{"id":"https://openalex.org/W2336775381","doi":null,"title":"Expression of hepcidin at the choroid plexus in normal aging rats is associated with IL-6/Stat3 signaling pathway.","display_name":"Expression of hepcidin at the choroid plexus in normal aging rats is associated with IL-6/Stat3 signaling pathway.","publication_year":2014,"publication_date":"2014-12-25","ids":{"openalex":"https://openalex.org/W2336775381","mag":"2336775381","pmid":"https://pubmed.ncbi.nlm.nih.gov/25516512"},"language":"en","primary_location":{"id":"pmid:25516512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25516512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067583266","display_name":"\u5218\u91cd\u658c","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I3018263800","display_name":"Huzhou Normal University","ror":"https://ror.org/04mvpxy20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3018263800"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong-Bin Liu","raw_affiliation_strings":["Department of Physiology, School of Medicine, Huzhou Normal College, Huzhou 313000, China; Department of Physiology, Wenzhou Medical University, Wenzhou 325000, China. liuchongbin1972@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Huzhou Normal College, Huzhou 313000, China; Department of Physiology, Wenzhou Medical University, Wenzhou 325000, China. liuchongbin1972@126.com","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I3018263800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057730752","display_name":"Wang Rui","orcid":"https://orcid.org/0009-0002-5061-5364","observed_orcids":["https://orcid.org/0009-0002-5061-5364","https://orcid.org/0000-0002-4101-9301"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057436816","display_name":"\u8463\u7f2a\u6b66","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miao-Wu Dong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019732841","display_name":"\u9ad8\u559c\u4ec1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi-Ren Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065350571","display_name":"\u4fde\u5cf0","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4245,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.64266775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"66","issue":"6","first_page":"639","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepcidin","display_name":"hepcidin","score":1.0},{"id":"https://openalex.org/keywords/choroid-plexus","display_name":"choroid plexus","score":1.0},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.640999972820282},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8899999856948853},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8299999833106995},{"id":"https://openalex.org/keywords/brain-iron-metabolism","display_name":"brain iron metabolism","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9829999804496765},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3320275545120239}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002831","descriptor_name":"Choroid Plexus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064451","descriptor_name":"Hepcidins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:25516512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25516512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},{"id":"mag:2336775381","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90118X/201406/663537256.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306555152","display_name":"\u751f\u7406\u5b66\u62a5","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u751f\u7406\u5b66\u62a5","raw_type":null},{"id":"mag:2396668131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25516512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1969905245","https://openalex.org/W1983588767","https://openalex.org/W1992880469","https://openalex.org/W2001484997","https://openalex.org/W2002953787","https://openalex.org/W2005438156","https://openalex.org/W2008329588","https://openalex.org/W2039279561","https://openalex.org/W2063142571","https://openalex.org/W2073476331","https://openalex.org/W2111709896","https://openalex.org/W2114570899","https://openalex.org/W2133750804","https://openalex.org/W2166625407"],"related_works":["https://openalex.org/W2396668131","https://openalex.org/W2314048740","https://openalex.org/W7120699912","https://openalex.org/W2171736037","https://openalex.org/W1458849739","https://openalex.org/W2510630146","https://openalex.org/W1980006234","https://openalex.org/W2010821127","https://openalex.org/W2139735067","https://openalex.org/W1812859256"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"has":[2],"revealed":[3],"that":[4,32,138,179,186],"brain":[5],"iron":[6,46],"concentrations":[7],"increase":[8,26],"with":[9,34,157,178,197],"aging,":[10],"and":[11,24,29,52,58,61,83,95,107,128,155,169,202],"the":[12,19,25,42,70,76,79,86,102,112,143,193,198,204],"choroid":[13],"plexus":[14],"(CP)":[15],"may":[16,188],"be":[17],"at":[18,85,111,114,142,192],"basis":[20],"of":[21,63,69,116,166,180],"iron-mediated":[22],"toxicity":[23],"in":[27,45,88,104,131,147,172,176],"inflammation":[28],"oxidative":[30],"stress":[31],"occurs":[33],"aging.":[35,90],"The":[36,67,135,164],"mechanism":[37],"involves":[38],"not":[39],"only":[40],"hepcidin,":[41],"key":[43],"hormone":[44],"metabolism,":[47],"but":[48],"also":[49],"iron-related":[50],"proteins":[51],"signaling-transduction":[53],"molecules,":[54],"such":[55],"as":[56],"IL-6":[57,187],"signal":[59],"transducer":[60],"activator":[62],"transcription":[64],"3":[65,151],"(Stat3).":[66],"aim":[68],"present":[71],"study":[72],"was":[73],"to":[74,100,152,161],"investigate":[75],"correlation":[77],"between":[78],"IL-6/Stat3":[80],"signaling":[81,206],"pathway":[82],"hepcidin":[84,139,181,190],"CP":[87,113,144],"normal":[89,173],"Quantitative":[91],"real":[92],"time":[93],"PCR":[94],"Western":[96],"blot":[97],"were":[98,175],"used":[99],"determine":[101],"alterations":[103,165],"specific":[105],"mRNA":[106,140,168],"corresponding":[108],"protein":[109,170],"changes":[110],"ages":[115],"3,":[117],"6,":[118],"9,":[119],"12,":[120],"15,":[121],"18,":[122],"21,":[123],"24,":[124],"27,":[125],"30,":[126],"33":[127],"36":[129,162],"months":[130],"Brown-Norway/Fischer":[132],"(B-N/F)":[133],"rats.":[134],"results":[136],"demonstrated":[137],"level":[141],"kept":[145],"stable":[146],"young":[148],"rats":[149],"(from":[150,159],"18":[153],"months),":[154],"increased":[156],"aging":[158,174],"21":[160],"months).":[163],"IL-6/p-Stat3":[167],"expressions":[171],"accordance":[177],"mRNA.":[182],"Our":[183],"data":[184],"suggest":[185],"regulate":[189],"expression":[191],"CP,":[194],"upon":[195],"interaction":[196],"cognate":[199],"cellular":[200],"receptor,":[201],"through":[203],"Stat3":[205],"transduction":[207],"pathway.":[208]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
