{"id":"https://openalex.org/W233736162","doi":"https://doi.org/10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","title":"Correction: GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn\u2019s Disease Model","display_name":"Correction: GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn\u2019s Disease Model","publication_year":2013,"publication_date":"2013-06-10","ids":{"openalex":"https://openalex.org/W233736162","doi":"https://doi.org/10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","mag":"233736162","pmid":"https://pubmed.ncbi.nlm.nih.gov/23762221","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677843"},"language":"en","primary_location":{"id":"doi:10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","doi":"https://doi.org/10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","is_oa":true,"landing_page_url":"https://doi.org/10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","pdf_url":"https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0050630","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"erratum","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0050630","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039597999","display_name":"Susan E. Alters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Susan E. Alters","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America","National Institutes of Health, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"National Institutes of Health, United States of America","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059354793","display_name":"Bryant McLaughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryant McLaughlin","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America","National Institutes of Health, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"National Institutes of Health, United States of America","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061800868","display_name":"Benjamin J Spink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Spink","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America","National Institutes of Health, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"National Institutes of Health, United States of America","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051837713","display_name":"Tigran Lachinyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tigran Lachinyan","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America","National Institutes of Health, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"National Institutes of Health, United States of America","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chia-wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-wei Wang","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America","National Institutes of Health, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"National Institutes of Health, United States of America","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087393461","display_name":"Vladimir N. Podust","orcid":"https://orcid.org/0000-0002-6134-7484","observed_orcids":["https://orcid.org/0000-0002-6134-7484"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Podust","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America","National Institutes of Health, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"National Institutes of Health, United States of America","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018783910","display_name":"Volker Schellenberger","orcid":"https://orcid.org/0000-0002-3491-8229","observed_orcids":["https://orcid.org/0000-0002-3491-8229"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Volker Schellenberger","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America","National Institutes of Health, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"National Institutes of Health, United States of America","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061394106","display_name":"Willem P.C. Stemmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210131535","display_name":"Amunix (United States)","ror":"https://ror.org/037sxey58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210131535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Willem P. C. Stemmer","raw_affiliation_strings":["Amunix Inc., Mountain View, California, United States of America","National Institutes of Health, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amunix Inc., Mountain View, California, United States of America","institution_ids":["https://openalex.org/I4210131535"]},{"raw_affiliation_string":"National Institutes of Health, United States of America","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039597999"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210131535"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":null,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-2","display_name":"glucagon-like peptide-2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/teduglutide","display_name":"teduglutide","score":0.972000002861023},{"id":"https://openalex.org/keywords/circulating-half-life","display_name":"serum half-life","score":0.7059999704360962},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8320000171661377},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9409999847412109},{"id":"https://openalex.org/keywords/indomethacin-induced-colitis","display_name":"indomethacin-induced colitis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/intestinal-growth","display_name":"intestinal growth","score":0.5130000114440918},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dosing-frequency","display_name":"dosing frequency","score":0.6959999799728394},{"id":"https://openalex.org/keywords/allometric-scaling","display_name":"allometric scaling","score":0.796999990940094},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.753000020980835},{"id":"https://openalex.org/keywords/short-bowel-syndrome","display_name":"short bowel syndrome","score":0.9679999947547913},{"id":"https://openalex.org/keywords/recombinant-protein","display_name":"recombinant protein","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.7342565059661865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4715029299259186},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4349590539932251},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3690261244773865},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.366647332906723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3438762426376343},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3297891616821289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2537923753261566}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053767","descriptor_name":"Glucagon-Like