{"id":"https://openalex.org/W2333335366","doi":"https://doi.org/10.1586/erm.12.18","title":"Detection of copy number alterations in acute myeloid leukemia and myelodysplastic syndromes","display_name":"Detection of copy number alterations in acute myeloid leukemia and myelodysplastic syndromes","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2333335366","doi":"https://doi.org/10.1586/erm.12.18","mag":"2333335366","pmid":"https://pubmed.ncbi.nlm.nih.gov/22468816"},"language":"en","primary_location":{"id":"doi:10.1586/erm.12.18","doi":"https://doi.org/10.1586/erm.12.18","is_oa":false,"landing_page_url":"https://doi.org/10.1586/erm.12.18","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114046358","display_name":"Meagan A. Jacoby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meagan A Jacoby","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, Division of Oncology, Stem Cell Biology Section, Campus Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, Division of Oncology, Stem Cell Biology Section, Campus Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018151522","display_name":"Matthew J. Walter","orcid":"https://orcid.org/0000-0002-7753-1091","observed_orcids":["https://orcid.org/0000-0002-7753-1091"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J Walter","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, Division of Oncology, Stem Cell Biology Section, Campus Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA; Siteman Cancer Center, Washington University, St Louis, MO, USA. mjwalter@dom.wustl.edu; Department of Genetics, Washington University, St Louis, MO, USA; Siteman Cancer Center, Washington University, St Louis, MO, USA. mjwalter@dom.wustl.edu","Department of Genetics, Washington University, St Louis, MO, USA","Department of Internal Medicine, Washington University School of Medicine, Division of Oncology, Stem Cell Biology Section, Campus Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, Division of Oncology, Stem Cell Biology Section, Campus Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA; Siteman Cancer Center, Washington University, St Louis, MO, USA. mjwalter@dom.wustl.edu; Department of Genetics, Washington University, St Louis, MO, USA; Siteman Cancer Center, Washington University, St Louis, MO, USA. mjwalter@dom.wustl.edu","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Genetics, Washington University, St Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, Division of Oncology, Stem Cell Biology Section, Campus Box 8007, 660 South Euclid Avenue, St Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":0.4627,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.41691542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"3","first_page":"253","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.4077000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":1.0},{"id":"https://openalex.org/keywords/chromosomal-deletion","display_name":"chromosomal deletion","score":0.9150000214576721},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.7580000162124634},{"id":"https://openalex.org/keywords/copy-neutral-loss-of-heterozygosity","display_name":"copy-neutral loss of heterozygosity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7730000019073486},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"cancer genomics","score":0.699999988079071},{"id":"https://openalex.org/keywords/array-based-genotyping","display_name":"array-based genotyping","score":0.6380000114440918},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.8676632642745972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7311298251152039},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.7024140357971191},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.6852859258651733},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.5975266695022583},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5623262524604797},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.534045398235321},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4779489040374756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45098787546157837},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4304550290107727},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41118359565734863},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4082348346710205},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3661666512489319},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15938717126846313},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.1330396831035614},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.12706425786018372}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009190","descriptor_name":"Myelodysplastic Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055028","descriptor_name":"Comparative Genomic