{"id":"https://openalex.org/W2336735359","doi":"https://doi.org/10.1056/nejm196110052651403","title":"Effects of Chlorothiazide on the Pancreas","display_name":"Effects of Chlorothiazide on the Pancreas","publication_year":1961,"publication_date":"1961-10-05","ids":{"openalex":"https://openalex.org/W2336735359","doi":"https://doi.org/10.1056/nejm196110052651403","mag":"2336735359","pmid":"https://pubmed.ncbi.nlm.nih.gov/13695602"},"language":"en","primary_location":{"id":"doi:10.1056/nejm196110052651403","doi":"https://doi.org/10.1056/nejm196110052651403","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm196110052651403","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040864308","display_name":"Allen L. Cornish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152118","display_name":"Lexington Clinic","ror":"https://ror.org/04pvxsf55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210152118"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen L. Cornish","raw_affiliation_strings":["Consultant in internal medicine, Lexington Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant in internal medicine, Lexington Clinic","institution_ids":["https://openalex.org/I4210152118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075869702","display_name":"James T. McClellan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152118","display_name":"Lexington Clinic","ror":"https://ror.org/04pvxsf55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210152118"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. McClellan","raw_affiliation_strings":["Director, Clinical Pathological Laboratories, Lexington Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Director, Clinical Pathological Laboratories, Lexington Clinic","institution_ids":["https://openalex.org/I4210152118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010701204","display_name":"DAVID H. JOHNSTON","orcid":"https://orcid.org/0000-0002-7078-7510","observed_orcids":["https://orcid.org/0000-0002-7078-7510"]},"institutions":[{"id":"https://openalex.org/I4210152118","display_name":"Lexington Clinic","ror":"https://ror.org/04pvxsf55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210152118"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David H. Johnston","raw_affiliation_strings":["Consultant in gastroenterology, Lexington Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultant in gastroenterology, Lexington Clinic","institution_ids":["https://openalex.org/I4210152118"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066913201","display_name":"Bernice Bright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernice Bright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":29.4841,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.99793729,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"265","issue":"14","first_page":"673","last_page":"675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.27730000019073486,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.13199999928474426,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlorothiazide","display_name":"chlorothiazide","score":1.0},{"id":"https://openalex.org/keywords/thiazide-diuretics","display_name":"thiazide diuretics","score":0.8159999847412109},{"id":"https://openalex.org/keywords/drug-induced-pancreatitis","display_name":"drug-induced pancreatitis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/pancreas","display_name":"pancreas","score":0.5860000252723694},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8610000014305115},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.5979999899864197},{"id":"https://openalex.org/keywords/electrolyte-depletion","display_name":"electrolyte depletion","score":0.6679999828338623},{"id":"https://openalex.org/keywords/skin-rash","display_name":"rash","score":0.5180000066757202},{"id":"https://openalex.org/keywords/jaundice","display_name":"jaundice","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C2779660313","wikidata":"https://www.wikidata.org/wiki/Q2603363","display_name":"Chlorothiazide","level":3,"score":0.9962513446807861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8812555074691772},{"id":"https://openalex.org/C2779918671","wikidata":"https://www.wikidata.org/wiki/Q200656","display_name":"Diuretic","level":2,"score":0.7636418342590332},{"id":"https://openalex.org/C2909018248","wikidata":"https://www.wikidata.org/wiki/Q1363741","display_name":"Exfoliative dermatitis","level":2,"score":0.5217355489730835},{"id":"https://openalex.org/C2780361556","wikidata":"https://www.wikidata.org/wiki/Q423930","display_name":"Hydrochlorothiazide","level":3,"score":0.5153717398643494},{"id":"https://openalex.org/C2778456037","wikidata":"https://www.wikidata.org/wiki/Q133244","display_name":"Jaundice","level":2,"score":0.5058955550193787},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4703376889228821},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3978666663169861},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3764655292034149},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29470711946487427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27816104888916016},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002740","descriptor_name":"Chlorothiazide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010179","descriptor_name":"Pancreas","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm196110052651403","doi":"https://doi.org/10.1056/nejm196110052651403","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm196110052651403","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:13695602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13695602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1996573943","https://openalex.org/W2040152616","https://openalex.org/W2056165738","https://openalex.org/W2062164904","https://openalex.org/W2062784077","https://openalex.org/W2073170058"],"related_works":["https://openalex.org/W2080781222","https://openalex.org/W2056165738","https://openalex.org/W2028110224","https://openalex.org/W2100065398","https://openalex.org/W1988024679","https://openalex.org/W2080299328","https://openalex.org/W2073058677","https://openalex.org/W2089483180","https://openalex.org/W2053552624","https://openalex.org/W2394708846"],"abstract_inverted_index":{"Since":[0],"its":[1,31],"introduction":[2],"into":[3],"clinical":[4],"use":[5,32],"in":[6],"1958":[7],"chlorothiazide":[8,45],"has":[9],"gained":[10],"widespread":[11],"acceptance":[12],"as":[13,47],"an":[14],"effective":[15,23],"diuretic":[16,49],"and":[17,35,57,91],"hypotensive":[18],"agent.":[19],"Because":[20],"it":[21],"is":[22],"when":[24],"taken":[25],"by":[26,43],"mouth,":[27],"patients":[28,40],"have":[29,51,75,79],"found":[30],"both":[33],"convenient":[34],"economical.":[36],"In":[37,93],"addition,":[38],"many":[39],"report":[41],"that":[42],"taking":[44],"daily":[46],"a":[48],"they":[50],"become":[52],"free":[53],"of":[54,59,72,83],"the":[55,69,73],"\"ups":[56],"downs\"":[58],"intermittent":[60],"mercurial":[61],"therapy.With":[62],"careful":[63],"administration":[64],"to":[65,95],"avoid":[66],"electrolyte":[67],"depletion,":[68],"toxic":[70],"effects":[71],"drug":[74],"been":[76,80],"rare.":[77],"There":[78],"scattered":[81],"reports":[82],"chlorothiazideinduced":[84],"papular":[85],"skin":[86],"rashes,1":[87],"exfoliative":[88],"dermatitis,2":[89],"purpura3":[90],"jaundice.4":[92],"addition":[94],"such":[96],"untoward":[97],"reactions":[98],".":[99,100,101]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
