{"id":"https://openalex.org/W2335937299","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.lb680","title":"The Influence of Excess Postexercise Leucine Ingestion on Markers of Autophagy in Skeletal Muscle of Older Men","display_name":"The Influence of Excess Postexercise Leucine Ingestion on Markers of Autophagy in Skeletal Muscle of Older Men","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W2335937299","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.lb680","mag":"2335937299"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.lb680","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.lb680","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.lb680","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060495785","display_name":"Andrew C. D\u2019Lugos","orcid":"https://orcid.org/0000-0003-0744-6489","observed_orcids":["https://orcid.org/0000-0003-0744-6489"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D'Lugos","raw_affiliation_strings":["Exercise Science and Wellness Arizona State University, Phoenix, Arizona, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exercise Science and Wellness Arizona State University, Phoenix, Arizona, United States","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061883359","display_name":"Paul T. Reidy","orcid":"https://orcid.org/0000-0002-3068-4429","observed_orcids":["https://orcid.org/0000-0002-3068-4429"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Reidy","raw_affiliation_strings":["Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004508574","display_name":"David M. Gundermann","orcid":"https://orcid.org/0009-0008-5847-4336","observed_orcids":["https://orcid.org/0009-0008-5847-4336"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gundermann","raw_affiliation_strings":["Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037897499","display_name":"Michael S. Borack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Borack","raw_affiliation_strings":["Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014318990","display_name":"Elena Volpi","orcid":"https://orcid.org/0000-0001-8776-0384","observed_orcids":["https://orcid.org/0000-0001-8776-0384"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Volpi","raw_affiliation_strings":["Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009813082","display_name":"Blake B. Rasmussen","orcid":"https://orcid.org/0000-0001-7854-5375","observed_orcids":["https://orcid.org/0000-0001-7854-5375"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blake Rasmussen","raw_affiliation_strings":["Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas, United States","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076259414","display_name":"Jared M. Dickinson","orcid":"https://orcid.org/0000-0003-3142-938X","observed_orcids":["https://orcid.org/0000-0003-3142-938X"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared Dickinson","raw_affiliation_strings":["Exercise Science and Wellness Arizona State University, Phoenix, Arizona, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exercise Science and Wellness Arizona State University, Phoenix, Arizona, United States","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14564621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.921999990940094},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9300000071525574},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.9750000238418579},{"id":"https://openalex.org/keywords/older-men","display_name":"older men","score":0.9359999895095825},{"id":"https://openalex.org/keywords/essential-amino-acids","display_name":"essential amino acids","score":0.7020000219345093},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bnip3","display_name":"BNIP3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gabarap","display_name":"GABARAP","score":0.9120000004768372},{"id":"https://openalex.org/keywords/lc3b","display_name":"LC3B","score":0.8289999961853027},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.9890000224113464},{"id":"https://openalex.org/keywords/vastus-lateralis","display_name":"vastus lateralis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.8230862021446228},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.7948644757270813},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7285538911819458},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7269076704978943},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7267743349075317},{"id":"https://openalex.org/C193230392","wikidata":"https://www.wikidata.org/wiki/Q1663054","display_name":"Ingestion","level":2,"score":0.6939855813980103},{"id":"https://openalex.org/C2776643329","wikidata":"https://www.wikidata.org/wiki/Q975459","display_name":"Vastus lateralis muscle","level":3,"score":0.6191936135292053},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5179402232170105},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4955977201461792},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.48883146047592163},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.48363196849823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4219132661819458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.343367338180542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30450257658958435},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2938370704650879},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2360612154006958},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06322574615478516},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.lb680","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.lb680","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.lb680","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G361551701","display_name":"Nutritional and Contractile Regulation of Muscle Growth","funder_award_id":"R01AR049877","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4769943427","display_name":"Interdisciplinary Predoctoral Rehabilitation Research Training","funder_award_id":"T32HD007539","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7615817203","display_name":"UTMB Clinical and Translational Science Award","funder_award_id":"UL1TR000071","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000888026","display_name":"UTMB Claude D. Pepper Older Americans Independence Center","funder_award_id":"P30AG024832","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2511349034","https://openalex.org/W152836646","https://openalex.org/W3174735554","https://openalex.org/W2102093001","https://openalex.org/W1903247969","https://openalex.org/W4214564999","https://openalex.org/W2041198637","https://openalex.org/W2796408712","https://openalex.org/W3103941043","https://openalex.org/W2040198130"],"abstract_inverted_index":{"The":[0,169],"goal":[1],"of":[2,10,40,48,85,111,171,207,222],"this":[3],"study":[4],"was":[5,113,129,142,166,173],"to":[6,58,82,106,228],"observe":[7],"the":[8,17,205,219],"role":[9],"excess":[11,67,232],"post":[12,124,158],"exercise":[13,25,125,159],"leucine":[14,55,68,234],"ingestion":[15,211],"on":[16],"autophagy":[18,86,197,217],"system":[19],"in":[20,27,87,117,134,144,175,190,201,218],"skeletal":[21,88,202,220],"muscle":[22,89,203,221],"following":[23,204],"resistance":[24],"(RE)":[26],"old":[28],"adults":[29],"over":[30],"a":[31,38,54,188],"24h":[32,103,123],"time":[33,150,180],"course.":[34],"Older":[35],"men":[36,224],"performed":[37],"bout":[39],"RE":[41,208],"and":[42,76,98,102,122,147,209,212],"at":[43,96,99,120,136,148,156,178],"1h":[44],"postexercise":[45,182,233],"ingested":[46],"10g":[47],"essential":[49],"amino":[50],"acids":[51],"(EAA)":[52],"containing":[53],"content":[56],"similar":[57],"high":[59],"quality":[60],"protein":[61,154],"(CTRL,":[62],"1.8g":[63],"leucine,":[64,71],"n=7)":[65],"or":[66],"(LEU,":[69],"3.5g":[70],"n=8).":[72],"Western":[73],"blot":[74],"(protein)":[75],"RT\u2010qPCR":[77],"(mRNA":[78],"expression)":[79],"were":[80],"used":[81],"examine":[83],"markers":[84,214],"(":[90],"vastus":[91],"lateralis":[92],")":[93],"biopsies":[94],"obtained":[95],"rest":[97],"2,":[100],"5,":[101],"postexercise.":[104],"Relative":[105],"basal":[107],"values,":[108],"mRNA":[109,140],"expression":[110,128,141],"Beclin1":[112],"increased":[114,130,155],"(1.3":[115],"fold)":[116,132],"both":[118,145,161,176],"groups":[119,146,162,177],"5h":[121,137,157],"(P<0.05).":[126,138],"BNIP3":[127],"(~1.3":[131],"only":[133],"LEU":[135],"GABARAP":[139],"unchanged":[143,167],"all":[149,179],"points":[151,181],"(P>0.05).":[152,168],"LC3BI":[153],"for":[160],"(P<0.05),":[163,183],"whereas":[164],"LC3BII":[165],"ratio":[170],"LC3BII/LC3BI":[172],"reduced":[174,200],"which":[184],"is":[185],"associated":[186,215],"with":[187,216],"decrease":[189],"autophagic":[191],"flux.":[192],"These":[193],"data":[194],"indicate":[195],"that":[196,213],"may":[198],"be":[199,229],"combination":[206],"EAA":[210],"older":[223],"do":[225],"not":[226],"appear":[227],"influenced":[230],"by":[231],"ingestion.":[235],"NIAMS":[236],"R01AR049877,":[237],"NIA":[238],"P30AG024832,":[239],"NIH":[240],"T32HD07539,":[241],"NCATS":[242],"UL1TR000071":[243]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
