{"id":"https://openalex.org/W2336620105","doi":"https://doi.org/10.1042/bj2630149","title":"Bradykinin and thrombin effects on polyphosphoinositide hydrolysis and prostacyclin production in endothelial cells","display_name":"Bradykinin and thrombin effects on polyphosphoinositide hydrolysis and prostacyclin production in endothelial cells","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W2336620105","doi":"https://doi.org/10.1042/bj2630149","mag":"2336620105","pmid":"https://pubmed.ncbi.nlm.nih.gov/2557820","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1133402"},"language":"en","primary_location":{"id":"doi:10.1042/bj2630149","doi":"https://doi.org/10.1042/bj2630149","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2630149","pdf_url":"https://portlandpress.com/biochemj/article-pdf/263/1/149/598227/bj2630149.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/263/1/149/598227/bj2630149.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109321156","display_name":"K. Bartha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Bartha","raw_affiliation_strings":["Department of Inflammation Research and Neurobiology Department, Troponwerke G.m.b.H. & Co. KG, Neurather Ring 1, 5000 Cologne 80, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation Research and Neurobiology Department, Troponwerke G.m.b.H. & Co. KG, Neurather Ring 1, 5000 Cologne 80, Federal Republic of Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068439786","display_name":"Reiner M\u00fcller-Peddinghaus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R M\u00fcller-Peddinghaus","raw_affiliation_strings":["Department of Inflammation Research and Neurobiology Department, Troponwerke G.m.b.H. & Co. KG, Neurather Ring 1, 5000 Cologne 80, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation Research and Neurobiology Department, Troponwerke G.m.b.H. & Co. KG, Neurather Ring 1, 5000 Cologne 80, Federal Republic of Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035340543","display_name":"Lucio A.A. Van Rooijen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L A Van Rooijen","raw_affiliation_strings":["Department of Inflammation Research and Neurobiology Department, Troponwerke G.m.b.H. & Co. KG, Neurather Ring 1, 5000 Cologne 80, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inflammation Research and Neurobiology Department, Troponwerke G.m.b.H. & Co. KG, Neurather Ring 1, 5000 Cologne 80, Federal Republic of Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8307,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.86992778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"263","issue":"1","first_page":"149","last_page":"155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.08749999850988388,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":1.0},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/polyphosphoinositide-hydrolysis","display_name":"polyphosphoinositide hydrolysis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"inositol trisphosphate","score":0.8899999856948853},{"id":"https://openalex.org/keywords/inositol-tetrakisphosphate","display_name":"inositol tetrakisphosphate","score":0.7329999804496765},{"id":"https://openalex.org/keywords/inositol-pentakisphosphate","display_name":"inositol pentakisphosphate","score":0.7620000243186951},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/inositol-phosphate-metabolism","display_name":"inositol phosphate metabolism","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.9437831044197083},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.8902970552444458},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.7553431391716003},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.7178449630737305},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.6492468118667603},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.5686771273612976},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4918484687805176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4686813950538635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45201003551483154},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43431156873703003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4028772711753845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3396472930908203},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26852649450302124},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2594355642795563},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.24379044771194458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1418617069721222}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010716","descriptor_name":"Phosphatidylinositols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011460","descriptor_name":"Prostaglandins F","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj2630149","doi":"https://doi.org/10.1042/bj2630149","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2630149","pdf_url":"https://portlandpress.com/biochemj/article-pdf/263/1/149/598227/bj2630149.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1133402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1133402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:2557820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2557820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj2630149","doi":"https://doi.org/10.1042/bj2630149","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj2630149","pdf_url":"https://portlandpress.com/biochemj/article-pdf/263/1/149/598227/bj2630149.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2336620105.pdf","grobid_xml":"https://content.openalex.org/works/W2336620105.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W68899276","https://openalex.org/W1561429200","https://openalex.org/W1561886676","https://openalex.org/W1582214791","https://openalex.org/W1604249157","https://openalex.org/W1659953295","https://openalex.org/W1973762684","https://openalex.org/W1977169351","https://openalex.org/W1979062318","https://openalex.org/W2001692359","https://openalex.org/W2031761655","https://openalex.org/W2032051833","https://openalex.org/W2036145275","https://openalex.org/W2038349917","https://openalex.org/W2052807725","https://openalex.org/W2066978812","https://openalex.org/W2068877244","https://openalex.org/W2087337235","https://openalex.org/W2087731975","https://openalex.org/W2088105479","https://openalex.org/W2121865211","https://openalex.org/W2123771690","https://openalex.org/W2130486890","https://openalex.org/W2132184473","https://openalex.org/W2145723813","https://openalex.org/W2245657173","https://openalex.org/W2263541816","https://openalex.org/W2320840870","https://openalex.org/W2338831915","https://openalex.org/W6630991863"],"related_works":["https://openalex.org/W2065583843","https://openalex.org/W2164541545","https://openalex.org/W2419177678","https://openalex.org/W1605921103","https://openalex.org/W2066615167","https://openalex.org/W1659953295","https://openalex.org/W1604249157","https://openalex.org/W2050096050","https://openalex.org/W2094571732","https://openalex.org/W2048357036"],"abstract_inverted_index":{"Prostacyclin":[0],"(PGI2)":[1],"production":[2,72,103,137],"by":[3],"thrombin-":[4],"and":[5,12,32,65,101,141,156,160],"bradykinin-stimulated":[6],"bovine":[7],"aortic":[8],"endothelial":[9,16,139],"cells":[10,17,140],"(BAEC)":[11],"human":[13],"umbilical":[14],"vein":[15],"(HUVEC)":[18],"was":[19,56],"related":[20,87],"to":[21,67,88,112,132,158],"the":[22,37,52,71,124,152],"receptor-linked":[23],"activation":[24],"of":[25,39,73,84,118,128,149,154],"inositide":[26],"hydrolysis.":[27],"Bradykinin":[28],"caused":[29,80],"a":[30,81,89,146],"rapid":[31],"transient":[33],"3-fold":[34],"increase":[35,45,134],"in":[36,42,46,51,61,75,91,104,135,138,151],"formation":[38,127],"inositol":[40,99,107],"polyphosphates":[41],"BAEC.":[43,76],"The":[44,120],"InsP3":[47,63],"reflected":[48],"changes":[49],"mainly":[50],"Ins(1,4,5)P3":[53,129],"isomer.":[54],"Thrombin":[55],"less":[57],"effective":[58],"than":[59],"bradykinin":[60,95],"increasing":[62],"levels":[64],"appeared":[66],"only":[68],"minimally":[69],"stimulate":[70],"PGI2":[74,92,102,136],"In":[77],"HUVEC,":[78],"thrombin":[79,159],"5-fold":[82],"elevation":[83],"Ins(1,4,5)P3,":[85],"closely":[86],"rise":[90],"production.":[93],"However,":[94],"did":[96],"not":[97],"affect":[98],"phosphates":[100,108],"HUVEC.":[105],"Other":[106],"were":[109],"also":[110],"assessed":[111],"obtain":[113],"information":[114],"on":[115],"putative":[116],"metabolism":[117],"Ins(1,4,5)P3.":[119],"present":[121],"study":[122],"supports":[123],"notion":[125],"that":[126],"is":[130],"linked":[131],"an":[133],"furthermore":[142],"provides":[143],"evidence":[144],"for":[145],"large":[147],"degree":[148],"heterogeneity":[150],"responses":[153],"BAEC":[155],"HUVEC":[157],"bradykinin.":[161]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}