{"id":"https://openalex.org/W2337484303","doi":"https://doi.org/10.1056/nejm197612302952703","title":"Circulating Immune Complexes in Infective Endocarditis","display_name":"Circulating Immune Complexes in Infective Endocarditis","publication_year":1976,"publication_date":"1976-12-30","ids":{"openalex":"https://openalex.org/W2337484303","doi":"https://doi.org/10.1056/nejm197612302952703","mag":"2337484303","pmid":"https://pubmed.ncbi.nlm.nih.gov/995157"},"language":"en","primary_location":{"id":"doi:10.1056/nejm197612302952703","doi":"https://doi.org/10.1056/nejm197612302952703","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197612302952703","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012131316","display_name":"Arnold S. Bayer","orcid":"https://orcid.org/0000-0003-1968-0192","observed_orcids":["https://orcid.org/0000-0003-1968-0192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnold S. Bayer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108420436","display_name":"Argyrios N. Theofilopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Argyrios N. Theofilopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113486254","display_name":"Robert A. Eisenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Eisenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111946610","display_name":"Frank J. Dixon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank J. Dixon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111527465","display_name":"Lucien B. Guze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucien B. Guze","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":31.1593,"has_fulltext":false,"cited_by_count":205,"citation_normalized_percentile":{"value":0.99885618,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"295","issue":"27","first_page":"1500","last_page":"1505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11153","display_name":"Streptococcal Infections and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/infective-endocarditis","display_name":"infective endocarditis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/circulating-immune-complexes","display_name":"circulating immune complexes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.7379999756813049},{"id":"https://openalex.org/keywords/hypocomplementemia","display_name":"hypocomplementemia","score":0.8610000014305115},{"id":"https://openalex.org/keywords/right-sided-infective-endocarditis","display_name":"right-sided endocarditis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/left-sided-infective-endocarditis","display_name":"left-sided endocarditis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.734000027179718},{"id":"https://openalex.org/keywords/antimicrobial-therapy","display_name":"antimicrobial therapy","score":0.6629999876022339},{"id":"https://openalex.org/keywords/surgical-treatment","display_name":"surgical treatment","score":0.5550000071525574},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2780176578","wikidata":"https://www.wikidata.org/wiki/Q2450598","display_name":"Infective endocarditis","level":2,"score":0.8754998445510864},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.8372668027877808},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7955148220062256},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7762019634246826},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6871299147605896},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6716005802154541},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5053908824920654},{"id":"https://openalex.org/C2778474638","wikidata":"https://www.wikidata.org/wiki/Q575241","display_name":"Immune complex","level":3,"score":0.4732533097267151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3260679244995117},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32018476724624634}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002177","descriptor_name":"Candidiasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004696","descriptor_name":"Endocarditis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004696","descriptor_name":"Endocarditis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004696","descriptor_name":"Endocarditis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004697","descriptor_name":"Endocarditis, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006556","descriptor_name":"Heroin Dependence","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm197612302952703","doi":"https://doi.org/10.1056/nejm197612302952703","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm197612302952703","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:995157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/995157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W312225353","https://openalex.org/W1496007523","https://openalex.org/W1586312749","https://openalex.org/W1974175318","https://openalex.org/W1983281213","https://openalex.org/W1990928593","https://openalex.org/W2007614835","https://openalex.org/W2014241927","https://openalex.org/W2024883391","https://openalex.org/W2025906486","https://openalex.org/W2059539437","https://openalex.org/W2061928782","https://openalex.org/W2069727739","https://openalex.org/W2082952629","https://openalex.org/W2090728209","https://openalex.org/W2116806886","https://openalex.org/W2126600548","https://openalex.org/W2168473506","https://openalex.org/W2331513080","https://openalex.org/W2339678028","https://openalex.org/W2399799143"],"related_works":["https://openalex.org/W2061241100","https://openalex.org/W2471551649","https://openalex.org/W2093701952","https://openalex.org/W2051652421","https://openalex.org/W2409502218","https://openalex.org/W1976406196","https://openalex.org/W2475140428","https://openalex.org/W2024212064","https://openalex.org/W2473762269","https://openalex.org/W2417456714"],"abstract_inverted_index":{"To":[0],"examine":[1],"further":[2],"the":[3,147,156],"role":[4],"of":[5,20,29,34,74,82,131,158],"immune-complex":[6,67,102],"deposition":[7],"in":[8,45,52,59,140,155],"infective":[9,16,159],"endocarditis,":[10],"we":[11],"studied":[12],"29":[13],"patients":[14,47,53,105],"with":[15,54,71,95,106,119,129],"endocarditis":[17,57,83,97],"for":[18],"presence":[19],"complement-containing":[21],"circulating":[22,101],"immune":[23,35,150],"complexes.":[24],"Ninety-seven":[25],"per":[26,41],"cent":[27],"(28":[28],"29)":[30],"had":[31,98],"serum":[32,141],"levels":[33,44,68,103,115],"complexes":[36,151],"greater":[37],"than":[38,51,64,78,86,92,104,111],"12":[39],"mug":[40],"milliliter.":[42],"Mean":[43],"these":[46],"were":[48,69],"significantly":[49,99],"higher":[50,100],"sepsis":[55],"without":[56],"or":[58,122],"normal":[60],"controls":[61],"(P":[62,76,84,90,109],"less":[63,77,85,91,110],"0.05).":[65,93],"Circulating":[66],"correlated":[70],"longer":[72],"duration":[73],"illness":[75],"0.025),":[79],"extravalvular":[80,132],"manifestations":[81],"0.025)":[87],"and":[88,138],"hypocomplementemia":[89],"Patients":[94],"right-sided":[96],"left-sided":[107],"involvement":[108],"0.025).":[112],"In":[113],"general,":[114],"fell":[116],"to":[117],"zero":[118],"successful":[120],"antimicrobial":[121],"surgical":[123],"therapy.":[124],"This":[125],"drop":[126],"was":[127],"concurrent":[128],"disappearance":[130],"signs,":[133],"blood":[134],"cultures":[135],"becoming":[136],"sterile,":[137],"rise":[139],"complement":[142],"levels.":[143],"These":[144],"findings":[145],"support":[146],"concept":[148],"that":[149],"may":[152],"be":[153],"important":[154],"pathogenesis":[157],"endocarditis.":[160]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
