{"id":"https://openalex.org/W2334494065","doi":"https://doi.org/10.1097/00005344-199808000-00021","title":"Effect of Long-Term Treatment with Enalapril in Streptozotocin Diabetic and DOCA Hypertensive Rats","display_name":"Effect of Long-Term Treatment with Enalapril in Streptozotocin Diabetic and DOCA Hypertensive Rats","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W2334494065","doi":"https://doi.org/10.1097/00005344-199808000-00021","mag":"2334494065","pmid":"https://pubmed.ncbi.nlm.nih.gov/9700996"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-199808000-00021","doi":"https://doi.org/10.1097/00005344-199808000-00021","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199808000-00021","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080504234","display_name":"Ramesh Kishorilal Goyal","orcid":"https://orcid.org/0000-0001-8179-6423","observed_orcids":["https://orcid.org/0000-0001-8179-6423"]},"institutions":[{"id":"https://openalex.org/I4210108063","display_name":"Cadila Pharmaceuticals (India)","ror":"https://ror.org/01yknwh75","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210108063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. K. Goyal","raw_affiliation_strings":["Department of Pharmacology, L.M. College of Pharmacy, Navrangpura, India","*Cadila Pharmaceuticals, Ghodasar,  Ahmedabad, India","Department of Pharmacology,  L. M. College of Pharmacy, Navrangpura","Received August 26, 1997","revision accepted February  20, 1998"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, L.M. College of Pharmacy, Navrangpura, India","institution_ids":[]},{"raw_affiliation_string":"*Cadila Pharmaceuticals, Ghodasar,  Ahmedabad, India","institution_ids":["https://openalex.org/I4210108063"]},{"raw_affiliation_string":"Department of Pharmacology,  L. M. College of Pharmacy, Navrangpura","institution_ids":[]},{"raw_affiliation_string":"Received August 26, 1997","institution_ids":[]},{"raw_affiliation_string":"revision accepted February  20, 1998","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112260523","display_name":"Milan Satia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108063","display_name":"Cadila Pharmaceuticals (India)","ror":"https://ror.org/01yknwh75","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210108063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. C. Satia","raw_affiliation_strings":["Department of Pharmacology,  L. M. College of Pharmacy, Navrangpura","*Cadila Pharmaceuticals, Ghodasar,  Ahmedabad, India","Received August 26, 1997","revision accepted February  20, 1998"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology,  L. M. College of Pharmacy, Navrangpura","institution_ids":[]},{"raw_affiliation_string":"*Cadila Pharmaceuticals, Ghodasar,  Ahmedabad, India","institution_ids":["https://openalex.org/I4210108063"]},{"raw_affiliation_string":"Received August 26, 1997","institution_ids":[]},{"raw_affiliation_string":"revision accepted February  20, 1998","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035992541","display_name":"RAMKRISHNA A. BANGARU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108063","display_name":"Cadila Pharmaceuticals (India)","ror":"https://ror.org/01yknwh75","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210108063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. A. Bangaru","raw_affiliation_strings":["Department of Pharmacology,  L. M. College of Pharmacy, Navrangpura","*Cadila Pharmaceuticals, Ghodasar,  Ahmedabad, India","Received August 26, 1997","revision accepted February  20, 1998"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology,  L. M. College of Pharmacy, Navrangpura","institution_ids":[]},{"raw_affiliation_string":"*Cadila Pharmaceuticals, Ghodasar,  Ahmedabad, India","institution_ids":["https://openalex.org/I4210108063"]},{"raw_affiliation_string":"Received August 26, 1997","institution_ids":[]},{"raw_affiliation_string":"revision accepted February  20, 1998","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086637981","display_name":"T.P. Gandhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108063","display_name":"Cadila Pharmaceuticals (India)","ror":"https://ror.org/01yknwh75","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210108063"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"T. P. Gandhi","raw_affiliation_strings":["Department of Pharmacology,  L. M. College of Pharmacy, Navrangpura","*Cadila Pharmaceuticals, Ghodasar,  Ahmedabad, India","Received August 26, 1997","revision accepted February  20, 1998"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology,  L. M. College of Pharmacy, Navrangpura","institution_ids":[]},{"raw_affiliation_string":"*Cadila Pharmaceuticals, Ghodasar,  Ahmedabad, India","institution_ids":["https://openalex.org/I4210108063"]},{"raw_affiliation_string":"Received August 26, 1997","institution_ids":[]},{"raw_affiliation_string":"revision accepted February  20, 1998","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086637981"],"corresponding_institution_ids":["https://openalex.org/I4210108063"],"apc_list":null,"apc_paid":null,"fwci":0.7506,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.77008067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"2","first_page":"317","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.07429999858140945,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enalapril","display_name":"enalapril","score":1.0},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/diabetic-hypertension","display_name":"diabetic hypertension","score":0.593999981880188},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme-inhibition","display_name":"angiotensin-converting enzyme