{"id":"https://openalex.org/W2334493919","doi":"https://doi.org/10.1097/00000372-199808000-00004","title":"Cytokeratin and Neurofilament Protein Staining in Merkel Cell Carcinoma of the Small Cell Type and Small Cell Carcinoma of the Lung","display_name":"Cytokeratin and Neurofilament Protein Staining in Merkel Cell Carcinoma of the Small Cell Type and Small Cell Carcinoma of the Lung","publication_year":1998,"publication_date":"1998-08-01","ids":{"openalex":"https://openalex.org/W2334493919","doi":"https://doi.org/10.1097/00000372-199808000-00004","mag":"2334493919","pmid":"https://pubmed.ncbi.nlm.nih.gov/9700371"},"language":"en","primary_location":{"id":"doi:10.1097/00000372-199808000-00004","doi":"https://doi.org/10.1097/00000372-199808000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000372-199808000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S86638576","display_name":"American Journal of Dermatopathology","issn_l":"0193-1091","issn":["0193-1091","1533-0311"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Dermatopathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ulrich Schmidt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I62318514","display_name":"University of Duisburg-Essen","ror":"https://ror.org/04mz5ra38","country_code":"DE","type":"education","lineage":["https://openalex.org/I62318514"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ulrich Schmidt","raw_affiliation_strings":["Department of Pathology, University Hospital, University of Essen, Germany","reprint requests to Dr. Ulrich Schmidt, Pathology/University Hospital,  University of Essen, Hufelandstr. 55, D-45147 Essen, Germany","the Department of Pathology, University Hospital, University of Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Hospital, University of Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]},{"raw_affiliation_string":"reprint requests to Dr. Ulrich Schmidt, Pathology/University Hospital,  University of Essen, Hufelandstr. 55, D-45147 Essen, Germany","institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"]},{"raw_affiliation_string":"the Department of Pathology, University Hospital, University of Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108603267","display_name":"Ulrike M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike M\u00fcller","raw_affiliation_strings":["the Department of Pathology, University Hospital, University of Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pathology, University Hospital, University of Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047405133","display_name":"Klaus Alfred Metz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Alfred Metz","raw_affiliation_strings":["the Department of Pathology, University Hospital, University of Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pathology, University Hospital, University of Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111987120","display_name":"Lutz\u2010Dietrich Leder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lutz-Dietrich Leder","raw_affiliation_strings":["the Department of Pathology, University Hospital, University of Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Department of Pathology, University Hospital, University of Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210119759","https://openalex.org/I62318514"],"apc_list":null,"apc_paid":null,"fwci":1.6655,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.85234131,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"20","issue":"4","first_page":"346","last_page":"351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/merkel-cell-carcinoma","display_name":"Merkel cell carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/small-cell-variant","display_name":"small cell variant","score":0.8500000238418579},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cytokeratin","display_name":"cytokeratin","score":0.7860000133514404},{"id":"https://openalex.org/keywords/neurofilament-proteins","display_name":"neurofilament proteins","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cytokeratin-20","display_name":"CK20","score":0.8769999742507935},{"id":"https://openalex.org/keywords/intermediate-filaments","display_name":"intermediate filaments","score":0.8659999966621399},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pancytokeratin","display_name":"pancytokeratin","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.9461387991905212},{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.7283375263214111},{"id":"https://openalex.org/C2780291066","wikidata":"https://www.wikidata.org/wiki/Q1570264","display_name":"Merkel cell","level":4,"score":0.7147089242935181},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7136984467506409},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.608977198600769},{"id":"https://openalex.org/C78383274","wikidata":"https://www.wikidata.org/wiki/Q421987","display_name":"Intermediate filament","level":4,"score":0.5970062017440796},{"id":"https://openalex.org/C2909444961","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small Cell Lung Carcinoma","level":4,"score":0.5241591930389404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5030335783958435},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.46478769183158875},{"id":"https://openalex.org/C50548948","wikidata":"https://www.wikidata.org/wiki/Q14907896","display_name":"Keratin 