Hybridization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1586/erm.12.18","doi":"https://doi.org/10.1586/erm.12.18","is_oa":false,"landing_page_url":"https://doi.org/10.1586/erm.12.18","pdf_url":null,"source":{"id":"https://openalex.org/S124386304","display_name":"Expert Review of Molecular Diagnostics","issn_l":"1473-7159","issn":["1473-7159","1744-8352"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Review of Molecular Diagnostics","raw_type":"journal-article"},{"id":"pmid:22468816","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22468816","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert review of molecular diagnostics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W187238933","https://openalex.org/W1851609974","https://openalex.org/W1963736125","https://openalex.org/W1966439190","https://openalex.org/W1972097827","https://openalex.org/W1983602304","https://openalex.org/W1983864360","https://openalex.org/W1984065010","https://openalex.org/W1988615111","https://openalex.org/W1988633385","https://openalex.org/W1994924914","https://openalex.org/W1996100423","https://openalex.org/W1997127542","https://openalex.org/W1999813105","https://openalex.org/W2012945687","https://openalex.org/W2023994677","https://openalex.org/W2025391163","https://openalex.org/W2032703975","https://openalex.org/W2033591831","https://openalex.org/W2038244338","https://openalex.org/W2039234691","https://openalex.org/W2049461277","https://openalex.org/W2054744711","https://openalex.org/W2058794589","https://openalex.org/W2060383229","https://openalex.org/W2061289307","https://openalex.org/W2064469303","https://openalex.org/W2066254965","https://openalex.org/W2068204472","https://openalex.org/W2071128187","https://openalex.org/W2072713007","https://openalex.org/W2073889874","https://openalex.org/W2079349819","https://openalex.org/W2082312262","https://openalex.org/W2083109253","https://openalex.org/W2085066928","https://openalex.org/W2088544552","https://openalex.org/W2091242855","https://openalex.org/W2093144236","https://openalex.org/W2093845572","https://openalex.org/W2097743943","https://openalex.org/W2100313064","https://openalex.org/W2105767692","https://openalex.org/W2107398329","https://openalex.org/W2109948920","https://openalex.org/W2111513802","https://openalex.org/W2116858301","https://openalex.org/W2119799188","https://openalex.org/W2119967034","https://openalex.org/W2121533623","https://openalex.org/W2123153650","https://openalex.org/W2131072337","https://openalex.org/W2134061682","https://openalex.org/W2135031820","https://openalex.org/W2137573050","https://openalex.org/W2144126823","https://openalex.org/W2144310197","https://openalex.org/W2147370638","https://openalex.org/W2148968593","https://openalex.org/W2149278033","https://openalex.org/W2149372853","https://openalex.org/W2153010521","https://openalex.org/W2157434480","https://openalex.org/W2157783208","https://openalex.org/W2164143675","https://openalex.org/W2165658132","https://openalex.org/W2168456635","https://openalex.org/W2169172058","https://openalex.org/W2533525011","https://openalex.org/W2539818926","https://openalex.org/W2586567058"],"related_works":["https://openalex.org/W2983111306","https://openalex.org/W2006254364","https://openalex.org/W7097046048","https://openalex.org/W2173014627","https://openalex.org/W2054744711","https://openalex.org/W6959774888","https://openalex.org/W1972097827","https://openalex.org/W2951434491","https://openalex.org/W2980395389","https://openalex.org/W2897936701"],"abstract_inverted_index":{"Chromosomal":[0],"deletions":[1],"and":[2,14,32,34,66,76,106,112],"amplifications":[3],"that":[4,21,52,71],"occur":[5],"in":[6,56],"affected":[7],"cells":[8],"from":[9,79],"patients":[10],"with":[11],"myelodysplastic":[12],"syndromes":[13],"acute":[15],"myeloid":[16,57],"leukemia":[17],"often":[18],"contain":[19],"genes":[20,51],"contribute":[22],"to":[23,47,83,95,123],"disease":[24],"pathogenesis.":[25],"Identification":[26],"of":[27,36,40,50,92,99,110],"copy":[28,37,103,107],"number":[29,104],"alterations":[30,105],"(deletions":[31],"amplifications)":[33],"regions":[35],"neutral":[38,108],"loss":[39,109],"heterozygosity":[41],"using":[42],"array-based":[43,69],"platforms":[44],"has":[45],"led":[46],"the":[48,64,68,80,90],"identification":[49],"are":[53],"commonly":[54],"mutated":[55],"malignancies.":[58],"In":[59],"this":[60,118],"article,":[61],"we":[62],"review":[63],"literature":[65],"highlight":[67],"studies":[70],"directly":[72],"compare":[73],"matched":[74],"normal":[75],"tumor":[77],"samples":[78],"same":[81],"individual":[82],"identify":[84,96],"somatic":[85],"alterations.":[86],"We":[87],"also":[88],"discuss":[89],"use":[91],"next-generation":[93],"sequencing":[94],"all":[97],"types":[98],"structural":[100],"variants,":[101],"including":[102],"heterozygosity,":[111],"provide":[113],"an":[114],"outlook":[115],"for":[116],"how":[117],"technology":[119],"may":[120],"be":[121],"used":[122],"interrogate":[124],"cancer":[125],"genomes.":[126]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
