{"id":"https://openalex.org/W2333877478","doi":"https://doi.org/10.1172/jci.insight.86082","title":"Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL","display_name":"Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL","publication_year":2016,"publication_date":"2016-04-06","ids":{"openalex":"https://openalex.org/W2333877478","doi":"https://doi.org/10.1172/jci.insight.86082","mag":"2333877478","pmid":"https://pubmed.ncbi.nlm.nih.gov/27123491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4844070"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.86082","doi":"https://doi.org/10.1172/jci.insight.86082","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.86082","pdf_url":"http://insight.jci.org/articles/view/86082/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/86082/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057234924","display_name":"Michelle L. Churchman","orcid":"https://orcid.org/0000-0002-6560-1056","observed_orcids":["https://orcid.org/0000-0002-6560-1056"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle L. Churchman","raw_affiliation_strings":["Department of Pathology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102933279","display_name":"Kathryn Evans","orcid":"https://orcid.org/0000-0001-8737-6358","observed_orcids":["https://orcid.org/0000-0001-8737-6358"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathryn Evans","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia"],"raw_orcid":"https://orcid.org/0000-0001-8737-6358","affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102858434","display_name":"Jennifer Richmond","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jennifer Richmond","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076838191","display_name":"Alissa K. Robbins","orcid":"https://orcid.org/0000-0001-6782-1565","observed_orcids":["https://orcid.org/0000-0001-6782-1565"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alissa Robbins","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011242905","display_name":"Luke Jones","orcid":"https://orcid.org/0000-0001-5207-3349","observed_orcids":["https://orcid.org/0000-0001-5207-3349"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Luke Jones","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109224276","display_name":"Irina M. Shapiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154584","display_name":"Verastem (United States)","ror":"https://ror.org/0562yk913","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154584"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina M. Shapiro","raw_affiliation_strings":["Verastem Inc., Needham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Verastem Inc., Needham, Massachusetts, USA","institution_ids":["https://openalex.org/I4210154584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073675187","display_name":"Jonathan A. Pachter","orcid":"https://orcid.org/0000-0002-0263-474X","observed_orcids":["https://orcid.org/0000-0002-0263-474X"]},"institutions":[{"id":"https://openalex.org/I4210154584","display_name":"Verastem (United States)","ror":"https://ror.org/0562yk913","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154584"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan A. Pachter","raw_affiliation_strings":["Verastem Inc., Needham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Verastem Inc., Needham, Massachusetts, USA","institution_ids":["https://openalex.org/I4210154584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074838425","display_name":"David T. Weaver","orcid":"https://orcid.org/0000-0001-8398-3919","observed_orcids":["https://orcid.org/0000-0001-8398-3919"]},"institutions":[{"id":"https://openalex.org/I4210154584","display_name":"Verastem (United States)","ror":"https://ror.org/0562yk913","country_code":"US","type":"company","lineage":["https://openalex.org/I4210154584"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Weaver","raw_affiliation_strings":["Verastem Inc., Needham, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Verastem Inc., Needham, Massachusetts, USA","institution_ids":["https://openalex.org/I4210154584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109173471","display_name":"Peter J. Houghton","orcid":"https://orcid.org/0000-0002-2400-8184","observed_orcids":["https://orcid.org/0000-0002-2400-8184"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Houghton","raw_affiliation_strings":["Greehey Children\u2019s Cancer Research Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health Science Center San Antonio, San Antonio, Texas, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046943976","display_name":"Malcolm Anders Smith","orcid":"https://orcid.org/0000-0001-9880-9876","observed_orcids":["https://orcid.org/0000-0001-9880-9876"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malcolm