{"id":"https://openalex.org/W2335529246","doi":"https://doi.org/10.1227/01.neu.0000452476.51442.18","title":"202 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence in Low-Grade Gliomas","display_name":"202 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence in Low-Grade Gliomas","publication_year":2014,"publication_date":"2014-07-18","ids":{"openalex":"https://openalex.org/W2335529246","doi":"https://doi.org/10.1227/01.neu.0000452476.51442.18","mag":"2335529246"},"language":"en","primary_location":{"id":"doi:10.1227/01.neu.0000452476.51442.18","doi":"https://doi.org/10.1227/01.neu.0000452476.51442.18","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000452476.51442.18","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036801462","display_name":"Pablo Andres Valdes","orcid":"https://orcid.org/0000-0002-6788-8003","observed_orcids":["https://orcid.org/0000-0002-6788-8003"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pablo A. Valdes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073644752","display_name":"Valerie L. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valerie L. Jacobs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023448259","display_name":"Brent T. Harris","orcid":"https://orcid.org/0000-0002-9746-4906","observed_orcids":["https://orcid.org/0000-0002-9746-4906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brent T. Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080602355","display_name":"Brian C. Wilson","orcid":"https://orcid.org/0000-0001-5543-666X","observed_orcids":["https://orcid.org/0000-0001-5543-666X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091509313","display_name":"Fr\u00e9d\u00e9ric Leblond","orcid":"https://orcid.org/0000-0002-8154-4952","observed_orcids":["https://orcid.org/0000-0002-8154-4952"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frederic Leblond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016359425","display_name":"Keith D. Paulsen","orcid":"https://orcid.org/0000-0002-6692-3196","observed_orcids":["https://orcid.org/0000-0002-6692-3196"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith Paulsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015692018","display_name":"David W. Roberts","orcid":"https://orcid.org/0000-0002-8677-3930","observed_orcids":["https://orcid.org/0000-0002-8677-3930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David W. Roberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1563,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55039853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"61","issue":"Supplement 1","first_page":"227","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.14229999482631683,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.968999981880188},{"id":"https://openalex.org/keywords/protoporphyrin-ix","display_name":"protoporphyrin IX","score":0.9940000176429749},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.9120000004768372},{"id":"https://openalex.org/keywords/fluorescence-guided-resection","display_name":"fluorescence-guided resection","score":0.9570000171661377},{"id":"https://openalex.org/keywords/quantitative-fluorescence-imaging","display_name":"quantitative fluorescence imaging","score":0.7070000171661377},{"id":"https://openalex.org/keywords/intraoperative-fluorescence","display_name":"intraoperative fluorescence","score":0.4909999966621399},{"id":"https://openalex.org/keywords/tumor-detection","display_name":"tumor detection","score":0.414000004529953},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.824999988079071},{"id":"https://openalex.org/keywords/glioma-surgery","display_name":"glioma surgery","score":0.4569999873638153},{"id":"https://openalex.org/keywords/glioma-molecular-subtypes","display_name":"glioma molecular subtypes","score":0.3490000069141388},{"id":"https://openalex.org/keywords/glioma-cell-of-origin","display_name":"glioma cell of origin","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.9023529291152954},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7781835794448853},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7368124723434448},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.7189186215400696},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.6578083038330078},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6181550621986389},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4797131419181824},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.4328831136226654},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4141630530357361},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.397876501083374},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