{"id":"https://openalex.org/W2338012602","doi":null,"title":"Treatment of endotoxic shock--the dilemma of vasopressor and vasodilator therapy.","display_name":"Treatment of endotoxic shock--the dilemma of vasopressor and vasodilator therapy.","publication_year":1962,"publication_date":"1962-02-01","ids":{"openalex":"https://openalex.org/W2338012602","mag":"2338012602","pmid":"https://pubmed.ncbi.nlm.nih.gov/14005656","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1574840"},"language":"en","primary_location":{"id":"pmid:14005656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14005656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"California medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112800612","display_name":"Max Harry Weil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M H WEIL","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009802383","display_name":"Robert B. Sudrann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R B SUDRANN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110165921","display_name":"Herbert Shubin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H SHUBIN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2952,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.95583795,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"96","issue":null,"first_page":"86","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxic-shock","display_name":"endotoxic shock","score":0.9470000267028809},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.7720000147819519},{"id":"https://openalex.org/keywords/vasopressor-support","display_name":"vasopressor therapy","score":0.875},{"id":"https://openalex.org/keywords/vasodilator-therapy","display_name":"vasodilator therapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.906000018119812},{"id":"https://openalex.org/keywords/sympathomimetic-drugs","display_name":"sympathomimetic drugs","score":0.8930000066757202},{"id":"https://openalex.org/keywords/sympatholytic-agents","display_name":"sympatholytic agents","score":0.8619999885559082},{"id":"https://openalex.org/keywords/adrenolytic-drugs","display_name":"adrenolytic drugs","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.6460000276565552},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8104087114334106},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.7913779020309448},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.7711804509162903},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.7610104084014893},{"id":"https://openalex.org/C2908519926","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstrictor Agents","level":3,"score":0.6916287541389465},{"id":"https://openalex.org/C2779760147","wikidata":"https://www.wikidata.org/wiki/Q1752522","display_name":"Sympatholytic","level":3,"score":0.6426543593406677},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5574547648429871},{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.510078489780426},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4943735599517822},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4646883010864258},{"id":"https://openalex.org/C2993366118","wikidata":"https://www.wikidata.org/wiki/Q1320276","display_name":"Hemorrhagic shock","level":3,"score":0.4482106864452362},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.31613314151763916},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2622467279434204}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000992","descriptor_name":"Antitoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001160","descriptor_name":"Arterioles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014118","descriptor_name":"Toxins, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014667","descriptor_name":"Vasopressins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:14005656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14005656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"California medicine","raw_type":"Journal Article"},{"id":"mag:2338012602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14005656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1968780731","https://openalex.org/W1979913416","https://openalex.org/W2001175760","https://openalex.org/W2005208257","https://openalex.org/W2056618994","https://openalex.org/W2107156272","https://openalex.org/W2335185258","https://openalex.org/W2400234656"],"related_works":["https://openalex.org/W2150106012","https://openalex.org/W4403923305","https://openalex.org/W2348154848","https://openalex.org/W2395676976","https://openalex.org/W2107156272","https://openalex.org/W2399386824","https://openalex.org/W2078824890","https://openalex.org/W2113568189","https://openalex.org/W2782618992","https://openalex.org/W2424812644"],"abstract_inverted_index":{"Hemodynamic":[0],"studies":[1],"have":[2,64],"demonstrated":[3],"that":[4],"the":[5,48,68,78,92,114],"fall":[6],"of":[7,35,50,80,94,113],"blood":[8],"pressure":[9],"in":[10,15,82,108],"shock":[11,36,81],"caused":[12,84],"by":[13,85],"endotoxin":[14],"dogs":[16,83],"does":[17],"not":[18,104,118],"result":[19],"primarily":[20],"from":[21],"dilatation":[22],"or":[23,61],"\"vasomotor":[24],"collapse.\"":[25],"Indeed,":[26],"vasoconstriction":[27],"is":[28,117],"increased":[29],"and":[30,59,72,128],"may":[31],"be":[32],"excessive.":[33],"Progression":[34],"has":[37,56],"recently":[38],"been":[39,57,65],"blamed":[40],"on":[41,126],"such":[42],"excessive":[43],"vasoconstriction.":[44],"For":[45],"this":[46],"reason":[47],"use":[49],"sympathomimetic":[51],"drugs":[52,74],"as":[53,130],"vasopressor":[54,71,101,115],"agents":[55,63,102],"challenged":[58],"sympatholytic":[60],"adrenolytic":[62],"recommended.":[66],"In":[67],"present":[69],"study,":[70],"vasodilator":[73],"were":[75,103],"used":[76,90,107],"for":[77],"treatment":[79],"endotoxin.":[86],"Vasodilator":[87],"drugs,":[88],"when":[89,106],"after":[91],"onset":[93],"shock,":[95],"hastened":[96],"a":[97,122],"fatal":[98],"outcome":[99],"but":[100],"detrimental":[105],"moderate":[109],"doses.":[110],"The":[111],"effectiveness":[112],"agent":[116],"necessarily":[119],"due":[120],"to":[121],"primary":[123],"vasoconstrictor":[124],"action":[125],"arteries":[127],"arterioles,":[129],"previously":[131],"assumed.":[132]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}