{"id":"https://openalex.org/W2334438679","doi":"https://doi.org/10.2174/1877912304666140304000133","title":"Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine","display_name":"Nanoparticle Drug Delivery Systems: Recent Patents and Applications in Nanomedicine","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W2334438679","doi":"https://doi.org/10.2174/1877912304666140304000133","mag":"2334438679"},"language":"en","primary_location":{"id":"doi:10.2174/1877912304666140304000133","doi":"https://doi.org/10.2174/1877912304666140304000133","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1877912304666140304000133","pdf_url":null,"source":{"id":"https://openalex.org/S4210236171","display_name":"Current Nanomedicine","issn_l":"1877-9123","issn":["1877-9123","1877-9131","2468-1873","2468-1881"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/I4403928277","host_organization_name":"Bentham Science Publishers (United Arab Emirates)","host_organization_lineage":["https://openalex.org/I4403928277"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Patents on Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115590972","display_name":"Pedro Henrique de Farias Martins","orcid":"https://orcid.org/0000-0002-7943-8093","observed_orcids":["https://orcid.org/0000-0002-7943-8093"]},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Pedro Martins","raw_affiliation_strings":["Department of Ci\u00eancias da Vida, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.,Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ci\u00eancias da Vida, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.,Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071202705","display_name":"Daniela Rosa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Rosa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026233373","display_name":"Alexandra Ramos Fernandes","orcid":"https://orcid.org/0000-0003-2054-4438","observed_orcids":["https://orcid.org/0000-0003-2054-4438"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Fernandes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5007842415","display_name":"Pedro Viana Baptista","orcid":"https://orcid.org/0000-0001-5255-7095","observed_orcids":["https://orcid.org/0000-0001-5255-7095"]},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Pedro V. Baptista","raw_affiliation_strings":["Department of Ci\u00eancias da Vida, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.,Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ci\u00eancias da Vida, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.,Portugal","institution_ids":["https://openalex.org/I83558840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007842415","https://openalex.org/A5115590972"],"corresponding_institution_ids":["https://openalex.org/I83558840"],"apc_list":null,"apc_paid":null,"fwci":1.7954,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.82635859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"3","issue":"2","first_page":"105","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.9190000295639038},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5600000023841858},{"id":"https://openalex.org/keywords/drug-carriers","display_name":"drug carriers","score":0.7789999842643738},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.765999972820282},{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.8069999814033508},{"id":"https://openalex.org/keywords/metal-nanoparticles","display_name":"metal nanoparticles","score":0.7850000262260437},{"id":"https://openalex.org/keywords/ceramic-nanoparticles","display_name":"ceramic nanoparticles","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5740000009536743},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6840000152587891},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.7480000257492065},{"id":"https://openalex.org/keywords/off-target-effects","display_name":"off-target