{"id":"https://openalex.org/W2334033863","doi":"https://doi.org/10.1158/1538-7445.am2013-lb-250","title":"Abstract LB-250: Development of a miR34-based cancer therapy.","display_name":"Abstract LB-250: Development of a miR34-based cancer therapy.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2334033863","doi":"https://doi.org/10.1158/1538-7445.am2013-lb-250","mag":"2334033863"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-lb-250","doi":"https://doi.org/10.1158/1538-7445.am2013-lb-250","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-lb-250","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026580581","display_name":"Chris L. Daige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122992","display_name":"Mirna Therapeutics (United States)","ror":"https://ror.org/02tdag098","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Daige","raw_affiliation_strings":["Mirna Therapeutics, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirna Therapeutics, Austin, TX","institution_ids":["https://openalex.org/I4210122992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003205845","display_name":"Jason F. Wiggins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122992","display_name":"Mirna Therapeutics (United States)","ror":"https://ror.org/02tdag098","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Wiggins","raw_affiliation_strings":["Mirna Therapeutics, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirna Therapeutics, Austin, TX","institution_ids":["https://openalex.org/I4210122992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049219088","display_name":"Leslie Priddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122992","display_name":"Mirna Therapeutics (United States)","ror":"https://ror.org/02tdag098","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Priddy","raw_affiliation_strings":["Mirna Therapeutics, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirna Therapeutics, Austin, TX","institution_ids":["https://openalex.org/I4210122992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108621795","display_name":"Kevin Kelnar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122992","display_name":"Mirna Therapeutics (United States)","ror":"https://ror.org/02tdag098","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Kelnar","raw_affiliation_strings":["Mirna Therapeutics, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirna Therapeutics, Austin, TX","institution_ids":["https://openalex.org/I4210122992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024978408","display_name":"Jane Y. Zhao","orcid":"https://orcid.org/0000-0003-1664-2035","observed_orcids":["https://orcid.org/0000-0003-1664-2035"]},"institutions":[{"id":"https://openalex.org/I4210122992","display_name":"Mirna Therapeutics (United States)","ror":"https://ror.org/02tdag098","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Zhao","raw_affiliation_strings":["Mirna Therapeutics, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirna Therapeutics, Austin, TX","institution_ids":["https://openalex.org/I4210122992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086967072","display_name":"Andreas G. Bader","orcid":"https://orcid.org/0009-0001-6301-9492","observed_orcids":["https://orcid.org/0009-0001-6301-9492"]},"institutions":[{"id":"https://openalex.org/I4210122992","display_name":"Mirna Therapeutics (United States)","ror":"https://ror.org/02tdag098","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andreas Bader","raw_affiliation_strings":["Mirna Therapeutics, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirna Therapeutics, Austin, TX","institution_ids":["https://openalex.org/I4210122992"]}]},{"author_position":"last","author":{"id":null,"display_name":"David Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122992","display_name":"Mirna Therapeutics (United States)","ror":"https://ror.org/02tdag098","country_code":"US","type":"company","lineage":["https://openalex.org/I4210122992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Brown","raw_affiliation_strings":["Mirna Therapeutics, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mirna Therapeutics, Austin, TX","institution_ids":["https://openalex.org/I4210122992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210122992"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"LB","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-34","display_name":"miR-34","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.8539999723434448},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.9729999899864197},{"id":"https://openalex.org/keywords/systemic-drug-delivery","display_name":"systemic drug