{"id":"https://openalex.org/W2336061426","doi":"https://doi.org/10.1042/bj1760505","title":"Effects of cholera toxin and guanosine 5\u2032-[\u03b2\u03b3-imido]triphosphate on \u03b2-adrenergic-receptor affinity","display_name":"Effects of cholera toxin and guanosine 5\u2032-[\u03b2\u03b3-imido]triphosphate on \u03b2-adrenergic-receptor affinity","publication_year":1978,"publication_date":"1978-11-15","ids":{"openalex":"https://openalex.org/W2336061426","doi":"https://doi.org/10.1042/bj1760505","mag":"2336061426","pmid":"https://pubmed.ncbi.nlm.nih.gov/217363","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1186259"},"language":"en","primary_location":{"id":"doi:10.1042/bj1760505","doi":"https://doi.org/10.1042/bj1760505","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1760505","pdf_url":"https://portlandpress.com/biochemj/article-pdf/176/2/505/782894/bj1760505.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/176/2/505/782894/bj1760505.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014017701","display_name":"Joseph F. Fischer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Fischer","raw_affiliation_strings":["Departments ofMedicine andPhysiology , Massachusetts General Hospital and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments ofMedicine andPhysiology , Massachusetts General Hospital and","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108232087","display_name":"Geoffrey W.G. Sharp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G W G Sharp","raw_affiliation_strings":["Harvard Medical School , Boston , MA 02114 , U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School , Boston , MA 02114 , U.S.A","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9391,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72490477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"176","issue":"2","first_page":"505","last_page":"510"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholera-toxin","display_name":"cholera toxin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.7950000166893005},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.9449999928474426},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8970000147819519},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dihydroalprenolol","display_name":"dihydroalprenolol","score":0.8820000290870667},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2777006276","wikidata":"https://www.wikidata.org/wiki/Q83586","display_name":"Cholera toxin","level":2,"score":0.8364163041114807},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.5806983113288879},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5726044178009033},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5456642508506775},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4649891257286072},{"id":"https://openalex.org/C2778166480","wikidata":"https://www.wikidata.org/wiki/Q6453151","display_name":"Toad","level":2,"score":0.45260491967201233},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44251203536987305},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.4385640025138855},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.43234843015670776},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4231216311454773},{"id":"https://openalex.org/C2778438532","wikidata":"https://www.wikidata.org/wiki/Q5276415","display_name":"Dihydroalprenolol","level":5,"score":0.41558384895324707},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3443424701690674},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30401647090911865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28034576773643494},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.25942862033843994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07558101415634155}],"mesh":[{"descriptor_ui":"D000526","descriptor_name":"Alprenolol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001001","descriptor_name":"Anura","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002772","descriptor_name":"Cholera Toxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004910","descriptor_name":"Erythrocyte Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006165","descriptor_name":"Guanylyl Imidodiphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011941","descriptor_name":"Receptors, Adrenergic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj1760505","doi":"https://doi.org/10.1042/bj1760505","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1760505","pdf_url":"https://portlandpress.com/biochemj/article-pdf/176/2/505/782894/bj1760505.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1186259","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1186259","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:217363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/217363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj1760505","doi":"https://doi.org/10.1042/bj1760505","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj1760505","pdf_url":"https://portlandpress.com/biochemj/article-pdf/176/2/505/782894/bj1760505.pdf","source":{"id":"https://openalex.org/S4210234214","display_name":"Biochemical Journal","issn_l":"0306-3283","issn":["0306-3283"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2336061426.pdf","grobid_xml":"https://content.openalex.org/works/W2336061426.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W83218127","https://openalex.org/W1500910904","https://openalex.org/W1528765423","https://openalex.org/W1545031061","https://openalex.org/W1556012018","https://openalex.org/W1577436652","https://openalex.org/W1596759602","https://openalex.org/W1640849052","https://openalex.org/W1775749144","https://openalex.org/W1924418294","https://openalex.org/W1967529159","https://openalex.org/W1996972993","https://openalex.org/W2023601764","https://openalex.org/W2024296404","https://openalex.org/W2041442975","https://openalex.org/W2042977621","https://openalex.org/W2049428504","https://openalex.org/W2064027278","https://openalex.org/W2076118656","https://openalex.org/W2079491912","https://openalex.org/W2130132977","https://openalex.org/W2138243399","https://openalex.org/W2206919302","https://openalex.org/W2286629616","https://openalex.org/W2395543477","https://openalex.org/W2414233442","https://openalex.org/W4290174190"],"related_works":["https://openalex.org/W2419580313","https://openalex.org/W316257063","https://openalex.org/W1555553627","https://openalex.org/W1624531326","https://openalex.org/W1513161378","https://openalex.org/W1967529159","https://openalex.org/W1640849052","https://openalex.org/W2076370185","https://openalex.org/W1965833276","https://openalex.org/W1988249258"],"abstract_inverted_index":{"A":[0],"comparison":[1],"was":[2,24,59,100],"made":[3],"of":[4,7,16,30,114,133],"the":[5,13,28,37,43,47,55,63,66,88,95,127,130,142],"effects":[6],"cholera":[8,75,115],"toxin":[9,76,116,128],"and":[10,32],"p[NH]ppG":[11,41],"on":[12,62],"binding":[14],"affinity":[15,45,64,80,96,120],"beta-adrenergic":[17],"receptors":[18],"in":[19,54,87,108],"toad":[20],"erythrocyte":[21,70],"membranes.":[22,111],"This":[23],"determined":[25],"by":[26],"studying":[27],"ability":[29,113],"isoproterenol":[31,49,82],"propranolol":[33],"to":[34,102,117],"compete":[35],"for":[36,46,65,81,97],"receptor":[38,44,79],"with":[39,74],"(-)-[3H]dihydroalprenolol.":[40],"decreased":[42],"agonist":[48],"(i.e.":[50,83],"a":[51,84],"'right'":[52],"shift":[53,86,106],"displacement-concentration":[56],"curve),":[57,90],"but":[58,91],"without":[60],"effect":[61],"antagonist":[67],"propranolol.":[68,98],"Toad":[69],"membranes":[71],"after":[72],"treatment":[73],"exhibited":[77],"increased":[78],"'left'":[85],"displacement":[89],"did":[92],"not":[93],"affect":[94],"p[NH[ppG":[99],"able":[101],"exert":[103],"its":[104],"right":[105],"even":[107],"cholera-toxin":[109],"treated":[110],"The":[112,136],"alter":[118],"beta-adrenergic-receptor":[119],"is":[121],"interpreted":[122],"as":[123],"further":[124],"evidence":[125],"that":[126],"affects":[129],"nucleotide-regulatory":[131],"component":[132,138],"adenylate":[134],"cyclase.":[135],"regulatory":[137],"affected":[139],"may":[140],"be":[141],"catecholamine-sensitive":[143],"guanosine":[144],"triphosphatase.":[145]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
