{"id":"https://openalex.org/W2334411596","doi":"https://doi.org/10.1016/j.ijid.2016.02.866","title":"Mycobacterial dormancy associated proteins: Role in the survival of bacteria under stress conditions","display_name":"Mycobacterial dormancy associated proteins: Role in the survival of bacteria under stress conditions","publication_year":2016,"publication_date":"2016-03-29","ids":{"openalex":"https://openalex.org/W2334411596","doi":"https://doi.org/10.1016/j.ijid.2016.02.866","mag":"2334411596"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijid.2016.02.866","doi":"https://doi.org/10.1016/j.ijid.2016.02.866","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2016.02.866","pdf_url":"http://www.ijidonline.com/article/S1201971216308451/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.ijidonline.com/article/S1201971216308451/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037532616","display_name":"Vidyullatha Peddireddy","orcid":"https://orcid.org/0000-0002-4816-777X","observed_orcids":["https://orcid.org/0000-0002-4816-777X"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"V. Peddireddy","raw_affiliation_strings":["University of Hyderabad, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hyderabad, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037868526","display_name":"Sankara Narayana Doddam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S.N. Doddam","raw_affiliation_strings":["University of Hyderabad, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hyderabad, Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045733858","display_name":"Niyaz Ahmed","orcid":"https://orcid.org/0000-0001-6425-7583","observed_orcids":["https://orcid.org/0000-0001-6425-7583"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N. Ahmed","raw_affiliation_strings":["University of Hyderabad, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hyderabad, Hyderabad, India","institution_ids":["https://openalex.org/I36893310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037532616"],"corresponding_institution_ids":["https://openalex.org/I36893310"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":{"value":2900,"currency":"USD","value_usd":2900},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02499156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"45","issue":null,"first_page":"405","last_page":"405"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dosr-regulon","display_name":"DosR regulon","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nitroreductase","display_name":"nitroreductase","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.8209999799728394},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/granuloma-formation","display_name":"granuloma formation","score":0.777999997138977},{"id":"https://openalex.org/keywords/latent-tuberculosis-infection","display_name":"latent tuberculosis infection","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8180000185966492},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6259999871253967},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7509999871253967},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8539999723434448},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/protein-protein-docking","display_name":"protein-protein docking","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C62361671","wikidata":"https://www.wikidata.org/wiki/Q1754612","display_name":"Regulon","level":4,"score":0.9641667008399963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6453548073768616},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.5195658206939697},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.45840293169021606},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4508426785469055},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.41769009828567505},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.41632360219955444},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.36671286821365356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3417230248451233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33563363552093506},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3206428289413452},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.2975321412086487},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21765515208244324},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.20792046189308167},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.19209018349647522},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ijid.2016.02.866","doi":"https://doi.org/10.1016/j.ijid.2016.02.866","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2016.02.866","pdf_url":"http://www.ijidonline.com/article/S1201971216308451/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ijid.2016.02.866","doi":"https://doi.org/10.1016/j.ijid.2016.02.866","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2016.02.866","pdf_url":"http://www.ijidonline.com/article/S1201971216308451/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2334411596.pdf","grobid_xml":"https://content.openalex.org/works/W2334411596.