effects","score":0.6290000081062317},{"id":"https://openalex.org/keywords/patents","display_name":"patents","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.8835673332214355},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7980751991271973},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6736164093017578},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6116839647293091},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4730773866176605},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.42406538128852844},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.42246484756469727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32198861241340637},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3111700713634491},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.29806917905807495}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1877912304666140304000133","doi":"https://doi.org/10.2174/1877912304666140304000133","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1877912304666140304000133","pdf_url":null,"source":{"id":"https://openalex.org/S4210236171","display_name":"Current Nanomedicine","issn_l":"1877-9123","issn":["1877-9123","1877-9131","2468-1873","2468-1881"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/I4403928277","host_organization_name":"Bentham Science Publishers (United Arab Emirates)","host_organization_lineage":["https://openalex.org/I4403928277"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Patents on Nanomedicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W3011556","https://openalex.org/W21132905","https://openalex.org/W32441581","https://openalex.org/W40517306","https://openalex.org/W55962664","https://openalex.org/W166748550","https://openalex.org/W612820322","https://openalex.org/W937042841","https://openalex.org/W1027614306","https://openalex.org/W1042490416","https://openalex.org/W1483368261","https://openalex.org/W1498177848","https://openalex.org/W1503410058","https://openalex.org/W1534373891","https://openalex.org/W1536294945","https://openalex.org/W1538681697","https://openalex.org/W1563580661","https://openalex.org/W1564553363","https://openalex.org/W1596204741","https://openalex.org/W1605943269","https://openalex.org/W1649683206","https://openalex.org/W1714822168","https://openalex.org/W1791569230","https://openalex.org/W1817596164","https://openalex.org/W1817865072","https://openalex.org/W1818189939","https://openalex.org/W1840014733","https://openalex.org/W1841829828","https://openalex.org/W1865814132","https://openalex.org/W1883148881","https://openalex.org/W1925329225","https://openalex.org/W1928801992","https://openalex.org/W1934395646","https://openalex.org/W1934437893","https://openalex.org/W1935641143","https://openalex.org/W1936102867","https://openalex.org/W1951174331","https://openalex.org/W1953876651","https://openalex.org/W1965432761","https://openalex.org/W1968103166","https://openalex.org/W1968302138","https://openalex.org/W1971938726","https://openalex.org/W1972180606","https://openalex.org/W1973130953","https://openalex.org/W1978686276","https://openalex.org/W1981412372","https://openalex.org/W1988394046","https://openalex.org/W1990053723","https://openalex.org/W1990663902","https://openalex.org/W1994024893","https://openalex.org/W1998346656","https://openalex.org/W1998989840","https://openalex.org/W1999990154","https://openalex.org/W2001165082","https://openalex.org/W2004472811","https://openalex.org/W2005655958","https://openalex.org/W2006986838","https://openalex.org/W2007330171","https://openalex.org/W2012135931","https://openalex.org/W2015755230","https://openalex.org/W2017568564","https://openalex.org/W2018107585","https://openalex.org/W2020535635","https://openalex.org/W2029905795","https://openalex.org/W2030147718","https://openalex.org/W2033468145","https://openalex.org/W2033852473","https://openalex.org/W2038998098","https://openalex.org/W2039415576","https://openalex.org/W2048101661","https://openalex.org/W2050688936","https://openalex.org/W2050886209","https://openalex.org/W2060673929","https://openalex.org/W2063061249","https://openalex.org/W2066796142","https://openalex.org/W2070808114","https://openalex.org/W2073932571","https://openalex.org/W2074610214","https://openalex.org/W2075585703","https://openalex.org/W2078866040","https://openalex.org/W2078937040","https://openalex.org/W2082511916","https://openalex.org/W2085470629","https://openalex.org/W2088467380","https://openalex.org/W2088998579","https://openalex.org/W2089155556","https://openalex.org/W2092934367","https://openalex.org/W2094672113","https://openalex.org/W2095412415","https://openalex.org/W2095710812","https://openalex.org/W2102449174","https://openalex.org/W2113604872","https://openalex.org/W2116833838","https://openalex.org/W2118561