{"id":"https://openalex.org/W2333713973","doi":"https://doi.org/10.1021/jm5009693","title":"Discovery of Carbohybrid-Based 2-Aminopyrimidine Analogues As a New Class of Rapid-Acting Antimalarial Agents Using Image-Based Cytological Profiling Assay","display_name":"Discovery of Carbohybrid-Based 2-Aminopyrimidine Analogues As a New Class of Rapid-Acting Antimalarial Agents Using Image-Based Cytological Profiling Assay","publication_year":2014,"publication_date":"2014-08-19","ids":{"openalex":"https://openalex.org/W2333713973","doi":"https://doi.org/10.1021/jm5009693","mag":"2333713973","pmid":"https://pubmed.ncbi.nlm.nih.gov/25137549"},"language":"en","primary_location":{"id":"doi:10.1021/jm5009693","doi":"https://doi.org/10.1021/jm5009693","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm5009693","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102780746","display_name":"Sukjun Lee","orcid":"https://orcid.org/0000-0001-6448-8103","observed_orcids":["https://orcid.org/0000-0001-6448-8103"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sukjun Lee","raw_affiliation_strings":["Early Discovery Program, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Discovery Program, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047410204","display_name":"Donghyun Lim","orcid":"https://orcid.org/0000-0002-6070-198X","observed_orcids":["https://orcid.org/0000-0002-6070-198X"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Donghyun Lim","raw_affiliation_strings":["WCU Department of Biophysics and Chemical Biology, Seoul National University, San 56-1, Shilim-dong, Gwanak-gu, Seoul 151-747, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WCU Department of Biophysics and Chemical Biology, Seoul National University, San 56-1, Shilim-dong, Gwanak-gu, Seoul 151-747, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eunyoung Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eunyoung Lee","raw_affiliation_strings":["Early Discovery Program, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Discovery Program, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003959534","display_name":"Nakyung Lee","orcid":"https://orcid.org/0000-0001-9496-5994","observed_orcids":["https://orcid.org/0000-0001-9496-5994"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nakyung Lee","raw_affiliation_strings":["Center for Neglected Diseases Drug Discovery (CND3), Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neglected Diseases Drug Discovery (CND3), Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026088399","display_name":"Honggun Lee","orcid":"https://orcid.org/0000-0003-0571-2261","observed_orcids":["https://orcid.org/0000-0003-0571-2261"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hong-gun Lee","raw_affiliation_strings":["Center for Core Technologies, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Core Technologies, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001249714","display_name":"Jonathan D. Cechetto","orcid":"https://orcid.org/0000-0002-1198-9761","observed_orcids":["https://orcid.org/0000-0002-1198-9761"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jonathan Cechetto","raw_affiliation_strings":["Center for Core Technologies, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Core Technologies, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039716848","display_name":"Michel Liuzzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Michel Liuzzi","raw_affiliation_strings":["Early Discovery Program, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Discovery Program, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037637932","display_name":"Lucio Holanda Freitas-Junior","orcid":"https://orcid.org/0000-0002-8904-7897","observed_orcids":["https://orcid.org/0000-0002-8904-7897"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Lucio H. Freitas-Junior","raw_affiliation_strings":["Center for Neglected Diseases Drug Discovery (CND3), Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neglected Diseases Drug Discovery (CND3), Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002548095","display_name":"Jin Sook Song","orcid":"https://orcid.org/0000-0001-8023-7769","observed_orcids":["https://orcid.org/0000-0001-8023-7769"]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Sook Song","raw_affiliation_strings":["Drug Discovery Platform Technology Group, Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery Platform Technology Group, Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080792622","display_name":"Myung Ae Bae","orcid":"https://orcid.org/0000-0002-2997-5018","observed_orcids":["https://orcid.org/0000-0002-2997-5018"]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myung Ae Bae","raw_affiliation_strings":["Drug Discovery Platform Technology Group, Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery Platform Technology Group, Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088592090","display_name":"Sangmi Oh","orcid":"https://orcid.org/0000-0003-0895-1110","observed_orcids":["https://orcid.org/0000-0003-0895-1110"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sangmi Oh","raw_affiliation_strings":["Medicinal Chemistry and Chemical Biology Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry and Chemical Biology Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083050906","display_name":"Lawrence S. Ayong","orcid":"https://orcid.org/0000-0001-7717-4832","observed_orcids":["https://orcid.org/0000-0001-7717-4832"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Lawrence Ayong","raw_affiliation_strings":["Early Discovery Program, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Discovery Program, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 463-400, Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091055050","display_name":"Seung Bum Park","orcid":"https://orcid.org/0000-0003-1753-1433","observed_orcids":["https://orcid.org/0000-0003-1753-1433"]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Seung Bum Park","raw_affiliation_strings":["Department of Chemistry, Seoul National University, Seoul 151-747, Korea","WCU Department of Biophysics and Chemical Biology, Seoul National University, San 56-1, Shilim-dong, Gwanak-gu, Seoul 151-747, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Seoul National University, Seoul 151-747, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"WCU Department of Biophysics and Chemical Biology, Seoul National University, San 56-1, Shilim-dong, Gwanak-gu, Seoul 