{"id":"https://openalex.org/W2334440407","doi":"https://doi.org/10.1055/s-0032-1323868","title":"Cholestatische Lebererkrankungen bei septischen Intensivpatienten: Nicht-obstruktive Cholestase versus Sekund\u00e4r sklerosierende Cholangitis","display_name":"Cholestatische Lebererkrankungen bei septischen Intensivpatienten: Nicht-obstruktive Cholestase versus Sekund\u00e4r sklerosierende Cholangitis","publication_year":2012,"publication_date":"2012-08-22","ids":{"openalex":"https://openalex.org/W2334440407","doi":"https://doi.org/10.1055/s-0032-1323868","mag":"2334440407"},"language":"de","primary_location":{"id":"doi:10.1055/s-0032-1323868","doi":"https://doi.org/10.1055/s-0032-1323868","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0032-1323868","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109164915","display_name":"GI Kirchner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"GI Kirchner","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015979307","display_name":"Petra Ruemmele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Ruemmele","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Institut f\u00fcr Pathologie, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Institut f\u00fcr Pathologie, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Wimmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M Wimmer","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058473174","display_name":"B G\u00f6hlmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B G\u00f6hlmann","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009504475","display_name":"Johannes Hartl","orcid":"https://orcid.org/0000-0002-4037-9938","observed_orcids":["https://orcid.org/0000-0002-4037-9938"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Hartl","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110305041","display_name":"Julia Langgartner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Langgartner","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069557337","display_name":"Bernd Salzberger","orcid":"https://orcid.org/0000-0002-9182-0455","observed_orcids":["https://orcid.org/0000-0002-9182-0455"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Salzberger","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012542609","display_name":"CM Gelbmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"CM Gelbmann","raw_affiliation_strings":["Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Regensburg, Klinik und Poliklinik f\u00fcr Innere Medizin I, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3129555431"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24812413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"50","issue":"08","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.1898999959230423,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.13600000739097595,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/secondary-sclerosing-cholangitis","display_name":"secondary sclerosing cholangitis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.9120000004768372},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.703000009059906},{"id":"https://openalex.org/keywords/sepsis-severity","display_name":"sepsis severity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.48399999737739563},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.6930000185966492},{"id":"https://openalex.org/keywords/intensive-care-unit-admission","display_name":"intensive care unit admission","score":0.4320000112056732},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.4129999876022339},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.38499999046325684},{"id":"https://openalex.org/keywords/apache-ii","display_name":"APACHE II score","score":0.4790000021457672},{"id":"https://openalex.org/keywords/saps-ii","display_name":"SAPS II","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8884481191635132},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6908978819847107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0032-1323868","doi":"https://doi.org/10.1055/s-0032-1323868","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0032-1323868","pdf_url":null,"source":{"id":"https://openalex.org/S189922908","display_name":"Zeitschrift f\u00fcr