{"id":"https://openalex.org/W2338314563","doi":null,"title":"INHIBITION OF AN EPIGENETIC MODULATOR, HISTONE DEACETYLASE BY PEITC IN BREAST CANCER - A DETAILED MECHANISTIC APPROACH.","display_name":"INHIBITION OF AN EPIGENETIC MODULATOR, HISTONE DEACETYLASE BY PEITC IN BREAST CANCER - A DETAILED MECHANISTIC APPROACH.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2338314563","mag":"2338314563"},"language":"en","primary_location":{"id":"mag:2338314563","doi":null,"is_oa":false,"landing_page_url":"http://journal.npaa.in/admin/ufile/1370859635IJTA_5_1-13.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052297426","display_name":"Madhumita Roy","orcid":"https://orcid.org/0000-0002-3551-8534","observed_orcids":["https://orcid.org/0000-0002-3551-8534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhumita Roy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3551-8534","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045915076","display_name":"Sutapa Mukherjee","orcid":"https://orcid.org/0000-0002-4411-7257","observed_orcids":["https://orcid.org/0000-0002-4411-7257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sutapa Mukherjee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4411-7257","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103424712","display_name":"Jaydip Biswas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaydip Biswas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1049,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.39526234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-deacetylase-inhibition","display_name":"histone deacetylase inhibition","score":0.9340000152587891},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8709999918937683},{"id":"https://openalex.org/keywords/isothiocyanates","display_name":"isothiocyanates","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hdac1","display_name":"HDAC1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":1.0},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6850000023841858},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9679999947547913},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.7720000147819519},{"id":"https://openalex.org/keywords/htert","display_name":"hTERT","score":0.984000027179718},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9390000104904175},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":1.0},{"id":"https://openalex.org/keywords/cyclin-d","display_name":"cyclin D","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9929999709129333},{"id":"https://openalex.org/keywords/epigenetic-modulation","display_name":"epigenetic modulation","score":0.6570000052452087},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C2780740852","wikidata":"https://www.wikidata.org/wiki/Q7181339","display_name":"Phenethyl isothiocyanate","level":3,"score":0.7565184831619263},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6016945838928223},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.5838613510131836},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5747008323669434},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.5433529019355774},{"id":"https://openalex.org/C71723506","wikidata":"https://www.wikidata.org/wiki/Q18026859","display_name":"Histone deacetylase 2","level":5,"score":0.5039576888084412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4969382584095001},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.48854026198387146},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4733063280582428},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.42869138717651367},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4246959984302521},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3875744342803955},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3385666608810425},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1967703104019165},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10093292593955994},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.055117249488830566}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2338314563","doi":null,"is_oa":false,"landing_page_url":"http://journal.npaa.in/admin/ufile/1370859635IJTA_5_1-13.