{"id":"https://openalex.org/W2337836103","doi":"https://doi.org/10.1042/cs0890591","title":"Relationship between Serum Tryptophan and Tryptophan Metabolite Levels after Tryptophan Ingestion in Normal Subjects and Age-Related Cataract Patients","display_name":"Relationship between Serum Tryptophan and Tryptophan Metabolite Levels after Tryptophan Ingestion in Normal Subjects and Age-Related Cataract Patients","publication_year":1995,"publication_date":"1995-12-01","ids":{"openalex":"https://openalex.org/W2337836103","doi":"https://doi.org/10.1042/cs0890591","mag":"2337836103","pmid":"https://pubmed.ncbi.nlm.nih.gov/8549077"},"language":"en","primary_location":{"id":"doi:10.1042/cs0890591","doi":"https://doi.org/10.1042/cs0890591","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0890591","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110058663","display_name":"Roger J.W. Truscott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Roger J. W. Truscott","raw_affiliation_strings":["Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014367455","display_name":"A. J. Elderfield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801395776","display_name":"Wollongong Hospital","ror":"https://ror.org/02d0e3p67","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2801395776"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anthony J. Elderfield","raw_affiliation_strings":["Department of Biochemistry, Wollongong Hospital, Wollongong, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wollongong Hospital, Wollongong, NSW, Australia","institution_ids":["https://openalex.org/I2801395776"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4734,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.54716981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"89","issue":"6","first_page":"591","last_page":"599"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-cataract","display_name":"senile cataract","score":0.984000027179718},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tryptophan-metabolites","display_name":"tryptophan metabolites","score":0.9079999923706055},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.890999972820282},{"id":"https://openalex.org/keywords/kynurenic-acid","display_name":"kynurenic acid","score":0.9399999976158142},{"id":"https://openalex.org/keywords/xanthurenic-acid","display_name":"xanthurenic acid","score":0.8980000019073486},{"id":"https://openalex.org/keywords/5-hydroxytryptophan","display_name":"5-hydroxytryptophan","score":0.9020000100135803},{"id":"https://openalex.org/keywords/anthranilic-acid","display_name":"anthranilic acid","score":0.9559999704360962},{"id":"https://openalex.org/keywords/protein-oxidation","display_name":"protein oxidation","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.9230411052703857},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.7272806763648987},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7167671918869019},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4858633875846863},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48175525665283203},{"id":"https://openalex.org/C2908944834","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan Metabolism","level":4,"score":0.4498542547225952},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39775359630584717},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35497117042541504},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3200008273124695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23896273970603943},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.08025714755058289}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D014977","descriptor_name":"Xanthurenates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062367","descriptor_name":"ortho-Aminobenzoates","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/cs0890591","doi":"https://doi.org/10.1042/cs0890591","is_oa":false,"landing_page_url":"https://doi.org/10.1042/cs0890591","pdf_url":null,"source":{"id":"https://openalex.org/S206649051","display_name":"Clinical Science","issn_l":"0143-5221","issn":["0143-5221","1470-8736"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Science","raw_type":"journal-article"},{"id":"pmid:8549077","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8549077","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical science (London, England : 1979)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1560537584","https://openalex.org/W16512064","https://openalex.org/W2111198280","https://openalex.org/W2395739944","https://openalex.org/W2414531016","https://openalex.org/W1971676372","https://openalex.org/W2420412550","https://openalex.org/W2901934383","https://openalex.org/W2072870433","https://openalex.org/W96346979"],"abstract_inverted_index":{"1.":[0],"Cataract":[1],"is":[2,213],"the":[3,11,14,26,35,72,88,154,159,225,234,248],"single":[4],"major":[5,215],"cause":[6],"of":[7,16,47,51,66,135,156,166,178,217,227,236,250],"blindness":[8],"worldwide;":[9],"however,":[10],"reasons":[12],"for":[13],"development":[15],"this":[17],"condition":[18],"remain":[19],"unknown.":[20],"It":[21],"has":[22,40],"been":[23,41,55],"suggested":[24],"that":[25,211],"essential":[27],"amino":[28],"acid":[29,105,170,180,202],"tryptophan":[30,48,85,183,251],"may":[31,230,245],"be":[32,82,231,242],"implicated":[33],"in":[34,57,68,84,87,153,173,187,194,224],"aetiology":[36],"but":[37,176,244],"definitive":[38],"evidence":[39],"lacking.":[42],"2.":[43],"The":[44,164,238],"serum":[45],"levels":[46,205],"and":[49,61,76,103,113,124,137,146,168,181],"seven":[50],"its":[52],"metabolites":[53],"have":[54],"measured":[56,107],"both":[58],"cataract":[59,119,174,219],"patients":[60,120,220],"control":[62,125,188],"subjects,":[63],"after":[64],"administration":[65],"tryptophan,":[67,196],"order":[69],"to":[70,77,233,241],"determine":[71],"typical":[73],"response":[74],"profile":[75],"discover":[78],"whether":[79],"differences":[80,152,193],"could":[81],"found":[83],"metabolism":[86,226],"two":[89,160],"groups.":[90],"3.":[91],"Tryptophan,":[92],"kynurenine,":[93],"kynurenic":[94,179],"acid,":[95,97,99,101,198,200,256],"xanthurenic":[96,201],"3-hydroxyanthranilic":[98,199],"5-hydroxyanthranilic":[100,169,255],"5-hydroxytryptophan":[102,204],"anthranilic":[104,197],"were":[106,130,139,162,171,184,206],"by":[108],"HPLC":[109],"with":[110,221],"dual":[111],"electrochemical":[112],"programmable":[114],"wavelength":[115],"fluorescence":[116],"detection.":[117],"Fasting":[118],"(n":[121,127],"=":[122,128],"42)":[123],"subjects":[126],"37)":[129],"given":[131],"an":[132],"oral":[133],"dose":[134],"L-tryptophan":[136],"sera":[138],"sampled":[140],"at":[141],"0,":[142],"1,":[143],"2,":[144],"4":[145],"6":[147],"h.":[148],"4.":[149],"Statistically":[150],"significant":[151,192],"distribution":[155],"data":[157],"between":[158],"groups":[161],"observed.":[163],"responses":[165],"kynurenine":[167],"higher":[172],"patients,":[175],"those":[177],"total":[182],"lower":[185],"than":[186],"subjects.":[189],"No":[190],"statistically":[191],"free":[195],"or":[203],"noted.":[207],"5.":[208],"We":[209],"conclude":[210],"there":[212],"a":[214,222],"subgroup":[216],"age-related":[218],"dysfunction":[223],"tryptophan.":[228],"This":[229],"related":[232],"onset":[235],"cataract.":[237],"mechanism":[239],"remains":[240],"established":[243],"operate":[246],"via":[247],"action":[249],"metabolites,":[252],"such":[253],"as":[254],"which":[257],"become":[258],"reactive":[259],"towards":[260],"protein":[261],"upon":[262],"oxidation.":[263]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