Peptide 2","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D053767","descriptor_name":"Glucagon-Like Peptide 2","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","doi":"https://doi.org/10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","is_oa":true,"landing_page_url":"https://doi.org/10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","pdf_url":"https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0050630","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2676471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677843","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3677843","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3677843","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23762221","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23762221","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Corrected and Republished Article"},{"id":"pmh:oai:doaj.org/article:284b942b9e2548579d164be13a0cbbea","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/284b942b9e2548579d164be13a0cbbea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 6 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","doi":"https://doi.org/10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","is_oa":true,"landing_page_url":"https://doi.org/10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb","pdf_url":"https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0050630","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W233736162.pdf","grobid_xml":"https://content.openalex.org/works/W233736162.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1752824908","https://openalex.org/W1977059612","https://openalex.org/W2002149953","https://openalex.org/W2002764863","https://openalex.org/W2006360844","https://openalex.org/W2013395086","https://openalex.org/W2015811602","https://openalex.org/W2017295150","https://openalex.org/W2041556752","https://openalex.org/W2073047768","https://openalex.org/W2098309233","https://openalex.org/W2100093779","https://openalex.org/W2104106240","https://openalex.org/W2109406717","https://openalex.org/W2109745718","https://openalex.org/W2110584203","https://openalex.org/W2125311831","https://openalex.org/W2127068727","https://openalex.org/W2130099691","https://openalex.org/W2152026434","https://openalex.org/W2160218747","https://openalex.org/W2162105656","https://openalex.org/W2162766966","https://openalex.org/W2166360124","https://openalex.org/W2170774855","https://openalex.org/W2178262235","https://openalex.org/W2413398201","https://openalex.org/W4233800797"],"related_works":["https://openalex.org/W2005188958","https://openalex.org/W2791350887","https://openalex.org/W2140551754","https://openalex.org/W7153184943","https://openalex.org/W2929465767","https://openalex.org/W3008194890","https://openalex.org/W2615158619","https://openalex.org/W1993260804","https://openalex.org/W2561341883","https://openalex.org/W4353016432"],"abstract_inverted_index":{"Objectives:":[0],"Glucagon-like":[1],"peptide":[2,106,165],"2":[3],"(GLP2)":[4],"is":[5,219],"an":[6],"intestinal":[7,16],"growth":[8,17],"factor":[9],"that":[10,162,266],"has":[11,39],"been":[12],"shown":[13],"to":[14,46,71,107,161,204,240],"stimulate":[15],"and":[18,29,42,60,73,78,90,125,130,153,186,188,207,216,221,235,250,263],"reduce":[19],"disease":[20,170,228],"severity":[21],"in":[22,57,63,122,137,144,148,166,199,209,224,260],"preclinical":[23,58,76,261],"models":[24,59],"of":[25,67,81,87,104,115,120,155,163,175,184,193,256,276],"short":[26],"bowel":[27,31],"syndrome":[28],"inflammatory":[30],"disease.Teduglutide,":[32],"a":[33,83,109,145,167,225,231,253,270],"recombinant":[34],"human":[35,254],"GLP2":[36,49],"variant":[37],"(GLP2-2G),":[38],"increased":[40,178],"half-life":[41,119,255],"stability":[43],"as":[44,202],"compared":[45,160,203],"the":[47,64,75,156,179,182,190,194,212],"native":[48],"peptide,":[50,206],"but":[51],"still":[52],"requires":[53],"twice":[54],"daily":[55,61],"dosing":[56,62,238,264],"clinic.The":[65],"goal":[66],"this":[68],"study":[69],"was":[70,99,127,159],"produce":[72],"characterize":[74],"pharmacokinetic":[77],"therapeutic":[79,272],"properties":[80],"GLP2-2G-XTEN,":[82],"novel,":[84],"long-acting":[85],"form":[86],"GLP2-2G.":[88],"Methodology":[89],"Results:A":[91],"GLP2-2G-XTEN":[92,121,141,157,176,213,218,267],"fusion":[93,103],"protein":[94,158],"with":[95],"extended":[96],"exposure":[97],"profile":[98],"produced":[100],"by":[101],"genetic":[102],"GLP2-2G":[105,164,205,241],"XTEN,":[108],"long,":[110],"unstructured,":[111],"non-repetitive,":[112],"hydrophilic":[113],"sequence":[114],"amino":[116],"acids.The":[117],"serum":[118],"mice,":[123],"rats":[124],"monkeys":[126],"34,":[128],"38":[129],"120":[131],"hours,":[132],"respectively.Intestinotrophic":[133],"effects":[134],"were":[135],"demonstrated":[136,197],"normal":[138],"rats,":[139],"where":[140],"administration":[142,174],"resulted":[143],"significant":[146],"increase":[147],"both":[149],"small":[150,195],"intestine":[151],"weight":[152],"length.Efficacy":[154],"rat":[168,226,249],"Crohn's":[169,227,280],"model,":[171],"indomethacin-induced":[172],"inflammation.Prophylactic":[173],"significantly":[177],"length,":[180],"reduced":[181,189],"number":[183],"trans-ulcerations":[185],"adhesions,":[187],"TNFa":[191],"content":[192],"intestine.GLP2-2G-XTEN":[196],"greater":[198],"vivo":[200],"potency":[201],"improvement":[208],"histopathology":[210],"supported":[211],"treatment":[214,275],"effects.Conclusions":[215],"Significance:":[217],"intestinotrophic":[220],"demonstrates":[222],"efficacy":[223],"model":[229],"requiring":[230],"lower":[232],"molar":[233],"dose":[234],"less":[236],"frequent":[237],"relative":[239],"peptide.Allometric":[242],"scaling":[243],"based":[244],"on":[245],"pharmacokinetics":[246,262],"from":[247],"mouse,":[248],"monkey":[251],"projects":[252],"240":[257],"hours.These":[258],"improvements":[259],"indicate":[265],"may":[268],"offer":[269],"superior":[271],"benefit":[273],"for":[274],"gastrointestinal":[277],"diseases":[278],"including":[279],"disease.":[281]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}