{"id":"https://openalex.org/W2335995018","doi":"https://doi.org/10.1182/blood.v122.21.1922.1922","title":"Targeting Glycolysis and Compensatory Mitochondrial Metabolism In An In Vivo Xenograft Model Of Multiple Myeloma With FDA Approved Ritonavir and Metformin","display_name":"Targeting Glycolysis and Compensatory Mitochondrial Metabolism In An In Vivo Xenograft Model Of Multiple Myeloma With FDA Approved Ritonavir and Metformin","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W2335995018","doi":"https://doi.org/10.1182/blood.v122.21.1922.1922","mag":"2335995018"},"language":"en","primary_location":{"id":"mag:2335995018","doi":"https://doi.org/10.1182/blood.v122.21.1922.1922","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/122/21/1922/14686/Targeting-Glycolysis-and-Compensatory","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087546630","display_name":"Sevim Dalva-Aydemir","orcid":"https://orcid.org/0000-0001-8957-9597","observed_orcids":["https://orcid.org/0000-0001-8957-9597"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sevim Dalva-Aydemir","raw_affiliation_strings":["Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine Northwestern University, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0001-8957-9597","affiliations":[{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076933593","display_name":"Kehinde Adekola","orcid":"https://orcid.org/0000-0001-7166-9308","observed_orcids":["https://orcid.org/0000-0001-7166-9308"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kehinde Adekola","raw_affiliation_strings":["Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine Northwestern University, Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0001-7166-9308","affiliations":[{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071844087","display_name":"Jennifer E. Koblinski","orcid":"https://orcid.org/0000-0002-7156-2030","observed_orcids":["https://orcid.org/0000-0002-7156-2030"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E. Koblinski","raw_affiliation_strings":["Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA,"],"raw_orcid":"https://orcid.org/0000-0002-7156-2030","affiliations":[{"raw_affiliation_string":"Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA,","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052048627","display_name":"Noopur S Raje","orcid":"https://orcid.org/0000-0003-3066-1275","observed_orcids":["https://orcid.org/0000-0003-3066-1275"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noopur Raje","raw_affiliation_strings":["Cancer Center - Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3066-1275","affiliations":[{"raw_affiliation_string":"Cancer Center - Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013430443","display_name":"Steven T. Rosen","orcid":"https://orcid.org/0000-0002-8818-7724","observed_orcids":["https://orcid.org/0000-0002-8818-7724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven T. Rosen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8818-7724","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5152573186","display_name":"FRCPA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FRCPA","raw_affiliation_strings":["Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago IL USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago IL USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16979232,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":"21","first_page":"1922","last_page":"1922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.7773000001907349,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.14669999480247498,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.06800000369548798,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/ritonavir","display_name":"ritonavir","score":0.9419999718666077},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":1.0},{"id":"https://openalex.org/keywords/glut4","display_name":"GLUT4","score":0.8050000071525574},{"id":"https://openalex.org/keywords/glucose-transporters","display_name":"glucose transporters","score":0.7369999885559082},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.6549999713897705},{"id":"https://openalex.org/keywords/glucose-deprivation","display_name":"glucose deprivation","score":0.6650000214576721},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5669999718666077},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7889999747276306},{"id":"https://openalex.org/keywords/plasma-cell-malignancy","display_name":"plasma