A. Smith","raw_affiliation_strings":["Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028049853","display_name":"Richard B. Lock","orcid":"https://orcid.org/0000-0002-3436-9071","observed_orcids":["https://orcid.org/0000-0002-3436-9071"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Richard B. Lock","raw_affiliation_strings":["Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048744038","display_name":"Charles Grenfell Mullighan","orcid":"https://orcid.org/0000-0002-1871-1850","observed_orcids":["https://orcid.org/0000-0002-1871-1850","https://orcid.org/0000-0002-1678-5864"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles G. Mullighan","raw_affiliation_strings":["Department of Pathology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":"https://orcid.org/0000-0002-1871-1850","affiliations":[{"raw_affiliation_string":"Department of Pathology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5048744038"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":6.7463,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.97112346,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"1","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.6190999746322632,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.3167000114917755,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-positive-b-cell-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9269999861717224},{"id":"https://openalex.org/keywords/vs-4718","display_name":"VS-4718","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.8410000205039978},{"id":"https://openalex.org/keywords/ikaros","display_name":"Ikaros","score":0.9850000143051147},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.7210000157356262},{"id":"https://openalex.org/keywords/fak-signaling","display_name":"FAK signaling","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.7596721649169922},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.7059386968612671},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6920539140701294},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5499493479728699},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5073532462120056},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.46203047037124634},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.4319145679473877},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43188953399658203},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.41454166173934937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41049641370773315},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39895790815353394},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3548010587692261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35075467824935913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33799219131469727},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33177274465560913},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29487287998199463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16614755988121033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12208044528961182},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.06888160109519958}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1172/jci.insight.86082","doi":"https://doi.org/10.1172/jci.insight.86082","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.86082","pdf_url":"http://insight.jci.org/articles/view/86082/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4844070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4844070","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"},{"id":"pmid:27123491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27123491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"},{"id":"pmh:oai:unsworks.library.unsw.edu.au:1959.4/unsworks_40523","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1959.4/unsworks_40523","pdf_url":"https://unsworks.unsw.edu.au/bitstreams/3c59fa24-10fd-457f-a641-54e312b71e48/download","source":{"id":"https://openalex.org/S4306401737","display_name":"UNSWorks (University of New South Wales, Sydney, Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40053085","host_organization_name":"Australian Defence Force Academy","host_organization_lineage":["https://openalex.org/I40053085"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jci Insight, 1, 4, e86082","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:unsworks.unsw.edu.au:1959.4/unsworks_40523","doi":null,"is_oa":true,"landing_page_url":"http://handle.unsw.edu.au/1959.4/unsworks_40523","pdf_url":null,"source":{"id":"https://openalex.org/S4377196481","display_name":"UNSWorks (UNSW Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I31746571","host_organization_name":"UNSW