8","level":3,"score":0.443711519241333},{"id":"https://openalex.org/C2779292878","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small-cell carcinoma","level":3,"score":0.43760496377944946},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42997974157333374},{"id":"https://openalex.org/C2778342957","wikidata":"https://www.wikidata.org/wiki/Q1711744","display_name":"Merkel cell carcinoma","level":3,"score":0.42085713148117065},{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.3979998826980591},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3576069474220276},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.2919967770576477},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.25523561239242554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19931712746620178},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007381","descriptor_name":"Intermediate Filament Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015266","descriptor_name":"Carcinoma, Merkel Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015266","descriptor_name":"Carcinoma, Merkel Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015266","descriptor_name":"Carcinoma, Merkel Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053554","descriptor_name":"Keratin-20","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000372-199808000-00004","doi":"https://doi.org/10.1097/00000372-199808000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000372-199808000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S86638576","display_name":"American Journal of Dermatopathology","issn_l":"0193-1091","issn":["0193-1091","1533-0311"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Dermatopathology","raw_type":"journal-article"},{"id":"pmid:9700371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9700371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of dermatopathology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W9179897","https://openalex.org/W54037680","https://openalex.org/W779860771","https://openalex.org/W1982990921","https://openalex.org/W1996583727","https://openalex.org/W2001845848","https://openalex.org/W2033655329","https://openalex.org/W2034303634","https://openalex.org/W2042113448","https://openalex.org/W2080881269","https://openalex.org/W2119739483","https://openalex.org/W2314976799","https://openalex.org/W2321672705","https://openalex.org/W2321805081","https://openalex.org/W2322237533","https://openalex.org/W2402822201","https://openalex.org/W2411503482","https://openalex.org/W2415858519","https://openalex.org/W2424483578","https://openalex.org/W4211027420"],"related_works":["https://openalex.org/W1982990921","https://openalex.org/W54037680","https://openalex.org/W2045790741","https://openalex.org/W2101133708","https://openalex.org/W1994797523","https://openalex.org/W2892954321","https://openalex.org/W4399869081","https://openalex.org/W2078577198","https://openalex.org/W1997181375","https://openalex.org/W2168269500"],"abstract_inverted_index":{"Merkel":[0],"cell":[1,7,16,38,84,119,185,204],"carcinoma":[2,17],"(MCC)":[3],"has":[4],"a":[5,60,153],"small":[6,15,37,83,118,184,203],"variant,":[8,186],"indistinguishable":[9],"in":[10,30,108,134,224],"hematoxylin-eosin":[11],"sections":[12],"from":[13,216],"metastatic":[14],"of":[18,35,70,78,81,111,116,138,156,172,176,180,182,202,211,219],"the":[19,36,82,135,139,173,183,196,209,217,225],"lung":[20],"(SCCL).":[21],"To":[22],"investigate":[23],"whether":[24],"intermediate":[25,113,212],"filament":[26],"expression":[27,155],"is":[28],"helpful":[29],"this":[31],"distinction,":[32],"17":[33],"MCCs":[34,55,174,205,213],"type":[39],"were":[40,187,192],"examined":[41],"for":[42],"cytokeratin,":[43],"as":[44,46],"well":[45],"neurofilament":[47,166,199],"protein":[48,167,200],"immunostaining,":[49],"and":[50,56,101,114,128,131,158,198],"compared":[51],"with":[52,90],"59":[53],"intermediate-type":[54,72],"22":[57],"SCCL.":[58],"With":[59],"pan-cytokeratin":[61,104],"cocktail":[62],"(cytokeratin":[63],"1-8,":[64],"10,":[65],"13-16,":[66],"19),":[67],"most":[68,150],"(39":[69],"55)":[71],"tumors":[73],"and,":[74],"more":[75],"important,":[76],"11":[77,181],"16":[79,117],"cases":[80,160],"variant":[85],"exhibited":[86],"focal":[87,99,125,130],"paranuclear":[88],"staining":[89,105,127],"dot-like":[91],"positivity,":[92,94],"crescentic":[93],"or":[95],"both.":[96],"A":[97],"combined":[98],"(dot-like/crescentic)":[100],"diffuse":[102,132,142,154],"cytoplasmic":[103,126],"was":[106,168],"seen":[107],"additional":[109],"8":[110],"55":[112],"4":[115],"MCCs.":[120],"Cytokeratin":[121],"20":[122,144,163],"also":[123],"evoked":[124],"occasionally":[129],"positivity":[133],"MCCs,":[136],"irrespective":[137],"subtype.":[140],"Exclusively":[141],"cytokeratin":[143,162,197],"patterns":[145,201],"did":[146],"not":[147],"occur.":[148],"Conversely,":[149],"SCCL":[151,191],"showed":[152],"pancytokeratin,":[157],"all":[159,190],"remained":[161],"negative.":[164,193],"When":[165],"applied,":[169],"approximately":[170],"half":[171],"(25":[175],"40),":[177],"including":[178],"7":[179],"positive,":[188],"whereas":[189],"In":[194],"conclusion,":[195],"are":[206],"identical":[207],"to":[208],"pattern":[210],"but":[214],"differ":[215],"profile":[218],"SCCL,":[220],"which":[221],"may":[222],"help":[223],"differential":[226],"diagnosis.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
