{"id":"https://openalex.org/W2335640508","doi":"https://doi.org/10.1515/znb-1970-0218","title":"Die Beziehung zwischen der cytotoxischen und elektrokinetischen Wirkung von Humanserum auf L-Zellen und Yoshida-Hepatom- Asciteszellen","display_name":"Die Beziehung zwischen der cytotoxischen und elektrokinetischen Wirkung von Humanserum auf L-Zellen und Yoshida-Hepatom- Asciteszellen","publication_year":1970,"publication_date":"1970-02-01","ids":{"openalex":"https://openalex.org/W2335640508","doi":"https://doi.org/10.1515/znb-1970-0218","mag":"2335640508"},"language":"de","primary_location":{"id":"doi:10.1515/znb-1970-0218","doi":"https://doi.org/10.1515/znb-1970-0218","is_oa":true,"landing_page_url":"https://doi.org/10.1515/znb-1970-0218","pdf_url":"https://www.degruyter.com/document/doi/10.1515/znb-1970-0218/pdf","source":{"id":"https://openalex.org/S104732370","display_name":"Zeitschrift f\u00fcr Naturforschung B","issn_l":"0044-3174","issn":["0044-3174","0341-0447","0932-0776","1865-7117"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Naturforschung B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.degruyter.com/document/doi/10.1515/znb-1970-0218/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012087369","display_name":"Harald von Boehmer","orcid":"https://orcid.org/0000-0002-9714-1613","observed_orcids":["https://orcid.org/0000-0002-9714-1613"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. von Boehmer","raw_affiliation_strings":["Max-Planck Institut f\u00fcr Biochemie, M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institut f\u00fcr Biochemie, M\u00fcnchen","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Renate Bayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Renate Bayer","raw_affiliation_strings":["Max-Planck Institut f\u00fcr Biochemie, M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institut f\u00fcr Biochemie, M\u00fcnchen","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013523970","display_name":"Volker Gladigau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"V. Gladigau","raw_affiliation_strings":["Max-Planck Institut f\u00fcr Biochemie, M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institut f\u00fcr Biochemie, M\u00fcnchen","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028031167","display_name":"Gerhard Ruhenstroth-Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G. Ruhenstroth-Bauer","raw_affiliation_strings":["Max-Planck Institut f\u00fcr Biochemie, M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max-Planck Institut f\u00fcr Biochemie, M\u00fcnchen","institution_ids":["https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149899117"],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":{"value":2400,"currency":"EUR","value_usd":2712},"fwci":1.7701,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.86903603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"2","first_page":"205","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.6069999933242798},{"id":"https://openalex.org/keywords/electrokinetics","display_name":"electrokinetic phenomena","score":0.7319999933242798},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.8980000019073486},{"id":"https://openalex.org/keywords/l-cells","display_name":"L cells","score":0.7789999842643738},{"id":"https://openalex.org/keywords/electrophoretic-mobility","display_name":"electrophoretic mobility","score":0.781000018119812},{"id":"https://openalex.org/keywords/antibody-antigen-binding","display_name":"antibody-antigen