{"id":"https://openalex.org/W2332995911","doi":"https://doi.org/10.1021/ja208567v","title":"Ultrastable, Redispersible, Small, and Highly Organomodified Mesoporous Silica Nanotherapeutics","display_name":"Ultrastable, Redispersible, Small, and Highly Organomodified Mesoporous Silica Nanotherapeutics","publication_year":2011,"publication_date":"2011-11-03","ids":{"openalex":"https://openalex.org/W2332995911","doi":"https://doi.org/10.1021/ja208567v","mag":"2332995911","pmid":"https://pubmed.ncbi.nlm.nih.gov/22050408"},"language":"en","primary_location":{"id":"doi:10.1021/ja208567v","doi":"https://doi.org/10.1021/ja208567v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja208567v","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000010847","display_name":"Yu\u2010Shen Lin","orcid":"https://orcid.org/0009-0006-4939-951X","observed_orcids":["https://orcid.org/0009-0006-4939-951X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Shen Lin","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049251933","display_name":"Nardine S. Abadeer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nardine Abadeer","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033738177","display_name":"Katie R. Hurley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie R. Hurley","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051055962","display_name":"Christy L. Haynes","orcid":"https://orcid.org/0000-0002-5420-5867","observed_orcids":["https://orcid.org/0000-0002-5420-5867"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christy L. Haynes","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051055962"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.7421,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.97815162,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"133","issue":"50","first_page":"20444","last_page":"20457"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10735","display_name":"Mesoporous Materials and Catalysis","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10735","display_name":"Mesoporous Materials and Catalysis","score":0.8403000235557556,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.15639999508857727,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11852","display_name":"Clay minerals and soil interactions","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesoporous-silica-nanoparticles","display_name":"mesoporous silica nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/redispersibility","display_name":"redispersibility","score":0.7120000123977661},{"id":"https://openalex.org/keywords/nanoparticle-stability","display_name":"nanoparticle stability","score":0.824999988079071},{"id":"https://openalex.org/keywords/hydrothermal-synthesis","display_name":"hydrothermal synthesis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/doxorubicin-loading","display_name":"doxorubicin loading","score":0.7210000157356262},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.6949999928474426},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nanoparticle-aggregation","display_name":"nanoparticle aggregation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2777496208","wikidata":"https://www.wikidata.org/wiki/Q17156473","display_name":"Mesoporous silica","level":4,"score":0.769780695438385},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.7297329306602478},{"id":"https://openalex.org/C82776694","wikidata":"https://www.wikidata.org/wiki/Q380049","display_name":"Mesoporous material","level":3,"score":0.7287493944168091},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.6537677049636841},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6337199807167053},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.5632885694503784},{"id":"https://openalex.org/C5913796","wikidata":"https://www.wikidata.org/wiki/Q6821574","display_name":"Mesoporous organosilica","level":5,"score":0.5326221585273743},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.5051530003547668},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5022351741790771},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.49753764271736145},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.4463474154472351},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.41798102855682373},{"id":"https://openalex.org/C2777521759","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microparticle","level":2,"score":0.41220778226852417},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3389618396759033},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21396905183792114},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012822","descriptor_name":"Silicon