{"id":"https://openalex.org/W2333838440","doi":"https://doi.org/10.2174/1874764711104030196","title":"Recent Advancements in Ligament Replacement","display_name":"Recent Advancements in Ligament Replacement","publication_year":2011,"publication_date":"2011-10-26","ids":{"openalex":"https://openalex.org/W2333838440","doi":"https://doi.org/10.2174/1874764711104030196","mag":"2333838440"},"language":"en","primary_location":{"id":"doi:10.2174/1874764711104030196","doi":"https://doi.org/10.2174/1874764711104030196","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1874764711104030196","pdf_url":null,"source":{"id":"https://openalex.org/S40195058","display_name":"Recent Patents on Biomedical Engineering","issn_l":"1874-7647","issn":["1874-7647","2211-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Patents on Biomedical Engineeringe","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004703441","display_name":"Emmanuel C. Ekwueme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emmanuel C. Ekwueme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051476880","display_name":"Albert L. Kwansa","orcid":"https://orcid.org/0000-0003-2221-3843","observed_orcids":["https://orcid.org/0000-0003-2221-3843","https://orcid.org/0000-0003-3946-5449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albert L. Kwansa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110353873","display_name":"Kevin Sharif","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Sharif","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025178975","display_name":"Saadiq F. El\u2010Amin","orcid":"https://orcid.org/0000-0001-9316-3172","observed_orcids":["https://orcid.org/0000-0001-9316-3172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saadiq F. El-Amin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034785099","display_name":"Joseph W. Freeman","orcid":"https://orcid.org/0000-0003-3656-9517","observed_orcids":["https://orcid.org/0000-0003-3656-9517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph W. Freeman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.28890822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"4","issue":"3","first_page":"196","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anterior-cruciate-ligament","display_name":"anterior cruciate ligament","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ligament-reconstruction","display_name":"ligament reconstruction","score":0.7509999871253967},{"id":"https://openalex.org/keywords/silk","display_name":"silk","score":0.48899999260902405},{"id":"https://openalex.org/keywords/poly-l-lactic-acid","display_name":"poly(L-lactic acid)","score":0.9860000014305115},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.9490000009536743},{"id":"https://openalex.org/keywords/scaffolds","display_name":"scaffolds","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.8870000243186951},{"id":"https://openalex.org/keywords/autograft","display_name":"autograft","score":0.8830000162124634},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/knee-stability","display_name":"knee stability","score":0.7459999918937683},{"id":"https://openalex.org/keywords/implant-stability","display_name":"implant stability","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C2778434673","wikidata":"https://www.wikidata.org/wiki/Q611127","display_name":"Anterior cruciate ligament","level":2,"score":0.8549191951751709},{"id":"https://openalex.org/C2779753412","wikidata":"https://www.wikidata.org/wiki/Q39888","display_name":"Ligament","level":2,"score":0.7372519969940186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5598609447479248},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.5480577349662781},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4641289710998535},{"id":"https://openalex.org/C2779699715","wikidata":"https://www.wikidata.org/wiki/Q3621623","display_name":"Cruciate ligament","level":3,"score":0.45083510875701904},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.4138641357421875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1874764711104030196","doi":"https://doi.org/10.2174/1874764711104030196","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1874764711104030196","pdf_url":null,"source":{"id":"https://openalex.org/S40195058","display_name":"Recent Patents on Biomedical Engineering","issn_l":"1874-7647","issn":["1874-7647","2211-3320"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Recent Patents on Biomedical