binding","score":0.4059999883174896},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.3190000057220459},{"id":"https://openalex.org/keywords/rabbit-serum","display_name":"rabbit serum","score":0.5270000100135803},{"id":"https://openalex.org/keywords/guinea-pig-serum","display_name":"guinea pig serum","score":0.796999990940094},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.4620000123977661},{"id":"https://openalex.org/keywords/cell-lysis","display_name":"cell lysis","score":0.578000009059906},{"id":"https://openalex.org/keywords/abo-blood-group","display_name":"ABO blood group system","score":0.6549999713897705},{"id":"https://openalex.org/keywords/rh-blood-group-system","display_name":"Rh blood group system","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6683439612388611},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44745370745658875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1675184965133667}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1515/znb-1970-0218","doi":"https://doi.org/10.1515/znb-1970-0218","is_oa":true,"landing_page_url":"https://doi.org/10.1515/znb-1970-0218","pdf_url":"https://www.degruyter.com/document/doi/10.1515/znb-1970-0218/pdf","source":{"id":"https://openalex.org/S104732370","display_name":"Zeitschrift f\u00fcr Naturforschung B","issn_l":"0044-3174","issn":["0044-3174","0341-0447","0932-0776","1865-7117"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Naturforschung B","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1515/znb-1970-0218","doi":"https://doi.org/10.1515/znb-1970-0218","is_oa":true,"landing_page_url":"https://doi.org/10.1515/znb-1970-0218","pdf_url":"https://www.degruyter.com/document/doi/10.1515/znb-1970-0218/pdf","source":{"id":"https://openalex.org/S104732370","display_name":"Zeitschrift f\u00fcr Naturforschung B","issn_l":"0044-3174","issn":["0044-3174","0341-0447","0932-0776","1865-7117"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Naturforschung B","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","id":"https://metadata.un.org/sdg/14","score":0.6700000166893005}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2335640508.pdf","grobid_xml":"https://content.openalex.org/works/W2335640508.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2808227077","https://openalex.org/W1983611471","https://openalex.org/W2091610735","https://openalex.org/W2044519959","https://openalex.org/W2067780225","https://openalex.org/W2001176192","https://openalex.org/W2416050808","https://openalex.org/W2410710447","https://openalex.org/W2068458126","https://openalex.org/W1585651493"],"abstract_inverted_index":{"Humanserum":[0,41,260],"reduziert":[1],"die":[2,182,193,216,273,283,304,321],"elektrophoretische":[3],"Beweglichkeit":[4,184,239,323],"von":[5,54,128,138,305,324,332],"L-":[6,168],"und":[7,48,84,159,169,243,261,297,300],"Yoshida-Hepatom-":[8],"Asciteszellen.":[9],"Eine":[10,76],"Ig-G-Globulin-Fraktion":[11],"A1F1":[12,197,296,318],"aus":[13],"dem":[14,28],"Serum":[15,29,235,254,278],"wirkt":[16],"nur":[17,106,172,327],"bei":[18,26,140,149,155,163,328,337],"niedriger":[19,329],"Ionen\u00adstarke":[20,339],"(\u03bc":[21],"=":[22],"0,03),":[23],"jedoch":[24,105,335],"nicht":[25,142],"einer":[27],"entsprechenden":[30],"Ionenst\u00e4rke.":[31],"Die":[32,112],"Untersuchung":[33],"dieses":[34],"Problems":[35],"f\u00fchrte":[36],"zu":[37],"folgenden":[38],"Befunden:":[39],"1.Im":[40],"kommen":[42],"komplementabh\u00e4ngige":[43],"cytotoxische