{"id":"https://openalex.org/W2336629944","doi":"https://doi.org/10.1074/jbc.m115.713248","title":"Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage","display_name":"Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage","publication_year":2016,"publication_date":"2016-04-19","ids":{"openalex":"https://openalex.org/W2336629944","doi":"https://doi.org/10.1074/jbc.m115.713248","mag":"2336629944","pmid":"https://pubmed.ncbi.nlm.nih.gov/27129240"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m115.713248","doi":"https://doi.org/10.1074/jbc.m115.713248","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.713248","pdf_url":"http://www.jbc.org/article/S0021925820394424/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820394424/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043870558","display_name":"Xiangzi Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangzi Han","raw_affiliation_strings":["From the Department of Pharmacology, Case Comprehensive Cancer Center, and","Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Case Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044417450","display_name":"Jinshan Tang","orcid":"https://orcid.org/0000-0003-0150-0595","observed_orcids":["https://orcid.org/0000-0003-0150-0595"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinshan Tang","raw_affiliation_strings":["the Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China","Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037205520","display_name":"Jingna Wang","orcid":"https://orcid.org/0000-0002-4612-9016","observed_orcids":["https://orcid.org/0000-0002-4612-9016"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jingna Wang","raw_affiliation_strings":["From the Department of Pharmacology, Case Comprehensive Cancer Center, and","Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Case Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Ren","raw_affiliation_strings":["From the Department of Pharmacology, Case Comprehensive Cancer Center, and","Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Case Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101606359","display_name":"Jinhua Zheng","orcid":"https://orcid.org/0000-0002-6605-1340","observed_orcids":["https://orcid.org/0000-0002-6605-1340"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinhua Zheng","raw_affiliation_strings":["From the Department of Pharmacology, Case Comprehensive Cancer Center, and","Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Case Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062624654","display_name":"Megan Gragg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Gragg","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106 and","Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106 and","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088294618","display_name":"Philip D. Kiser","orcid":"https://orcid.org/0000-0003-1184-9539","observed_orcids":["https://orcid.org/0000-0003-1184-9539"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Kiser","raw_affiliation_strings":["From the Department of Pharmacology, Case Comprehensive Cancer Center, and","Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Case Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043902466","display_name":"Paul S.\u2010H. Park","orcid":"https://orcid.org/0000-0002-1638-9693","observed_orcids":["https://orcid.org/0000-0002-1638-9693"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S.H. Park","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106 and","Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106 and","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045657649","display_name":"Krzysztof Palczewski","orcid":"https://orcid.org/0000-0002-0788-545X","observed_orcids":["https://orcid.org/0000-0002-0788-545X"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krzysztof Palczewski","raw_affiliation_strings":["From the Department of Pharmacology, Case Comprehensive Cancer Center, and","Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Case Comprehensive Cancer Center, and","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110621428","display_name":"Xin\u2010Sheng Yao","orcid":"https://orcid.org/0000-0002-5067-9694","observed_orcids":["https://orcid.org/0000-0002-5067-9694"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinsheng Yao","raw_affiliation_strings":["the Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China","Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100716320","display_name":"Youwei Zhang","orcid":"https://orcid.org/0000-0001-9374-329X","observed_orcids":["https://orcid.org/0000-0001-9374-329X"]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Youwei Zhang","raw_affiliation_strings":["From the Department of Pharmacology, Case Comprehensive Cancer Center, and yxz169@case.edu","Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology, Case Comprehensive Cancer Center, and yxz169@case.edu","institution_ids":["https://openalex.org/I4390039247"]},{"raw_affiliation_string":"Department of Pharmacology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100716320"],"corresponding_institution_ids":["https://openalex.org/I4390039247","https://openalex.org/I58956616"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.2039,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.78562786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"291","issue":"25","first_page":"12951","last_page":"12959"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8489999771118164},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8939999938011169},{"id":"https://openalex.org/keywords/atr-phosphorylation","display_name":"ATR phosphorylation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/intramolecular-interactions","display_name":"intramolecular interactions","score":0.9789999723434448},{"id":"https://openalex.org/keywords/closed-conformation","display_name":"closed conformation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/fluorescence-resonance-energy-transfer","display_name":"fluorescence resonance energy transfer","score":0.6309999823570251},{"id":"https://openalex.org/keywords/bimolecular-fluorescence-complementation","display_name":"bimolecular fluorescence complementation","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.849845290184021},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.8071358799934387},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6949867606163025},{"id":"https://openalex.org/C2910325170","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"Checkpoint Kinase 