{"id":"https://openalex.org/W2338265482","doi":null,"title":"Perspectives Series: Molecular Medicine in Genetically Engineered Animals","display_name":"Perspectives Series: Molecular Medicine in Genetically Engineered Animals","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2338265482","mag":"2338265482"},"language":"en","primary_location":{"id":"mag:2338265482","doi":null,"is_oa":false,"landing_page_url":"http://maxweber.hunter.cuny.edu/pub/eres/BIOL750_HENDERSON/206Rajewsky.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012958604","display_name":"Klaus Rajewsky","orcid":"https://orcid.org/0000-0002-6633-6370","observed_orcids":["https://orcid.org/0000-0002-6633-6370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klaus Rajewsky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6633-6370","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055794847","display_name":"Hua Gu","orcid":"https://orcid.org/0000-0002-0019-6168","observed_orcids":["https://orcid.org/0000-0002-0019-6168","https://orcid.org/0000-0002-0024-2240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071396382","display_name":"Ralf K\u00fchn","orcid":"https://orcid.org/0000-0003-1694-9803","observed_orcids":["https://orcid.org/0000-0003-1694-9803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralf K\u00fchn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1694-9803","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043324387","display_name":"Werner M\u00fcller","orcid":"https://orcid.org/0000-0002-1297-9725","observed_orcids":["https://orcid.org/0000-0002-1297-9725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Werner M\u00fcller","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1297-9725","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038694084","display_name":"J\u00fcrgen Roes","orcid":"https://orcid.org/0000-0003-3235-2345","observed_orcids":["https://orcid.org/0000-0003-3235-2345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Roes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3235-2345","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013096304","display_name":"Frieder Schwenk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frieder Schwenk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1665,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.43976998,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetically-modified-animals","display_name":"transgenic animals","score":0.9190000295639038},{"id":"https://openalex.org/keywords/germline-transmission","display_name":"germline transmission","score":0.8970000147819519},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/microinjection","display_name":"microinjection","score":0.8629999756813049},{"id":"https://openalex.org/keywords/gene-expression-modulation","display_name":"gene expression modulation","score":0.621999979019165},{"id":"https://openalex.org/keywords/molecular-medicine","display_name":"molecular medicine","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.76384437084198},{"id":"https://openalex.org/C3019111730","wikidata":"https://www.wikidata.org/wiki/Q159236","display_name":"Genetically engineered","level":3,"score":0.6645907163619995},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5888180136680603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5511606335639954},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5446587800979614},{"id":"https://openalex.org/C51456166","wikidata":"https://www.wikidata.org/wiki/Q182726","display_name":"Genetically modified organism","level":3,"score":0.5355470180511475},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.4891946315765381},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.46925851702690125},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4563979506492615},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3567965626716614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3004339933395386},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2413451373577118}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2338265482","doi":null,"is_oa":false,"landing_page_url":"http://maxweber.hunter.cuny.edu/pub/eres/BIOL750_HENDERSON/206Rajewsky.