{"id":"https://openalex.org/W2333767446","doi":"https://doi.org/10.1097/sla.0b013e3182708b57","title":"Evolution of Surgical Treatment for Perihilar Cholangiocarcinoma","display_name":"Evolution of Surgical Treatment for Perihilar Cholangiocarcinoma","publication_year":2012,"publication_date":"2012-10-11","ids":{"openalex":"https://openalex.org/W2333767446","doi":"https://doi.org/10.1097/sla.0b013e3182708b57","mag":"2333767446","pmid":"https://pubmed.ncbi.nlm.nih.gov/23059502"},"language":"en","primary_location":{"id":"doi:10.1097/sla.0b013e3182708b57","doi":"https://doi.org/10.1097/sla.0b013e3182708b57","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sla.0b013e3182708b57","pdf_url":null,"source":{"id":"https://openalex.org/S157664895","display_name":"Annals of Surgery","issn_l":"0003-4932","issn":["0003-4932","1528-1140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112513039","display_name":"Masato Nagino","orcid":"https://orcid.org/0000-0003-2238-0633","observed_orcids":["https://orcid.org/0000-0003-2238-0633"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masato Nagino","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. nagino@med.nagoya-u.ac.jp","Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. nagino@med.nagoya-u.ac.jp","institution_ids":["https://openalex.org/I60134161"]},{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060579946","display_name":"Tomoki Ebata","orcid":"https://orcid.org/0000-0002-8247-7050","observed_orcids":["https://orcid.org/0000-0002-8247-7050"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tomoki Ebata","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052829488","display_name":"Yukihiro Yokoyama","orcid":"https://orcid.org/0000-0003-2385-5610","observed_orcids":["https://orcid.org/0000-0003-2385-5610"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yukihiro Yokoyama","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081840313","display_name":"Tsuyoshi Igami","orcid":"https://orcid.org/0000-0003-2049-6704","observed_orcids":["https://orcid.org/0000-0003-2049-6704"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tsuyoshi Igami","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007816797","display_name":"Gen Sugawara","orcid":"https://orcid.org/0000-0002-2443-065X","observed_orcids":["https://orcid.org/0000-0002-2443-065X"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Gen Sugawara","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032295043","display_name":"Yu Takahashi","orcid":"https://orcid.org/0000-0003-3066-023X","observed_orcids":["https://orcid.org/0000-0003-3066-023X","https://orcid.org/0009-0004-5891-3176"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yu Takahashi","raw_affiliation_strings":["Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113944864","display_name":"Yuji Nimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Nimura","raw_affiliation_strings":["Aichi Cancer Center, Nagoya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aichi Cancer Center, Nagoya, Japan","institution_ids":["https://openalex.org/I4210133851"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007816797","https://openalex.org/A5032295043","https://openalex.org/A5052829488","https://openalex.org/A5060579946","https://openalex.org/A5081840313","https://openalex.org/A5112513039"],"corresponding_institution_ids":["https://openalex.org/I60134161"],"apc_list":null,"apc_paid":null,"fwci":26.0168,"has_fulltext":false,"cited_by_count":667,"citation_normalized_percentile":{"value":0.99831736,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"258","issue":"1","first_page":"129","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hilar-cholangiocarcinoma","display_name":"hilar cholangiocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/surgical-resection","display_name":"surgical resection","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bile-duct-resection","display_name":"bile duct resection","score":0.7070000171661377},{"id":"https://openalex.org/keywords/perioperative-care","display_name":"perioperative care","score":0.5699999928474426},{"id":"https://openalex.org/keywords/postoperative-morbidity","display_name":"postoperative morbidity","score":0.7940000295639038},{"id":"https://openalex.org/keywords/postoperative-mortality","display_name":"postoperative mortality","score":0.8679999709129333},{"id":"https://openalex.org/keywords/disease-specific-survival","display_name":"disease-specific survival","score":0.9729999899864197},{"id":"https://openalex.org/keywords/evolution-of-surgical-techniques","display_name":"surgical technique evolution","score":0.48399999737739563},{"id":"https://openalex.org/keywords/liver-resection-outcomes","display_name":"liver