Gastroenterologie","issn_l":"0044-2771","issn":["0044-2771","1439-7803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Gastroenterologie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2312699508","https://openalex.org/W2548970976","https://openalex.org/W2903146759","https://openalex.org/W2509590025","https://openalex.org/W1525721121","https://openalex.org/W2128360517","https://openalex.org/W2045799546","https://openalex.org/W2329692466","https://openalex.org/W2811378824","https://openalex.org/W4250274560"],"abstract_inverted_index":{"Hintergrund:":[0],"Bei":[1],"septischen":[2,69],"Patienten":[3,62,72,76],"(CIP=critical":[4],"ill":[5],"patients)":[6],"wird":[7,44],"h\u00e4ufig":[8],"eine":[9,18,40,237,277],"Nicht-obstruktive":[10],"Cholestase":[11],"(NOC-CIP)":[12],"beobachtet.":[13],"In":[14],"seltenen":[15],"F\u00e4llen":[16],"entsteht":[17],"sekund\u00e4r":[19],"sklerosierende":[20],"Cholangitis":[21],"(SC-CIP).":[22],"Eine":[23,96],"Unterscheidung":[24],"beider":[25],"Ursachen":[26],"ist":[27,37],"anhand":[28],"von":[29,67,234],"Laborwerten":[30],"nicht":[31],"m\u00f6glich.":[32],"Die":[33,90,146,182,216,232,258],"Pathogenese":[34],"der":[35,42,128,148,168,218,262,280],"SC-CIP":[36,59,91,110,247,281],"unklar,":[38],"aber":[39,225],"Isch\u00e4mie":[41],"Gallenwege":[43],"vermutet.":[45],"Ziel":[46],"dieser":[47],"Studie":[48],"war":[49,220,228,264],"es,":[50],"m\u00f6gliche":[51],"Risikofaktoren":[52],"f\u00fcr":[53],"die":[54,102,162,166,173,226,244],"Entwicklung":[55,245],"einer":[56,246],"NOC-CIP":[57,97,109,283],"oder":[58,236,248],"zu":[60],"entdecken.":[61],"und":[63,85,155,171,175,188,282],"Methoden:":[64],"Klinische":[65],"Daten":[66],"50":[68],"Intensivpatienten":[70,288],"(27":[71],"mit":[73,77],"SC-CIP,":[74],"23":[75],"NOC-CIP)":[78],"wurden":[79,88,204],"analysiert.":[80],"Viele":[81],"klinische,":[82],"h\u00e4modynamische,":[83],"Beatmungs-":[84],"medikament\u00f6se":[86],"Behandlungsparameter":[87],"bestimmt.":[89],"wurde":[92,98],"mittels":[93],"ERCP":[94],"diagnostiziert.":[95],"angenommen,":[99],"wenn":[100],"sich":[101,151,157],"Cholestaseparameter":[103,255],"im":[104],"Verlauf":[105],"wieder":[106],"normalisierten.":[107],"Tab.1:":[108],"Alter":[111],"(Jahre)":[112],"57\u00b111":[113],"53\u00b116":[114],"n.s.":[115,119,126,134,139],"M\u00e4nner/Frauen":[116],"19/4":[117],"19/8":[118],"Dauer":[120,127,163,167,217],"des":[121,164],"Intensivaufenthaltes":[122],"(Tage)":[123,131],"38,7\u00b125,7":[124],"49,4\u00b123,9":[125],"mechanischen":[129,169],"Beamtung":[130],"29,3.\u00b115,8":[132],"38,9\u00b124,1":[133],"APACHE":[135],"II":[136,141],"13,6\u00b15,9":[137],"11,4\u00b15,3":[138],"SAPS":[140],"31,5\u00b112,4":[142],"27,5\u00b112,5":[143],"n.s":[144],"Ergebnisse:":[145],"Schwere":[147],"Sepsis":[149],"unterschied":[150],"bei":[152,197,200,206,221,229,265,269],"den":[153],"SC-CIP-":[154,198],"NOC-CIP-Patienten":[156,230],"signifikant":[158,195,223,253],"(Tab.1).":[159],"Das":[160],"Alter,":[161],"Intensivaufenthaltes,":[165],"Beatmung":[170,260],"auch":[172],"APACHE-":[174],"SAPS-Scores":[176],"waren":[177,194],"vergleichbar":[178],"in":[179,261],"beiden":[180],"Gruppen.":[181],"Alkalische":[183],"Phosphatase":[184],"(1085\u00b1973":[185],"vs.":[186,192],"422\u00b1185U/l)":[187],"das":[189],"Bilirubin":[190],"(168\u00b1149":[191],"77\u00b156\u00b5mol/l)":[193],"h\u00f6her":[196],"als":[199,256,268],"NOC-CIP-Patienten.":[201,257,270],"Mechanische":[202],"Beatmungsprobleme":[203],"\u00f6fter":[205],"SC-CIP-Patienten":[207,222,251,266],"beobachtet":[208],"(FiO":[209],"2":[210],"-Konzentration":[211],"h\u00f6her,":[212],"h\u00e4ufiger":[213],"Bauchlagerung":[214],"notwendig).":[215],"Katcholamingabe":[219],"l\u00e4nger,":[224],"Katecholamin-Dosis":[227],"h\u00f6her.":[231],"Gabe":[233],"Steroiden":[235],"H\u00e4modialyse":[238],"hatten":[239],"keinen":[240,274],"signifikanten":[241],"Einfluss":[242],"auf":[243],"NOC-CIP.":[249],"Schlussfolgerung:":[250],"haben":[252],"h\u00f6here":[254],"mechanische":[259],"Initialphase":[263],"schwieriger":[267],"Es":[271],"gibt":[272],"bisher":[273],"Einzelparameter,":[275],"welcher":[276],"Differenzierung":[278],"zwischen":[279],"erlaubt.":[284],"Gastroenterologische":[285],"Probleme":[286],"beim":[287],"Donnerstag,":[289],"20.":[290],"September":[291],"2012/10:30\u201312:00/Saal":[292],"E":[293]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}