Dioxide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ja208567v","doi":"https://doi.org/10.1021/ja208567v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ja208567v","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:22050408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22050408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320332748","display_name":"College of Science and Engineering, University of Minnesota","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1968293067","https://openalex.org/W1975139160","https://openalex.org/W1981199702","https://openalex.org/W2001168539","https://openalex.org/W2003229108","https://openalex.org/W2012302306","https://openalex.org/W2012867962","https://openalex.org/W2013328140","https://openalex.org/W2019336608","https://openalex.org/W2024638097","https://openalex.org/W2030178950","https://openalex.org/W2038379069","https://openalex.org/W2039630219","https://openalex.org/W2048056641","https://openalex.org/W2048734425","https://openalex.org/W2055182511","https://openalex.org/W2059996514","https://openalex.org/W2060887828","https://openalex.org/W2067882794","https://openalex.org/W2072864417","https://openalex.org/W2073641595","https://openalex.org/W2082990150","https://openalex.org/W2094005944","https://openalex.org/W2097853638","https://openalex.org/W2099108227","https://openalex.org/W2130994318","https://openalex.org/W2137167358","https://openalex.org/W2138861644","https://openalex.org/W2149307600","https://openalex.org/W2157313891","https://openalex.org/W2158155063","https://openalex.org/W2164060969","https://openalex.org/W2313641807","https://openalex.org/W2315865916","https://openalex.org/W3023255929"],"related_works":["https://openalex.org/W3083025319","https://openalex.org/W4405299666","https://openalex.org/W2038379069","https://openalex.org/W4400313940","https://openalex.org/W4416292606","https://openalex.org/W2159149391","https://openalex.org/W2107576380","https://openalex.org/W2317140633","https://openalex.org/W3004452006","https://openalex.org/W4405418811"],"abstract_inverted_index":{"Practical":[0],"biomedical":[1,215],"application":[2],"of":[3,32,107,148],"mesoporous":[4,29,49,125,133,163,206],"silica":[5,30,50,126,134,164,207],"nanoparticles":[6,31,51,169,191,208],"is":[7],"limited":[8],"by":[9,54],"poor":[10],"particle":[11],"dispersity":[12],"and":[13,38,67,71,94,123,131,152,166,204],"stability":[14],"due":[15],"to":[16,74,90,119,179,193],"serious":[17],"irreversible":[18],"aggregation":[19],"in":[20,78,97,140,174,213],"biological":[21,98],"media.":[22],"To":[23],"solve":[24],"this":[25,113],"problem,":[26],"hydrothermally":[27],"treated":[28],"small":[33,102,205],"size":[34,103],"with":[35,188],"dual-organosilane":[36],"(hydrophilic":[37],"hydrophobic":[39],"silane)":[40],"surface":[41],"modification":[42],"have":[43],"been":[44],"synthesized.":[45],"These":[46,197],"highly":[47,129,161,201],"organomodified":[48],"were":[52],"characterized":[53],"transmission":[55],"electron":[56],"microscopy,":[57],"X-ray":[58],"diffraction,":[59],"N(2)":[60],"adsorption-desorption,":[61],"dynamic":[62],"light":[63],"scattering,":[64],"zeta":[65],"potential,":[66],"solid-state":[68],"(29)Si":[69],"NMR,":[70],"they":[72,86],"prove":[73],"be":[75,88,117,157,172],"very":[76],"stable":[77,130,162],"simulated":[79],"body":[80],"fluid":[81],"at":[82,108],"physiological":[83],"temperature.":[84],"Additionally,":[85],"can":[87,116,156,170],"dried":[89],"a":[91,105],"powdered":[92],"solid":[93],"easily":[95],"redispersed":[96],"media,":[99],"maintaining":[100],"their":[101],"for":[104,212],"period":[106],"least":[109],"15":[110],"days.":[111],"Furthermore,":[112],"preparation":[114],"method":[115],"expanded":[118],"synthesize":[120],"redispersible":[121,132],"fluorescent":[122],"magnetic":[124],"nanoparticles.":[127],"The":[128],"NPs":[135],"show":[136],"minimal":[137],"toxicity":[138],"during":[139],"vitro":[141],"cellular":[142],"assays.":[143],"Most":[144],"importantly,":[145],"two":[146],"types":[147],"doxorubicin,":[149,155],"water-soluble":[150,154,189,195],"doxorubicin":[151],"poorly":[153],"loaded":[158],"into":[159],"these":[160,167],"nanoparticles,":[165],"drug-loaded":[168],"also":[171],"well-redispersed":[173],"aqueous":[175],"solution.":[176],"Enhanced":[177],"cytotoxicity":[178],"cervical":[180],"cancer":[181],"(HeLa)":[182],"cells":[183],"was":[184],"found":[185],"upon":[186],"treatment":[187],"doxorubicin-loaded":[190],"compared":[192],"free":[194],"doxorubicin.":[196],"results":[198],"suggest":[199],"that":[200],"stable,":[202],"redispersible,":[203],"are":[209],"promising":[210],"agents":[211],"vivo":[214],"applications.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
