{"id":"https://openalex.org/W2335949569","doi":null,"title":"Clinical study of transplantation of neural stem cells in therapy of inherited cerebellar atrophy.","display_name":"Clinical study of transplantation of neural stem cells in therapy of inherited cerebellar atrophy.","publication_year":2009,"publication_date":"2009-08-18","ids":{"openalex":"https://openalex.org/W2335949569","mag":"2335949569","pmid":"https://pubmed.ncbi.nlm.nih.gov/19727238"},"language":"en","primary_location":{"id":"pmid:19727238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19727238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112097831","display_name":"Zengmin Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140386","display_name":"PLA Navy General Hospital","ror":"https://ror.org/036dyz052","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140386"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeng-min Tian","raw_affiliation_strings":["Department of Neurosurgery, General Hospital of Navy, Beijing 100048, China. tianzengmin@sina.com","Department of Neurosurgery, General Hospital of Navy, Beijing 100048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, General Hospital of Navy, Beijing 100048, China. tianzengmin@sina.com","institution_ids":["https://openalex.org/I4210140386"]},{"raw_affiliation_string":"Department of Neurosurgery, General Hospital of Navy, Beijing 100048, China","institution_ids":["https://openalex.org/I4210140386"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100357761","display_name":"Tao Chen","orcid":"https://orcid.org/0000-0002-6552-3457","observed_orcids":["https://orcid.org/0000-0002-6552-3457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029200701","display_name":"Nanbert A. Zhong","orcid":"https://orcid.org/0000-0002-3242-5308","observed_orcids":["https://orcid.org/0000-0002-3242-5308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanbert Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078343111","display_name":"Zhichao Li","orcid":"https://orcid.org/0000-0001-6803-6876","observed_orcids":["https://orcid.org/0000-0001-6803-6876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-chao Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Yin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Yin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Shuang Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuang Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5531,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.62983245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"41","issue":"4","first_page":"456","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.2671000063419342,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.2671000063419342,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.1460999995470047,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-stem-cell-transplantation","display_name":"neural stem cell transplantation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neurospheres","display_name":"neurospheres","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dentate-nucleus","display_name":"dentate nucleus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/in-vitro-cell-expansion","display_name":"in vitro cell expansion","score":0.6909999847412109},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7186971306800842},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6625248193740845},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.6273888945579529},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.60218745470047},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5620124340057373},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4984166622161865},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.48631343245506287},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.4858059883117676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44042953848838806},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4337322413921356},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.42750829458236694},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37800583243370056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36528152227401733},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33705565333366394},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.32087138295173645},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31133031845092773},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.22219210863113403},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1990787386894226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1247306764125824},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05612722039222717},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009849","descriptor_name":"Olivopontocerebellar Atrophies","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053686","descriptor_name":"Fetal Stem Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:19727238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19727238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2375568892","https://openalex.org/W2376022777","https://openalex.org/W2382896809","https://openalex.org/W2010571107","https://openalex.org/W2392835903","https://openalex.org/W7057202964","https://openalex.org/W2388232202","https://openalex.org/W2379853538","https://openalex.org/W3005740785","https://openalex.org/W2329107604"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,12,43,94,97,105,145],"clinical":[4],"effect":[5],"of":[6,14,28,46,82,128],"neural":[7,132],"stem":[8,133],"cell":[9,134],"transplantation":[10,127],"in":[11,34,90,93,129,153],"treatment":[13,140],"inherited":[15,142],"cerebellar":[16],"atrophy":[17],"(CA).":[18],"METHODS:":[19],"The":[20,36,80,126],"cells":[21,81],"from":[22,73],"human":[23],"fetal":[24,83],"cerebellum":[25,84],"(8-10":[26],"weeks":[27],"gestation)":[29],"were":[30,39,68,85,108],"grown":[31],"and":[32,57,117,138],"expanded":[33,86],"vitro.":[35],"cultured":[37,131],"neurospheres":[38],"then":[40],"planted":[41],"into":[42],"dentate":[44],"nuclei":[45],"patients":[47,54],"by":[48,70,87],"stereo":[49],"tactic":[50],"operation.":[51],"Totally,":[52],"12":[53],"(7":[55],"males":[56],"5":[58],"females":[59],"with":[60],"age":[61],"ranging":[62],"22-62":[63],"years,":[64],"mean":[65],"43":[66],"years)":[67],"treated":[69],"this":[71],"operation":[72],"August":[74,77],"2006":[75],"to":[76,150],"2008.":[78],"RESULTS:":[79],"10(7)":[88],"folds":[89],"undifferentiated":[91],"state":[92],"culture.":[95],"After":[96],"operation,":[98],"no":[99],"rejection":[100],"was":[101],"detected.":[102],"Follow":[103],"up,":[104],"effective":[106,139],"rates":[107],"58.3%":[109],"after":[110,114],"3":[111],"months,":[112,116],"75.0%":[113],"6":[115],"66.7%":[118],"for":[119,141],"12-24":[120],"months":[121],"(mean":[122],"18":[123],"months).":[124],"CONCLUSION:":[125],"vitro":[130],"is":[135],"a":[136],"feasible":[137],"CA,":[143],"but":[144],"long":[146],"term":[147],"effectiveness":[148],"need":[149],"be":[151],"taken":[152],"consideration.":[154]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}