{"id":"https://openalex.org/W2336038108","doi":"https://doi.org/10.1152/ajpcell.1998.274.6.c1592","title":"Release of dopamine and norepinephrine by hypoxia from PC-12 cells","display_name":"Release of dopamine and norepinephrine by hypoxia from PC-12 cells","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2336038108","doi":"https://doi.org/10.1152/ajpcell.1998.274.6.c1592","mag":"2336038108","pmid":"https://pubmed.ncbi.nlm.nih.gov/9611124"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.1998.274.6.c1592","doi":"https://doi.org/10.1152/ajpcell.1998.274.6.c1592","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1998.274.6.c1592","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107896162","display_name":"Ganesh Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ganesh K. Kumar","raw_affiliation_strings":["Departments of Biochemistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113485474","display_name":"Jeffrey L. Overholt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey L. Overholt","raw_affiliation_strings":["Physiology and Biophysics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019947366","display_name":"Gary R. Bright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary R. Bright","raw_affiliation_strings":["Anatomy, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048170194","display_name":"K. Y. Hui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwong Y. Hui","raw_affiliation_strings":["Biomedical Engineering, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026541271","display_name":"Hongwen Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongwen Lu","raw_affiliation_strings":["Physiology and Biophysics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003821715","display_name":"Mikl\u00f3s Gratzl","orcid":"https://orcid.org/0000-0001-8798-7394","observed_orcids":["https://orcid.org/0000-0001-8798-7394"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miklos Gratzl","raw_affiliation_strings":["Biomedical Engineering, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064414704","display_name":"Nanduri R. Prabhakar","orcid":"https://orcid.org/0000-0003-4570-1380","observed_orcids":["https://orcid.org/0000-0003-4570-1380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanduri R. Prabhakar","raw_affiliation_strings":["Physiology and Biophysics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology and Biophysics,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2379,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.88975485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"274","issue":"6","first_page":"C1592","last_page":"C1600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.30219998955726624,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dopamine-release","display_name":"dopamine release","score":0.9259999990463257},{"id":"https://openalex.org/keywords/noradrenaline-release","display_name":"noradrenaline release","score":1.0},{"id":"https://openalex.org/keywords/catecholamine-release","display_name":"catecholamine release","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pheochromocytoma-cells","display_name":"pheochromocytoma cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/calcium-dependent-secretion","display_name":"calcium-dependent secretion","score":0.546999990940094},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.9309999942779541},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.921999990940094},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bisindolylmaleimide-i","display_name":"bisindolylmaleimide I","score":0.9919999837875366},{"id":"https://openalex.org/keywords/potassium-evoked-release","display_name":"potassium-evoked release","score":0.722000002861023},{"id":"https://openalex.org/keywords/stimulus-secretion-coupling","display_name":"stimulus-secretion coupling","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.7313410043716431},{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.7303557991981506},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5963220596313477},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5822092294692993},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5598416924476624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5521959066390991},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5269029140472412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5144805908203125},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4893876910209656},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4861997961997986},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4708511233329773},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3954216539859772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26173096895217896},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16367793083190918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.157759428024292},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008301","descriptor_name":"Maleimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.1998.274.6.c1592","doi":"https://doi.org/10.1152/ajpcell.1998.274.6.c1592","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.1998.274.6.c1592","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:9611124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9611124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2088245336","display_name":"Control