{"id":"https://openalex.org/W2333058030","doi":"https://doi.org/10.1055/s-0034-1388545","title":"Erhaltungstherapie mit Olaparib nach platinhaltiger Re-induktion bei platinsensitivem ser\u00f6sem Ovarialkarzinomrezidiv: eine Placebo-kontrollierte Phase II Studie","display_name":"Erhaltungstherapie mit Olaparib nach platinhaltiger Re-induktion bei platinsensitivem ser\u00f6sem Ovarialkarzinomrezidiv: eine Placebo-kontrollierte Phase II Studie","publication_year":2014,"publication_date":"2014-09-05","ids":{"openalex":"https://openalex.org/W2333058030","doi":"https://doi.org/10.1055/s-0034-1388545","mag":"2333058030"},"language":"de","primary_location":{"id":"doi:10.1055/s-0034-1388545","doi":"https://doi.org/10.1055/s-0034-1388545","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1388545","pdf_url":null,"source":{"id":"https://openalex.org/S146294059","display_name":"Geburtshilfe und Frauenheilkunde","issn_l":"0016-5751","issn":["0016-5751","1438-8804","2199-6989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geburtshilfe und Frauenheilkunde","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078567055","display_name":"Philipp Harter","orcid":"https://orcid.org/0000-0002-9663-5005","observed_orcids":["https://orcid.org/0000-0002-9663-5005"]},"institutions":[{"id":"https://openalex.org/I4210146447","display_name":"Kliniken Essen-Mitte","ror":"https://ror.org/03v958f45","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210146447"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P Harter","raw_affiliation_strings":["Kliniken Essen-Mitte, Gyn\u00e4kologie & Gyn\u00e4kologische Onkologie, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kliniken Essen-Mitte, Gyn\u00e4kologie & Gyn\u00e4kologische Onkologie, Essen, Germany","institution_ids":["https://openalex.org/I4210146447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047695952","display_name":"Andreas du Bois","orcid":"https://orcid.org/0000-0002-8477-506X","observed_orcids":["https://orcid.org/0000-0002-8477-506X"]},"institutions":[{"id":"https://openalex.org/I4210146447","display_name":"Kliniken Essen-Mitte","ror":"https://ror.org/03v958f45","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210146447"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A du Bois","raw_affiliation_strings":["Kliniken Essen-Mitte, Gyn\u00e4kologie & Gyn\u00e4kologische Onkologie, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kliniken Essen-Mitte, Gyn\u00e4kologie & Gyn\u00e4kologische Onkologie, Essen, Germany","institution_ids":["https://openalex.org/I4210146447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050467390","display_name":"Pauline Wimberger","orcid":"https://orcid.org/0000-0002-7380-577X","observed_orcids":["https://orcid.org/0000-0002-7380-577X"]},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P WImberger","raw_affiliation_strings":["Universit\u00e4tsklinikum Essen, Frauenklinik, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Essen, Frauenklinik, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110450109","display_name":"Barbara Schmalfeldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Schmalfeldt","raw_affiliation_strings":["Klinikum rechts der Isar der Technischen Univ. M\u00fcnchen, Frauenklinik und Poliklinik, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum rechts der Isar der Technischen Univ. M\u00fcnchen, Frauenklinik und Poliklinik, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020357121","display_name":"G\u00fcnter Emons","orcid":"https://orcid.org/0000-0003-2318-5610","observed_orcids":["https://orcid.org/0000-0003-2318-5610"]},"institutions":[{"id":"https://openalex.org/I4210116730","display_name":"Universit\u00e4tsmedizin G\u00f6ttingen","ror":"https://ror.org/021ft0n22","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210116730"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G Emons","raw_affiliation_strings":["Universit\u00e4tsklinik, Zentrum f\u00fcr Frauenheilkunde, G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinik, Zentrum f\u00fcr Frauenheilkunde, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210116730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044504864","display_name":"R. Kreienberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R