Sydney","host_organization_lineage":["https://openalex.org/I31746571"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.86082","doi":"https://doi.org/10.1172/jci.insight.86082","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.86082","pdf_url":"http://insight.jci.org/articles/view/86082/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1388267649","display_name":"Pediatric Preclinical Testing Program","funder_award_id":"n01cm42216-11-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2954099590","display_name":null,"funder_award_id":"CA021765","funder_id":"https://openalex.org/F4320310040","funder_display_name":"St. Jude Children's Research Hospital"},{"id":"https://openalex.org/G425884651","display_name":null,"funder_award_id":"P30 CA021765","funder_id":"https://openalex.org/F4320310040","funder_display_name":"St. Jude Children's Research Hospital"},{"id":"https://openalex.org/G4869702982","display_name":null,"funder_award_id":"CA021765","funder_id":"https://openalex.org/F4320313598","funder_display_name":"American Lebanese Syrian Associated Charities"},{"id":"https://openalex.org/G5277985768","display_name":null,"funder_award_id":"N01 CM042216","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308906","display_name":"St. Baldrick's Foundation","ror":"https://ror.org/03h1gea69"},{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2333877478.pdf","grobid_xml":"https://content.openalex.org/works/W2333877478.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1641958014","https://openalex.org/W1901988103","https://openalex.org/W1964812787","https://openalex.org/W1973621054","https://openalex.org/W1973886069","https://openalex.org/W1976209487","https://openalex.org/W1984065010","https://openalex.org/W1989645452","https://openalex.org/W1993792708","https://openalex.org/W1994447945","https://openalex.org/W1994568187","https://openalex.org/W1997121235","https://openalex.org/W2008271309","https://openalex.org/W2032564152","https://openalex.org/W2035749206","https://openalex.org/W2042396191","https://openalex.org/W2044423100","https://openalex.org/W2044895919","https://openalex.org/W2045977586","https://openalex.org/W2047597898","https://openalex.org/W2085540799","https://openalex.org/W2090946356","https://openalex.org/W2100996687","https://openalex.org/W2105512558","https://openalex.org/W2106392592","https://openalex.org/W2119967034","https://openalex.org/W2127226843","https://openalex.org/W2133118937","https://openalex.org/W2146173960","https://openalex.org/W2146473098","https://openalex.org/W2147109509","https://openalex.org/W2147270774","https://openalex.org/W2158026056","https://openalex.org/W2158136052","https://openalex.org/W2169758210","https://openalex.org/W2191507484","https://openalex.org/W2329365382","https://openalex.org/W4242432882"],"related_works":["https://openalex.org/W2572339734","https://openalex.org/W773397075","https://openalex.org/W2258328295","https://openalex.org/W2551657950","https://openalex.org/W2065215145","https://openalex.org/W2979788116","https://openalex.org/W2515047728","https://openalex.org/W2550978226","https://openalex.org/W2739894552","https://openalex.org/W2111321718"],"abstract_inverted_index":{"BCR-ABL1":[0],"+":[1,8,40,78,130,150],"B":[2],"progenitor":[3],"acute":[4],"lymphoblastic":[5],"leukemia":[6],"(Ph":[7],"B-ALL)":[9],"is":[10,74,116],"an":[11,117],"aggressive":[12],"disease":[13],"that":[14,72,87],"frequently":[15],"responds":[16],"poorly":[17],"to":[18,59,103,120],"currently":[19],"available":[20],"therapies.":[21],"Alterations":[22],"in":[23,35,76,83,109,128,133,145],"IKZF1":[24,154],",":[25],"which":[26],"encodes":[27],"the":[28,60,88,122,135],"lymphoid":[29],"transcription":[30],"factor":[31],"Ikaros,":[32],"are":[33,43],"present":[34],"over":[36],"80%":[37],"of":[38,125,153],"Ph":[39,77,129,149],"ALL":[41],"and":[42,54,66,86,97,142],"associated":[44],"with":[45,80,114],"a":[46],"stem":[47,63],"cell\u2013like":[48],"phenotype,":[49],"aberrant":[50,94],"adhesion":[51,58],"molecule":[52],"expression":[53],"signaling,":[55],"leukemic":[56,98],"cell":[57,64,99],"bone":[61],"marrow":[62],"niche,":[65],"poor":[67],"outcome.":[68],"Here,":[69],"we":[70],"show":[71],"FAK1":[73],"upregulated":[75],"B-ALL":[79],"further":[81],"overexpression":[82,127],"IKZF1-altered":[84],"cells":[85],"FAK":[89,95,113,126],"inhibitor":[90],"VS-4718":[91,115],"potently":[92],"inhibits":[93],"signaling":[96],"adhesion,":[100],"potentiating":[101],"responsiveness":[102],"tyrosine":[104],"kinase":[105],"inhibitors,":[106],"inducing":[107],"cure":[108],"vivo.":[110],"Thus,":[111],"targeting":[112],"attractive":[118],"approach":[119],"overcome":[121],"deleterious":[123],"effects":[124],"B-ALL,":[131,151],"particularly":[132],"abrogating":[134],"adhesive":[136],"phenotype":[137],"induced":[138],"by":[139],"Ikaros":[140],"alterations,":[141],"warrants":[143],"evaluation":[144],"clinical":[146],"trials":[147],"for":[148],"regardless":[152],"status.":[155]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
