{"id":"https://openalex.org/W2333820249","doi":"https://doi.org/10.2307/3282169","title":"Secretory Protein Biosynthesis in Snail Hemocytes: In vitro Modulation by Larval Schistosome Excretory-Secretory Products","display_name":"Secretory Protein Biosynthesis in Snail Hemocytes: In vitro Modulation by Larval Schistosome Excretory-Secretory Products","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W2333820249","doi":"https://doi.org/10.2307/3282169","mag":"2333820249","pmid":"https://pubmed.ncbi.nlm.nih.gov/3397815"},"language":"en","primary_location":{"id":"doi:10.2307/3282169","doi":"https://doi.org/10.2307/3282169","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3282169","pdf_url":null,"source":{"id":"https://openalex.org/S31573680","display_name":"Journal of Parasitology","issn_l":"0022-3395","issn":["0022-3395","1937-2345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316431","host_organization_name":"American Society of Parasitologists","host_organization_lineage":["https://openalex.org/P4310316431"],"host_organization_lineage_names":["American Society of Parasitologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2307/3282169","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008692407","display_name":"Timothy P. Yoshino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy P. Yoshino","raw_affiliation_strings":["Department of Zoology, University of Oklahoma, Norman 73019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, University of Oklahoma, Norman 73019","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113662616","display_name":"Michael J. Lodes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Lodes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2461,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.80566577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"74","issue":"4","first_page":"538","last_page":"538"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.8804000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.10379999876022339,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excretory-secretory-products","display_name":"excretory-secretory products","score":0.9010000228881836},{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9679999947547913},{"id":"https://openalex.org/keywords/biomphalaria-glabrata","display_name":"Biomphalaria glabrata","score":0.9850000143051147},{"id":"https://openalex.org/keywords/snail-resistance-to-schistosomiasis","display_name":"snail resistance to schistosomiasis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/snail-parasite-interaction","display_name":"snail-parasite interaction","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.8360393643379211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8348472118377686},{"id":"https://openalex.org/C2776453879","wikidata":"https://www.wikidata.org/wiki/Q1835536","display_name":"Biomphalaria glabrata","level":5,"score":0.7680988311767578},{"id":"https://openalex.org/C156399914","wikidata":"https://www.wikidata.org/wiki/Q7444454","display_name":"Secretory protein","level":3,"score":0.5772314667701721},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.5760017037391663},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.5531055331230164},{"id":"https://openalex.org/C16527932","wikidata":"https://www.wikidata.org/wiki/Q1112860","display_name":"Excretory system","level":2,"score":0.5138240456581116},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5070977210998535},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.504794716835022},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45918720960617065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.457913339138031},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.43365681171417236},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3749878406524658},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20180171728134155},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.13202884793281555},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.11530473828315735},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.09412676095962524},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001700","descriptor_name":"Biomphalaria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001773","descriptor_name":"Blood Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006434","descriptor_name":"Hemocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010452","descriptor_name":"Peptide Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010779","descriptor_name":"Photofluorography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2307/3282169","doi":"https://doi.org/10.2307/3282169","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3282169","pdf_url":null,"source":{"id":"https://openalex.org/S31573680","display_name":"Journal of Parasitology","issn_l":"0022-3395","issn":["0022-3395","1937-2345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316431","host_organization_name":"American Society of Parasitologists","host_organization_lineage":["https://openalex.org/P4310316431"],"host_organization_lineage_names":["American Society of Parasitologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Parasitology","raw_type":"journal-article"},{"id":"pmid:3397815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3397815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of parasitology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2307/3282169","doi":"https://doi.org/10.2307/3282169","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3282169","pdf_url":null,"source":{"id":"https://openalex.org/S31573680","display_name":"Journal of