Kreienberg","raw_affiliation_strings":["Universit\u00e4tsklinikum Ulm, Frauenklinik, Ulm, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Ulm, Frauenklinik, Ulm, Germany","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022527560","display_name":"Felix Hilpert","orcid":"https://orcid.org/0000-0002-3492-9577","observed_orcids":["https://orcid.org/0000-0002-3492-9577"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F Hilpert","raw_affiliation_strings":["Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Frauenklinik, Kiel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4tsklinikum Schleswig-Holstein Campus Kiel, Frauenklinik, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111675530","display_name":"HJ L\u00fcck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HJ L\u00fcck","raw_affiliation_strings":["Praxis am Pelikanplatz, Gyn\u00e4kologische Onkologie, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Praxis am Pelikanplatz, Gyn\u00e4kologische Onkologie, Hannover, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058249824","display_name":"Ursula A. Matulonis","orcid":"https://orcid.org/0000-0002-3103-6992","observed_orcids":["https://orcid.org/0000-0002-3103-6992"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"U Matulonis","raw_affiliation_strings":["Dana-Farber Cancer Institute, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009351129","display_name":"Charlie Gourley","orcid":"https://orcid.org/0000-0002-2377-7221","observed_orcids":["https://orcid.org/0000-0002-2377-7221"]},"institutions":[{"id":"https://openalex.org/I2802581871","display_name":"Edinburgh Cancer Research","ror":"https://ror.org/05a7t9b67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I2802581871","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Gourley","raw_affiliation_strings":["University of Edinburgh Cancer Research UK Centre, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh Cancer Research UK Centre, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I2802581871","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021894535","display_name":"Michael Leonard Friedlander","orcid":"https://orcid.org/0000-0003-3090-795X","observed_orcids":["https://orcid.org/0000-0003-3090-795X"]},"institutions":[{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M Friedlander","raw_affiliation_strings":["Prince of Wales Hospital, Randwick, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Prince of Wales Hospital, Randwick, Australia","institution_ids":["https://openalex.org/I4210108821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058535647","display_name":"Ignace B. Vergote","orcid":"https://orcid.org/0000-0002-7589-8981","observed_orcids":["https://orcid.org/0000-0002-7589-8981"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"I Vergote","raw_affiliation_strings":["University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047753094","display_name":"Gordon J.S. Rustin","orcid":"https://orcid.org/0000-0002-2749-5467","observed_orcids":["https://orcid.org/0000-0002-2749-5467"]},"institutions":[{"id":"https://openalex.org/I2801038905","display_name":"Mount Vernon Hospital","ror":"https://ror.org/04am5a125","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799786270","https://openalex.org/I2801038905"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G Rustin","raw_affiliation_strings":["Mount Vernon Hospital, Northwood, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Vernon Hospital, Northwood, United Kingdom","institution_ids":["https://openalex.org/I2801038905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057650466","display_name":"C. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"C Scott","raw_affiliation_strings":["Royal Melbourne Hospital, Parkville, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Melbourne Hospital, Parkville, Australia","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084392138","display_name":"Werner Meier","orcid":"https://orcid.org/0000-0003-2508-5410","observed_orcids":["https://orcid.org/0000-0003-2508-5410"]},"institutions":[{"id":"https://openalex.org/I4210124232","display_name":"Evangelisches Krankenhaus D\u00fcsseldorf","ror":"https://ror.org/036j3hh72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210124232"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W