Engineeringe","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W71466223","https://openalex.org/W81527584","https://openalex.org/W84249847","https://openalex.org/W147451129","https://openalex.org/W167209471","https://openalex.org/W179345940","https://openalex.org/W202137580","https://openalex.org/W1558142965","https://openalex.org/W1570639441","https://openalex.org/W1639679612","https://openalex.org/W1950904482","https://openalex.org/W1961369231","https://openalex.org/W1970611007","https://openalex.org/W1972098647","https://openalex.org/W1978523154","https://openalex.org/W1979041517","https://openalex.org/W1982962944","https://openalex.org/W1999324485","https://openalex.org/W2005740395","https://openalex.org/W2006762534","https://openalex.org/W2008029193","https://openalex.org/W2011661715","https://openalex.org/W2012736920","https://openalex.org/W2026173616","https://openalex.org/W2032788174","https://openalex.org/W2043393256","https://openalex.org/W2047837369","https://openalex.org/W2048149237","https://openalex.org/W2048769067","https://openalex.org/W2053284589","https://openalex.org/W2057732114","https://openalex.org/W2063124204","https://openalex.org/W2063539658","https://openalex.org/W2072585807","https://openalex.org/W2093146166","https://openalex.org/W2095241133","https://openalex.org/W2095470662","https://openalex.org/W2095505123","https://openalex.org/W2104328456","https://openalex.org/W2107657275","https://openalex.org/W2114272290","https://openalex.org/W2115250707","https://openalex.org/W2123349384","https://openalex.org/W2130021740","https://openalex.org/W2134367348","https://openalex.org/W2134487012","https://openalex.org/W2134711555","https://openalex.org/W2136652158","https://openalex.org/W2141412603","https://openalex.org/W2142376244","https://openalex.org/W2143654986","https://openalex.org/W2144173766","https://openalex.org/W2146092834","https://openalex.org/W2148476302","https://openalex.org/W2150295226","https://openalex.org/W2157908104","https://openalex.org/W2163649189","https://openalex.org/W2167689517","https://openalex.org/W2169520502","https://openalex.org/W2241830359","https://openalex.org/W2260840647","https://openalex.org/W2290172307","https://openalex.org/W2400589048","https://openalex.org/W2408734357","https://openalex.org/W3101011389","https://openalex.org/W3151182428"],"related_works":["https://openalex.org/W2112528691","https://openalex.org/W7099794700","https://openalex.org/W7134479443","https://openalex.org/W2159713669","https://openalex.org/W81527584","https://openalex.org/W1538382355","https://openalex.org/W2053284589","https://openalex.org/W2070978404","https://openalex.org/W4288620976","https://openalex.org/W2258527561"],"abstract_inverted_index":{"The":[0],"anterior":[1,126],"cruciate":[2,111,127],"ligament":[3,19,82,112,130,135],"(ACL)":[4],"is":[5,13],"important":[6],"for":[7,48],"knee":[8,22],"stability":[9,72],"and":[10,23,46,52,94,105],"kinematics.":[11],"It":[12],"also":[14],"the":[15,21,49,55,60,92],"most":[16],"commonly":[17],"injured":[18],"of":[20,54,62,103],"due":[24],"to":[25,42,69,75],"its":[26,95],"poor":[27],"healing":[28],"potential,":[29],"severe":[30],"damage":[31],"warrants":[32],"surgical":[33],"intervention":[34],"including":[35],"complete":[36],"replacement.":[37],"Therefore,":[38],"investigators":[39],"have":[40],"begun":[41],"pursue":[43],"new":[44],"techniques":[45],"devices":[47],"repair,":[50],"regeneration,":[51],"replacement":[53,98],"ACL.":[56],"These":[57],"options":[58],"involve":[59],"use":[61],"mechanically":[63],"functional":[64],"grafts":[65],"that":[66],"are":[67],"designed":[68],"increase":[70],"implant":[71],"in":[73,84],"order":[74],"withstand":[76],"normal":[77],"mechanical":[78],"loads":[79],"(while":[80],"promoting":[81],"development":[83],"some":[85],"cases).":[86],"This":[87],"article":[88],"presents":[89],"background":[90],"on":[91],"ACL":[93],"replacement,":[96],"novel":[97],"approaches":[99],"utilizing":[100],"a":[101],"variety":[102],"materials,":[104],"recent":[106],"patent":[107],"coverage.":[108],"Keywords:":[109],"Anterior":[110],"(ACL),":[113],"silk,":[114],"poly":[115],"(L-lactic":[116],"acid)":[117],"(PLLA),":[118],"xenograft,":[119],"scaffold,":[120],"polymer,":[121],"tissue":[122],"engineering,":[123],"lactic":[124],"acid,":[125],"ligament,":[128],"surgery,":[129],"reconstructions,":[131],"Autografts,":[132],"immunogenic":[133],"response,":[134],"replacements,":[136],"femoral-tibial":[137],"articulation,":[138],"augmentation":[139]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
