{"id":"https://openalex.org/W2333344337","doi":"https://doi.org/10.1097/dad.0000000000000126","title":"Immunohistochemical Expression of Sperm-Associated Antigen 9 in Nonmelanoma Skin Cancer","display_name":"Immunohistochemical Expression of Sperm-Associated Antigen 9 in Nonmelanoma Skin Cancer","publication_year":2014,"publication_date":"2014-07-16","ids":{"openalex":"https://openalex.org/W2333344337","doi":"https://doi.org/10.1097/dad.0000000000000126","mag":"2333344337","pmid":"https://pubmed.ncbi.nlm.nih.gov/25033008"},"language":"en","primary_location":{"id":"doi:10.1097/dad.0000000000000126","doi":"https://doi.org/10.1097/dad.0000000000000126","is_oa":false,"landing_page_url":"https://doi.org/10.1097/dad.0000000000000126","pdf_url":null,"source":{"id":"https://openalex.org/S86638576","display_name":"American Journal of Dermatopathology","issn_l":"0193-1091","issn":["0193-1091","1533-0311"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Dermatopathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076154362","display_name":"Iman Seleit","orcid":"https://orcid.org/0000-0002-3669-5006","observed_orcids":["https://orcid.org/0000-0002-3669-5006"]},"institutions":[{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Iman Seleit","raw_affiliation_strings":["*Department of Dermatology, Andrology and STDs; and \u2020Department of Pathology, Faculty of Medicine, Menoufiya University, Egypt","Department of Dermatology, Andrology and STDs"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Dermatology, Andrology and STDs; and \u2020Department of Pathology, Faculty of Medicine, Menoufiya University, Egypt","institution_ids":["https://openalex.org/I63601056"]},{"raw_affiliation_string":"Department of Dermatology, Andrology and STDs","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110261576","display_name":"Ola Ahmed Bakry","orcid":"https://orcid.org/0000-0003-0319-4480","observed_orcids":["https://orcid.org/0000-0003-0319-4480"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ola Ahmed Bakry","raw_affiliation_strings":["Department of Dermatology, Andrology and STDs","Department of Dermatology, Andrology and STDs; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Andrology and STDs","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatology, Andrology and STDs; and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061859876","display_name":"Rehab Monir Samaka","orcid":"https://orcid.org/0000-0002-1369-0026","observed_orcids":["https://orcid.org/0000-0002-1369-0026"]},"institutions":[{"id":"https://openalex.org/I63601056","display_name":"Menoufia University","ror":"https://ror.org/05sjrb944","country_code":"EG","type":"education","lineage":["https://openalex.org/I63601056"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rehab Munir Samaka","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Menoufiya University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Menoufiya University, Egypt","institution_ids":["https://openalex.org/I63601056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039367469","display_name":"Mona Abdel Malak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mona Abdel Malak","raw_affiliation_strings":["Department of Dermatology, Andrology and STDs","Department of Dermatology, Andrology and STDs; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Andrology and STDs","institution_ids":[]},{"raw_affiliation_string":"Department of Dermatology, Andrology and STDs; and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039367469","https://openalex.org/A5076154362","https://openalex.org/A5110261576"],"corresponding_institution_ids":["https://openalex.org/I63601056"],"apc_list":null,"apc_paid":null,"fwci":1.0267,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73871771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"1","first_page":"38","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11868","display_name":"Cancer and Skin Lesions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spag9","display_name":"SPAG9","score":0.9430000185966492},{"id":"https://openalex.org/keywords/non-melanoma-skin-cancer","display_name":"non-melanoma skin cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/basal-cell-carcinoma","display_name":"basal cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.7839999794960022},{"id":"https://openalex.org/keywords/inflammatory-cells","display_name":"inflammatory cells","score":0.5519999861717224},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.7699999809265137},{"id":"https://openalex.org/keywords/protein-expression","display_name":"protein expression","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7415071725845337},{"id":"https://openalex.org/C2778804307","wikidata":"https://www.wikidata.org/wiki/Q809758","display_name":"Basal cell carcinoma","level":3,"score":0.6846555471420288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6497863531112671},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.623855471611023},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.543581485748291},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49276211857795715},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45701342821121216},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.44457677006721497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3256361484527588},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.3162917494773865}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002280","descriptor_name":"Basal