Meier","raw_affiliation_strings":["Ev. Krankenhaus, Frauenklinik und Geburtshilfe, D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ev. Krankenhaus, Frauenklinik und Geburtshilfe, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I4210124232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058238015","display_name":"Ronnie Shapira\u2010Frommer","orcid":"https://orcid.org/0000-0001-6170-080X","observed_orcids":["https://orcid.org/0000-0001-6170-080X"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"R Shapira-Frommer","raw_affiliation_strings":["Chaim Sheba Medical Center, Tel Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chaim Sheba Medical Center, Tel Hashomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039578268","display_name":"Tamar Safra","orcid":"https://orcid.org/0000-0001-6910-6426","observed_orcids":["https://orcid.org/0000-0001-6910-6426"]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"T Safra","raw_affiliation_strings":["Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067743297","display_name":"Daniela Elena Matei","orcid":"https://orcid.org/0000-0003-2169-5035","observed_orcids":["https://orcid.org/0000-0003-2169-5035"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Matei","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Fielding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Fielding","raw_affiliation_strings":["AstraZeneca, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021692424","display_name":"E Mapherson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E Mapherson","raw_affiliation_strings":["AstraZeneca, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087646089","display_name":"Brian Andrew Dougherty","orcid":"https://orcid.org/0000-0002-0093-1142","observed_orcids":["https://orcid.org/0000-0002-0093-1142"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Dougherty","raw_affiliation_strings":["AstraZeneca, Waltham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Waltham, United States","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054164745","display_name":"JM Juergensmeier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"JM Juergensmeier","raw_affiliation_strings":["AstraZeneca, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111925004","display_name":"Maria C. M. Orr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Orr","raw_affiliation_strings":["AstraZeneca, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AstraZeneca, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079383798","display_name":"Jonathan Andrew Ledermann","orcid":"https://orcid.org/0000-0003-3799-3539","observed_orcids":["https://orcid.org/0000-0003-3799-3539"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Ledermann","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":21,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3206,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64965758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"74","issue":"S 01","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olaparib","display_name":"olaparib","score":0.9900000095367432},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.925000011920929},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":0.8059999942779541},{"id":"https://openalex.org/keywords/brca-status","display_name":"BRCA mutation status","score":0.796999990940094},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8360000252723694},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.414000004529953},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.4790000021457672},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.5619999766349792},{"id":"https://openalex.org/keywords/nausea-and-vomiting","display_name":"nausea and vomiting","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.9060878753662109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6316848397254944},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6027458906173706},{"id":"https://openalex.org/C2779138821","wikidata":"https://www.wikidata.org/wiki/Q7118227","display_name":"PARP