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1902126081","https://openalex.org/W1970779989","https://openalex.org/W1973010440","https://openalex.org/W1985093548","https://openalex.org/W1985139470","https://openalex.org/W1999804894","https://openalex.org/W2001502548","https://openalex.org/W2002435695","https://openalex.org/W2015735594","https://openalex.org/W2031925353","https://openalex.org/W2038898265","https://openalex.org/W2046024621","https://openalex.org/W2053197455","https://openalex.org/W2056979603","https://openalex.org/W2077867380","https://openalex.org/W2087267625","https://openalex.org/W2090741373","https://openalex.org/W2092094501","https://openalex.org/W2096330673","https://openalex.org/W2097852826","https://openalex.org/W2103130607","https://openalex.org/W2106679392","https://openalex.org/W2127824295","https://openalex.org/W2130042720","https://openalex.org/W2136884049","https://openalex.org/W2144991906","https://openalex.org/W2155725346","https://openalex.org/W2159479890","https://openalex.org/W2161245725","https://openalex.org/W2164311213","https://openalex.org/W2164713773","https://openalex.org/W2165717337","https://openalex.org/W2170172182","https://openalex.org/W2171318557","https://openalex.org/W2267785789"],"related_works":["https://openalex.org/W2331722302","https://openalex.org/W2765654507","https://openalex.org/W2080545362","https://openalex.org/W221397782","https://openalex.org/W4407342072","https://openalex.org/W2316008600","https://openalex.org/W2027897452","https://openalex.org/W2281212369","https://openalex.org/W2468663235","https://openalex.org/W2039054105"],"abstract_inverted_index":{"Histone":[0],"deacetylases":[1],"(HDACs)":[2],"are":[3,50,165],"enzymes":[4],"that":[5,98,282],"modify":[6],"the":[7,16,70,76,92,102,180,185,195,199,220,241],"architecture":[8],"of":[9,18,32,44,53,60,64,69,78,94,104,143,153,156,173,182,187,198,205,214,226,232,243,248,257,271,294],"chromatin":[10],"leading":[11],"to":[12,74,90,167,240],"decreased":[13],"gene":[14],"expression,":[15],"effect":[17,77],"which":[19,55,193,266],"may":[20,237,277],"be":[21,238,278,284],"reversed":[22],"by":[23,208,212],"HDAC":[24,88,144],"inhibition.":[25],"The":[26,67],"balance":[27],"between":[28],"acetylation":[29,152],"and":[30,47,89,109,114,133,146,159,162,184,228,235,250],"deacetylation":[31],"histones":[33,157],"play":[34,168],"a":[35,80,169,261,268,279],"key":[36],"role":[37,170],"in":[38,84,117,171,218,290],"many":[39],"biological":[40],"events":[41],"including":[42],"regulation":[43,172],"cell":[45,123,127,137,221,262,272],"proliferation":[46],"cancer.":[48],"There":[49],"certain":[51],"inhibitors":[52,62],"HDACs":[54,107],"showed":[56],"toxicity,":[57],"therefore":[58,276],"search":[59],"natural":[61,81],"is":[63,73,194,210,267],"tremendous":[65],"importance.":[66],"aim":[68],"present":[71],"study":[72],"investigate":[75],"PEITC,":[79],"isothiocyanate":[82],"found":[83,97],"cruciferous":[85],"vegetables":[86],"on":[87],"elucidate":[91],"mechanism":[93],"action.":[95],"We":[96],"PEITC":[99,176,209,223,275],"significantly":[100],"inhibited":[101,179],"expression":[103,186],"class":[105],"I":[106],"(HDAC1":[108],"HDAC2),":[110],"both":[111,219],"at":[112],"protein":[113],"genetic":[115],"level":[116],"two":[118],"different":[119],"human":[120,188],"breast":[121,125,135,291],"cancer":[122,136,292],"lines:":[124],"adenocarcinoma":[126],"MCF-7,":[128],"having":[129,139],"wild":[130],"type":[131],"p53":[132,161,233,295],"metastatic":[134],"MDA-MB-231,":[138],"mutated":[140],"p53.":[141],"Inhibition":[142],"1":[145],"2":[147],"were":[148,252],"associated":[149,253],"with":[150,254],"increased":[151],"lysine":[154],"residues":[155],"H3":[158],"H4.":[160],"cMyc":[163],"expressions":[164,247],"expected":[166],"telomerase":[174,183,189,200],"activity.":[175,202],"furthermore":[177],"markedly":[178],"activity":[181],"reverse":[190],"transcriptase":[191],"(hTERT),":[192],"main":[196],"determinant":[197],"enzymatic":[201],"Transcriptional":[203],"downregulation":[204,242,256],"hTERT":[206],"mRNA":[207],"mediated":[211],"repression":[213],"transcription":[215],"factor":[216],"c-Myc":[217,244],"lines.":[222],"induced":[224],"upregulation":[225],"p21":[227,249],"p27":[229,251],"proteins":[230],"independent":[231],"status":[234],"this":[236],"due":[239],"expression.":[245],"Elevated":[246],"concommitant":[255],"cyclin":[258],"D":[259],"level,":[260],"cycle":[263,273],"regulatory":[264],"protein,":[265],"probable":[269],"cause":[270],"arrest.":[274],"potential":[280],"compound":[281],"can":[283],"used":[285],"as":[286],"an":[287],"antitumor":[288],"agent":[289],"irrespective":[293],"status.":[296]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}