{"id":"https://openalex.org/W2336024291","doi":null,"title":"APC, \u03b2-catenin and E-cadherin protein expression in colon crypts in the Markers of Adenomatous Polyps II (MAP II) study","display_name":"APC, \u03b2-catenin and E-cadherin protein expression in colon crypts in the Markers of Adenomatous Polyps II (MAP II) study","publication_year":2006,"publication_date":"2006-04-15","ids":{"openalex":"https://openalex.org/W2336024291","mag":"2336024291"},"language":"en","primary_location":{"id":"mag:2336024291","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/66/8_Supplement/164.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023642264","display_name":"Chiranjeev Dash","orcid":"https://orcid.org/0000-0002-3314-8461","observed_orcids":["https://orcid.org/0000-0002-3314-8461"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiranjeev Dash","raw_affiliation_strings":["Emory University, Atlanta, GA and University of South Carolina, Columbia, SC"],"raw_orcid":"https://orcid.org/0000-0002-3314-8461","affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA and University of South Carolina, Columbia, SC","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065231902","display_name":"Valerie Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie Kennedy","raw_affiliation_strings":["Emory University, Atlanta, GA and University of South Carolina, Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA and University of South Carolina, Columbia, SC","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056577980","display_name":"Roberd M. Bostick","orcid":"https://orcid.org/0000-0001-8626-4186","observed_orcids":["https://orcid.org/0000-0001-8626-4186"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberd M. Bostick","raw_affiliation_strings":["Emory University, Atlanta, GA and University of South Carolina, Columbia, SC"],"raw_orcid":"https://orcid.org/0000-0001-8626-4186","affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA and University of South Carolina, Columbia, SC","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16669895,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":null,"first_page":"164","last_page":"164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.5336999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.44850000739097595,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apc","display_name":"APC","score":0.7860000133514404},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":1.0},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7559999823570251},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/colonic-crypts","display_name":"colonic crypts","score":0.6549999713897705},{"id":"https://openalex.org/keywords/colorectal-cancer-risk","display_name":"colorectal cancer risk","score":0.5640000104904175},{"id":"https://openalex.org/keywords/colorectal-cancer-prevention","display_name":"colorectal cancer prevention","score":0.6039999723434448},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.5770000219345093},{"id":"https://openalex.org/keywords/immunohistochemistry-image-analysis","display_name":"immunohistochemistry image analysis","score":0.621999979019165},{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.7557626962661743},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6538078188896179},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5643580555915833},{"id":"https://openalex.org/C2780814781","wikidata":"https://www.wikidata.org/wiki/Q1369011","display_name":"Familial adenomatous polyposis","level":4,"score":0.5485943555831909},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5158857107162476},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.49529972672462463},{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.4940841495990753},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.451568603515625},{"id":"https://openalex.org/C2776861080","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Colorectal adenoma","level":4,"score":0.4410795271396637},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43577301502227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41798773407936096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40206262469291687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4005514979362488},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3671761155128479},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35107356309890747},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20939689874649048},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19787248969078064},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1233525276184082}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2336024291","doi":null,"is_oa":false,"landing_page_url":"https://cancerres.aacrjournals.org/content/66/8_Supplement/164.1","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