inhibitor","level":5,"score":0.5496448278427124},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.48330047726631165},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4501839876174927},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.2840328812599182},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20999333262443542},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05537894368171692},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.04549551010131836},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0034-1388545","doi":"https://doi.org/10.1055/s-0034-1388545","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0034-1388545","pdf_url":null,"source":{"id":"https://openalex.org/S146294059","display_name":"Geburtshilfe und Frauenheilkunde","issn_l":"0016-5751","issn":["0016-5751","1438-8804","2199-6989"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Geburtshilfe und Frauenheilkunde","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2792765610","https://openalex.org/W2130078242","https://openalex.org/W1996017104","https://openalex.org/W4214850127","https://openalex.org/W7033011867","https://openalex.org/W2160466424","https://openalex.org/W4235021050","https://openalex.org/W4236289131","https://openalex.org/W2088376108","https://openalex.org/W2604185746"],"abstract_inverted_index":{"Rationale:":[0],"Olaparib":[1,39,80,184,219,247],"ist":[2,220],"ein":[3,180,207],"oraler":[4],"Poly":[5],"(Adenosin":[6],"Diphosphat":[7],"[ADP]-Ribose)":[8],"Polymerase":[9],"(PARP)":[10],"Inhibitor,":[11],"der":[12,48,157,160,211,238],"bei":[13,68,169,224,248],"Patientinnen":[14,56,96,161,171,225],"mit":[15,57,135,226],"high":[16,228],"grade":[17,229],"ser\u00f6sem":[18],"Ovarialkarzinom":[19],"unabh\u00e4ngig":[20],"vom":[21,52],"BRCA-Status":[22,53],"Aktivit\u00e4t":[23],"gezeigt":[24],"hat.":[25],"In":[26,44,153,175,237],"dieser":[27,176],"randomisierten,":[28],"doppelblinden,":[29],"multizentrischen,":[30],"placebo-kontrollierten":[31],"Phase":[32,254],"II":[33],"Studie":[34],"wurde":[35,47,109,156],"die":[36,60,244],"Wirksamkeit":[37],"von":[38,185,246],"als":[40,221],"Erhaltungstherapie":[41,222],"untersucht":[42,162],"(NCT00753545).":[43],"nachfolgenden":[45],"Analysen":[46,155],"Effekt":[49],"in":[50,79],"Abh\u00e4ngigkeit":[51],"untersucht.":[54],"Methodik:":[55],"platinsensitivem":[58],"Ovarialkarzinomrezidiv,":[59,230],"bereits":[61],"\u22652":[62],"platinhaltige":[63],"Therapien":[64],"erhalten":[65],"hatten":[66],"und":[67,100,123,164],"denen":[69],"eine":[70,172,233],"partielle":[71],"oder":[72],"komplette":[73],"Response":[74],"erreicht":[75],"wurde,":[76],"wurden":[77,97],"randomisiert":[78],"2":[81],"\u00d7":[82],"400":[83],"mg/d":[84],"versus":[85],"Placebo.":[86],"Prim\u00e4rer":[87],"Endpunkt":[88],"war":[89,131],"das":[90],"progressionsfreie":[91],"\u00dcberleben":[92],"(PFS).":[93],"Ergebnis:":[94],"265":[95],"randomisiert.":[98],"Patientinnen-":[99],"Tumorcharakteristika":[101],"waren":[102],"zwischen":[103],"beiden":[104],"Armen":[105],"ausgeglichen.":[106],"An":[107],"Nebenwirkungen":[108],"h\u00e4ufiger":[110],"\u00dcbelkeit":[111],"(68%":[112],"vs.":[113,117,121,126,138,187],"35%),":[114],"Fatigue":[115],"(49%":[116],"38%),":[118],"Erbrechen":[119],"(32%":[120],"14%)":[122],"An\u00e4mie":[124],"(17%":[125],"5%)":[127],"berichtet.":[128],"Das":[129],"PFS":[130,191],"im":[132,190,213,251],"experimentellen":[133],"Arm":[134],"median":[136],"8,4":[137],"4,8":[139],"Monaten":[140,189],"signifikant":[141],"l\u00e4nger":[142],"(HR,":[143],"0,35;":[144],"95%":[145,194],"CI":[146,195],"0,25":[147],"\u2013":[148,197],"0,49;":[149],"p":[150,199],"<":[151,200],"0,001).":[152],"weiteren":[154],"BRCA":[158,173,234,249],"Status":[159],"(Keimbahn":[163],"Tumorgewebe).":[165],"Hierbei":[166],"zeigte":[167,178,204],"sich":[168,179,205],"136":[170],"Mutation.":[174],"Gruppe":[177],"signifikanter":[181,208],"Vorteil":[182,209],"durch":[183],"11,2":[186],"4,3":[188],"(HR":[192],"0,19;":[193],"0,11":[196],"0,32;":[198],"0,0001).":[201],"Des":[202],"Weiteren":[203],"auch":[206],"bzgl":[210],"Lebensqualit\u00e4t":[212],"TOI":[214],"(Trial":[215],"outcome":[216],"index).":[217],"Schlussfolgerung:":[218],"wirksam":[223],"platinsensiblem":[227],"insbesondere":[231],"wenn":[232],"Mutation":[235,250],"vorliegt.":[236],"AGO-OVAR":[239],"2,23/SOLO":[240],"2-Studie":[241],"(NCT01874353)":[242],"wird":[243],"Effektivit\u00e4t":[245],"Rahmen":[252],"einer":[253],"III-Studie":[255],"\u00fcberpr\u00fcft.":[256]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
