{"id":"https://openalex.org/W2335898267","doi":null,"title":"Differences in atherosclerotic coronary heart disease between subjects with and without rheumatoid arthritis.","display_name":"Differences in atherosclerotic coronary heart disease between subjects with and without rheumatoid arthritis.","publication_year":2007,"publication_date":"2007-05-01","ids":{"openalex":"https://openalex.org/W2335898267","mag":"2335898267","pmid":"https://pubmed.ncbi.nlm.nih.gov/17361987"},"language":"en","primary_location":{"id":"pmid:17361987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17361987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108990340","display_name":"Marie Christine Aubry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-Christine Aubry","raw_affiliation_strings":["Divisions of Anatomic Pathology, Health Science Research, Biostatistics, and Rheumatology, Mayo Clinic, Rochester, Minnesota 55905, USA. aubry.mariechristine@mayo.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Anatomic Pathology, Health Science Research, Biostatistics, and Rheumatology, Mayo Clinic, Rochester, Minnesota 55905, USA. aubry.mariechristine@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072285339","display_name":"Hilal Maradit Kremers","orcid":"https://orcid.org/0000-0003-3882-602X","observed_orcids":["https://orcid.org/0000-0003-3882-602X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hilal Maradit-Kremers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051825328","display_name":"Megan S. Reinalda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan S Reinalda","raw_affiliation_strings":["Mayo Clinic Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091454890","display_name":"Cynthia S. Crowson","orcid":"https://orcid.org/0000-0001-5847-7475","observed_orcids":["https://orcid.org/0000-0001-5847-7475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia S Crowson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045846939","display_name":"William D. Edwards","orcid":"https://orcid.org/0000-0003-2682-9469","observed_orcids":["https://orcid.org/0000-0003-2682-9469"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D Edwards","raw_affiliation_strings":["Mayo Clinic Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106342090","display_name":"Sherine E. Gabriel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sherine E Gabriel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8112,"has_fulltext":false,"cited_by_count":197,"citation_normalized_percentile":{"value":0.97282445,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"34","issue":"5","first_page":"937","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0925000011920929,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.765999972820282},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/vulnerable-plaque","display_name":"vulnerable plaque","score":0.8489999771118164},{"id":"https://openalex.org/keywords/plaque-inflammation","display_name":"plaque inflammation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/unstable-plaque","display_name":"plaque vulnerability","score":0.7099999785423279},{"id":"https://openalex.org/keywords/coronary-stenosis","display_name":"coronary artery stenosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/left-anterior-descending-artery","display_name":"left anterior descending artery","score":0.8169999718666077},{"id":"https://openalex.org/keywords/left-circumflex-artery","display_name":"left circumflex artery","score":0.871999979019165},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9657309055328369},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.7446797490119934},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7346859574317932},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6533729434013367},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6110286712646484},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.5832288265228271},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.5824486017227173},{"id":"https://openalex.org/C2776716733","wikidata":"https://www.wikidata.org/wiki/Q1890226","display_name":"Adventitia","level":2,"score":0.5677711367607117},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.5558988451957703},{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.5394412279129028},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4220088720321655}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003324","descriptor_name":"Coronary Artery Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008910","descriptor_name":"Minnesota","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17361987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17361987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Comparative