{"id":"https://openalex.org/W2334698761","doi":"https://doi.org/10.1158/1940-6207.prev-12-b105","title":"Abstract B105: Postmenopausal plasma sex hormone levels and subsequent risk of breast cancer over 20 years of follow-up","display_name":"Abstract B105: Postmenopausal plasma sex hormone levels and subsequent risk of breast cancer over 20 years of follow-up","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2334698761","doi":"https://doi.org/10.1158/1940-6207.prev-12-b105","mag":"2334698761"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.prev-12-b105","doi":"https://doi.org/10.1158/1940-6207.prev-12-b105","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.prev-12-b105","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100704029","display_name":"Xuehong Zhang","orcid":"https://orcid.org/0000-0002-8260-8508","observed_orcids":["https://orcid.org/0000-0002-8260-8508"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuehong Zhang","raw_affiliation_strings":["1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2University of Massachusetts, Amherst, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2University of Massachusetts, Amherst, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054091966","display_name":"Shelley S. Tworoger","orcid":"https://orcid.org/0000-0002-6986-7046","observed_orcids":["https://orcid.org/0000-0002-6986-7046"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shelley S. Tworoger","raw_affiliation_strings":["1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2University of Massachusetts, Amherst, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2University of Massachusetts, Amherst, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014551852","display_name":"A. Heather Eliassen","orcid":"https://orcid.org/0000-0002-3961-6609","observed_orcids":["https://orcid.org/0000-0002-3961-6609"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Heather Eliassen","raw_affiliation_strings":["1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2University of Massachusetts, Amherst, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2University of Massachusetts, Amherst, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008373933","display_name":"Susan E. Hankinson","orcid":"https://orcid.org/0000-0001-9155-3767","observed_orcids":["https://orcid.org/0000-0001-9155-3767"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan E. Hankinson","raw_affiliation_strings":["1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2University of Massachusetts, Amherst, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2University of Massachusetts, Amherst, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"11_Supplement","first_page":"B105","last_page":"B105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.25200000405311584,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.2101999968290329,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postmenopausal-breast-cancer","display_name":"postmenopausal breast cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/plasma-sex-hormones","display_name":"plasma sex hormones","score":0.9539999961853027},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9639999866485596},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.8059999942779541},{"id":"https://openalex.org/keywords/dehydroepiandrosterone-sulfate","display_name":"dehydroepiandrosterone sulfate","score":0.9300000071525574},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/free-testosterone","display_name":"free testosterone","score":0.5630000233650208},{"id":"https://openalex.org/keywords/free-estradiol","display_name":"free estradiol","score":0.9179999828338623},{"id":"https://openalex.org/keywords/breast-cancer-risk-prediction","display_name":"breast cancer risk prediction","score":0.7229999899864197},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.7509999871253967},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.671999990940094},{"id":"https://openalex.org/keywords/progesterone-receptor-negative-breast-cancer","display_name":"progesterone receptor-negative breast cancer","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nurses-health-study","display_name":"Nurses' Health Study","score":0.7020000219345093},{"id":"https://openalex.org/keywords/postmenopausal-hormone-use","display_name":"postmenopausal hormone use","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7582899332046509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7536724209785461},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.6875306367874146},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.5659810304641724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5497345924377441},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5076695680618286},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4816783368587494},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4706375300884247},{"id":"https://openalex.org/C2780657110","wikidata":"https://www.wikidata.org/wiki/Q2505402","display_name":"Dehydroepiandrosterone sulfate","level":4,"score":0.45314890146255493},{"id":"https://openalex.org/C148759681","wikidata":"https://www.wikidata.org/wiki/Q2005375","display_name":"Nurses' Health