resection outcomes","score":0.42399999499320984},{"id":"https://openalex.org/keywords/central-hepatectomy","display_name":"central hepatectomy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/r0-resection-margin","display_name":"R0 resection margin","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9786639213562012},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.7234413027763367},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5858364701271057},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5615670084953308},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.5109526515007019},{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.5106239914894104},{"id":"https://openalex.org/C2776640808","wikidata":"https://www.wikidata.org/wiki/Q475260","display_name":"Klatskin tumor","level":3,"score":0.478437215089798},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.43923404812812805},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4255684018135071},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.3849322497844696},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.3348895311355591},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18968433141708374},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001653","descriptor_name":"Bile Ducts, Intrahepatic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004621","descriptor_name":"Embolization, Therapeutic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016577","descriptor_name":"Pancreaticoduodenectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/sla.0b013e3182708b57","doi":"https://doi.org/10.1097/sla.0b013e3182708b57","is_oa":false,"landing_page_url":"https://doi.org/10.1097/sla.0b013e3182708b57","pdf_url":null,"source":{"id":"https://openalex.org/S157664895","display_name":"Annals of Surgery","issn_l":"0003-4932","issn":["0003-4932","1528-1140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Surgery","raw_type":"journal-article"},{"id":"pmid:23059502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23059502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of surgery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W108680517","https://openalex.org/W1499997759","https://openalex.org/W1577522894","https://openalex.org/W1965111637","https://openalex.org/W1966664212","https://openalex.org/W1969511539","https://openalex.org/W1971409448","https://openalex.org/W1971456747","https://openalex.org/W1971541605","https://openalex.org/W1973268573","https://openalex.org/W1974026082","https://openalex.org/W1975895704","https://openalex.org/W1977559690","https://openalex.org/W1980948970","https://openalex.org/W1981125110","https://openalex.org/W1982432235","https://openalex.org/W1982742398","https://openalex.org/W1983208778","https://openalex.org/W1987155248","https://openalex.org/W1989387462","https://openalex.org/W1989397971","https://openalex.org/W1989634186","https://openalex.org/W1998917414","https://openalex.org/W1999835276","https://openalex.org/W2008242411","https://openalex.org/W2009284687","https://openalex.org/W2010040021","https://openalex.org/W2013289012","https://openalex.org/W2015787771","https://openalex.org/W2019438357","https://openalex.org/W2029652643","https://openalex.org/W2034770797","https://openalex.org/W2035040851","https://openalex.org/W2035254040","https://openalex.org/W2038268626","https://openalex.org/W2041210801","https://openalex.org/W2046543069","https://openalex.org/W2047442441","https://openalex.org/W2051264401","https://openalex.org/W2052853518","https://openalex.org/W2053038457","https://openalex.org/W2053274880","https://openalex.org/W2054278834","https://openalex.org/W2055712625","https://openalex.org/W2058183684","https://openalex.org/W2060731557","https://openalex.org/W2065601794","https://openalex.org/W2070453606","https://openalex.org/W2072953518","https://openalex.org/W2073801722","https://openalex.org/W2073963371","https://openalex.org/W2075644682","https://openalex.org/W2075957912","https://openalex.org/W2085498077","https://openalex.org/W2086686513","https://openalex.org/W2091182394","https://openalex.org/W2093273760","https://openalex.org/W2094317823","https://openalex.org/W2095194355","https://openalex.org/W2095634270","https://openalex.org/W2110284028","https://openalex.org/W2115261608","https://openalex.org/W2117853299","https://openalex.org/W2123524720","https://openalex.org/W2129197203","https://openalex.org/W2130947236","https://openalex.org/W2134833177","https://openalex.org/W2137869551","https://openalex.org/W2142460968","https://openalex.org/W2147796106","https://openalex.org/W2153358651","https://openalex.org/W2301602970","https://openalex.org/W2315040241","https://openalex.org/W2317265960","https://openalex.org