Parasitology","issn_l":"0022-3395","issn":["0022-3395","1937-2345"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310316431","host_organization_name":"American Society of Parasitologists","host_organization_lineage":["https://openalex.org/P4310316431"],"host_organization_lineage_names":["American Society of Parasitologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Parasitology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G350499776","display_name":null,"funder_award_id":"AI 15503","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5445973539","display_name":null,"funder_award_id":"AI00491","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G573956953","display_name":null,"funder_award_id":"AI-02656","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1979492674","https://openalex.org/W1981985636","https://openalex.org/W1993488072","https://openalex.org/W2007388511","https://openalex.org/W2018497777","https://openalex.org/W2029865727","https://openalex.org/W2034277598","https://openalex.org/W2035077274","https://openalex.org/W2041718969","https://openalex.org/W2043541124","https://openalex.org/W2048169084","https://openalex.org/W2054626058","https://openalex.org/W2058998227","https://openalex.org/W2064369260","https://openalex.org/W2070647507","https://openalex.org/W2074141881","https://openalex.org/W2085160309","https://openalex.org/W2127023454","https://openalex.org/W2332158710","https://openalex.org/W2332400242","https://openalex.org/W2333241321","https://openalex.org/W2410439383","https://openalex.org/W2418732936","https://openalex.org/W2504816579","https://openalex.org/W3022563089"],"related_works":["https://openalex.org/W2053459247","https://openalex.org/W2073334863","https://openalex.org/W2902568625","https://openalex.org/W2007723483","https://openalex.org/W2009280875","https://openalex.org/W2027908975","https://openalex.org/W4301930440","https://openalex.org/W2327437181","https://openalex.org/W2330159963","https://openalex.org/W2012372990"],"abstract_inverted_index":{"Circulating":[0],"hemocytes":[1,59,124,135,160,279,318],"of":[2,12,26,38,51,60,71,79,106,118,125,141,149,164,169,218,220,228,231,238,245,263,269,282,288,291,298,314],"the":[3,36,68,104,116,147,165,190,200,226,229,243,260,324],"snail,":[4],"Biomphalaria":[5],"glabrata,":[6],"synthesize":[7],"and":[8,96,129,136,242,286,294],"secrete":[9],"a":[10,61,112,119,130,142,170,214,250,289],"variety":[11,290],"polypeptides":[13,41],"when":[14],"maintained":[15],"in":[16,18,43,89,103,115,133,138,157,162,213,249,283],"vitro":[17,284],"serum-free":[19],"medium":[20],"containing":[21],"[35S]":[22],"methionine.":[23],"SDS-PAGE/fluorographic":[24],"analysis":[25],"supernatants":[27,90,179],"from":[28,45,77,91],"resistant":[29,80,317],"snail":[30,81,127,159,196,278],"(10-R2-OK":[31],"strain)":[32],"hemocyte":[33,192,207,240,271],"cultures":[34,100],"revealed":[35],"presence":[37,244],"numerous":[39],"labeled":[40,185],"ranging":[42],"Mr":[44],"220":[46],"to":[47,176,235,319,326],"14":[48],"kDa.":[49,224],"Most":[50],"these":[52,328],"same":[53],"proteins":[54,241],"were":[55],"also":[56],"produced":[57],"by":[58,123],"susceptible":[62,315],"B.":[63,172],"glabrata":[64,173],"strain":[65],"(M-line),":[66],"but":[67],"overall":[69],"rate":[70],"secretory":[72,121,152,272],"protein":[73,153,186,208],"synthesis":[74,105,117,154,237,285],"was":[75,111,155],"reduced":[76],"that":[78,189,277,295,323],"cells.":[82],"In":[83],"addition,":[84],"excretory-secretory":[85],"(ES)":[86],"products":[87,234,297,321],"contained":[88],"Schistosoma":[92],"mansoni":[93],"miracidial":[94],"transformation":[95],"1-day":[97],"primary":[98],"sporocyst":[99],"stimulated":[101],"increases":[102],"various":[107],"polypeptides.":[108,273],"Particularly":[109],"striking":[110],"3-fold":[113],"increase":[114,132],"66-kDa":[120],"polypeptide":[122],"both":[126],"strains,":[128],"concomitant":[131],"M-line":[134,166],"decrease":[137],"10-R2-OK":[139,158],"cells":[140,329],"63-kDa":[143],"polypeptide.":[144],"Overall,":[145],"however,":[146],"level":[148],"ES":[150,202,296],"product-induced":[151],"greater":[156,221],"than":[161,222,256],"those":[163],"strain.":[167],"Exposure":[168],"nonhemocytic":[171],"cell":[174],"line":[175],"parasite":[177,233],"culture":[178],"had":[180],"no":[181],"stimulatory/inhibitory":[182],"effect":[183],"on":[184],"ouput,":[187],"suggesting":[188],"observed":[191],"response":[193,313],"may":[194,334],"be":[195,331],"cell-type":[197],"specific.":[198],"Finally,":[199],"larval":[201,265,300,320],"components":[203,266],"responsible":[204],"for":[205],"modulating":[206],"metabolism":[209],"are":[210,280],"mainly":[211],"concentrated":[212],"heat-stable":[215],"fraction":[216,254],"composed":[217],"molecules":[219],"30":[223],"However,":[225],"loss":[227],"ability":[230],"heated":[232],"stimulate":[236,305],"certain":[239],"minor":[246],"stimulating":[247],"activity":[248],"low":[251],"molecular":[252],"weight":[253],"(less":[255],"10":[257],"kDa)":[258],"implies":[259],"possible":[261],"existence":[262],"multiple":[264],"affecting":[267],"formation":[268],"specific":[270],"It":[274],"is":[275],"concluded":[276],"capable":[281],"secretion":[287],"methionine-containing":[292],"polypeptides,":[293],"early":[299],"schistosomes":[301],"can":[302,330],"modulate":[303],"(i.e.,":[304],"or":[306],"inhibit)":[307],"this":[308],"metabolic":[309],"process.":[310],"A":[311],"differential":[312],"vs.":[316],"suggests":[322],"degree":[325],"which":[327],"metabolically":[332],"activated":[333],"determine":[335],"their":[336],"cytotoxic":[337],"effectiveness.":[338]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