Study","level":3,"score":0.44807153940200806},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4319136440753937},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.43149295449256897},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.41923367977142334},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3720494508743286},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3699910640716553},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3360058665275574}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.prev-12-b105","doi":"https://doi.org/10.1158/1940-6207.prev-12-b105","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.prev-12-b105","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026122583","https://openalex.org/W2019534570","https://openalex.org/W7098236521","https://openalex.org/W1967607481","https://openalex.org/W2122100237","https://openalex.org/W2012353756","https://openalex.org/W2111830451","https://openalex.org/W2123130972","https://openalex.org/W2126588098","https://openalex.org/W2112025328"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Although":[2],"plasma":[3,448],"estrogen":[4],"and":[5,116,149,200,222,306,335,399,452],"androgen":[6],"levels":[7,49,214,451],"are":[8],"significantly":[9,350],"positively":[10],"associated":[11],"with":[12,272,342],"risk":[13,33,54,172,236,422,454],"of":[14,44,151,213,215,229,237,276,345,355,423,455,461,467],"postmenopausal":[15,122,126,418],"breast":[16,31,52,170,238,284,293,427,456],"cancer,":[17],"it":[18],"is":[19,94],"unknown":[20],"how":[21,61],"long":[22],"a":[23,99,233],"single":[24,412],"blood":[25,70,130,152,182,258,317,413],"hormone":[26,48,81,91,352,415,424,450],"measure":[27],"can":[28,72,420],"predict":[29,421],"subsequent":[30,453],"cancer":[32,53,64,171,239,285,294,428,457],"as":[34],"most":[35,76],"prior":[36],"studies":[37],"have":[38],"included":[39],"less":[40,282],"than":[41],"10":[42,185,279],"years":[43,68,186,253,321,460],"follow-up.":[45],"If":[46],"including":[47],"into":[50],"current":[51],"prediction":[55],"models":[56],"improves":[57],"discriminative":[58],"ability,":[59],"evaluating":[60],"the":[62,75,86,105,162,180,210,226,270,287,343,347,356,360,365,468],"hormone/breast":[63],"association":[65],"varies":[66],"by":[67,89,167,264,351],"since":[69],"collection":[71,259],"help":[73],"determine":[74],"relevant":[77],"time":[78,150],"period":[79],"for":[80,169,179,190,193,196,202,262,291,299,304,310,316,328,333,339,374,382,386,396,407,429],"measures.":[82],"In":[83],"addition,":[84],"whether":[85],"associations":[87,348],"vary":[88],"tumor":[90],"receptor":[92,353,425],"status":[93,354],"unclear.":[95],"Methods:":[96],"We":[97,154],"conducted":[98],"prospective":[100],"nested":[101],"case-control":[102],"analysis":[103],"within":[104],"Nurses'":[106],"Health":[107],"Study":[108],"cohort.":[109],"Blood":[110],"samples":[111,318],"were":[112,134,143,188,231,244,295,324,370],"collected":[113,184,319],"in":[114,118,209,417,476],"1989-1990":[115],"then":[117],"2000-2002.":[119],"Among":[120],"eligible":[121],"women":[123,208,419],"not":[124],"using":[125],"hormones":[127,277],"(PMH)":[128],"at":[129,232],"collection,":[131],"796":[132],"cases":[133,146,248],"diagnosed":[135,249],"through":[136],"June,":[137],"2010.":[138],"Two":[139],"control":[140],"subjects":[141],"(n=1,583)":[142],"matched":[144],"to":[145,160,225,431],"on":[147,474],"age":[148],"collection.":[153],"used":[155],"unconditional":[156],"logistic":[157],"regression":[158],"analyses":[159],"estimate":[161],"relative":[163],"risks":[164,243],"(RRs,":[165],"95%CIs)":[166],"controlling":[168],"factors.":[173],"Results:":[174],"The":[175,312],"intra-class":[176],"correlation":[177],"coefficients":[178],"two":[181],"measures":[183],"apart":[187],"0.69":[189],"estradiol,":[191,216,218,300,329],"0.71":[192],"testosterone,":[194,219,221,305,334],"0.54":[195],"dehydroepiandrosterone":[197],"sulfate":[198],"(DHEAS),":[199],"0.74":[201],"sex":[203,414,449],"hormone-binding":[204],"globulin":[205],"(SHBG).":[206],"Overall,":[207],"top":[211],"25%":[212,228],"free":[217,220],"DHEAS":[223],"(compared":[224],"lowest":[227,273,368],"levels)":[230],"50-107%":[234],"higher":[235],"(all":[240,260],"p-trends<0.004).":[241],"Relative":[242],"similar":[245],"when":[246],"comparing":[247,269,364],"1-10":[250],"vs.":[251,367,378,392,403],"11-20":[252,320],"(and":[254],"16-20":[255],"years)":[256],"after":[257],"p-values":[261],"interaction":[263],"follow-up":[265],"period>0.15).":[266],"For":[267,358],"example,":[268,359],"highest":[271,366],"(reference)":[274],"quartile":[275,369],"measured":[278],"year":[280],"or":[281],"before":[283,322],"diagnosis,":[286],"multivariable":[288,361],"RRs":[289,314,362],"(95%CIs)":[290,315,363],"overall":[292],"2.0":[296,325],"(1.4-2.7;":[297],"p-trend<0.001)":[298,373,391],"1.4":[301],"(1.1-1.9;":[302],"p-trend=0.001)":[303],"0.63":[307],"(0.47-0.85;":[308],"p-trend=0.006)":[309],"SHBG.":[311,340],"comparable":[313],"diagnosis":[323],"(1.3-3.1;":[326],"p-trend=0.002)":[327],"1.6":[330],"(1.0-2.4;":[331],"p-trend=0.11)":[332],"0.68":[336],"(0.44-1.04;":[337],"p-trend=0.04)":[338],"Importantly,":[341],"exception":[344],"DHEAS,":[346],"varied":[349],"tumor.":[357],"2.8":[371],"(2.0-4.0;":[372],"ER+/PR+":[375],"tumors":[376,384],"(n=347)":[377],"1.1":[379],"(0.6-2.1;":[380],"p-trend=0.98)":[381],"ER-/PR-":[383],"(n=80)":[385],"estradiol":[387],"(p-heterogeneity<0.01),":[388,398],"1.8":[389],"(1.3-2.5;":[390],"0.6":[393],"(0.3-1.2;":[394],"p-trend=0.35)":[395],"testosterone":[397],"0.46":[400],"(0.31-0.67;":[401],"p-trend=0.01)":[402],"1.07":[404],"(0.56-2.06;":[405],"p-trend=0.67)":[406],"SHBG":[408],"(p-heterogeneity=0.01).":[409],"Conclusions:":[410],"A":[411],"measurement":[416],"positive":[426],"up":[430],"20":[432,459],"years.":[433],"Citation":[434],"Format:":[435],"Xuehong":[436],"Zhang,":[437],"Shelley":[438],"S.":[439],"Tworoger,":[440],"A.":[441],"Heather":[442],"Eliassen,":[443],"Susan":[444],"E.":[445],"Hankinson.":[446],"Postmenopausal":[447],"over":[458],"follow":[462],"up.":[463],"[abstract].":[464],"In:":[465],"Proceedings":[466],"Eleventh":[469],"Annual":[470],"AACR":[471],"International":[472],"Conference":[473],"Frontiers":[475],"Cancer":[477,488],"Prevention":[478],"Research;":[479],"2012":[480],"Oct":[481],"16-19;":[482],"Anaheim,":[483],"CA.":[484],"Philadelphia":[485],"(PA):":[486],"AACR;":[487],"Prev":[489],"Res":[490],"2012;5(11":[491],"Suppl):Abstract":[492],"nr":[493],"B105.":[494]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2016-06-24T00:00:00"}