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076675845","https://openalex.org/W7163525600","https://openalex.org/W2339535613","https://openalex.org/W2794356147","https://openalex.org/W2170056136","https://openalex.org/W3146024620","https://openalex.org/W4205897560","https://openalex.org/W2120960383","https://openalex.org/W4312187668","https://openalex.org/W2955711346"],"abstract_inverted_index":{"Background:":[0],"Mycobacterium":[1],"tuberculosis,":[2],"the":[3,16,28,40,62,70,129,170,176,223,324,349,352],"cause":[4],"of":[5,15,39,54,67,69,74,84,117,131,225,265,291,314,327,341,346,351],"tuberculosis":[6,76],"in":[7,12,20,42,198,251,273,344],"humans,":[8],"is":[9,77,107],"present":[10],"approximately":[11],"one":[13],"third":[14],"world's":[17],"population,":[18],"mostly":[19],"a":[21,43,51,274,338],"dormant":[22],"state.":[23],"The":[24,65,331],"proteins":[25,73,91,159,213,343],"encoded":[26,174],"by":[27,58,175,233],"dormancy":[29],"survival":[30,38],"regulon":[31,72,172],"(DosR":[32],"regulon)":[33],"are":[34,82,93,318],"mainly":[35],"responsible":[36,111],"for":[37,112],"bacilli":[41],"latent":[44],"form.":[45],"To":[46],"maintain":[47],"latency,":[48],"mycobacteria":[49],"orchestrate":[50],"balanced":[52],"interplay":[53],"different":[55,97],"cytokines":[56,193,293],"secreted":[57],"immune":[59],"cells":[60,188,238,255],"during":[61],"granulomatous":[63],"stage.":[64],"function":[66],"most":[68],"DosR":[71,171],"M.":[75],"unknown.":[78],"Rv3131":[79,100,151,178,227,260,285],"and":[80,88,106,115,133,144,152,157,179,184,201,207,228,242,261,269,286,297,307],"Rv2004c":[81,122,153,308],"members":[83],"DoSR":[85],"antigens":[86],"category":[87],"conserved":[89],"hypothetical":[90],"which":[92],"significantly":[94,248],"up-regulated":[95],"under":[96,119],"stress":[98],"conditions.":[99,121],"contains":[101],"FMN":[102],"binding":[103,137],"nitroreductase":[104],"domain":[105],"predicted":[108],"to":[109,125,190,322,337],"be":[110,126,196],"virulence,":[113],"detoxification":[114],"adaptation":[116],"bacteria":[118],"hostile":[120],"was":[123,219,271],"reported":[124],"localized":[127],"on":[128,301],"surface":[130,304],"M.tb":[132],"its":[134,202],"high":[135],"active":[136],"peptide":[138],"sequence":[139],"interacts":[140],"with":[141,216,230,240,258,283,348],"U937":[142],"macrophages":[143,183],"A549":[145],"epithelial":[146],"cells.":[147,235],"Methods":[148],"&":[149],"Materials:":[150],"genes":[154,177],"were":[155,160,247,256],"cloned":[156],"respective":[158],"purified.":[161],"Results:":[162],"In":[163,236],"this":[164],"study,":[165],"we":[166],"have":[167],"shown":[168],"that":[169,194,211],"proteins,":[173],"Rv2004c,":[180,262],"can":[181],"stimulate":[182],"peripheral":[185],"blood":[186],"mononuclear":[187],"(PBMC)":[189],"secrete":[191],"important":[192],"may":[195],"significant":[197],"granuloma":[199],"formation":[200],"maintenance.":[203],"Computational":[204],"modeling,":[205],"docking":[206],"simulation":[208],"study":[209],"suggested":[210],"these":[212,328,342],"might":[214],"interact":[215],"TLR2.":[217,315],"This":[218],"further":[220],"confirmed":[221],"through":[222],"interaction":[224],"recombinant":[226,259,284],"2004c":[229],"TLR2":[231],"expressed":[232],"HEK293":[234],"THP-1":[237,254,302],"treated":[239,257,282],"RV3131":[241,306],"2004c,":[243,287],"Tlr2":[244],"mRNA":[245],"levels":[246],"increased.":[249],"When":[250],"vitro":[252],"differentiated":[253],"increased":[263,312],"secretion":[264,290],"TNF-":[266],"\u03b1,":[267],"IL-1b":[268,296],"IL-8":[270],"observed":[272],"dose":[275],"dependent":[276],"manner.":[277],"Similarly,":[278],"human":[279],"PBMCs":[280],"when":[281],"showed":[288],"upregulated":[289],"pro-inflammatory":[292,353],"IFN-\u027c,":[294],"TNF-\u03b1,":[295],"IL-8.":[298],"FACS":[299],"analyses":[300],"cell":[303],"following":[305],"protein":[309],"treatment":[310],"demonstrated":[311],"expression":[313],"Further":[316],"experiments":[317],"being":[319],"carried":[320],"out":[321],"decipher":[323],"functional":[325],"role":[326,340],"proteins.":[329],"Conclusion:":[330],"cytokine":[332],"profiles":[333],"dissected":[334],"herein":[335],"point":[336],"possible":[339],"maintenance":[345],"latency":[347],"help":[350],"responses.":[354]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-06T09:10:53.072986","created_date":"2016-06-24T00:00:00"}
