{"id":"https://openalex.org/W2334327465","doi":"https://doi.org/10.3181/00379727-118-29788","title":"Independence of Luteinizing Hormone and Adrenocorticotrophin Secretion in the Rat","display_name":"Independence of Luteinizing Hormone and Adrenocorticotrophin Secretion in the Rat","publication_year":1965,"publication_date":"1965-01-01","ids":{"openalex":"https://openalex.org/W2334327465","doi":"https://doi.org/10.3181/00379727-118-29788","mag":"2334327465","pmid":"https://pubmed.ncbi.nlm.nih.gov/14254537"},"language":"en","primary_location":{"id":"doi:10.3181/00379727-118-29788","doi":"https://doi.org/10.3181/00379727-118-29788","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-118-29788","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111957720","display_name":"V. DOMINGO RAMIREZ","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. D. Ramirez","raw_affiliation_strings":["Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":null,"display_name":"D. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Moore","raw_affiliation_strings":["Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069185819","display_name":"Samuel M. McCann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. McCann","raw_affiliation_strings":["Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, University of Pennsylvania, Philadelphia","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.15570776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"1","first_page":"169","last_page":"173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.6743000149726868,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.210099995136261,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.052799999713897705,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9240000247955322},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8830000162124634},{"id":"https://openalex.org/keywords/acth-secretion","display_name":"ACTH secretion","score":0.7329999804496765},{"id":"https://openalex.org/keywords/luteinizing-hormone-secretion","display_name":"luteinizing hormone secretion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.8360000252723694},{"id":"https://openalex.org/keywords/estradiol-benzoate","display_name":"estradiol benzoate","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8080000281333923},{"id":"https://openalex.org/keywords/adrenal-weight","display_name":"adrenal weight","score":0.7070000171661377},{"id":"https://openalex.org/keywords/gonadotrophs","display_name":"gonadotrophs","score":0.7099999785423279},{"id":"https://openalex.org/keywords/ovarian-steroids","display_name":"ovarian steroids","score":0.5400000214576721},{"id":"https://openalex.org/keywords/corticosteroid-feedback","display_name":"corticosteroid feedback","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.92592453956604},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.9197296500205994},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.6546369194984436},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.6060886979103088},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5410205125808716},{"id":"https://openalex.org/C2778506572","wikidata":"https://www.wikidata.org/wiki/Q11450699","display_name":"Estradiol benzoate","level":4,"score":0.5004045963287354},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.4860268235206604},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.47706472873687744},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4575999081134796},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4524763822555542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4191990792751312},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36665552854537964}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002369","descriptor_name":"Castration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009919","descriptor_name":"Orchiectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010827","descriptor_name":"Physiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010902","descriptor_name":"Pituitary Gland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3181/00379727-118-29788","doi":"https://doi.org/10.3181/00379727-118-29788","is_oa":false,"landing_page_url":"https://doi.org/10.3181/00379727-118-29788","pdf_url":null,"source":{"id":"https://openalex.org/S67514239","display_name":"Experimental Biology and Medicine","issn_l":"0071-3384","issn":["0071-3384","1535-3699","1535-3702"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:14254537","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14254537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2035021492","https://openalex.org/W2018898149","https://openalex.org/W1995863458","https://openalex.org/W2063489388","https://openalex.org/W1978477951","https://openalex.org/W1963782914","https://openalex.org/W2079065271","https://openalex.org/W2084425137","https://openalex.org/W2005530129","https://openalex.org/W2167124768"],"abstract_inverted_index":{"1.":[0],"Adrenalectomy":[1],"of":[2,20,41,48,65,103,111],"spayed":[3],"rats":[4,43],"produced":[5],"a":[6,45],"borderline":[7],"rise":[8],"in":[9,91,100,108],"plasma":[10,25,52],"LH,":[11],"whereas":[12,79],"acute":[13],"or":[14],"chronic":[15],"treatment":[16,28],"with":[17,29,44],"large":[18,46],"doses":[19],"cortisol":[21,30],"failed":[22],"to":[23,67],"alter":[24],"LH.":[26],"Chronic":[27],"lowered":[31,51,75],"pituitary":[32,36,80],"ACTH":[33,81,107,117],"and":[34,106],"elevated":[35],"LH":[37,53,72,99,126],"slightly.":[38],"2.":[39],"Treatment":[40],"ovariectomized":[42],"dose":[47],"estradiol":[49],"benzoate":[50],"while":[54],"adrenal":[55,66],"weight":[56,61,69],"remained":[57],"unchanged.":[58],"Since":[59],"body":[60,68],"fell,":[62],"the":[63,101,109,120],"ratio":[64],"rose.":[70],"Pituitary":[71],"was":[73,82,87],"markedly":[74],"by":[76],"this":[77],"treatment,":[78],"slightly":[83],"elevated.":[84],"3.":[85],"It":[86],"concluded":[88],"that":[89,123],"alteration":[90],"target":[92],"gland":[93],"steroids":[94],"produces":[95],"specific":[96],"effects":[97],"on":[98],"case":[102,110],"ovarian":[104],"steroids,":[105],"cortical":[112],"steroids.":[113],"Estrogen":[114],"can":[115],"stimulate":[116],"secretion":[118],"at":[119],"same":[121],"time":[122],"it":[124],"inhibits":[125],"secretion.":[127]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
