{"id":"https://openalex.org/W2334510754","doi":"https://doi.org/10.1097/shk.0b013e318268deb2","title":"Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia (Shock 37(6), 645\u2013652, 2012)","display_name":"Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia (Shock 37(6), 645\u2013652, 2012)","publication_year":2012,"publication_date":"2012-09-18","ids":{"openalex":"https://openalex.org/W2334510754","doi":"https://doi.org/10.1097/shk.0b013e318268deb2","mag":"2334510754","pmid":"https://pubmed.ncbi.nlm.nih.gov/22986794"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0b013e318268deb2","doi":"https://doi.org/10.1097/shk.0b013e318268deb2","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0b013e318268deb2","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022511880","display_name":"JingYao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JingYao Zhang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100353178","display_name":"Chang Liu","orcid":"https://orcid.org/0000-0002-7318-1004","observed_orcids":["https://orcid.org/0000-0002-7318-1004","https://orcid.org/0009-0003-9801-3984","https://orcid.org/0000-0002-1996-7647","https://orcid.org/0000-0003-1784-0877"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Liu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110490263","display_name":"Ming\u2010Hui Tai","orcid":"https://orcid.org/0000-0002-3540-5425","observed_orcids":["https://orcid.org/0000-0002-3540-5425"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MingHui Tai","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030352138","display_name":"Kai Qu","orcid":"https://orcid.org/0000-0002-1138-3727","observed_orcids":["https://orcid.org/0000-0002-1138-3727"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Qu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi\u2019an Jiaotong University, China","institution_ids":["https://openalex.org/I4210121771"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210121771"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"4","first_page":"444","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.7379999756813049},{"id":"https://openalex.org/keywords/global-cerebral-ischemia","display_name":"global cerebral ischemia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hydrogen-therapy","display_name":"hydrogen treatment","score":0.5789999961853027},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.6100000143051147},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.3790000081062317},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5870000123977661},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.7789999842643738},{"id":"https://openalex.org/keywords/brain-protection","display_name":"cerebral protection","score":0.44600000977516174},{"id":"https://openalex.org/keywords/hydrogen-rich-saline","display_name":"hydrogen-rich saline","score":0.5860000252723694},{"id":"https://openalex.org/keywords/polymicrobial-sepsis","display_name":"polymicrobial sepsis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.6809999942779541},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.984000027179718},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.3449999988079071},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.3930000066757202},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6281940340995789},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5371497273445129},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5049996972084045},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.4881969094276428},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.429251104593277},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3842747211456299},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32354748249053955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24598923325538635},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08588692545890808}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/shk.0b013e318268deb2","doi":"https://doi.org/10.1097/shk.0b013e318268deb2","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0b013e318268deb2","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:22986794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22986794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1970973267","https://openalex.org/W2119465990","https://openalex.org/W2169657429"],"related_works":["https://openalex.org/W1970973267","https://openalex.org/W132597102","https://openalex.org/W2044992203","https://openalex.org/W3211288194","https://openalex.org/W2135190066","https://openalex.org/W6996068452","https://openalex.org/W2149239535","https://openalex.org/W2798040078","https://openalex.org/W2075096314","https://openalex.org/W6986609154"],"abstract_inverted_index":{"Effect":[0],"of":[1,8,41,56,63,99,102,116,140,152,158,172,205,221,262,279,335,391,403,408,447,454,460,523,535,559,566],"Hydrogen":[2],"Gas":[3],"on":[4,178,394,432,537],"the":[5,18,46,66,74,78,86,91,100,103,114,129,138,150,153,179,202,213,218,222,228,242,260,267,280,286,298,302,322,333,336,340,347,349,354,357,363,372,375,378,395,406,425,433,437,440,448,452,455,461,485,506,518,521,524,533,538,548],"Survival":[6],"Rate":[7],"Mice":[9],"Following":[10],"Global":[11],"Cerebral":[12],"Ischemia.":[13],"Shock":[14],"37(6):645\u2013652,":[15],"2012":[16],"To":[17],"Editor":[19],"In":[20,65,289],"2007,":[21],"an":[22,528],"article":[23],"about":[24,230],