{"id":"https://openalex.org/W2336044299","doi":"https://doi.org/10.1016/j.cmi.2016.02.013","title":"The benefits of integration","display_name":"The benefits of integration","publication_year":2016,"publication_date":"2016-04-01","ids":{"openalex":"https://openalex.org/W2336044299","doi":"https://doi.org/10.1016/j.cmi.2016.02.013","mag":"2336044299","pmid":"https://pubmed.ncbi.nlm.nih.gov/27107301"},"language":"en","primary_location":{"id":"doi:10.1016/j.cmi.2016.02.013","doi":"https://doi.org/10.1016/j.cmi.2016.02.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmi.2016.02.013","pdf_url":"http://www.clinicalmicrobiologyandinfection.com/article/S1198743X1630057X/pdf","source":{"id":"https://openalex.org/S71414007","display_name":"Clinical Microbiology and Infection","issn_l":"1198-743X","issn":["1198-743X","1469-0691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology and Infection","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.clinicalmicrobiologyandinfection.com/article/S1198743X1630057X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012546332","display_name":"Angela Ciuffi","orcid":"https://orcid.org/0000-0003-2333-513X","observed_orcids":["https://orcid.org/0000-0003-2333-513X"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"A. Ciuffi","raw_affiliation_strings":["Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: Angela.Ciuffi@chuv.ch","Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: Angela.Ciuffi@chuv.ch","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]},{"raw_affiliation_string":"Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012546332"],"corresponding_institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":{"value":3780,"currency":"USD","value_usd":3780},"fwci":0.4931,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.35465116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"4","first_page":"324","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retroviral-integration","display_name":"retroviral integration","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.9139999747276306},{"id":"https://openalex.org/keywords/reverse-transcription","display_name":"reverse transcription","score":0.7950000166893005},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.7580000162124634},{"id":"https://openalex.org/keywords/proviral-dna","display_name":"proviral DNA","score":0.4819999933242798},{"id":"https://openalex.org/keywords/viral-persistence","display_name":"viral persistence","score":0.5350000262260437},{"id":"https://openalex.org/keywords/retroviruses","display_name":"retroviruses","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7039371728897095},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5659836530685425},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5657060146331787},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5598858594894409},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5568283796310425},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5183071494102478},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5182169079780579},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4416137635707855},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41105547547340393},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.4108966290950775},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1914023756980896},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.08626800775527954}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.cmi.2016.02.013","doi":"https://doi.org/10.1016/j.cmi.2016.02.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmi.2016.02.013","pdf_url":"http://www.clinicalmicrobiologyandinfection.com/article/S1198743X1630057X/pdf","source":{"id":"https://openalex.org/S71414007","display_name":"Clinical Microbiology and Infection","issn_l":"1198-743X","issn":["1198-743X","1469-0691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology and Infection","raw_type":"journal-article"},{"id":"pmid:27107301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27107301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases","raw_type":"Journal Article"},{"id":"pmh:oai:serval.unil.ch:BIB_7E4EEA73958C","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_7E4EEA73958C","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 22, no. 4, pp. 324-332","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:iris.unil.ch:iris/138184","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/138184","pdf_url":"https://iris.unil.ch/bitstreams/ef949b8d-95a6-4e4c-b9aa-b98d583f50c8/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review article"}],"best_oa_location":{"id":"doi:10.1016/j.cmi.2016.02.013","doi":"https://doi.org/10.1016/j.cmi.2016.02.