{"id":"https://openalex.org/W2334593497","doi":"https://doi.org/10.1016/s0959-8049(12)71959-7","title":"161 Investigation of Resistance to BRAF Inhibitors in Colon Cancer: Mutation and Chemosensitivity Profiling of 20 Human Colon Cancer Cell Lines","display_name":"161 Investigation of Resistance to BRAF Inhibitors in Colon Cancer: Mutation and Chemosensitivity Profiling of 20 Human Colon Cancer Cell Lines","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2334593497","doi":"https://doi.org/10.1016/s0959-8049(12)71959-7","mag":"2334593497"},"language":"en","primary_location":{"id":"doi:10.1016/s0959-8049(12)71959-7","doi":"https://doi.org/10.1016/s0959-8049(12)71959-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-8049(12)71959-7","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086545510","display_name":"Gerhard Kelter","orcid":"https://orcid.org/0000-0001-5545-5334","observed_orcids":["https://orcid.org/0000-0001-5545-5334"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Kelter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020203684","display_name":"Rebekka Krumbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Krumbach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072211114","display_name":"Torsten Giesemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Giesemann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028752254","display_name":"Vincent Vuaroqueaux","orcid":"https://orcid.org/0000-0001-9120-5332","observed_orcids":["https://orcid.org/0000-0001-9120-5332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Vuaroqueaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061709384","display_name":"Fr\u00e9d\u00e9ric Foucault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Foucault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091156106","display_name":"Thomas M. Metz","orcid":"https://orcid.org/0000-0002-3152-0418","observed_orcids":["https://orcid.org/0000-0002-3152-0418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Metz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017511312","display_name":"Thomas Metcalfe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Metcalfe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062304427","display_name":"Heinz\u2010Herbert Fiebig","orcid":"https://orcid.org/0000-0001-6222-7321","observed_orcids":["https://orcid.org/0000-0001-6222-7321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.H. Fiebig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2539925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"48","issue":null,"first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-inhibitors","display_name":"BRAF inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8730000257492065},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/colon-cancer-cell-lines","display_name":"colon cancer cell lines","score":0.8140000104904175},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7541634440422058},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6332552433013916},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4159296751022339},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39010071754455566},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3841833472251892},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.337353378534317},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3330467939376831},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20127227902412415},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1730259358882904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1528480350971222}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0959-8049(12)71959-7","doi":"https://doi.org/10.1016/s0959-8049(12)71959-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0959-8049(12)71959-7","pdf_url":null,"source":{"id":"https://openalex.org/S16731738","display_name":"European Journal of Cancer","issn_l":"0959-8049","issn":["0959-8049","1879-0852"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034751446","https://openalex.org/W2313037686","https://openalex.org/W2560265550","https://openalex.org/W2071780912","https://openalex.org/W2004227921","https://openalex.org/W7098187334","https://openalex.org/W2972197281","https://openalex.org/W2038603726","https://openalex.org/W4210332210","https://openalex.org/W7217477817"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2016-06-24T00:00:00"}