delivery","score":0.597000002861023},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.718999981880188},{"id":"https://openalex.org/keywords/met","display_name":"MET","score":0.6320000290870667},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.5699999928474426},{"id":"https://openalex.org/keywords/toxicology","display_name":"toxicology","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.610853910446167},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6027488708496094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5869899392127991},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5480797290802002},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4954274892807007},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.48082220554351807},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4569329619407654},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.43039843440055847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29220306873321533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27597367763519287},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1614115834236145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-lb-250","doi":"https://doi.org/10.1158/1538-7445.am2013-lb-250","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-lb-250","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2885153192","https://openalex.org/W1982535632","https://openalex.org/W2004112393","https://openalex.org/W2587438040","https://openalex.org/W2720419091","https://openalex.org/W2325223515","https://openalex.org/W2140477106","https://openalex.org/W2921638830","https://openalex.org/W2780566941","https://openalex.org/W2890861601"],"abstract_inverted_index":{"Abstract":[0],"miR-34":[1,34,107],"is":[2],"a":[3,31,88,94,209,238,260],"tumor":[4,135,198,239],"suppressor":[5,240],"miRNA":[6],"that":[7,37,92,195,203,220],"functions":[8],"within":[9],"the":[10,15,54,156,163,193,204,230,234,268,273],"p53":[11,157],"pathway":[12,158],"and":[13,26,43,67,75,117,159,167,187],"regulates":[14],"expression":[16],"of":[17,33,50,56,96,101,131,141,147,233,237,259,267,272],"more":[18],"than":[19,192],"twenty":[20],"oncogenes,":[21],"including":[22],"MET,":[23,165],"MYC,":[24],"WNT,":[25],"MYB.":[27],"We":[28],"have":[29,208],"created":[30],"mimic":[32],"called":[35,90],"miR-Rx34":[36,51,78],"induces":[38],"cell":[39],"cycle":[40],"arrest,":[41],"senescence,":[42],"apoptosis":[44],"in":[45,82,106,109,122,137,162,170,181,185,200,213,225],"cancer":[46,57,214,262],"cells.":[47],"Transient":[48],"transfection":[49],"significantly":[52],"reduces":[53],"proliferation":[55],"cells":[58],"derived":[59],"from":[60,151],"patients":[61],"with":[62,218],"liver,":[63,114],"lung,":[64,115],"breast,":[65],"colon,":[66],"pancreatic":[68],"cancers":[69],"as":[70,72],"well":[71],"melanoma,":[73],"lymphoma,":[74],"multiple":[76],"myeloma.":[77],"has":[79,93],"been":[80],"encapsulated":[81],"an":[83,126],"anionic":[84],"liposome":[85],"to":[86,154,223],"produce":[87,196],"particle":[89],"MRX34":[91,102,132,148,180,219],"diameter":[95],"~120":[97],"nm.":[98],"Intravenous":[99],"injections":[100],"causes":[103,133],"dose-dependent":[104],"increases":[105],"levels":[108],"liver":[110,142,171],"tumor,":[111,113],"lung":[112],"spleen,":[116],"other":[118],"highly":[119],"vascularized":[120],"tissues":[121],"mice":[123],"without":[124],"inducing":[125],"immune":[127],"response.":[128],"Systemic":[129],"delivery":[130],"complete":[134,197],"regression":[136,199],"two":[138],"orthotopic":[139],"models":[140],"cancer.":[143],"The":[144,173],"exceptional":[145],"potency":[146],"likely":[149],"results":[150],"its":[152],"capacity":[153],"stimulate":[155],"down-regulate":[160],"genes":[161],"wnt/B-catenin,":[164],"MAPK,":[166],"VegF":[168],"pathways":[169],"tumors.":[172],"no":[174],"adverse":[175],"effects":[176],"level":[177],"observed":[178],"for":[179,276],"IND-enabling":[182],"toxicology":[183],"studies":[184,217],"monkeys":[186],"rats":[188],"are":[189,221],"10-100-fold":[190],"higher":[191],"doses":[194],"mice,":[201],"suggesting":[202],"drug":[205],"candidate":[206],"will":[207,228],"broad":[210],"therapeutic":[211,235],"window":[212],"patients.":[215],"Clinical":[216],"expected":[222],"begin":[224],"early":[226],"2013":[227,279],"provide":[229],"first":[231],"measure":[232],"potential":[236],"miRNA.":[241],"Citation":[242],"Format:":[243],"Chris":[244],"Daige,":[245],"Jason":[246],"Wiggins,":[247],"Leslie":[248],"Priddy,":[249],"Kevin":[250],"Kelnar,":[251],"Jane":[252],"Zhao,":[253],"Andreas":[254],"Bader,":[255],"David":[256],"Brown.":[257],"Development":[258],"miR34-based":[261],"therapy.":[263],"[abstract].":[264],"In:":[265],"Proceedings":[266],"104th":[269],"Annual":[270],"Meeting":[271],"American":[274],"Association":[275],"Cancer":[277,287],"Research;":[278],"Apr":[280],"6-10;":[281],"Washington,":[282],"DC.":[283],"Philadelphia":[284],"(PA):":[285],"AACR;":[286],"Res":[288],"2013;73(8":[289],"Suppl):Abstract":[290],"nr":[291],"LB-250.":[292],"doi:10.1158/1538-7445.AM2013-LB-250":[293]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