/W2394911519","https://openalex.org/W2399350583","https://openalex.org/W3142118791"],"related_works":["https://openalex.org/W7155779548","https://openalex.org/W2997074227","https://openalex.org/W2036074013","https://openalex.org/W2566694498","https://openalex.org/W2114073677","https://openalex.org/W4407939305","https://openalex.org/W2086166662","https://openalex.org/W1984183158","https://openalex.org/W2057911866","https://openalex.org/W2801933734"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"review":[2],"our":[3],"34-year":[4],"experience":[5],"with":[6,63,142,269,342],"574":[7,70,201],"consecutive":[8,61],"resections":[9],"for":[10,33,199,352,361],"perihilar":[11,34,64,336],"cholangiocarcinoma":[12,65,337],"and":[13,54,92,98,118,132,183,216,255,290,348,354],"to":[14,166,192,232,241,305],"evaluate":[15],"the":[16,148,170,200,227,236,261,264,281,297,300,308,328],"progress":[17],"made":[18],"in":[19,129,147,169,226,235,263,299],"surgical":[20,31,42,130,344],"treatment":[21,43,334],"of":[22,44,59,68,77,87,127,145,176,230,239,280,307,335,370],"this":[23,45],"disease.":[24],"BACKGROUND:":[25],"Few":[26],"studies":[27],"have":[28],"reported":[29],"improved":[30],"outcomes":[32],"cholangiocarcinoma;":[35],"therefore,":[36],"it":[37],"is":[38,374],"still":[39,140,365],"unclear":[40],"whether":[41],"intractable":[46],"disease":[47,178],"has":[48,90,115,122,154,185,338],"progressed.":[49],"METHODS:":[50],"Between":[51],"April":[52],"1977":[53,240],"December":[55],"2010,":[56],"a":[57,143],"total":[58],"754":[60],"patients":[62,80,203,257,292,356,363],"were":[66,81,102],"treated,":[67],"whom":[69],"(76.1%)":[71],"underwent":[72],"resection.":[73],"The":[74,85,174,196,221],"medical":[75],"records":[76],"these":[78],"resected":[79],"retrospectively":[82],"reviewed.":[83],"RESULTS:":[84],"incidence":[86],"major":[88],"hepatectomies":[89,97],"increased,":[91],"limited":[93],"resections,":[94,101],"including":[95],"central":[96],"bile":[99],"duct":[100],"rarely":[103],"performed.":[104],"Combined":[105],"vascular":[106],"resection":[107],"was":[108,139,207,223,267,275,303,327,357,364],"being":[109],"used":[110],"more":[111],"often.":[112],"Operative":[113],"time":[114],"become":[116],"shorter,":[117],"intraoperative":[119],"blood":[120],"loss":[121],"also":[123,155],"decreased":[124,136,156,346],"significantly.":[125],"Because":[126],"refinements":[128],"techniques":[131],"perioperative":[133],"management,":[134],"morbidity":[135],"significantly":[137,157,187,224,276],"but":[138],"high,":[141],"rate":[144,153],"43.1%":[146],"last":[149,171],"5":[150,172],"years.":[151,173],"Mortality":[152],"(P":[158,284],"<":[159,250,285],"0.001)":[160],"from":[161,188],"11.1%":[162],"(8/72)":[163],"before":[164,190],"1990":[165],"1.4%":[167],"(3/218)":[168],"ratio":[175],"advanced":[177],"defined":[179],"as":[180],"pStage":[181],"IVA":[182],"IVB":[184],"increased":[186,349],"49.4%":[189],"2000":[191,242],"61.4%":[193],"after":[194],"2001.":[195],"disease-specific":[197],"survival":[198,222,262,298,360],"study":[202],"(including":[204],"all":[205],"deaths)":[206],"44.3%":[208],"at":[209,213,218,246,271,314],"year":[210,214,219,247,272,315],"3,":[211],"32.5%":[212],"5,":[215,248,273,316],"19.9%":[217],"10.":[220],"better":[225,277],"later":[228,265,301],"period":[229,238,266,283,302,310],"2001":[231],"2010":[233],"than":[234,278],"earlier":[237,282,309],"(38.1%":[243],"vs":[244,312],"23.1%":[245],"P":[249,317],"0.001).":[251,286],"For":[252,287],"pM0,":[253,288],"R0,":[254,289],"pN0":[256,355],"(n":[258,293],"=":[259,294,318],"243),":[260],"good":[268],"67.1%":[270],"which":[274],"that":[279,306,323,368],"pN1":[291,362],"142),":[295],"however,":[296],"similar":[304],"(22.1%":[311],"14.6%":[313],"0.647).":[319],"Multivariate":[320],"analysis":[321],"revealed":[322],"lymph":[324],"node":[325],"metastasis":[326],"strongest":[329],"prognostic":[330],"indicator.":[331],"CONCLUSIONS:":[332],"Surgical":[333],"been":[339],"evolving":[340],"steadily,":[341],"expanded":[343],"indication,":[345],"mortality,":[347],"survival.":[350],"Survival":[351],"R0":[353],"satisfactory,":[358],"whereas":[359],"poor,":[366],"suggesting":[367],"establishment":[369],"effective":[371],"adjuvant":[372],"chemotherapy":[373],"needed.":[375]},"counts_by_year":[{"year":2026,"cited_by_count":42},{"year":2025,"cited_by_count":59},{"year":2024,"cited_by_count":53},{"year":2023,"cited_by_count":59},{"year":2022,"cited_by_count":53},{"year":2021,"cited_by_count":70},{"year":2020,"cited_by_count":69},{"year":2019,"cited_by_count":47},{"year":2018,"cited_by_count":53},{"year":2017,"cited_by_count":33},{"year":2016,"cited_by_count":49},{"year":2015,"cited_by_count":31},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}