2330007255077362},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19421735405921936},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.08209678530693054},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.061297208070755005},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1227/01.neu.0000452476.51442.18","doi":"https://doi.org/10.1227/01.neu.0000452476.51442.18","is_oa":false,"landing_page_url":"https://doi.org/10.1227/01.neu.0000452476.51442.18","pdf_url":null,"source":{"id":"https://openalex.org/S111727011","display_name":"Neurosurgery","issn_l":"0148-396X","issn":["0148-396X","1081-1281","1524-4040"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurosurgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1680005262","https://openalex.org/W2944846938","https://openalex.org/W2057120578","https://openalex.org/W2156913009","https://openalex.org/W2946645533","https://openalex.org/W3169851471","https://openalex.org/W2012168402","https://openalex.org/W2142451976","https://openalex.org/W2886579043","https://openalex.org/W4281803758"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Fluorescence-guided":[1],"resection":[2],"using":[3,39,58,258,308],"5-aminolevulinic":[4],"acid-induced":[5],"protoporphyrin":[6],"IX":[7],"(ALA-PpIX)":[8],"has":[9],"shown":[10,31],"promising":[11],"results":[12,278],"in":[13,25,36,66,268,279,290,304,319],"high-grade":[14,37,327],"gliomas.":[15,27,68,328],"However,":[16],"few":[17],"studies":[18],"have":[19,29,248],"investigated":[20],"the":[21,96,127,272,298,314],"utility":[22],"of":[23,75,82,95,103,130,139,147,195,202,221,228,238,256,266,288,317,323],"ALA-PpIX":[24,267,318],"low-grade":[26,67,76],"We":[28,283],"previously":[30],"significantly":[32],"improved":[33],"diagnostic":[34,128,200,219,281,315],"performance":[35,129,316],"gliomas":[38],"a":[40,73,154,175,199,218,225],"quantitative":[41,64,101,215,259,309],"technique":[42],"for":[43,326],"fluorescence-guidance":[44],"compared":[45],"to":[46,85,125],"state-of-the-art":[47],"visible":[48,148,196,207,276,299,324],"fluorescence":[49,62,65,99,132,197,208,216,260,277,300],"imaging":[50],"techniques.":[51],"Here":[52],"we":[53,311],"present":[54],"our":[55],"initial":[56,264,306],"experience":[57,265,307],"both":[59,131],"visible,":[60,97],"subjective":[61],"and":[63,100,113,296],"METHODS:":[69],"Twelve":[70],"patients":[71],"with":[72,153,271],"diagnosis":[74],"glioma":[77],"were":[78,107,242,293],"administered":[79],"20":[80],"mg/kg":[81],"ALA":[83],"prior":[84],"surgery":[86],"under":[87],"an":[88],"institutional":[89],"Review":[90],"Board":[91],"approved":[92],"protocol.":[93],"Assessments":[94],"red":[98],"measurements":[102],"PpIX":[104],"concentrations":[105],"(CPpIX)":[106],"obtained":[108],"from":[109],"multiple":[110],"locations":[111],"intraoperatively,":[112],"subsequently":[114],"biopsy":[115],"specimens":[116,240],"underwent":[117],"neuropathological":[118],"analysis.":[119],"Receiver":[120],"operating":[121],"characteristic":[122],"(ROC)":[123],"analysis":[124,194],"assess":[126],"guidance":[133],"techniques":[134],"was":[135],"performed.":[136],"RESULTS:":[137],"Five":[138],"12":[140],"tumors":[141],"demonstrated":[142],"at":[143],"least":[144],"1":[145],"instance":[146],"fluorescence.":[149],"Normal":[150],"tissue":[151],"presented":[152],"mean":[155,176],"CPpIX":[156,177,229,257,289],"=":[157,161,164,167,170,178,182,185,188,191,206,212,233],"51.0":[158],"ng/mL":[159,180],"[min":[160,181],"0.0,":[162,183],"25th-percentile":[163,184],"1.0,":[165,186],"75th-percentile":[166,187],"5.0,":[168],"max":[169,190],"567.0],":[171],"while":[172],"tumor":[173,239],"had":[174],"766.0":[179],"177.0,":[189],"10540.0].":[192],"ROC":[193],"yielded":[198,217],"accuracy":[201,220],"38.0%":[203],"(cut-off":[204],"threshold":[205,227],"score":[209],"\u22651,":[210],"AUC":[211,232],"0.514),":[213],"whereas":[214],"67":[222],"%":[223],"(for":[224],"cut-off":[226],">5.6":[230],"ng/mL,":[231],"0.66).":[234],"Further,":[235,303],"45%":[236],"(9/20)":[237],"that":[241,275,292,313,322],"not":[243],"visibly":[244],"fluorescent,":[245],"which":[246],"would":[247],"otherwise":[249],"gone":[250],"undetected,":[251],"accumulated":[252],"diagnostically":[253,285],"significant":[254,286],"levels":[255,287],"measurements.":[261],"CONCLUSION:":[262],"This":[263],"LGG":[269,320],"concurs":[270],"literature":[273],"understanding":[274],"poor":[280],"accuracies.":[282],"found":[284,312],"LGGs":[291],"non-visibly":[294],"fluorescent":[295],"below":[297],"detection":[301],"threshold.":[302],"this":[305],"methods,":[310],"approaches":[321],"methods":[325]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