Study"},{"id":"mag:2335898267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17361987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G89179543","display_name":"Beyond Heart Disease in Rheumatoid Arthritis: Multimorbidity","funder_award_id":"R01AR046849","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W28583584","https://openalex.org/W64169420","https://openalex.org/W80760624","https://openalex.org/W201422399","https://openalex.org/W1785226454","https://openalex.org/W1933994239","https://openalex.org/W1959979631","https://openalex.org/W1968746191","https://openalex.org/W1974356653","https://openalex.org/W1975149587","https://openalex.org/W1991510093","https://openalex.org/W1991622216","https://openalex.org/W1993160453","https://openalex.org/W1995641184","https://openalex.org/W2010802321","https://openalex.org/W2013279724","https://openalex.org/W2021157316","https://openalex.org/W2035292279","https://openalex.org/W2037882607","https://openalex.org/W2043265520","https://openalex.org/W2051687805","https://openalex.org/W2054004405","https://openalex.org/W2070088851","https://openalex.org/W2086578266","https://openalex.org/W2090560337","https://openalex.org/W2094941678","https://openalex.org/W2101619700","https://openalex.org/W2129352413","https://openalex.org/W2134050709","https://openalex.org/W2135590375","https://openalex.org/W2152129452","https://openalex.org/W2152348310","https://openalex.org/W2159193498","https://openalex.org/W2160427887","https://openalex.org/W2314388020","https://openalex.org/W2324841714","https://openalex.org/W2335455113","https://openalex.org/W2470053489"],"related_works":["https://openalex.org/W2164272003","https://openalex.org/W2189396170","https://openalex.org/W3112385714","https://openalex.org/W2049011280","https://openalex.org/W4283711106","https://openalex.org/W2465604135","https://openalex.org/W2335685760","https://openalex.org/W1532892004","https://openalex.org/W2054004405","https://openalex.org/W2324100578"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Patients":[1,114],"with":[2,25,55,150,221,262],"rheumatoid":[3],"arthritis":[4],"(RA)":[5],"are":[6],"at":[7,120],"increased":[8],"risk":[9],"for":[10,67,219,252],"cardiovascular":[11,253],"diseases":[12],"(CVD).":[13],"We":[14],"compared":[15,242],"the":[16,50,199,249],"histologic":[17,68,228],"features":[18],"of":[19,49,58,72,81,92,140,144,153,166,201,209,230,235],"coronary":[20,86,146],"artery":[21,162,178,211],"disease":[22],"in":[23,76,129,138,159,173,183,195,197,239,260],"patients":[24,33,167,184,241,261],"RA":[26,32,240],"and":[27,36,41,53,60,84,96,115,125,207,237,255],"non-RA":[28,47],"controls.":[29,244],"METHODS:":[30],"Forty-one":[31],"who":[34],"died":[35],"underwent":[37],"autopsy":[38,61],"between":[39,111],"1985":[40],"2003":[42],"were":[43,65,88,106,127,179,217],"matched":[44],"to":[45,108,243],"82":[46],"controls":[48,116,154,186],"same":[51],"age":[52,119],"sex":[54],"similar":[56,118],"history":[57],"CVD":[59],"date.":[62],"Coronary":[63],"arteries":[64],"submitted":[66],"evaluation.":[69],"The":[70,79,90],"grade":[71,139,156],"stenosis":[73,141],"was":[74,102,134,191,226],"evaluated":[75],"each":[77,100],"artery.":[78],"numbers":[80],"vulnerable":[82,97],"plaques":[83,172],"acute":[85,145],"lesions":[87,158],"counted.":[89],"composition":[91],"a":[93],"representative":[94],"stable":[95],"plaque":[98],"from":[99],"vessel":[101],"evaluated.":[103],"Chi-square":[104],"tests":[105],"used":[107],"compare":[109],"differences":[110,246],"groups.":[112,131],"RESULTS:":[113],"had":[117,155],"death":[121],"(mean":[122],"79":[123],"yrs)":[124],"61%":[126],"female":[128],"both":[130,198],"Overall,":[132],"there":[133],"no":[135],"significant":[136],"difference":[137],"or":[142],"number":[143],"lesions.":[147],"Among":[148],"subjects":[149,220],"CVD,":[151],"54%":[152],"3-4":[157],"left":[160,174,202],"main":[161],"versus":[163],"only":[164],"7%":[165],"(p":[168,187,204,212],"=":[169,188,205,213],"0.023).":[170],"Vulnerable":[171],"anterior":[175],"descending":[176],"(LAD)":[177],"significantly":[180],"more":[181,193],"common":[182],"than":[185],"0.018).":[189],"Inflammation":[190],"observed":[192],"frequently":[194],"patients,":[196],"media":[200],"circumflex":[203],"0.005)":[206],"adventitia":[208],"LAD":[210],"0.024).":[214],"Similar":[215],"trends":[216],"seen":[218],"heart":[222],"failure.":[223],"CONCLUSION:":[224],"There":[225],"less":[227],"evidence":[229,234],"atherosclerosis":[231],"but":[232],"greater":[233],"inflammation":[236],"instability":[238],"These":[245],"suggest":[247],"that":[248],"mechanisms":[250],"responsible":[251],"morbidity":[254],"mortality":[256],"may":[257],"be":[258],"different":[259],"RA.":[263]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}