[16],"factor":[17,144],"for":[18,145,343],"postmenopausal":[19],"estrogen":[20,452],"receptor":[21,72,81,201],"(ER)":[22],"positive":[23,38,91,147,279],"breast":[24,86,93,148,160,337,439],"cancer.":[25,149],"Recently,":[26],"our":[27],"laboratory":[28],"reported":[29,124,283],"that":[30,35,137,178,433],"obesity-prone":[31],"MMTV-TGF-\u03b1":[32,62],"transgenic":[33],"mice":[34,63,74],"develop":[36],"ER":[37,90,114],"mammary":[39],"tumors":[40,87],"(MT)":[41],"had":[42,51],"shorter":[43],"MT":[44],"latency,":[45],"were":[46,64,282,346],"younger":[47],"at":[48,370],"death":[49],"and":[50,88,106,157,260,274,298,327,350,459],"higher":[52],"serum":[53],"leptin":[54,68,71,80,100,108,156,200,204,250,294,373,422,437],"levels":[55,288],"compared":[56,219],"to":[57,101,125,127,135,171,220,284,291,331],"controls.":[58],"In":[59,111,353,379,392,428],"additional":[60],"studies":[61],"crossbred":[65],"with":[66,249,321],"obese":[67],"deficient":[69,73],"or":[70,246,311,405,448],"but":[75,223,374],"no":[76],"MTs":[77],"developed.":[78],"The":[79],"has":[82,328],"been":[83,329],"identified":[84],"human":[92],"cancer":[94,161,338,440],"cell":[95,120,167,188,208,256,339,390,441],"lines.":[96,391],"Also":[97],"addition":[98],"of":[99,130,155,193,198,210,228,240,266,357,383,407,436,450],"these":[102,131,430],"cells":[103,216,222,233,269,281,366,398],"increased":[104,224,254],"proliferation":[105],"activated":[107],"signaling":[109,195,423],"pathways.":[110],"contrast,":[112,380],"the":[113,138,153,163,194,199,211,225,229,238,264,267,308,355,381,403,434,446,451],"alpha":[115],"(ER\u03b1)":[116],"negative":[117,165,214],"MDA-MB-231":[118],"(MDA-wt)":[119],"line":[121,168],"was":[122,169,270,359,385],"not":[123,302,375],"respond":[126],"leptin.":[128],"Integration":[129],"findings":[132],"led":[133],"us":[134],"hypothesize":[136],"adipokine,":[139,316],"leptin,":[140,292],"growth":[143,226,257,265,442],"ER\u03b1":[146,158,164,174,213,230,278],"To":[150],"further":[151],"define":[152],"role":[154],"progression,":[162],"MDA-wt":[166,215,268,310,349,377],"modified":[170],"stably":[172],"express":[173],"(line":[175],"MDA-ER\u03b15)":[176],"so":[177],"only":[179],"single":[181],"gene":[182],"difference":[183],"could":[184],"be":[185],"compared.":[186],"Both":[187,341],"lines":[189],"expressed":[190,347],"similar":[191],"amounts":[192],"(long)":[196],"isoform":[197],"(Ob-Rb).":[202],"Importantly,":[203],"(100":[205,251],"ng/ml)":[206,245,252],"reduced":[207],"number":[209],"parental":[212,309],"by":[217,234,258,272,348,362,445],"11%":[218],"untreated":[221],"rate":[227],"positive,":[231],"MDA-ER\u03b15,":[232],"21%":[235],"even":[236],"absence":[239,406,449],"estradiol.":[241],"Estradiol":[242],"alone":[243],"(10":[244],"combination":[248],"also":[253],"MDA-ER\u03b15":[255,312,351,365,397],"41%":[259],"57%":[261],"respectively":[262],"whereas":[263],"decreased":[271],"10%":[273],"8%":[275],"respectively.":[276],"Previously,":[277],"MCF-7":[280],"increase":[285,303],"aromatase":[286,304],"P450":[287,305],"response":[290],"however,":[293],"concentrations":[295],"between":[296],"25":[297],"100":[299,371],"ng/ml":[300,372],"did":[301],"either":[307],"cells.":[313,352,378],"A":[314],"second":[315],"adiponectin,":[317,344],"inversely":[319],"correlated":[320],"body":[322],"mass":[323],"index":[324],"humans":[326],"proposed":[330],"act":[332],"as":[333],"brake":[335],"growth.":[340],"receptors":[342],"AdipoR1/R2,":[345],"addition,":[354],"expression":[356],"AdipoR1":[358],"down":[360,386],"regulated":[361,387],"40%":[363],"after":[367],"24":[368],"hours":[369],"level":[382],"AdipoR2":[384],"both":[389],"an":[393],"vivo":[395],"experiment,":[396],"grew":[399],"equally":[400],"well":[401],"presence":[404,447],"exogenous":[408],"estradiol":[409],"when":[410],"implanted":[411],"into":[412],"intact":[413],"female":[414],"Rag1":[415],"athymic":[416],"mice.":[417],"We":[418],"are":[419],"currently":[420],"evaluating":[421],"pathways":[424],"vitro":[426],".":[427],"general,":[429],"results":[431],"indicate":[432],"effect":[435],"mediated":[444],"receptor.":[453],"(Support:":[454],"Breast":[455],"Research":[457],"Foundation":[458],"Hormel":[460],"Foundation)":[461]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