of Respiratory Skeletal and Smooth Muscle","funder_award_id":"P01HL025830","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6701165127","display_name":"ADRENERGIC MECHANISMS IN CAROTID BODY CHEMORECEPTION","funder_award_id":"R01HL045780","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8912463277","display_name":"ADRENERGIC MECHANISMS IN CAROTID BODY CHEMORECEPTION","funder_award_id":"K04HL002599","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W88545136","https://openalex.org/W948550917","https://openalex.org/W1538325952","https://openalex.org/W1969269984","https://openalex.org/W1983905487","https://openalex.org/W1989180817","https://openalex.org/W1992735337","https://openalex.org/W1996927223","https://openalex.org/W1998385128","https://openalex.org/W2006516000","https://openalex.org/W2007450872","https://openalex.org/W2019987584","https://openalex.org/W2025754202","https://openalex.org/W2025940399","https://openalex.org/W2028165995","https://openalex.org/W2028559188","https://openalex.org/W2030740718","https://openalex.org/W2041596868","https://openalex.org/W2046738892","https://openalex.org/W2053776712","https://openalex.org/W2057808940","https://openalex.org/W2060215528","https://openalex.org/W2065900635","https://openalex.org/W2070539878","https://openalex.org/W2080679632","https://openalex.org/W2083623305","https://openalex.org/W2089257688","https://openalex.org/W2092557019","https://openalex.org/W2106805091","https://openalex.org/W2120154519","https://openalex.org/W2159310780","https://openalex.org/W2171633355","https://openalex.org/W2178592917","https://openalex.org/W2228770015","https://openalex.org/W2499505205"],"related_works":["https://openalex.org/W1975589409","https://openalex.org/W2046407288","https://openalex.org/W2080801486","https://openalex.org/W2031146851","https://openalex.org/W1971561692","https://openalex.org/W2009207963","https://openalex.org/W2087484267","https://openalex.org/W2073615105","https://openalex.org/W1994731084","https://openalex.org/W2194588223"],"abstract_inverted_index":{"We":[0],"examined":[1],"the":[2,7,23,72,75,95,102,133,140,178,237],"effects":[3],"of":[4,9,25,62,74,93,97,104,125,139,144,149,157,240],"hypoxia":[5,207],"on":[6,132,177,197],"release":[8,34,96,103,115,156,184,222,239],"dopamine":[10],"(DA)":[11],"and":[12,21,27,77,83,128,136,160,172,200,213],"norepinephrine":[13],"(NE)":[14],"from":[15,210],"rat":[16],"pheochromocytoma":[17],"12":[18],"(PC-12)":[19],"cells":[20,212],"assessed":[22],"involvement":[24],"Ca2+":[26,146,151],"protein":[28,190,232],"kinases":[29,233],"in":[30,108,219,236],"stimulus-secretion":[31],"coupling.":[32],"Catecholamine":[33],"was":[35,99,116],"monitored":[36],"by":[37,47],"microvoltammetry":[38],"using":[39],"a":[40,79,163,216],"carbon":[41],"fiber":[42],"electrode":[43],"as":[44,46],"well":[45],"HPLC":[48],"coupled":[49],"with":[50],"electrochemical":[51],"detection":[52],"(ECD).":[53],"Microvoltammetric":[54],"analysis":[55,87],"showed":[56],"that":[57,206,231],"hypoxia-induced":[58,126,155,182],"catecholamine":[59],"secretion":[60],"(PO2":[61],"medium":[63],"approximately":[64,117],"40":[65],"mmHg)":[66],"occurred":[67],"within":[68],"1":[69],"min":[70],"after":[71],"onset":[73],"stimulus":[76],"reached":[78],"plateau":[80],"between":[81],"10":[82],"15":[84],"min.":[85],"HPLC-ECD":[86],"revealed":[88],"that,":[89,214],"at":[90],"any":[91],"level":[92],"PO2,":[94,220],"NE":[98,121,127,161,183,199,221,241],"greater":[100,119,224],"than":[101,120,186,225],"DA.":[105],"In":[106],"contrast,":[107],"response":[109],"to":[110,162],"K+":[111],"(80":[112],"mM),":[113],"DA":[114,129,159,187,201,226],"11-fold":[118],"release.":[122,188,227],"The":[123],"magnitude":[124],"releases":[130,208],"depended":[131],"passage,":[134],"source,":[135],"culture":[137],"conditions":[138],"PC-12":[141,211],"cells.":[142],"Omission":[143],"extracellular":[145],"or":[147],"addition":[148],"voltage-gated":[150],"channel":[152],"blockers":[153],"attenuated":[154,181],"both":[158],"similar":[164],"extent.":[165],"Protein":[166],"kinase":[167,191],"inhibitors,":[168],"staurosporine":[169],"(200":[170],"nM)":[171],"bisindolylmaleimide":[173],"I":[174],"(2":[175],"microM),":[176],"other":[179],"hand,":[180],"more":[185],"However,":[189],"inhibitors":[192],"had":[193],"no":[194],"significant":[195],"effect":[196],"K+-induced":[198],"releases.":[202],"These":[203],"results":[204],"demonstrate":[205],"catecholamines":[209],"for":[215],"given":[217],"change":[218],"is":[223,229],"It":[228],"suggested":[230],"are":[234],"involved":[235],"enhanced":[238],"during":[242],"hypoxia.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}