606","https://openalex.org/W2125424530","https://openalex.org/W2130342580","https://openalex.org/W2137680707","https://openalex.org/W2139411218","https://openalex.org/W2139990511","https://openalex.org/W2140813917","https://openalex.org/W2142504874","https://openalex.org/W2143783415","https://openalex.org/W2148048623","https://openalex.org/W2149984051","https://openalex.org/W2153571573","https://openalex.org/W2154575303","https://openalex.org/W2156977135","https://openalex.org/W2161549583","https://openalex.org/W2163374013","https://openalex.org/W2164520862","https://openalex.org/W2164535005","https://openalex.org/W2169498622","https://openalex.org/W2169623960","https://openalex.org/W2172300019","https://openalex.org/W2183560382","https://openalex.org/W2183963442","https://openalex.org/W2184415153","https://openalex.org/W2192333227","https://openalex.org/W2207511866","https://openalex.org/W2269459406","https://openalex.org/W2297130492","https://openalex.org/W2306646604","https://openalex.org/W2307075200","https://openalex.org/W2310381007","https://openalex.org/W2313443077","https://openalex.org/W2321170337","https://openalex.org/W2327708905","https://openalex.org/W2328097219","https://openalex.org/W2397752595","https://openalex.org/W2813918010","https://openalex.org/W2814460904","https://openalex.org/W2816547263","https://openalex.org/W2830375520","https://openalex.org/W2848536983","https://openalex.org/W2849595972","https://openalex.org/W2873914546","https://openalex.org/W2875283442","https://openalex.org/W2955255430","https://openalex.org/W3022880157","https://openalex.org/W3151178129"],"related_works":["https://openalex.org/W3164456052","https://openalex.org/W3146898350","https://openalex.org/W7091325654","https://openalex.org/W3054751018","https://openalex.org/W7117764377","https://openalex.org/W2613010597","https://openalex.org/W4385623189","https://openalex.org/W7115005767","https://openalex.org/W4324142851","https://openalex.org/W7161822341"],"abstract_inverted_index":{"Traditional":[0],"methods":[1],"of":[2,28,46,124,142,155],"drug":[3,42,65,84,109,159,179,181,183],"delivery":[4,43,66,160],"present":[5],"several":[6],"drawbacks,":[7],"mainly":[8],"due":[9],"to":[10,21,25,38,53,98,166],"off-target":[11],"effects":[12],"that":[13],"may":[14],"originate":[15],"severe":[16],"side":[17],"and":[18,40,52,59,74,77,133,144],"toxic":[19],"effect":[20],"healthy":[22],"tissues.":[23],"Parallel":[24],"the":[26,49,55,92,99,122,139,172],"development":[27],"novel":[29,156],"more":[30],"effective":[31],"drugs,":[32],"particular":[33],"effort":[34],"has":[35],"been":[36,120],"dedicated":[37],"develop":[39],"optimize":[41],"vehicles":[44],"capable":[45],"specifically":[47],"targeting":[48],"required":[50,100],"tissue/organ":[51],"deliver":[54],"cargo":[56],"only":[57],"where":[58],"when":[60],"it":[61],"is":[62,135],"needed.":[63],"New":[64],"systems":[67,165],"based":[68,158],"on":[69,138],"nanoscale":[70,105],"devices":[71],"showing":[72],"new":[73],"improved":[75],"pharmacokinetic":[76],"pharmacodynamics":[78],"properties":[79],"like":[80],"enhanced":[81],"bioavailability,":[82],"high":[83],"loading":[85],"or":[86,116],"systemic":[87],"stability":[88],"have":[89,119],"surged":[90],"in":[91,129],"past":[93],"decade":[94],"as":[95,112],"promising":[96],"solutions":[97],"therapeutic":[101],"efficacy.":[102],"Amongst":[103],"these":[104],"vectors,":[106],"nanoparticles":[107],"for":[108,131],"delivery,":[110,182],"such":[111],"polymeric,":[113],"lipidbased,":[114],"ceramic":[115],"metallic":[117],"nanoparticles,":[118,168,186],"at":[121],"forefront":[123],"pharmaceutical":[125],"development.":[126],"The":[127],"interest":[128],"nanomedicine":[130],"treatment":[132],"diagnosis":[134],"clearly":[136],"reflected":[137],"increasing":[140],"number":[141],"publications":[143],"issued":[145],"patents":[146],"every":[147],"year.":[148],"Here,":[149],"we":[150],"provide":[151],"a":[152],"broad":[153],"overview":[154],"nanoparticle":[157],"systems,":[161],"ranging":[162],"from":[163],"polymeric":[164],"metal":[167],"while":[169],"simultaneously":[170],"listing":[171],"most":[173],"relevant":[174],"related":[175],"patents.":[176,188],"Keywords:":[177],"Cancer,":[178],"carriers,":[180],"targeting,":[184],"nanomedicine,":[185],"nanotechnology,":[187]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