":[44,113],"Antik\u00f6rper":[45,134],"gegen":[46,135],"L-Zellen":[47,74,136,150],"Yoshida-Hepatom-Asciteszellen":[49],"(YA-Zellen)":[50],"vor.":[51],"W\u00e4hrend":[52],"30":[53],"51":[55],"untersuchten":[56,97],"Humanseren":[57],"jeweils":[58,70,100,272],"\u00fcber":[59,101],"90%":[60,72,102],"der":[61,73,85,103,110,187,201,203,221,268,294],"YA-Zellen":[62,92,118,139,156,170],"lysierten,":[63],"wirkten":[64],"alle":[65],"46":[66],"untersuditen":[67],"Seren":[68,175],"auf":[69,121,181,279],"iiber":[71],"cytotoxisch.":[75],"Korrelation":[77],"zwischen":[78],"den":[79],"Blutgruppen":[80],"ABO":[81],"oder":[82,153,219,233],"Rh":[83],"cyto-":[86],"toxischen":[87],"Aktivitat":[88],"des":[89,115,277,312],"Humanserums":[90],"gegeniiber":[91],"besteht":[93],"nicht.":[94],"Alle":[95],"6":[96],"Kaninchenseren":[98],"lysierten":[99],"YA-Zellen,":[104,263],"weniger":[107],"als":[108],"20%":[109],"L-Zellen.":[111,301],"Wirkung":[114],"Kaninchenserums":[116],"gegen\u00fcber":[117],"ist":[119],"ebenfalls":[120,246],"ein":[122],"Anti-":[123],"korper-Komplement-System":[124],"zur\u00fcckzuf\u00fchren.":[125],"2.Der":[126],"schon":[127],"FEDOROFF":[129],"et":[130],"al.":[131],"9":[132],"beschriebene":[133],"kann":[137,146],"0\u00b0":[141],"adsorbiert":[143],"werden.":[144],"3.Meerschweinchenkomplement":[145],"weder":[147],"Humankomplement":[148],"noch":[151],"Human-":[152,158],"Kaninchenkomplement":[154,160],"ersetzen.":[157],"dagegen":[161],"sind":[162,171],"beiden":[164],"Zellarten":[165],"austauschbar.":[166],"4.Bei":[167],"cytotoxisch":[173,230],"aktive":[174],"elektrokinetisch":[176,211,309],"wirksam.":[177],"Der":[178],"verlangsamende":[179],"Effekt":[180],"elektrophoretischen":[183,238],"wird":[185],"in":[186,194,236],"Hauptsache":[188],"durch":[189,205,217,229,252,282],"Anlagerung":[190],"bestimmter":[191],"Ig-G-Globuline,":[192],"unserer":[195],"Ig-G-Fraktion":[196,295,317],"enthalten":[198],"sind,":[199],"nach":[200,247],"Sch\u00e4digung":[202],"Zellen":[204,307,326,334],"das":[206],"Antikorper-Komplement-System":[207],"hervorgerufen,":[208],"welches":[209],"allein":[210,319],"kaum":[212],"wirksam":[213],"ist.":[214],"5.Zellen,":[215],"Hitzebehandlung":[218],"infolge":[220],"Pr\u00e4paration":[222],"ihre":[223],"Vitalit\u00e4t":[224],"eingeb\u00fc\u00dft":[225],"haben,":[226],"werden":[227,245],"auch":[228,251,336],"schwach":[231],"wirksames":[232],"inaktiviertes":[234],"ihrer":[237],"verlangsamt.":[240],"Menschliche":[241],"Leukozyten":[242,265],"Leberparenchymzellen":[244,267],"einem":[248],"nicht-antik\u00f6rper-bedingten":[249],"Vitalit\u00e4tsverlust":[250],"autologes":[253],"elek\u00adtrokinetisch":[255],"ver\u00e4ndert.":[256],"6.In":[257],"Adsorptionsversuchen":[258],"mit":[259,293],"L-Zellen,":[262],"autologen":[264],"sowie":[266],"Ratte":[269],"l\u00e4\u00dft":[270],"sich":[271],"zellelektrophoretisch":[274],"erfa\u00dfbare":[275],"Aktivi\u00adt\u00e4t":[276],"eine":[280],"Zellart":[281,285],"andere":[284],"vermindern.":[286],"Das":[287],"gleiche":[288],"Ergebnis":[289],"liefern":[290],"analoge":[291],"Versuche":[292],"hitzeget\u00f6teten":[298],"YA-":[299],"Demnach":[302],"zeigen":[303],"nicht-vitalen":[306,333],"adsorbierten":[308],"wirksamen":[310],"Ig-G-Globuline":[311],"Hu\u00admanserums":[313],"keine":[314],"Zellspezifit\u00e4t.":[315],"7.Die":[316],"vermindert":[320],"elektrophoretisdie":[322],"vitalen":[325],"Ionenst\u00e4rke":[330],"(0,03),":[331],"hoher":[338],"(0,15).":[340]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}