{"id":"https://openalex.org/W2335609753","doi":"https://doi.org/10.1021/jp2010716","title":"Membrane Phosphate Headgroups' Modulation of Permeation of Alkaline Cations in Gramicidin Channels","display_name":"Membrane Phosphate Headgroups' Modulation of Permeation of Alkaline Cations in Gramicidin Channels","publication_year":2011,"publication_date":"2011-04-11","ids":{"openalex":"https://openalex.org/W2335609753","doi":"https://doi.org/10.1021/jp2010716","mag":"2335609753","pmid":"https://pubmed.ncbi.nlm.nih.gov/21480613"},"language":"en","primary_location":{"id":"doi:10.1021/jp2010716","doi":"https://doi.org/10.1021/jp2010716","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp2010716","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028099291","display_name":"Carlos Godoy","orcid":"https://orcid.org/0000-0001-8846-3242","observed_orcids":["https://orcid.org/0000-0001-8846-3242"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I3019322962","display_name":"Universidade Brasil","ror":"https://ror.org/04031z735","country_code":"BR","type":"education","lineage":["https://openalex.org/I3019322962"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Carlos Marcelo G. de Godoy","raw_affiliation_strings":["Department of Cell and Molecular Physiology, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, United States, and Centro de Engenharia Biom\u00e9dica, Universidade Camilo Castelo Branco, Parque Tecnol\u00f3gico, Rodovia Presidente Dutra km 138, S\u00e3o Jose dos Campos, S\u00e3o Paulo 12247-047, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Physiology, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, United States, and Centro de Engenharia Biom\u00e9dica, Universidade Camilo Castelo Branco, Parque Tecnol\u00f3gico, Rodovia Presidente Dutra km 138, S\u00e3o Jose dos Campos, S\u00e3o Paulo 12247-047, Brasil","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I3019322962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088989450","display_name":"Samuel Cukierman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I3019322962","display_name":"Universidade Brasil","ror":"https://ror.org/04031z735","country_code":"BR","type":"education","lineage":["https://openalex.org/I3019322962"]}],"countries":["BR","US"],"is_corresponding":true,"raw_author_name":"Samuel Cukierman","raw_affiliation_strings":["Department of Cell and Molecular Physiology, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, United States, and Centro de Engenharia Biom\u00e9dica, Universidade Camilo Castelo Branco, Parque Tecnol\u00f3gico, Rodovia Presidente Dutra km 138, S\u00e3o Jose dos Campos, S\u00e3o Paulo 12247-047, Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Physiology, Loyola University Medical Center, 2160 South First Avenue, Maywood, Illinois 60153, United States, and Centro de Engenharia Biom\u00e9dica, Universidade Camilo Castelo Branco, Parque Tecnol\u00f3gico, Rodovia Presidente Dutra km 138, S\u00e3o Jose dos Campos, S\u00e3o Paulo 12247-047, Brasil","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I3019322962"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088989450"],"corresponding_institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I3019322962"],"apc_list":null,"apc_paid":null,"fwci":0.1297,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52588969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"115","issue":"17","first_page":"5026","last_page":"5031"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gramicidin-a-channel","display_name":"gramicidin A channel","score":0.9440000057220459},{"id":"https://openalex.org/keywords/proton-transfer","display_name":"proton transfer","score":0.5009999871253967},{"id":"https://openalex.org/keywords/phospholipid-membranes","display_name":"phospholipid membranes","score":0.9660000205039978},{"id":"https://openalex.org/keywords/single-channel-conductance","display_name":"single-channel conductance","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ionic-strength-effects","display_name":"ionic strength