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmi.2016.02.013","pdf_url":"http://www.clinicalmicrobiologyandinfection.com/article/S1198743X1630057X/pdf","source":{"id":"https://openalex.org/S71414007","display_name":"Clinical Microbiology and Infection","issn_l":"1198-743X","issn":["1198-743X","1469-0691"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Microbiology and Infection","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1323383031","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4104599821","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6246193552","display_name":"Dynamics of HIV latency and reactivation at population and single-cell level","funder_award_id":"146579","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6872874447","display_name":"Paving the way towards HIV eradication/control","funder_award_id":"305762","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2336044299.pdf","grobid_xml":"https://content.openalex.org/works/W2336044299.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W148950072","https://openalex.org/W767471067","https://openalex.org/W869813667","https://openalex.org/W900440242","https://openalex.org/W930992439","https://openalex.org/W1543402161","https://openalex.org/W1552738748","https://openalex.org/W1554602478","https://openalex.org/W1572583106","https://openalex.org/W1589425511","https://openalex.org/W1637867377","https://openalex.org/W1863001271","https://openalex.org/W1967301672","https://openalex.org/W1976477813","https://openalex.org/W1978150606","https://openalex.org/W1979705716","https://openalex.org/W1983135362","https://openalex.org/W2003425131","https://openalex.org/W2006765654","https://openalex.org/W2010465583","https://openalex.org/W2022269865","https://openalex.org/W2024445339","https://openalex.org/W2026984588","https://openalex.org/W2027694180","https://openalex.org/W2030949296","https://openalex.org/W2034118113","https://openalex.org/W2035858595","https://openalex.org/W2049687913","https://openalex.org/W2052766340","https://openalex.org/W2053218283","https://openalex.org/W2053524220","https://openalex.org/W2057479340","https://openalex.org/W2064416623","https://openalex.org/W2078738195","https://openalex.org/W2082485360","https://openalex.org/W2088713020","https://openalex.org/W2091663902","https://openalex.org/W2094331955","https://openalex.org/W2106494657","https://openalex.org/W2109570247","https://openalex.org/W2110921380","https://openalex.org/W2112702228","https://openalex.org/W2114538357","https://openalex.org/W2117840598","https://openalex.org/W2120902492","https://openalex.org/W2122523609","https://openalex.org/W2124860395","https://openalex.org/W2127867655","https://openalex.org/W2128712095","https://openalex.org/W2129457098","https://openalex.org/W2131200208","https://openalex.org/W2131649633","https://openalex.org/W2133931128","https://openalex.org/W2135800359","https://openalex.org/W2146614388","https://openalex.org/W2153148487","https://openalex.org/W2155321442","https://openalex.org/W2157011379","https://openalex.org/W2158419452","https://openalex.org/W2166473260","https://openalex.org/W2176753208","https://openalex.org/W2188299120","https://openalex.org/W2321437261","https://openalex.org/W2410466647","https://openalex.org/W2487557543","https://openalex.org/W6634335440"],"related_works":["https://openalex.org/W4206618567","https://openalex.org/W4238411900","https://openalex.org/W106185503","https://openalex.org/W2500619648","https://openalex.org/W1999828630","https://openalex.org/W2049426292","https://openalex.org/W2418018165","https://openalex.org/W18475619","https://openalex.org/W148950072","https://openalex.org/W118939831"],"abstract_inverted_index":{"Retroviruses,":[0],"including":[1],"the":[2,34,39,44,50,54,57,66,88,91],"human":[3],"immunodeficiency":[4],"virus":[5,55,89],"(HIV),":[6],"are":[7],"notorious":[8],"for":[9,29,86],"two":[10],"essential":[11,28],"steps":[12],"of":[13,38,53,74],"their":[14],"viral":[15,40],"replication:":[16],"reverse":[17],"transcription":[18],"and":[19,32,76,90],"integration.":[20],"This":[21],"latter":[22],"property":[23],"is":[24],"considered":[25],"to":[26,49,70],"be":[27],"productive":[30],"replication":[31],"ensures":[33],"stable":[35],"long-term":[36],"insertion":[37],"genome":[41],"sequence":[42],"in":[43],"host":[45],"chromatin,":[46],"thereby":[47],"leading":[48],"life-long":[51],"association":[52],"with":[56],"infected":[58,92],"cell.":[59],"Using":[60],"HIV":[61],"as":[62,80,82],"a":[63],"prototypic":[64],"example,":[65],"present":[67],"review":[68],"aims":[69],"provide":[71],"an":[72],"overview":[73],"how":[75],"where":[77],"integration":[78],"occurs,":[79],"well":[81],"presenting":[83],"general":[84],"consequences":[85],"both":[87],"host.":[93]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}