"hydrogen":[25,71,111,173,198,223,231,254,299,313,337,350,358,379,426,494,536],"acting":[26],"as":[27,301],"a":[28,38,54,58,175,295,384,389,429,444,481,496,542],"miracle":[29,498],"therapy":[30,500],"was":[31,43],"published":[32,162],"in":[33,124,163,277,544,547],"Nature,":[34],"it":[35,274,317,475,478,515],"symbolized":[36],"that":[37,70,110,170,197,237,297,387,424,474,493],"new":[39,281,497],"field":[40,239,546],"medicine":[42],"created.":[44],"At":[45],"same":[47],"time,":[48],"Ohsawa":[49],"et":[50,166,192],"al,":[51],"(1)":[52],"provided":[53],"template":[55],"such":[57,159,263,326],"study,":[59],"which":[60,96,283],"attracted":[61],"hundreds":[62],"followers.":[64],"research,":[67],"they":[68],"discovered":[69],"gas":[72,199],"has":[73,113,388,428],"ability":[75,115],"to":[76,145,235,371,484,505,513],"protect":[77],"brain":[79],"against":[80],"ischemia-reperfusion":[81],"injury,":[82],"through":[83,436],"selectively":[84],"eliminating":[85],"toxic":[87],"oxygen":[88,463],"radicals,":[89],"especially":[90],"hydroxyl":[92],"radicals":[93],"and":[94,120,135,147,187,246,272,312,377,398,435,458],"peroxynitrite,":[95],"are":[97],"two":[98],"strongest":[101],"oxidant":[104],"species.":[105],"The":[106,381,562],"follow-up":[107],"studies":[108,160],"proved":[109,216],"really":[112,476],"antioxidant,":[117],"anti-inflammatory,":[118],"antiapoptotic,":[119],"other":[121,519],"protective":[122],"effects":[123,393],"various":[125],"organ":[126],"systems,":[127],"including":[128,451],"lung,":[130],"liver,":[131],"heart,":[132],"kidneys,":[133],"intestines,":[134],"brain.":[136],"And":[137],"way":[139],"delivery":[141],"developed":[142],"from":[143],"inhalation":[144,171,343],"drinking":[146],"at":[148],"last":[149],"injection":[151,345],"hydrogen-rich":[154],"saline":[155],"(2).":[156,315],"Two":[157],"were":[161,249],"Shock.":[164],"Xie":[165],"al.":[167,193],"(3)":[168],"found":[169],"had":[174,234,240],"good":[176],"effect":[177,220,324,431,534],"murine":[180],"polymicrobial":[181],"sepsis":[182],"via":[183],"reducing":[184],"oxidative":[185],"stress":[186],"HMGB1":[188],"release.":[189],"Recently,":[190],"Nagatani":[191],"(4)":[194],"first":[195,351],"reported":[196],"could":[200,258,318],"increase":[201,453],"survival":[203],"rate":[204],"mice":[206],"following":[207],"global":[208],"cerebral":[209],"ischemia":[210],"by":[211,252],"impacting":[212],"autophagy.":[214],"It":[215],"again":[217],"magic":[219],"therapy.":[224],"When":[225],"we":[226,233,331,421],"reviewed":[227],"articles":[229],"medicine,":[232],"admit":[236],"this":[238,470,545],"met":[241],"bottleneck.":[243],"Although":[244],"more":[245,247],"diseases":[248],"proven":[250],"effective":[251],"using":[253],"therapy,":[255],"no":[256,367,503],"one":[257,368],"reach":[259],"essence":[261],"miraculous":[264],"phenomenon.":[265],"Now":[266],"traditional":[268,486],"mechanism":[269,525],"is":[270,275,383,405,495,526],"questioned":[271],"challenged;":[273],"badly":[276],"need":[278],"blood,":[282],"can":[284,360,420,442,472,540],"enrich":[285],"theory":[287,471],"systems.":[288],"my":[290],"previous":[291],"article,":[292],"I":[293],"submitted":[294],"concept":[296],"acted":[300],"fourth":[303],"gaseous":[304],"signaling":[305],"molecule":[306,359,427],"after":[307],"nitric":[308],"oxide,":[309],"carbon":[310],"monoxide,":[311],"sulfide":[314],"Obviously,":[316],"not":[319,422],"explain":[320],"completely":[321],"huge":[323],"under":[325],"small":[327],"doses.":[328],"So":[329],"when":[330],"rethought":[332],"process":[334],"admitted":[338],"into":[339,346,362],"organisms,":[341],"whatever":[342],"or":[344,412,465],"abdomen,":[348],"contacted":[352],"with":[353,501],"vessels,":[355],"meaning":[356],"penetrate":[361],"microcirculation":[364,376,382,539],"straightforward.":[365],"Unfortunately,":[366],"paid":[369],"attention":[370],"relationship":[373],"between":[374],"molecule.":[380],"complex":[385],"system":[386],"lot":[390],"important":[392],"whole":[396],"physiology":[397],"pathology":[399],"processes":[400],"(5).":[401],"One":[402],"these":[404],"amplification":[407,438],"some":[409,413,466],"signal":[410],"molecules":[411],"proteins\u2014the":[414],"cascade":[415],"reaction":[416],"(6).":[417],"So,":[418],"why":[419],"predict":[423],"positive":[430],"microcirculation,":[434],"effect,":[439],"organism":[441],"produce":[443],"remarkable":[445],"variation":[446],"biochemical":[449],"indicator,":[450],"antioxidant":[456],"enzyme":[457],"elimination":[459],"reactive":[462],"species":[464],"inflammatory":[467],"factors?":[468],"If":[469],"prove":[473],"existed,":[477],"will":[479],"be":[480,541],"perfect":[482],"complement":[483],"theory.":[487],"Thus,":[488],"many":[489],"researches":[490],"have":[491],"demonstrated":[492],"medical":[499],"almost":[502],"harm":[504],"organism.":[507],"We":[508,531],"should":[509],"try":[510],"our":[511],"best":[512],"make":[514],"bench-to-bed.":[516],"On":[517],"hand,":[520],"exploration":[522],"also":[527],"eager":[529],"necessity.":[530],"believe":[532],"breakthrough":[543],"future.":[549],"JingYao":[550],"Zhang":[551],"Chang":[552],"Liu":[553],"MingHui":[554],"Tai":[555],"Kai":[556],"Qu":[557],"Department":[558],"Hepatobiliary":[560],"Surgery":[561],"First":[563],"Affiliated":[564],"Hospital":[565],"Xi\u2019an":[567],"Jiaotong":[568],"University":[569],"Xi\u2019an,":[570],"China":[571]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