effects","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.8896818161010742},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.761829137802124},{"id":"https://openalex.org/C2779650302","wikidata":"https://www.wikidata.org/wiki/Q418980","display_name":"Gramicidin","level":3,"score":0.739983320236206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7342842221260071},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5902559757232666},{"id":"https://openalex.org/C2776952329","wikidata":"https://www.wikidata.org/wiki/Q420004","display_name":"Glycerophospholipid","level":4,"score":0.500274658203125},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.4793449342250824},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46483561396598816},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.45134350657463074},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4498450458049774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26335662603378296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006096","descriptor_name":"Gramicidin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008563","descriptor_name":"Membrane Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008672","descriptor_name":"Metals, Alkali","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050178","descriptor_name":"Monoglycerides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jp2010716","doi":"https://doi.org/10.1021/jp2010716","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp2010716","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmid:21480613","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21480613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2179243218","display_name":null,"funder_award_id":"GM05976","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1482715024","https://openalex.org/W1580315781","https://openalex.org/W1857651432","https://openalex.org/W1964477055","https://openalex.org/W1965970812","https://openalex.org/W1967135823","https://openalex.org/W1971698720","https://openalex.org/W1972921528","https://openalex.org/W1977748684","https://openalex.org/W1977991511","https://openalex.org/W1986665610","https://openalex.org/W1987488965","https://openalex.org/W1991838495","https://openalex.org/W1991993300","https://openalex.org/W1992303171","https://openalex.org/W1996708503","https://openalex.org/W1999556717","https://openalex.org/W2005496553","https://openalex.org/W2012523642","https://openalex.org/W2017550994","https://openalex.org/W2018223865","https://openalex.org/W2018622490","https://openalex.org/W2019070685","https://openalex.org/W2029232020","https://openalex.org/W2032315776","https://openalex.org/W2042447779","https://openalex.org/W2043251868","https://openalex.org/W2046020097","https://openalex.org/W2050624758","https://openalex.org/W2051808851","https://openalex.org/W2053301395","https://openalex.org/W2065476796","https://openalex.org/W2067518491","https://openalex.org/W2068964976","https://openalex.org/W2070895853","https://openalex.org/W2082283206","https://openalex.org/W2082314566","https://openalex.org/W2093596096","https://openalex.org/W2122074593","https://openalex.org/W2128882835","https://openalex.org/W2137530264","https://openalex.org/W2156892356","https://openalex.org/W2163699775"],"related_works":["https://openalex.org/W2046020097","https://openalex.org/W2018223865","https://openalex.org/W2005470966","https://openalex.org/W2053301395","https://openalex.org/W2078344803","https://openalex.org/W1999556717","https://openalex.org/W1979086674","https://openalex.org/W1983474954","https://openalex.org/W4220909637","https://openalex.org/W2586882753"],"abstract_inverted_index":{"The":[0,10,98,139],"function":[1],"of":[2,12,38,46,70,90,100],"membrane":[3,32],"proteins":[4],"is":[5,19,51,77],"modulated":[6],"by":[7],"lipid":[8],"bilayers.":[9],"permeation":[11,45,115,121],"ions":[13],"in":[14,22,41,48,54,57,67,103,111,122,128,144],"gramicidin":[15],"A":[16],"channels":[17,50,64,136],"(gA)":[18],"markedly":[20],"distinct":[21],"monoglyceride":[23,58],"and":[24,92,94,96,116,148],"phospholipid":[25,55],"membranes.":[26,59],"It":[27,76],"was":[28],"previously":[29],"demonstrated":[30,78],"that":[31,79],"phosphate":[33,101],"headgroups":[34,102],"accelerate":[35],"the":[36,44,107,118],"rate":[37],"proton":[39,119],"transfer":[40,120],"gA.":[42],"However,":[43],"alkalines":[47,84],"gA":[49,63,123,135],"considerably":[52],"slower":[53],"than":[56],"In":[60,125],"this":[61],"study,":[62],"were":[65],"reconstituted":[66],"various":[68],"membranes":[69,104,127],"ceramides,":[71],"monoglycerides,":[72],"phospholipids,":[73],"or":[74],"sphingolipids.":[75],"single":[80],"channel":[81],"conductances":[82],"to":[83,146],"are":[85,142],"similar":[86],"among":[87],"bilayers":[88],"consisting":[89],"phospholipids":[91],"sphingolipids,":[93],"ceramides":[95],"monoglycerides.":[97],"presence":[99],"(and":[105],"not":[106],"double":[108],"acyl":[109],"chains":[110],"lipids)":[112],"attenuates":[113],"alkaline":[114],"enhances":[117],"channels.":[124],"ceramide":[126],"low":[129],"ionic":[130],"strength":[131],"(<250":[132],"mM)":[133],"solutions,":[134],"become":[137],"dysfunctional.":[138],"experimental":[140],"results":[141],"discussed":[143],"regard":[145],"membrane/solution":[147],"membrane/protein":[149],"interfaces.":[150]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
