{"id":"https://openalex.org/W2333264274","doi":"https://doi.org/10.2116/bunsekikagaku.63.909","title":"SI-traceable Purity Evaluation of Non-protein Amino Acid as Reference Materials by Using 1H NMR Spectroscopy","display_name":"SI-traceable Purity Evaluation of Non-protein Amino Acid as Reference Materials by Using 1H NMR Spectroscopy","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2333264274","doi":"https://doi.org/10.2116/bunsekikagaku.63.909","mag":"2333264274"},"language":"en","primary_location":{"id":"doi:10.2116/bunsekikagaku.63.909","doi":"https://doi.org/10.2116/bunsekikagaku.63.909","is_oa":true,"landing_page_url":"https://doi.org/10.2116/bunsekikagaku.63.909","pdf_url":"https://www.jstage.jst.go.jp/article/bunsekikagaku/63/11/63_909/_pdf","source":{"id":"https://openalex.org/S30364472","display_name":"BUNSEKI KAGAKU","issn_l":"0525-1931","issn":["0525-1931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313437","host_organization_name":"Japan Society for Analytical Chemistry","host_organization_lineage":["https://openalex.org/P4310313437"],"host_organization_lineage_names":["Japan Society for Analytical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BUNSEKI KAGAKU","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/bunsekikagaku/63/11/63_909/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017655936","display_name":"Naoki Saito","orcid":"https://orcid.org/0000-0001-8471-3451","observed_orcids":["https://orcid.org/0000-0001-8471-3451"]},"institutions":[{"id":"https://openalex.org/I4405273829","display_name":"National Metrology Institute of Japan","ror":"https://ror.org/00j3eeb74","country_code":"JP","type":"government","lineage":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki SAITO","raw_affiliation_strings":["National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)","institution_ids":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101953917","display_name":"Takeshi Y. Saito","orcid":"https://orcid.org/0000-0003-2221-8388","observed_orcids":["https://orcid.org/0000-0003-2221-8388"]},"institutions":[{"id":"https://openalex.org/I4405273829","display_name":"National Metrology Institute of Japan","ror":"https://ror.org/00j3eeb74","country_code":"JP","type":"government","lineage":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi SAITO","raw_affiliation_strings":["National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)","institution_ids":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085886446","display_name":"Taichi Yamazaki","orcid":"https://orcid.org/0000-0002-7545-4467","observed_orcids":["https://orcid.org/0000-0002-7545-4467"]},"institutions":[{"id":"https://openalex.org/I4405273829","display_name":"National Metrology Institute of Japan","ror":"https://ror.org/00j3eeb74","country_code":"JP","type":"government","lineage":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taichi YAMAZAKI","raw_affiliation_strings":["National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)","institution_ids":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075685103","display_name":"Hisashi Kato","orcid":"https://orcid.org/0000-0003-4395-8369","observed_orcids":["https://orcid.org/0000-0003-4395-8369"]},"institutions":[{"id":"https://openalex.org/I4405273829","display_name":"National Metrology Institute of Japan","ror":"https://ror.org/00j3eeb74","country_code":"JP","type":"government","lineage":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisashi KATO","raw_affiliation_strings":["National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)","institution_ids":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008603395","display_name":"Toshihide Ihara","orcid":"https://orcid.org/0000-0001-8864-8976","observed_orcids":["https://orcid.org/0000-0001-8864-8976"]},"institutions":[{"id":"https://openalex.org/I4405273829","display_name":"National Metrology Institute of Japan","ror":"https://ror.org/00j3eeb74","country_code":"JP","type":"government","lineage":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]},{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihide IHARA","raw_affiliation_strings":["National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST)","institution_ids":["https://openalex.org/I4405273829","https://openalex.org/I73613424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8576,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.8816602,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"63","issue":"11","first_page":"909","last_page":"913"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11890","display_name":"Scientific Measurement and Uncertainty Evaluation","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/3105","display_name":"Instrumentation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11890","display_name":"Scientific Measurement and Uncertainty Evaluation","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/3105","display_name":"Instrumentation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-protein-amino-acids","display_name":"non-protein amino acids","score":0.9819999933242798},{"id":"https://openalex.org/keywords/purity-evaluation","display_name":"purity evaluation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/si-traceability","display_name":"SI traceability","score":0.9470000267028809},{"id":"https://openalex.org/keywords/1h-nmr-spectroscopy","display_name":"1H NMR","score":0.9210000038146973},{"id":"https://openalex.org/keywords/titration-method","display_name":"titration method","score":0.6620000004768372},{"id":"https://openalex.org/keywords/analytical-accuracy","display_name":"analytical