151-747, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5083050906","https://openalex.org/A5091055050"],"corresponding_institution_ids":["https://openalex.org/I136761661","https://openalex.org/I139264467"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.879,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.9363168,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"57","issue":"17","first_page":"7425","last_page":"7434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.9639999866485596},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9879999756813049},{"id":"https://openalex.org/keywords/multidrug-resistant-malaria","display_name":"multidrug-resistant malaria","score":0.9179999828338623},{"id":"https://openalex.org/keywords/diversity-oriented-synthesis","display_name":"diversity-oriented synthesis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9319999814033508},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8622470498085022},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.7028099894523621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5773629546165466},{"id":"https://openalex.org/C96529984","wikidata":"https://www.wikidata.org/wiki/Q286136","display_name":"EC50","level":3,"score":0.572871208190918},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5256539583206177},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4991273880004883},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.45388537645339966},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.37154895067214966},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3614785671234131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24813807010650635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20195886492729187},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14269402623176575}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008018","descriptor_name":"Life Cycle Stages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D008288","descriptor_name":"Malaria","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016788","descriptor_name":"Plasmodium chabaudi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016788","descriptor_name":"Plasmodium chabaudi","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm5009693","doi":"https://doi.org/10.1021/jm5009693","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm5009693","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:25137549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25137549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2454878560","display_name":null,"funder_award_id":"2010-0019766","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5330599030","display_name":null,"funder_award_id":"2012M3A9C4048780","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8467803832","display_name":null,"funder_award_id":"2014R1A3A2030423","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322105","display_name":"Korea Institute of Science and Technology Information","ror":"https://ror.org/01k4yrm29"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W266480648","https://openalex.org/W1965440941","https://openalex.org/W1972907204","https://openalex.org/W1978468542","https://openalex.org/W1993492661","https://openalex.org/W2013104419","https://openalex.org/W2020827084","https://openalex.org/W2023633070","https://openalex.org/W2026718176","https://openalex.org/W2040713555","https://openalex.org/W2046041725","https://openalex.org/W2068398647","https://openalex.org/W2069312954","https://openalex.org/W2086170170","https://openalex.org/W2087956351","https://openalex.org/W2090798807","https://openalex.org/W2095554063","https://openalex.org/W2105723673","https://openalex.org/W2107849319","https://openalex.org/W2110243445","https://openalex.org/W2115323998","https://openalex.org/W2117102082","https://openalex.org/W2135155264","https://openalex.org/W2161311583","https://openalex.org/W2162842262","https://openalex.org/W2162913513","https://openalex.org/W2168950392","https://openalex.org/W2170680268","https://openalex.org/W2171565780","https://openalex.org/W2316428747","https://openalex.org/W2323360723","https://openalex.org/W2333484720","https://openalex.org/W2471164209"],"related_works":["https://openalex.org/W2115225189","https://openalex.org/W3195545424","https://openalex.org/W3194343017","https://openalex.org/W3121860547","https://openalex.org/W3008444660","https://openalex.org/W7097649963","https://openalex.org/W2787083249","https://openalex.org/W2128988919","https://openalex.org/W7222824467","https://openalex.org/W2136905362"],"abstract_inverted_index":{"New":[0],"antimalarial":[1,20,104],"agents":[2,28],"that":[3],"exhibit":[4],"multistage":[5],"activities":[6,77],"against":[7,78,113],"drug-resistant":[8],"strains":[9,81],"of":[10,26,50,55,69,82,94,108,130,141],"malaria":[11,127],"parasites":[12],"represent":[13],"good":[14],"starting":[15],"points":[16],"for":[17,40],"developing":[18],"next-generation":[19],"therapies.":[21],"To":[22],"facilitate":[23],"the":[24,30,67,92,101],"progression":[25],"such":[27],"into":[29],"development":[31],"phase,":[32],"we":[33],"developed":[34],"an":[35],"image-based":[36],"parasitological":[37],"screening":[38,54],"method":[39],"defining":[41],"drug":[42],"effects":[43],"on":[44],"different":[45],"asexual":[46],"life":[47],"cycle":[48],"stages":[49,140],"Plasmodium":[51],"falciparum.":[52,85],"High-throughput":[53],"a":[56],"newly":[57],"assembled":[58],"diversity-oriented":[59],"synthetic":[60],"library":[61],"using":[62],"this":[63],"approach":[64],"led":[65,90],"to":[66,91],"identification":[68,93],"carbohybrid-based":[70],"2-aminopyrimidine":[71],"compounds":[72],"with":[73],"fast-acting":[74],"growth":[75],"inhibitory":[76],"three":[79,115],"laboratory":[80],"multidrug-resistant":[83,142],"P.":[84,116,143],"Our":[86],"structure-activity":[87],"relationship":[88],"study":[89],"two":[95],"derivatives":[96],"(8aA":[97],"and":[98,110,125,132],"11aA)":[99],"as":[100],"most":[102],"promising":[103],"candidates":[105],"(mean":[106],"EC50":[107],"0.130":[109],"0.096":[111],"\u03bcM":[112],"all":[114,137],"falciparum":[117,144],"strains,":[118],"selectivity":[119],"indices":[120],">600,":[121],"microsomal":[122],"stabilities":[123],">80%,":[124],"mouse":[126],"ED50":[128],"values":[129],"0.32":[131],"0.12":[133],"mg/kg/day,":[134],"respectively),":[135],"targeting":[136],"major":[138],"blood":[139],"parasites.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
