{"id":"https://openalex.org/W2337072306","doi":null,"title":"Combinatorial and independent effects of exercise and myostatin/activin blocking on muscle gene expression profiling","display_name":"Combinatorial and independent effects of exercise and myostatin/activin blocking on muscle gene expression profiling","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2337072306","mag":"2337072306"},"language":"en","primary_location":{"id":"pmh:oai:jyx.jyu.fi:123456789/42563","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-201312022706","pdf_url":"https://jyx.jyu.fi/bitstreams/9c112cf9-67ef-45a8-a29a-934c6b07b775/download","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://jyx.jyu.fi/bitstreams/9c112cf9-67ef-45a8-a29a-934c6b07b775/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057087286","display_name":"Konstantinos-Georgios G. Papaioannou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Konstantinos-Georgios G. Papaioannou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057087286"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mdx-mice","display_name":"mdx mice","score":0.8859999775886536},{"id":"https://openalex.org/keywords/myostatin-inhibition","display_name":"myostatin inhibition","score":0.781000018119812},{"id":"https://openalex.org/keywords/aerobic-exercise","display_name":"aerobic exercise","score":0.9860000014305115},{"id":"https://openalex.org/keywords/muscle-gene-expression","display_name":"muscle gene expression","score":0.8629999756813049},{"id":"https://openalex.org/keywords/aerobic-metabolism","display_name":"aerobic metabolism","score":0.6610000133514404},{"id":"https://openalex.org/keywords/oxidative-damage","display_name":"oxidative damage","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9300000071525574},{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.9419999718666077},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.9629999995231628},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.7490000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.8324558138847351},{"id":"https://openalex.org/C22517002","wikidata":"https://www.wikidata.org/wiki/Q14905179","display_name":"ACVR2B","level":4,"score":0.5547133684158325},{"id":"https://openalex.org/C38643226","wikidata":"https://www.wikidata.org/wiki/Q4677604","display_name":"Activin type 2 receptors","level":4,"score":0.5109876394271851},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4715333580970764},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.46580296754837036},{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.45870599150657654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45611709356307983},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45275330543518066},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4481988847255707},{"id":"https://openalex.org/C2778649528","wikidata":"https://www.wikidata.org/wiki/Q4677603","display_name":"Activin receptor","level":3,"score":0.4473695158958435},{"id":"https://openalex.org/C2778831791","wikidata":"https://www.wikidata.org/wiki/Q408122","display_name":"Follistatin","level":2,"score":0.43945321440696716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3665660619735718},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35305821895599365},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3411993384361267},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25955188274383545},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22463813424110413},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.09619131684303284},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.07602629065513611},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jyx.jyu.fi:123456789/42563","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-201312022706","pdf_url":"https://jyx.jyu.fi/bitstreams/9c112cf9-67ef-45a8-a29a-934c6b07b775/download","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:2337072306","doi":null,"is_oa":false,"landing_page_url":"https://jyx.jyu.fi/handle/123456789/42563","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jyx.jyu.fi:123456789/42563","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:NBN:fi:jyu-201312022706","pdf_url":"https://jyx.jyu.fi/bitstreams/9c112cf9-67ef-45a8-a29a-934c6b07b775/download","source":{"id":"https://openalex.org/S4306400563","display_name":"Jyv\u00e4skyl\u00e4 University Digital Archive (University of Jyv\u00e4skyl\u00e4)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94722563","host_organization_name":"University of Jyv\u00e4skyl\u00e4","host_organization_lineage":["https://openalex.org/I94722563"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2337072306.pdf","grobid_xml":"https://content.openalex.org/works/W2337072306.