{"id":"https://openalex.org/W2335677249","doi":"https://doi.org/10.1097/00062752-200211000-00004","title":"Reconstitution of thymic function after stem cell transplantation in humans","display_name":"Reconstitution of thymic function after stem cell transplantation in humans","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W2335677249","doi":"https://doi.org/10.1097/00062752-200211000-00004","mag":"2335677249","pmid":"https://pubmed.ncbi.nlm.nih.gov/12394170"},"language":"en","primary_location":{"id":"doi:10.1097/00062752-200211000-00004","doi":"https://doi.org/10.1097/00062752-200211000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00062752-200211000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S15004046","display_name":"Current Opinion in Hematology","issn_l":"1065-6251","issn":["1065-6251","1080-8213","1531-7048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Hematology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062706815","display_name":"Frances T. Hakim","orcid":"https://orcid.org/0000-0003-2507-8229","observed_orcids":["https://orcid.org/0000-0003-2507-8229"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frances T. Hakim","raw_affiliation_strings":["Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1907, USA. fhakim@helix.nih.gov","Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","e-mail: [email\u00a0protected]","to Frances T. Hakim, PhD, Bldg. 10, Rm. 12N226, Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1907, USA. fhakim@helix.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"e-mail: [email\u00a0protected]","institution_ids":[]},{"raw_affiliation_string":"to Frances T. Hakim, PhD, Bldg. 10, Rm. 12N226, Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1907, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066218992","display_name":"Ronald E. Gress","orcid":"https://orcid.org/0000-0001-8259-5332","observed_orcids":["https://orcid.org/0000-0001-8259-5332"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald E. Gress","raw_affiliation_strings":["Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062706815"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":0.7445,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.61682243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"6","first_page":"490","last_page":"496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymic-function","display_name":"thymic function","score":0.8059999942779541},{"id":"https://openalex.org/keywords/t-cell-repopulation","display_name":"T cell repopulation","score":0.746999979019165},{"id":"https://openalex.org/keywords/thymopoiesis","display_name":"thymopoiesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.890999972820282},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.9240000247955322},{"id":"https://openalex.org/keywords/t-cell-receptor-diversity","display_name":"T cell receptor diversity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/antigenic-stimulation","display_name":"antigen stimulation","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2780918802","wikidata":"https://www.wikidata.org/wiki/Q25091543","display_name":"Repopulation","level":4,"score":0.8436227440834045},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7003248929977417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6998485326766968},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6573803424835205},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.6452174782752991},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5822096467018127},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5414426922798157},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.437042236328125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31895148754119873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12999099493026733},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.10653221607208252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08559656143188477},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006085","descriptor_name":"Graft Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00062752-200211000-00004","doi":"https://doi.org/10.1097/00062752-200211000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00062752-200211000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S15004046","display_name":"Current Opinion in Hematology","issn_l":"1065-6251","issn":["1065-6251","1080-8213","1531-7048"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Hematology","raw_type":"journal-article"},{"id":"pmid:12394170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12394170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in hematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W66152330","https://openalex.org/W118686632","https://openalex.org/W144046564","https://openalex.org/W266182593","https://openalex.org/W333942075","https://openalex.org/W951670699","https://openalex.org/W989783833","https://openalex.org/W1574011925","https://openalex.org/W1581000856","https://openalex.org/W1639799914","https://openalex.org/W1966432380","https://openalex.org/W1985266927","https://openalex.org/W1988495621","https://openalex.org/W1992031335","https://openalex.org/W1995236521","https://openalex.org/W2001882080","https://openalex.org/W2020400573","https://openalex.org/W2034530063","https://openalex.org/W2035441902","https://openalex.org/W2050233649","https://openalex.org/W2051728885","https://openalex.org/W2061873791","https://openalex.org/W2065541632","https://openalex.org/W2076360498","https://openalex.org/W2078659852","https://openalex.org/W2083490629","https://openalex.org/W2090810530","https://openalex.org/W2104445137","https://openalex.org/W2108238886","https://openalex.org/W2110314836","https://openalex.org/W2121976570","https://openalex.org/W2123434358","https://openalex.org/W2124295081","https://openalex.org/W2141147574","https://openalex.org/W2143566188","https://openalex.org/W2144729402","https://openalex.org/W2159897712","https://openalex.org/W2165156556","https://openalex.org/W2169779391","https://openalex.org/W2219670565","https://openalex.org/W2290604176","https://openalex.org/W2319958744","https://openalex.org/W2323390294","https://openalex.org/W2326418404","https://openalex.org/W2329927796","https://openalex.org/W4365410999"],"related_works":["https://openalex.org/W3119829124","https://openalex.org/W2562288262","https://openalex.org/W2922840548","https://openalex.org/W2148674632","https://openalex.org/W2046100979","https://openalex.org/W3012557881","https://openalex.org/W2037249391","https://openalex.org/W2368392267","https://openalex.org/W7073998405","https://openalex.org/W2095386847"],"abstract_inverted_index":{"The":[0,81],"reconstitution":[1],"of":[2,9,28,75,87],"T-cell":[3,35],"populations":[4],"is":[5,52,56],"a":[6,69],"critical":[7,70],"component":[8],"immune":[10],"recovery":[11,74],"after":[12],"allogeneic":[13],"stem":[14],"cell":[15],"transplantation.":[16],"Recent":[17],"studies":[18],"have":[19],"used":[20],"new":[21,92],"techniques":[22],"to":[23,67,94],"focus":[24],"on":[25],"the":[26,73,85],"interplay":[27],"thymopoiesis":[29,63],"and":[30,43,55,78],"peripheral":[31],"expansion":[32,51],"that":[33],"defines":[34],"repopulation.":[36,80],"Peripheral":[37],"expansion,":[38],"driven":[39],"by":[40,58],"host":[41],"cytokines":[42],"antigenic":[44],"stimulation,":[45],"dominates":[46],"early":[47],"recovery.":[48,96],"However,":[49],"this":[50],"often":[53],"transient":[54],"characterized":[57],"limited":[59],"repertoire":[60,76],"diversity.":[61],"Renewed":[62],"has":[64],"been":[65],"found":[66],"play":[68],"role":[71],"in":[72],"diversity":[77],"stable":[79],"insights":[82],"gained":[83],"into":[84],"regulation":[86],"these":[88],"processes":[89],"may":[90],"provide":[91],"therapies":[93],"enhance":[95]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}