2","level":5,"score":0.4706161618232727},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4581131339073181},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4280811548233032},{"id":"https://openalex.org/C68748289","wikidata":"https://www.wikidata.org/wiki/Q18030783","display_name":"DNA-PKcs","level":4,"score":0.4220735430717468},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4152892231941223},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3802169859409332},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.32462984323501587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23403596878051758},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.21460041403770447},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.19271865487098694},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.15194585919380188},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13504111766815186},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.06858515739440918}],"mesh":[{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031541","descriptor_name":"Fluorescence Resonance Energy Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1074/jbc.m115.713248","doi":"https://doi.org/10.1074/jbc.m115.713248","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.713248","pdf_url":"http://www.jbc.org/article/S0021925820394424/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:27129240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27129240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4321668","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4933214","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4933214","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4933214","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt4b54c83k","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4b54c83k","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, vol 291, iss 25","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m115.713248","doi":"https://doi.org/10.1074/jbc.m115.713248","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m115.713248","pdf_url":"http://www.jbc.org/article/S0021925820394424/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1540503468","display_name":null,"funder_award_id":"T32EY024236","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2973630922","display_name":null,"funder_award_id":"ACS RSG-15\u2013042 DMC","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G4183155088","display_name":null,"funder_award_id":"R01EY021731","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8734466035","display_name":"Spatiotemporal Regulation of Chk1 in Cell Biology, Cancer Etiology and Therapy","funder_award_id":"R01CA163214","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000162321","display_name":null,"funder_award_id":"R01EY021731","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2336629944.pdf","grobid_xml":"https://content.openalex.org/works/W2336629944.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W613396043","https://openalex.org/W1594035260","https://openalex.org/W1596797500","https://openalex.org/W1964720982","https://openalex.org/W1994909028","https://openalex.org/W1995571036","https://openalex.org/W1995766341","https://openalex.org/W1996160970","https://openalex.org/W2008270238","https://openalex.org/W2017168705","https://openalex.org/W2017356487","https://openalex.org/W2021085149","https://openalex.org/W2023860520","https://openalex.org/W2028375591","https://openalex.org/W2034570201","https://openalex.org/W2041234392","https://openalex.org/W2042883687","https://openalex.org/W2045305010","https://openalex.org/W2059182662","https://openalex.org/W2071088216","https://openalex.org/W2076763802","https://openalex.org/W2082018870","https://openalex.org/W2086038348","https://openalex.org/W2088231104","https://openalex.org/W2088461960","https://openalex.org/W2092499625","https://openalex.org/W2111403239","https://openalex.org/W2112190173","https://openalex.org/W2112481873","https://openalex.org/W2116575638","https://openalex.org/W2117273743","https://openalex.org/W2118266991","https://openalex.org/W2123538605","https://openalex.org/W2123955384","https://openalex.org/W2128123424","https://openalex.org/W2134487183","https://openalex.org/W2134493631","https://openalex.org/W2145200068","https://openalex.org/W2145577568","https://openalex.org/W2152113981","https://openalex.org/W2154141161","https://openalex.org/W2165357372","https://openalex.org/W2169658668","https://openalex.org/W2266724717","https://openalex.org/W2345721759","https://openalex.org/W2417162333","https://openalex.org/W4255907357","https://openalex.org/W6716743743"],"related_works":["https://openalex.org/W2147331022","https://openalex.org/W2528137095","https://openalex.org/W2225210933","https://openalex.org/W2118629005","https://openalex.org/W2012595248","https://openalex.org/W1887764107","https://openalex.org/W2019969911","https://openalex.org/W1997759534","https://openalex.org/W2045219100","https://openalex.org/W2091782725"],"abstract_inverted_index":{"Phosphorylation":[0],"of":[1,31,88,157,167],"Chk1":[2,21,32,38,64,79,141,168],"by":[3,132,143],"ataxia":[4],"telangiectasia-mutated":[5],"and":[6,71,105,154],"Rad3-related":[7],"(ATR)":[8],"is":[9,118],"critical":[10],"for":[11,120],"checkpoint":[12],"activation":[13,33,65,169],"upon":[14],"DNA":[15,51,89,144,172],"damage.":[16],"However,":[17,54],"how":[18],"phosphorylation":[19,36,142],"activates":[20],"remains":[22],"unclear.":[23],"Many":[24],"studies":[25],"suggest":[26],"a":[27,40,82,96,133],"conformational":[28],"change":[29],"model":[30],"in":[34,85],"which":[35],"shifts":[37],"from":[39],"closed":[41,83,148],"inactive":[42],"conformation":[43,48,84,156],"to":[44,61,76,135,151],"an":[45,92,152],"open":[46,153],"active":[47],"during":[49,170],"the":[50,86,101,106,115,129,147,165,171],"damage":[52,90,145,173],"response.":[53,174],"no":[55],"structural":[56],"study":[57],"has":[58],"been":[59],"reported":[60],"support":[62],"this":[63,121],"model.":[66],"Here":[67],"we":[68],"used":[69],"FRET":[70],"bimolecular":[72],"fluorescence":[73],"complementary":[74],"techniques":[75],"show":[77],"that":[78,127],"indeed":[80],"maintains":[81],"absence":[87],"through":[91],"intramolecular":[93,122,130],"interaction":[94,131],"between":[95],"region":[97],"(residues":[98],"31-87)":[99],"at":[100,114],"N-terminal":[102],"kinase":[103],"domain":[104],"distal":[107],"C":[108,116],"terminus.":[109],"A":[110],"highly":[111],"conserved":[112],"Leu-449":[113,134],"terminus":[117],"important":[119],"interaction.":[123],"We":[124],"further":[125],"showed":[126],"abolishing":[128],"Arg":[136],"mutation":[137],"or":[138],"inducing":[139],"ATR-dependent":[140],"disrupts":[146],"conformation,":[149],"leading":[150],"activated":[155],"Chk1.":[158],"These":[159],"data":[160],"provide":[161],"significant":[162],"insight":[163],"into":[164],"mechanisms":[166]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