accuracy","score":0.5889999866485596},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6632986068725586},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.6489229202270508},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5851025581359863},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.5367129445075989},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.46550944447517395},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.4492741823196411},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.43578779697418213},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3441160023212433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12317505478858948},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.1172347366809845},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09965837001800537},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.08823755383491516},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2116/bunsekikagaku.63.909","doi":"https://doi.org/10.2116/bunsekikagaku.63.909","is_oa":true,"landing_page_url":"https://doi.org/10.2116/bunsekikagaku.63.909","pdf_url":"https://www.jstage.jst.go.jp/article/bunsekikagaku/63/11/63_909/_pdf","source":{"id":"https://openalex.org/S30364472","display_name":"BUNSEKI KAGAKU","issn_l":"0525-1931","issn":["0525-1931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313437","host_organization_name":"Japan Society for Analytical Chemistry","host_organization_lineage":["https://openalex.org/P4310313437"],"host_organization_lineage_names":["Japan Society for Analytical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BUNSEKI KAGAKU","raw_type":"journal-article"},{"id":"mag:2411442564","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/130004712999","pdf_url":null,"source":{"id":"https://openalex.org/S4306544238","display_name":"\u5206\u6790\u5316\u5b66","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5206\u6790\u5316\u5b66","raw_type":null},{"id":"mag:374218062","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/40020264422","pdf_url":null,"source":{"id":"https://openalex.org/S4306544238","display_name":"\u5206\u6790\u5316\u5b66","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u5206\u6790\u5316\u5b66","raw_type":null}],"best_oa_location":{"id":"doi:10.2116/bunsekikagaku.63.909","doi":"https://doi.org/10.2116/bunsekikagaku.63.909","is_oa":true,"landing_page_url":"https://doi.org/10.2116/bunsekikagaku.63.909","pdf_url":"https://www.jstage.jst.go.jp/article/bunsekikagaku/63/11/63_909/_pdf","source":{"id":"https://openalex.org/S30364472","display_name":"BUNSEKI KAGAKU","issn_l":"0525-1931","issn":["0525-1931"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310313437","host_organization_name":"Japan Society for Analytical Chemistry","host_organization_lineage":["https://openalex.org/P4310313437"],"host_organization_lineage_names":["Japan Society for Analytical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BUNSEKI KAGAKU","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2333264274.pdf","grobid_xml":"https://content.openalex.org/works/W2333264274.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1567439221","https://openalex.org/W1972686384","https://openalex.org/W2411442564","https://openalex.org/W7165782527","https://openalex.org/W4414390584","https://openalex.org/W374218062","https://openalex.org/W3125995484","https://openalex.org/W3085818174","https://openalex.org/W2015323335","https://openalex.org/W4401403110"],"abstract_inverted_index":{"In":[0,46,148],"recent":[1],"years,":[2],"it":[3,28,57,90,223],"was":[4,174,185,218,224],"become":[5],"increasingly":[6],"important":[7],"to":[8,31,60,69,187,226,228],"conduct":[9],"quantitative":[10,132],"analyses":[11],"of":[12,15,43,54,73,80,101,118,145,155,158,181,204,234,237],"several":[13],"kinds":[14,157,203],"protein":[16],"and":[17,114,216,231],"non-protein":[18,81,159,238],"amino":[19,62,82,102,160,198,239],"acids":[20,83,161],"in":[21,94,209],"the":[22,70,95,121,146,168,179,182,193,202,207,210,235],"human":[23],"blood.":[24],"By":[25],"doing":[26],"so,":[27],"is":[29,58,91,129,135],"possible":[30],"detect":[32],"cancer":[33],"focus":[34],"positivity":[35],"at":[36],"an":[37],"early":[38],"stage":[39],"by":[40,162,191,243],"monitoring":[41],"profile":[42],"their":[44],"concentrations.":[45],"clinical":[47],"tests":[48],"that":[49,66,134],"strongly":[50],"require":[51,111],"high":[52],"reliability":[53],"analytical":[55,169,183,211],"values,":[56],"essential":[59],"use":[61],"acid":[63,103,240],"reference":[64,78,104,241],"materials":[65,79,242],"are":[67,84],"traceable":[68],"International":[71],"System":[72],"Units":[74],"(SI).":[75],"However,":[76],"SI-traceable":[77],"not":[85,136],"generally":[86,92],"supplied":[87],"worldwide.":[88],"Although":[89],"used":[93],"titration":[96,172,217],"method":[97,110,133,173],"for":[98,196],"purity":[99,106,153,236],"evaluations":[100,107,154,233],"materials,":[105],"using":[108,163,244],"this":[109,149],"much":[112],"time":[113],"a":[115,130,142,171],"large":[116],"amount":[117,144],"sample.":[119,147],"On":[120],"other":[122],"hand,":[123],"Nuclear":[124],"Magnetic":[125],"Resonance":[126],"(NMR)":[127],"spectroscopy":[128],"rapid":[131,230],"only":[137],"SI-traceable,":[138],"but":[139],"also":[140],"requires":[141],"small":[143],"study,":[150],"we":[151],"demonstrated":[152],"20":[156],"1H":[164,214,245],"NMR.":[165],"To":[166],"verify":[167],"value,":[170],"used.":[175],"From":[176],"our":[177],"results,":[178],"accuracy":[180],"value":[184],"evaluated":[186],"be":[188],"approximately":[189],"1%":[190],"optimizing":[192],"experimental":[194],"conditions":[195],"each":[197],"acid,":[199],"such":[200],"as":[201],"solvent.":[205],"Furthermore,":[206],"difference":[208],"values":[212],"between":[213],"NMR":[215,246],"0.5%":[219],"or":[220],"less.":[221],"Therefore,":[222],"confirmed":[225],"able":[227],"perform":[229],"accurate":[232],"spectroscopy.":[247]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}