2429272886","https://openalex.org/W1537902360","https://openalex.org/W2113523987","https://openalex.org/W7048825134","https://openalex.org/W2015679424","https://openalex.org/W2033282924","https://openalex.org/W1667956316","https://openalex.org/W2796228620","https://openalex.org/W2386146695","https://openalex.org/W2112558428"],"abstract_inverted_index":{"688":[0],"The":[3,27,214],"APC":[5,31,79,184,191,224,360,407,452],"Pathway":[6],",":[7,32],"a":[8,43,84,288],"major":[9],"pathway":[10,453],"in":[11,17,58,60,77,98,106,120,134,172,194,202,207,258,325,331,384,454,463],"colorectal":[12,96,455],"cancers,":[13],"involves":[14],"functional":[15],"alterations":[16,76],"the":[18,21,69,74,78,121,124,147,153,166,181,195,199,208,218,229,241,245,249,259,264,281,285,294,297,300,319,326,357,385,399,411,415,447,451],"components":[19],"of":[20,55,93,136,158,169,190,198,223,228,236,248,263,284,296,311,322,359,406,432,450,466],"Wnt":[23],"signaling":[25],"system.":[26],"\u201cgateway\u201d":[28],"gene,":[29],"functions":[33],"to":[34,162,175,217,361,420,423,460],"degrade":[35],"\u03b2-catenin":[36,112,232,237,362,433],"which":[37,99],"is":[38,83],"pro-proliferative":[39],"and":[40,52,113,118,131,143,164,211,244,254,270,305,336,363,381,408,457],"regulates":[41],"E-cadherin,":[42],"cell":[44],"adhesion":[45],"molecule":[46],"integral":[47],"for":[48,140,251,302,398],"colon":[49,62,125,154,327,386],"crypt":[50,155,250,286,387,416],"structure":[51],"function.":[53],"Quantification":[54],"these":[56,323],"biomarkers":[57,324,467],"crypts":[59],"normal-appearing":[61,137],"mucosa":[63],"may":[64],"help":[65],"us":[66],"better":[67],"understand":[68],"phenotypic":[70,439,464],"changes":[71,462],"associated":[72],"with":[73,287],"genetic":[75,448],"pathway.":[80],"MAP":[81,148],"II":[82,149],"community,":[85],"colonoscopy-based,":[86],"case-control":[87,367],"study":[88],"(49":[89],"cases,":[90,215],"154":[91],"controls)":[92],"incident":[94],"sporadic":[95],"adenoma,":[97,456],"adult":[100],"residents":[101],"aged":[102],"30-74":[103],"years":[104],"residing":[105],"Columbia,":[107],"SC":[108],"were":[109,116],"enrolled.":[110],"APC,":[111,379],"E-cadherin":[114,273,276,312,364,382,409],"levels":[115,227,405],"detected":[117],"quantified":[119],"cells":[122],"lining":[123],"crypt,":[126],"by":[127],"automated":[128],"immunohistochemical":[129],"methods":[130],"image":[132,392],"analysis,":[133],"biopsies":[135],"rectal":[138],"tissue,":[139],"20":[141,144],"cases":[142,203,253,269,304,307,335],"controls,":[145,188,219,306],"from":[146,160,418,446],"study.":[150],"We":[151,316],"divided":[152],"into":[156],"deciles":[157],"height":[159],"base":[161,419],"apex":[163],"measured":[165,318],"signal":[167],"intensity":[168],"biomarker":[170,177],"expression":[171,189,222,277,310,321,465],"each":[173],"decile":[174],"construct":[176],"distribution":[178,185,233,265,274,291,298,383],"profiles":[179],"along":[180,414],"crypt.":[182,230,328],":":[186,234,275],"In":[187],"was":[192,205,238,266,278,299],"highest":[193,206],"upper":[196,212],"30%":[197],"crypts,":[200],"whereas":[201],"it":[204],"lower":[209,221,309],"20%":[210],"20%.":[213],"relative":[216],"had":[220,308,403],"at":[225,240,280,313],"all":[226,314],"Expression":[235],"lowest":[239,279],"very":[242,246],"bottom":[243],"top":[247],"both":[252,303],"controls.":[255,271],"No":[256],"difference":[257,330],"amount":[260],"or":[261],"shape":[262,295],"evident":[267],"between":[268,334],"two":[282],"ends":[283],"relatively":[289],"stable":[290],"in-between.":[292],"Although":[293],"same":[301],"levels.":[315],"also":[317,365],"total":[320],"Proportional":[329],"crude":[332],"means":[333],"controls":[337],"were:":[338],"APC:":[339],"\u221224.6%,":[341],"p=0.18":[342],";":[343,348,373],"\u03b2-catenin:":[344],"-4.3%,":[346],"p=0.73":[347],"E-cadherin:":[349],"-8.4%,":[351],"p=0.77":[352],".":[353],"Further":[354],"analyses":[355],"comparing":[356],"ratio":[358],"revealed":[366],"differences":[368,440],"(APC/\u03b2-catenin:":[369],"-29.5%,":[371],"p=0.14":[372],"APC/E-cadherin:":[374],"-40.3%,":[376],"p=0.15":[377],").":[378],"\u03b2-catenin,":[380],"based":[388],"on":[389],"fully":[390],"quantitative":[391],"analysis":[393],"procedures":[394],"are":[395,468],"being":[396],"presented":[397],"first":[400],"time.":[401],"Cases":[402],"decreased":[404],"but":[410],"pattern":[412],"varied":[413],"axis":[417],"apex.":[421],"Contrary":[422],"expectations,":[424],"we":[425],"did":[426],"not":[427],"find":[428],"an":[429],"elevated":[430],"level":[431],"among":[434],"cases.":[435],"These":[436],"findings":[437],"suggest":[438],"that":[441],"cannot":[442],"be":[443],"predicted":[444],"solely":[445],"model":[449],"further":[458],"studies":[459],"investigate":[461],"needed.":[469]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}