cell malignancy","score":0.6190000176429749},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.7070000171661377},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.3370000123977661},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2777952866","wikidata":"https://www.wikidata.org/wiki/Q24722601","display_name":"GLUT1","level":4,"score":0.804365873336792},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.6684553623199463},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.645433783531189},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.5691444277763367},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5072998404502869},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4591900408267975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43710464239120483},{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.4362073540687561},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.419671893119812},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40263086557388306},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23978474736213684},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21349099278450012},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1586446464061737},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.08609390258789062},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.06957012414932251},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2335995018","doi":"https://doi.org/10.1182/blood.v122.21.1922.1922","is_oa":false,"landing_page_url":"https://ashpublications.org/blood/article/122/21/1922/14686/Targeting-Glycolysis-and-Compensatory","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2592951193","https://openalex.org/W1970955677","https://openalex.org/W3213493541","https://openalex.org/W2748609851","https://openalex.org/W2044122087","https://openalex.org/W2337073704","https://openalex.org/W2217524423","https://openalex.org/W4389258293","https://openalex.org/W2989283355","https://openalex.org/W2969447100"],"abstract_inverted_index":{"Introduction":[0],"Multiple":[1],"Myeloma":[2],"(MM)":[3],"is":[4,27,583],"an":[5,38,122],"incurable":[6],"plasma":[7],"cell":[8,71,144,160,503,557,562],"malignancy":[9],"accounting":[10],"for":[11,57,74,110,265,600,623],"11,000":[12],"deaths":[13,21],"annually":[14],"in":[15,61,81,142,153,166,167,212,236,340,369,375,434,456,501,505,515,520,548,586],"the":[16,43,82,104,211,220,223,298,324,350,355,358,402,445,453,492,542,601,624],"US":[17],"and":[18,63,262,335,345,372,424,474,488,526,529,553,555,559,621,628],"20%":[19],"of":[20,29,84,107,129,136,205,215,240,337,352,360,440,466,479,485,494,510,532,544,598,603,626,636],"from":[22],"all":[23],"hematological":[24],"malignancies.":[25],"MM":[26,66,78,111,130,143,180,561,627],"one":[28],"myriad":[30],"malignancies":[31],"exhibiting":[32],"enhanced":[33],"glucose":[34,54,59,76,85,139,266,333,417],"consumption":[35,423,487],"associated":[36],"with":[37,132,192,292,431,472,482,496,522,568,577],"aerobic":[39],"glycolytic":[40],"phenotype":[41],"(i.e.":[42],"Warburg":[44],"effect).":[45],"We":[46,347,409,450,538],"have":[47,410,420,539,574],"previously":[48,252,411],"published":[49],"a":[50,115,231,237,483,612],"study":[51,207],"defining":[52],"key":[53],"transporters":[55],"responsible":[56],"facilitating":[58],"entry":[60,140],"myeloma":[62,159,243,255],"observed":[64],"that":[65,120,182,194,413,427,452,518],"cells":[67,79,131,172,181,235,244,296,371,392,406,414,455],"rely":[68],"on":[69,126,259,297,357],"constitutively":[70],"surface-localized":[72],"GLUT4":[73,88,109,155],"basal":[75],"consumption.":[77],"cultured":[80],"absence":[83],"or":[86,96,146,219,225,247,294,300,316,323,354,362],"upon":[87],"suppression":[89],"exhibit":[90,571],"either":[91],"overt":[92],"apoptosis":[93,368,419,480],"(sensitive":[94],"phenotype)":[95],"growth":[97,147],"arrest":[98],"(resistant":[99],"phenotype).":[100],"To":[101,149],"further":[102,188],"demonstrate":[103,476],"clinical":[105],"utility":[106],"targeting":[108,154],"therapy":[112],"we":[113,156,195,443],"tested":[114,444],"HIV":[116,564,604,606],"protease":[117],"inhibitor":[118,448],"ritonavir":[119,137,310,400,461,473,495,519,569,620],"has":[121],"off-target":[123],"inhibitory":[124],"effect":[125],"GLUT4.":[127],"Treatment":[128],"physiologically":[133],"achievable":[134],"concentrations":[135],"blocks":[138],"resulting":[141],"death":[145],"suppression.":[148],"determine":[150,210],"ritonavir\u2019s":[151],"specificity":[152],"generated":[157,250],"KMS11":[158,242],"lines":[161],"over-expressing":[162,377],"GLUT1.":[163],"As":[164],"anticipated,":[165],"vitro":[168,470],"studies":[169,471,610],"GLUT1":[170,248,295,363,376,390],"overexpressing":[171],"were":[173,183,187,249,289,306,326,343,393,407,458],"found":[174,394],"to":[175,178,185,209,395,399,416,436,460,463,638],"be":[176,396,429],"resistant":[177,184,415],"ritonavir.":[179],"glucose-deprivation":[186],"sensitized":[189],"when":[190],"co-treated":[191],"metformin,":[193],"believe":[196],"targets":[197],"compensatory":[198],"mitochondrial":[199,425,441,467],"complex":[200,446],"I":[201],"activity.":[202],"The":[203],"objective":[204],"this":[206,545,580],"was":[208],"vivo":[213,387,457,506,516],"efficacy":[214,543],"combinatorial":[216,614],"ritonavir,":[217],"metformin":[218,317,475,497,523,578,599,622],"combination":[221,325,356,521,581],"using":[222],"KMS11-GLUT1":[224],"GFP":[226,246,404],"(green":[227],"fluorescent":[228],"protein,":[229],"as":[230,251,379],"negative":[232],"control)":[233],"expressing":[234,245,364,391,405],"xenograft":[238],"model":[239],"MM.\n\nMethods":[241],"described":[253],"(Multiple":[254],"exhibits":[256],"novel":[257],"dependence":[258],"GLUT4,":[260],"GLUT8,":[261],"GLUT11:":[263],"implications":[264],"transporter-directed":[267],"therapy.":[268],"McBrayer":[269],"SK,":[270],"Cheng":[271],"JC,":[272],"Singhal":[273],"S,":[274],"Krett":[275],"NL,":[276],"Rosen":[277],"ST,":[278],"Shanmugam":[279],"M.":[280],"Blood.":[281],"2012":[282],"May":[283],"17;119(20)":[284],").":[285],"NOD":[286],"SCID":[287],"mice":[288],"injected":[290],"subcutaneously":[291],"KMS11-GFP":[293,361,370,454],"left":[299],"right":[301],"side,":[302],"respectively.":[303],"When":[304],"tumors":[305],"approximately":[307],"125":[308],"mm3,":[309],"50":[311],"mgs/kg":[312],"by":[313,320],"oral":[314],"gavage":[315],"(125":[318],"mgs/kg)":[319],"i.p.":[321],"injection":[322],"administered":[327],"daily.":[328],"Tumor":[329],"volumes,":[330],"weight,":[331],"survival,":[332],"uptake":[334],"analysis":[336],"specific":[338],"proteins":[339],"tumor":[341],"lysates":[342],"performed.\n\nResults":[344],"Conclusions":[346],"first":[348],"evaluated":[349],"impact":[351],"ritonavir/metformin":[353],"viability":[359],"cells.":[365],"Ritonavir":[366],"elicits":[367,498],"less":[373],"so":[374],"cells,":[378],"anticipated":[380],"(McBrayer":[381],"S":[382],"et.al":[383,591],"Blood":[384],"2012).":[385],"In":[386,469],",":[388],"however":[389],"highly":[397],"sensitive":[398],"while":[401],"parental":[403],"resistant.":[408],"determined":[412],"deprivation-elicited":[418],"increased":[421,464],"oxygen":[422,486],"metabolism":[426],"can":[428],"targeted":[430],"metformin.":[432,449],"Therefore,":[433],"order":[435],"target":[437],"potential":[438],"upregulation":[439],"OXPHOS":[442],"1":[447],"hypothesized":[451],"insensitive":[459],"due":[462],"engagement":[465],"OXPHOS.":[468],"potent":[477,499,613],"elicitation":[478],"correlating":[481],"loss":[484],"coupled":[489],"respiration.":[490],"Indeed,":[491],"administration":[493],"toxicity":[500],"both":[502],"types":[504],".":[507,593],"An":[508],"investigation":[509],"cellular":[511],"signaling":[512],"pathways":[513],"engaged":[514],"indicates":[517],"suppresses":[524,530],"AKT":[525],"AMPK":[527],"activity":[528],"expression":[531],"pro-survival":[533],"BCL-2":[534],"family":[535],"member":[536],"MCL-1.":[537],"also":[540],"demonstrated":[541],"treatment":[546,582,602,625],"regimen":[547,615],"CLL":[549],"primary":[550],"patient":[551],"samples":[552],"DLBCL":[554],"mantle":[556],"lymphoma":[558],"other":[560,630],"lines.":[563],"patients":[565],"chronically":[566],"treated":[567,576],"who":[570],"diabetic":[572],"symptoms":[573],"been":[575],"indicating":[579],"well":[584],"tolerated":[585],"humans":[587],"(":[588],"Kohli,":[589],"R.,":[590],"2007":[592],"A":[594],"randomized":[595],"placebo-controlled":[596],"trial":[597],"lipodystrophy.":[605],"Med":[607],"8:420-426).":[608],"Our":[609],"reveal":[611],"involving":[616],"repurposed,":[617],"FDA":[618],"approved,":[619],"potentially":[629],"glucose-driven":[631],"malignancies.\n\nDisclosures:":[632],"No":[633],"relevant":[634],"conflicts":[635],"interest":[637],"declare.":[639]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}