inhibition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.6520000100135803},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.6190000176429749},{"id":"https://openalex.org/keywords/hypoinsulinemia","display_name":"hypoinsulinemia","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.9390000104904175},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6359999775886536},{"id":"https://openalex.org/keywords/heart-weight","display_name":"heart weight","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.593999981880188},{"id":"https://openalex.org/keywords/glycosuria","display_name":"glycosuria","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2775940317","wikidata":"https://www.wikidata.org/wiki/Q422185","display_name":"Enalapril","level":4,"score":0.9335653781890869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8403934240341187},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8054755926132202},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7068018913269043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.681537389755249},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.6772189140319824},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.614321231842041},{"id":"https://openalex.org/C2781214132","wikidata":"https://www.wikidata.org/wiki/Q1136213","display_name":"Glycosuria","level":3,"score":0.6033223867416382},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5134835839271545},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.47387123107910156},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4582480788230896},{"id":"https://openalex.org/C2779479957","wikidata":"https://www.wikidata.org/wiki/Q421119","display_name":"Captopril","level":3,"score":0.41796061396598816}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003900","descriptor_name":"Desoxycorticosterone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004656","descriptor_name":"Enalapril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-199808000-00021","doi":"https://doi.org/10.1097/00005344-199808000-00021","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199808000-00021","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:9700996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9700996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W140325393","https://openalex.org/W1966616313","https://openalex.org/W1974874590","https://openalex.org/W1976442813","https://openalex.org/W1980870044","https://openalex.org/W2010668187","https://openalex.org/W2032115642","https://openalex.org/W2040828603","https://openalex.org/W2049029428","https://openalex.org/W2059688625","https://openalex.org/W2070692648","https://openalex.org/W2078172684","https://openalex.org/W2093921718","https://openalex.org/W2094910754","https://openalex.org/W2096028766","https://openalex.org/W2101652320","https://openalex.org/W2122228543","https://openalex.org/W2129925176","https://openalex.org/W2326120821","https://openalex.org/W2400103198","https://openalex.org/W2413799224"],"related_works":["https://openalex.org/W1969826164","https://openalex.org/W2437655088","https://openalex.org/W2130772843","https://openalex.org/W2067624916","https://openalex.org/W2333584533","https://openalex.org/W2418761108","https://openalex.org/W2040623308","https://openalex.org/W2461532850","https://openalex.org/W60535804","https://openalex.org/W4408823509"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,59,66,161,176,180,185,236],"effects":[3,226],"of":[4,68,103,113,227],"long-term":[5],"treatment":[6],"with":[7,170],"enalapril":[8,171,206,240],"(5":[9,53],"mg/kg/day":[10],"orally)":[11],"on":[12,212,235],"various":[13],"biochemical":[14],"and":[15,22,79,83,92,111,123,130,179,191,215,229,239,246],"cardiovascular":[16],"complications":[17],"in":[18,132,136,148,156,160,175,184,189,193,198,222,244],"streptozotocin":[19,38],"(STZ)":[20],"diabetic":[21,32,162,199,223,245,247],"deoxycorticosterone":[23,43],"acetate":[24,44],"(DOCA)":[25],"hypertensive":[26,34,248],"rats.":[27],"Female":[28],"Wistar":[29],"rats":[30],"made":[31],"or":[33,35,42,50],"both":[36],"by":[37,58,88,97,141,205],"(STZ;":[39],"45":[40],"mg/kg)":[41,54],"(DOCA;":[45],"10":[46],"mg/kg,":[47],"p.o.,":[48],"daily)":[49],"both.":[51],"Enalapril":[52,208],"was":[55,241],"administered":[56],"daily":[57],"oral":[60],"route":[61],"for":[62],"6":[63,69],"weeks.":[64],"At":[65],"end":[67],"weeks,":[70],"blood":[71,149,166,177],"samples":[72],"were":[73,86,95,196,202,232],"taken":[74],"to":[75],"analyze":[76],"glucose,":[77],"insulin,":[78],"lipids.":[80],"Blood":[81],"pressure":[82,128,178],"heart":[84,100,181,186],"rate":[85],"recorded":[87,96],"a":[89],"noninvasive":[90],"technique,":[91],"cardiac":[93],"functions":[94],"Neely's":[98],"working":[99],"preparation.":[101],"Injection":[102],"STZ":[104,228],"produced":[105,118],"severe":[106],"glycosuria":[107],"(>2%),":[108],"hyperglycemia,":[109],"hypoinsulinemia,":[110],"loss":[112],"body":[114],"weight.":[115,182],"It":[116],"also":[117,203],"hypercholesterolemia,":[119],"hypertriglyceridemia,":[120],"hypertension,":[121],"bradycardia,":[122],"decreased":[124],"left":[125,137],"ventricular":[126,138],"developed":[127],"(LVDP)":[129],"increase":[131,174,192],"angiotensin-converting":[133],"enzyme":[134],"(ACE)":[135],"tissue.":[139],"DOCA":[140,164,230],"itself":[142],"did":[143,216],"not":[144,217,233],"produce":[145],"any":[146],"change":[147],"glucose":[150,214],"but":[151],"reduced":[152,165],"serum":[153],"insulin":[154,220],"levels":[155,221],"nondiabetic":[157],"animals.":[158,224,249],"However,":[159],"group,":[163],"sugar":[167],"levels.":[168],"Treatment":[169],"prevented":[172,204],"an":[173],"Decrease":[183],"rate,":[187],"reduction":[188],"LVDP,":[190],"intracardiac":[194],"activity":[195],"observed":[197],"rats;":[200],"these":[201],"treatment.":[207],"had":[209],"no":[210],"effect":[211],"plasma":[213,219],"modify":[218],"The":[225],"together":[231],"additive":[234],"investigated":[237],"parameters,":[238],"similarly":[242],"efficient":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}