Cell Carcinoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/dad.0000000000000126","doi":"https://doi.org/10.1097/dad.0000000000000126","is_oa":false,"landing_page_url":"https://doi.org/10.1097/dad.0000000000000126","pdf_url":null,"source":{"id":"https://openalex.org/S86638576","display_name":"American Journal of Dermatopathology","issn_l":"0193-1091","issn":["0193-1091","1533-0311"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Dermatopathology","raw_type":"journal-article"},{"id":"pmid:25033008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25033008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of dermatopathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W142538597","https://openalex.org/W246556682","https://openalex.org/W1650797637","https://openalex.org/W1892496998","https://openalex.org/W1961598420","https://openalex.org/W1972254353","https://openalex.org/W1974182363","https://openalex.org/W1975637040","https://openalex.org/W1984903682","https://openalex.org/W1985738617","https://openalex.org/W2003340323","https://openalex.org/W2011351979","https://openalex.org/W2017091481","https://openalex.org/W2026366604","https://openalex.org/W2029524208","https://openalex.org/W2032275493","https://openalex.org/W2042316019","https://openalex.org/W2048085539","https://openalex.org/W2051940153","https://openalex.org/W2067497387","https://openalex.org/W2072604311","https://openalex.org/W2074574979","https://openalex.org/W2094653699","https://openalex.org/W2099119979","https://openalex.org/W2101040530","https://openalex.org/W2101485657","https://openalex.org/W2110884016","https://openalex.org/W2111193962","https://openalex.org/W2113021053","https://openalex.org/W2118740209","https://openalex.org/W2132990166","https://openalex.org/W2154863195","https://openalex.org/W2170497494","https://openalex.org/W2171407623","https://openalex.org/W2172016540","https://openalex.org/W2322842522","https://openalex.org/W6609392040","https://openalex.org/W6685298892"],"related_works":["https://openalex.org/W3165314473","https://openalex.org/W2192719731","https://openalex.org/W2612799580","https://openalex.org/W1971708659","https://openalex.org/W2147006147","https://openalex.org/W3002380968","https://openalex.org/W3044173733","https://openalex.org/W1997466583","https://openalex.org/W2384191706","https://openalex.org/W1036748837"],"abstract_inverted_index":{"Sperm-associated":[0],"antigen":[1],"9":[2],"(SPAG9)":[3],"is":[4,224,248],"a":[5,106,186],"scaffold":[6],"protein":[7],"for":[8],"c-Jun-NH2-kinases,":[9],"which":[10],"play":[11],"an":[12,241,249],"important":[13],"role":[14,46,244],"in":[15,29,34,47,60,120,126,133,138,153,161,204,214,226,233,265,273,278],"cell":[16,82,90],"survival,":[17],"proliferation,":[18],"apoptosis,":[19],"and":[20,68,85,93,101,125,140,144,158,181,185,193,269],"tumor":[21,194],"development.":[22],"SPAG9":[23,109,117,178,190,211,223],"was":[24,42,111,118,136,151,159,175,196,212],"claimed":[25],"to":[26,43,236,253,260],"be":[27,231],"involved":[28],"the":[30,48],"pathogenesis":[31,49],"of":[32,39,50,63,76,122,128,142,155],"carcinoma":[33,83,91],"different":[35],"organs.":[36],"The":[37],"aim":[38],"this":[40],"work":[41],"investigate":[44],"its":[45,56,246,262],"nonmelanoma":[51],"skin":[52,61,97,280],"cancer":[53],"(NMSC)":[54],"through":[55],"immunohistochemical":[57],"(IHC)":[58],"localization":[59],"biopsies":[62,98],"these":[64],"tumors.":[65],"This":[66],"retrospective":[67],"prospective":[69],"study":[70],"included":[71],"67":[72],"cutaneous":[73],"specimens;":[74],"42":[75],"NMSC":[77,215,227,254],"[20":[78],"cases":[79,87,124,157],"with":[80,88,218],"basal":[81],"(BCC)":[84],"22":[86],"squamous":[89],"(SCC)]":[92],"25":[94],"normal":[95,219,279],"sun-exposed":[96],"from":[99],"age":[100],"gender-matched":[102],"healthy":[103],"subjects":[104],"as":[105],"control":[107],"group.":[108],"expression":[110,132,150,247,277],"evaluated":[112,232],"using":[113],"standard":[114],"IHC":[115],"techniques.":[116],"expressed":[119,225],"90%":[121],"BCC":[123,143,156],"81.8%":[127],"SCC":[129,145,163,182],"cases.":[130,164,228,275],"Positive":[131,148],"inflammatory":[134],"cells":[135],"detected":[137,152,198],"100%":[139],"63.6%":[141],"cases,":[146],"respectively.":[147],"stromal":[149],"20%":[154],"absent":[160],"all":[162],"A":[165],"significant":[166,187],"negative":[167],"correlation":[168],"(r":[169],"=":[170,173,209],"-0.55,":[171],"P":[172],"0.008)":[174],"noted":[176],"between":[177,189],"H":[179,191],"score":[180,192],"histological":[183],"grade":[184,195,205],"association":[188],"also":[197],"where":[199],"higher":[200],"values":[201],"were":[202],"present":[203],"I":[206],"tumors":[207],"(P":[208],"0.001).":[210],"upregulated":[213],"when":[216],"compared":[217],"skin.":[220],"In":[221],"conclusion,":[222],"It":[229],"should":[230],"large-scale":[234],"studies":[235,257],"determine":[237,261],"if":[238],"it":[239],"plays":[240],"active":[242],"pathogenic":[243],"or":[245],"epiphenomenon":[250],"not":[251],"related":[252],"pathogenesis.":[255],"Large-scale":[256],"are":[258],"warranted":[259],"potential":[263],"utility":[264],"guiding":[266],"treatment":[267],"decisions":[268],"following":[270],"disease":[271],"progression":[272],"theses":[274],"Its":[276],"needs":[281],"further":[282],"investigation.":[283]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}