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W109749587","https://openalex.org/W377152997","https://openalex.org/W1963962309","https://openalex.org/W1971189666","https://openalex.org/W1971958312","https://openalex.org/W1972641070","https://openalex.org/W1974187375","https://openalex.org/W1980606567","https://openalex.org/W1982858450","https://openalex.org/W1984196560","https://openalex.org/W1988907383","https://openalex.org/W1989888013","https://openalex.org/W2000156550","https://openalex.org/W2003164015","https://openalex.org/W2012938174","https://openalex.org/W2021052502","https://openalex.org/W2021624757","https://openalex.org/W2026352655","https://openalex.org/W2026362182","https://openalex.org/W2027575551","https://openalex.org/W2028026223","https://openalex.org/W2034848911","https://openalex.org/W2047820724","https://openalex.org/W2048936161","https://openalex.org/W2051765375","https://openalex.org/W2053079324","https://openalex.org/W2056818201","https://openalex.org/W2059257635","https://openalex.org/W2060800156","https://openalex.org/W2065717274","https://openalex.org/W2076405375","https://openalex.org/W2079804929","https://openalex.org/W2083685478","https://openalex.org/W2095627243","https://openalex.org/W2097680159","https://openalex.org/W2098481973","https://openalex.org/W2098872033","https://openalex.org/W2104729808","https://openalex.org/W2113711812","https://openalex.org/W2120701650","https://openalex.org/W2128340767","https://openalex.org/W2134539584","https://openalex.org/W2136282778","https://openalex.org/W2138553207","https://openalex.org/W2141879632","https://openalex.org/W2143888267","https://openalex.org/W2149795455","https://openalex.org/W2152049867","https://openalex.org/W2155892659","https://openalex.org/W2159443359","https://openalex.org/W2160578478","https://openalex.org/W2163239863","https://openalex.org/W2165784689","https://openalex.org/W2165995731","https://openalex.org/W2166059867","https://openalex.org/W2169469223","https://openalex.org/W2171890134","https://openalex.org/W2394652464","https://openalex.org/W2418828562","https://openalex.org/W2965858921","https://openalex.org/W4323053893"],"related_works":["https://openalex.org/W2027357664","https://openalex.org/W2128016467","https://openalex.org/W2076438107","https://openalex.org/W2151814706","https://openalex.org/W2143012649","https://openalex.org/W2049649386","https://openalex.org/W2512273774","https://openalex.org/W1992476810","https://openalex.org/W105044048","https://openalex.org/W2234748026"],"abstract_inverted_index":{"The":[0,47,114,127,171],"administration":[1],"of":[2,7,49,58,61,72,103,116,134,147,154,162,241],"soluble":[3],"ligand":[4],"binding":[5],"domain":[6,16],"type":[8],"IIb":[9],"activin":[10],"receptor":[11],"fused":[12],"to":[13,22,27,33,54,99,237],"the":[14,50,56,59,80,88,101,104,131,143,148,152,160,182,194,239],"Fc":[15],"(sActRIIB-Fc)":[17],"has":[18],"been":[19],"recently":[20],"shown":[21],"attenuate":[23],"dystrophic":[24,137],"pathology":[25,215,246],"and":[26,64,91,106,112,199,216,221,247],"increase":[28],"muscle":[29,68,90,107,138],"mass,":[30],"but":[31,232],"also":[32],"supress":[34],"aerobic":[35,39,45,65,178],"metabolism.":[36],"In":[37],"contrast,":[38],"exercise":[40,66,135,155],"is":[41,187,235],"known":[42],"for":[43,210],"promoting":[44],"capacity.":[46],"aim":[48],"present":[51],"thesis":[52],"was":[53,85,97,118],"investigate":[55],"effects":[57,102,133],"combination":[60,153],"myostatin/activin":[62,157],"blocking":[63],"on":[67,109],"gene":[69,110,144,185],"expression":[70,145,186],"profile":[71,146],"a":[73,207,225],"in":[74,136,177,184,189,197,213,218,244],"Duchenne":[75],"Muscular":[76],"Dystrophy":[77],"(DMD)":[78],"model,":[79],"mdx":[81],"mouse.":[82],"Microarray":[83],"analysis":[84],"conducted":[86],"from":[87],"gastrocnemius":[89],"Gene":[92],"Set":[93],"Enrichement":[94],"Analysis":[95],"(GSEA)":[96],"performed":[98],"examine":[100],"treatments":[105],"dystrophy":[108],"sets":[111],"pathways.":[113,192],"level":[115],"significance":[117],"set":[119],"at":[120],"False":[121],"Discovery":[122],"Rate":[123],"(FDR)":[124],"<":[125],"0.05.":[126],"results":[128],"indicate":[129,224],"that":[130],"beneficial":[132],"induce":[139],"transcription":[140],"responses":[141],"towards":[142],"healthy":[149],"muscle.":[150],"Furthermore,":[151],"with":[156],"inhibition":[158],"combines":[159],"benefits":[161],"each":[163],"intervention":[164],"alone,":[165],"without":[166],"any":[167],"obvious":[168],"side":[169],"effect.":[170],"most":[172],"profound":[173],"changes":[174],"were":[175],"observed":[176],"metabolism":[179,201,223],"pathways,":[180],"where":[181],"shift":[183],"presented":[188],"many":[190],"different":[191],"Moreover,":[193],"elevated":[195],"expressions":[196],"glutathione":[198],"drug":[200],"by":[202],"cytochrome":[203],"P450":[204],"pathways":[205],"suggest":[206],"possible":[208,226,249],"role":[209,240],"oxidative":[211,242],"damage":[212,243],"DMD":[214,245],"increases":[217],"BCAAs":[219],"degradation":[220],"lipid":[222],"connection":[227],"between":[228],"these":[229],"two":[230],"processes,":[231],"further":[233],"research":[234],"needed":[236],"explore":[238],"their":[248],"connections.":[250]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}