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":203,"referenced_works":["https://openalex.org/W124775406","https://openalex.org/W127815550","https://openalex.org/W154007311","https://openalex.org/W250451609","https://openalex.org/W276979351","https://openalex.org/W575693168","https://openalex.org/W1204884779","https://openalex.org/W1441409552","https://openalex.org/W1482359363","https://openalex.org/W1482605042","https://openalex.org/W1484624969","https://openalex.org/W1492344672","https://openalex.org/W1505549268","https://openalex.org/W1513206616","https://openalex.org/W1525682554","https://openalex.org/W1535510845","https://openalex.org/W1581398592","https://openalex.org/W1586539673","https://openalex.org/W1594396900","https://openalex.org/W1595316354","https://openalex.org/W1601944560","https://openalex.org/W1616865676","https://openalex.org/W1678580492","https://openalex.org/W1810029706","https://openalex.org/W1811045671","https://openalex.org/W1850435450","https://openalex.org/W1857574091","https://openalex.org/W1859624620","https://openalex.org/W1899469043","https://openalex.org/W1902334072","https://openalex.org/W1909729402","https://openalex.org/W1925667723","https://openalex.org/W1948275303","https://openalex.org/W1963819227","https://openalex.org/W1964814612","https://openalex.org/W1964901748","https://openalex.org/W1965864404","https://openalex.org/W1967287827","https://openalex.org/W1967569359","https://openalex.org/W1968098810","https://openalex.org/W1968963646","https://openalex.org/W1969022737","https://openalex.org/W1971760578","https://openalex.org/W1972249453","https://openalex.org/W1973862215","https://openalex.org/W1974159422","https://openalex.org/W1974951139","https://openalex.org/W1976685755","https://openalex.org/W1981047025","https://openalex.org/W1981149320","https://openalex.org/W1982433998","https://openalex.org/W1983755641","https://openalex.org/W1984020249","https://openalex.org/W1984684498","https://openalex.org/W1985634042","https://openalex.org/W1986783707","https://openalex.org/W1988309865","https://openalex.org/W1991613479","https://openalex.org/W1993834457","https://openalex.org/W1994831934","https://openalex.org/W1995697852","https://openalex.org/W1996152050","https://openalex.org/W1996621338","https://openalex.org/W1996749102","https://openalex.org/W1998123608","https://openalex.org/W1999251970","https://openalex.org/W1999516176","https://openalex.org/W2000678289","https://openalex.org/W2000927180","https://openalex.org/W2001260034","https://openalex.org/W2002652075","https://openalex.org/W2005275397","https://openalex.org/W2007335266","https://openalex.org/W2008087295","https://openalex.org/W2009407478","https://openalex.org/W2011632934","https://openalex.org/W2012674191","https://openalex.org/W2013306854","https://openalex.org/W2013359336","https://openalex.org/W2015219383","https://openalex.org/W2015617337","https://openalex.org/W2015739079","https://openalex.org/W2016331998","https://openalex.org/W2016651552","https://openalex.org/W2017444651","https://openalex.org/W2018168127","https://openalex.org/W2018834244","https://openalex.org/W2020128838","https://openalex.org/W2021494076","https://openalex.org/W2021598200","https://openalex.org/W2021952728","https://openalex.org/W2022123949","https://openalex.org/W2022281203","https://openalex.org/W2023322190","https://openalex.org/W2026654302","https://openalex.org/W2026688799","https://openalex.org/W2028196271","https://openalex.org/W2028352245","https://openalex.org/W2028744022","https://openalex.org/W2029083758","https://openalex.org/W2029863396","https://openalex.org/W2032678451","https://openalex.org/W2038970416","https://openalex.org/W2039706860","https://openalex.org/W2040113209","https://openalex.org/W2040215337","https://openalex.org/W2040529976","https://openalex.org/W2041230279","https://openalex.org/W2042464108","https://openalex.org/W2044958266","https://openalex.org/W2045424066","https://openalex.org/W2045899482","https://openalex.org/W2046516822","https://openalex.org/W2046975694","https://openalex.org/W2048139403","https://openalex.org/W2048890665","https://openalex.org/W2050130095","https://openalex.org/W2051332153","https://openalex.org/W2051740914","https://openalex.org/W2053200644","https://openalex.org/W2053700159","https://openalex.org/W2055568103","https://openalex.org/W2055859583","https://openalex.org/W2057159461","https://openalex.org/W2057463656","https://openalex.org/W2057471793","https://openalex.org/W2058755882","https://openalex.org/W2059171126","https://openalex.org/W2059692282","https://openalex.org/W2061624989","https://openalex.org/W2062210226","https://openalex.org/W2062723580","https://openalex.org/W2063636969","https://openalex.org/W2064449236","https://openalex.org/W2065519715","https://openalex.org/W2067961064","https://openalex.org/W2068281991","https://openalex.org/W2069449601","https://openalex.org/W2070981327","https://openalex.org/W2071970498","https://openalex.org/W2074434853","https://openalex.org/W2074705578","https://openalex.org/W2075350569","https://openalex.org/W2076033729","https://openalex.org/W2077425788","https://openalex.org/W2080592158","https://openalex.org/W2082201094","https://openalex.org/W2082643661","https://openalex.org/W2083249295","https://openalex.org/W2084126214","https://openalex.org/W2084773215","https://openalex.org/W2085848981","https://openalex.org/W2086732426","https://openalex.org/W2089461678","https://openalex.org/W2090429649","https://openalex.org/W2090983403","https://openalex.org/W2091193879","https://openalex.org/W2091833091","https://openalex.org/W2091994827","https://openalex.org/W2092806325","https://openalex.org/W2094479420","https://openalex.org/W2095310293","https://openalex.org/W2097066872","https://openalex.org/W2101037254","https://openalex.org/W2101710059","https://openalex.org/W2102161788","https://openalex.org/W2103478108","https://openalex.org/W2111806565","https://openalex.org/W2118529037","https://openalex.org/W2120297737","https://openalex.org/W2120613619","https://openalex.org/W2121140770","https://openalex.org/W2122034269","https://openalex.org/W2125387769","https://openalex.org/W2125723285","https://openalex.org/W2127957518","https://openalex.org/W2129644762","https://openalex.org/W2129859001","https://openalex.org/W2130662470","https://openalex.org/W2131095976","https://openalex.org/W2132505135","https://openalex.org/W2136023141","https://openalex.org/W2138371592","https://openalex.org/W2140338297","https://openalex.org/W2144789700","https://openalex.org/W2145623185","https://openalex.org/W2146150145","https://openalex.org/W2146433699","https://openalex.org/W2146865782","https://openalex.org/W2147951044","https://openalex.org/W2151902657","https://openalex.org/W2159562139","https://openalex.org/W2159648706","https://openalex.org/W2166797660","https://openalex.org/W2167963503","https://openalex.org/W2170122514","https://openalex.org/W2180906670","https://openalex.org/W2294929520","https://openalex.org/W2299338986","https://openalex.org/W2403776446","https://openalex.org/W2413587777","https://openalex.org/W2418208573","https://openalex.org/W4298837189"],"related_works":["https://openalex.org/W7098772640","https://openalex.org/W7100370948","https://openalex.org/W2905155092","https://openalex.org/W1994830050","https://openalex.org/W2735992956","https://openalex.org/W1844314177","https://openalex.org/W2072730968","https://openalex.org/W2151099398","https://openalex.org/W2137831390","https://openalex.org/W1732113068"],"abstract_inverted_index":{"Advances":[0],"in":[1,19,21],"biotechnology":[2],"over":[3],"the":[4,13,27,71,80,89,119],"last":[5],"ten":[6],"years":[7],"have":[8],"made":[9],"it":[10,128],"possible":[11,49],"for":[12,76,103,111],"researcher":[14],"to":[15,54,69,107,124],"alter":[16],"gene":[17],"expression":[18],"vivo":[20],"many":[22],"diverse":[23],"ways":[24],"(1).":[25],"With":[26],"establishment":[28],"of":[29,85,91,94,121],"embryonic":[30],"stem":[31],"(ES)":[32],"1":[33],"cell":[34],"technology":[35,123],"(2),":[36],"more":[37],"subtle":[38],"and":[39,66],"precise":[40],"alterations":[41],"can":[42],"now":[43],"be":[44,70],"achieved":[45,61],"than":[46],"were":[47],"previously":[48],"using":[50],"microinjection":[51,67],"techniques.":[52],"However,":[53],"date":[55],"germline":[56],"transmission":[57],"has":[58,82],"only":[59],"been":[60],"with":[62,132],"mouse":[63,81],"ES":[64],"cells,":[65],"continues":[68],"method":[72],"most":[73],"widely":[74],"used":[75,102],"other":[77,97],"species.":[78],"While":[79],"a":[83],"number":[84],"advantages,":[86],"not":[87],"least":[88],"depth":[90],"our":[92],"knowledge":[93],"its":[95],"genetics,":[96],"species":[98,126],"are":[99],"being":[100],"increasingly":[101],"transgenic":[104,122],"studies":[105],"due":[106],"their":[108],"greater":[109],"suitability":[110],"addressing":[112],"specific":[113],"questions.":[114],"We":[115],"will":[116],"briefly":[117],"review":[118],"application":[120],"nonmurine":[125],"as":[127],"stands":[129],"at":[130],"present,":[131],"par":[133]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
